TNFalpha promotes osteogenic differentiation of human mesenchymal stem cells by triggering the NF-kappaB signaling pathway.

[1]  Y. Min,et al.  Baicalein stimulates osteoblast differentiation via coordinating activation of MAP kinases and transcription factors , 2008, Journal of cellular biochemistry.

[2]  D. Docheva,et al.  IKK-2 is required for TNF-α-induced invasion and proliferation of human mesenchymal stem cells , 2008, Journal of Molecular Medicine.

[3]  S. Tuck,et al.  The cell biology of bone metabolism , 2008, Journal of Clinical Pathology.

[4]  F. De Luca,et al.  Nuclear Factor-κB p65 Facilitates Longitudinal Bone Growth by Inducing Growth Plate Chondrocyte Proliferation and Differentiation and by Preventing Apoptosis* , 2007, Journal of Biological Chemistry.

[5]  T. Wirth,et al.  BOB.1/OBF.1 controls the balance of TH1 and TH2 immune responses , 2007, The EMBO journal.

[6]  T. Wirth,et al.  Constitutive IKK2 activation in acinar cells is sufficient to induce pancreatitis in vivo. , 2007, The Journal of clinical investigation.

[7]  A. Cowin,et al.  TNF‐α Mediates p38 MAP Kinase Activation and Negatively Regulates Bone Formation at the Injured Growth Plate in Rats , 2006, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[8]  K. Matsushima,et al.  Regulation of ALP Activity by TNF-α on Human Dental Pulp , 2006 .

[9]  A. Bertone,et al.  Gene‐mediated osteogenic differentiation of stem cells by bone morphogenetic proteins‐2 or ‐6 , 2006, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[10]  J. Rubin,et al.  Transcriptional Regulation of the Osterix (Osx, Sp7) Promoter by Tumor Necrosis Factor Identifies Disparate Effects of Mitogen-activated Protein Kinase and NFκB Pathways* , 2006, Journal of Biological Chemistry.

[11]  M. T. Hasan,et al.  IKK mediates ischemia-induced neuronal death , 2005, Nature Medicine.

[12]  H. Hondermarck,et al.  The antiapoptotic effect of fibroblast growth factor-2 is mediated through nuclear factor-κB activation induced via interaction between Akt and IκB kinase-β in breast cancer cells , 2005, Oncogene.

[13]  Z. Ungvari,et al.  Regulation of Bone Morphogenetic Protein-2 Expression in Endothelial Cells , 2005 .

[14]  A. Parfitt,et al.  Rosiglitazone causes bone loss in mice by suppressing osteoblast differentiation and bone formation. , 2005, Endocrinology.

[15]  Weihua Xiao Advances in NF-kappaB signaling transduction and transcription. , 2004, Cellular & molecular immunology.

[16]  Jörg Fiedler,et al.  To go or not to go: Migration of human mesenchymal progenitor cells stimulated by isoforms of PDGF , 2004, Journal of cellular biochemistry.

[17]  Su‐Li Cheng,et al.  αvβ Integrins Play an Essential Role in BMP‐2 Induction of Osteoblast Differentiation , 2004 .

[18]  Pingping Shen,et al.  NF-kappaB and its regulation on the immune system. , 2004, Cellular & molecular immunology.

[19]  Andreas Sommer,et al.  NF-κB is essential for epithelial-mesenchymal transition and metastasis in a model of breast cancer progression , 2004 .

[20]  R. Brenner,et al.  Identification of subpopulations with characteristics of mesenchymal progenitor cells from human osteoarthritic cartilage using triple staining for cell surface markers , 2004, Arthritis research & therapy.

[21]  M. Karin,et al.  The two NF-κB activation pathways and their role in innate and adaptive immunity , 2004 .

[22]  Hang Zheng,et al.  Oxidative stress inhibits osteoblastic differentiation of bone cells by ERK and NF-kappaB. , 2004, Biochemical and biophysical research communications.

[23]  Harald J. Maier,et al.  Critical Role of RelB Serine 368 for Dimerization and p100 Stabilization* , 2003, Journal of Biological Chemistry.

[24]  A. Baldwin,et al.  NF-κB mediates inhibition of mesenchymal cell differentiation through a posttranscriptional gene silencing mechanism , 2003 .

[25]  Hyo-Sang Park,et al.  BMP-2-induced Osterix expression is mediated by Dlx5 but is independent of Runx2. , 2003, Biochemical and biophysical research communications.

[26]  Di Chen,et al.  NF-κB Specifically Activates BMP-2 Gene Expression in Growth Plate Chondrocytes in Vivo and in a Chondrocyte Cell Line in Vitro* , 2003, Journal of Biological Chemistry.

[27]  W. Maloney,et al.  Stimulation of BMP-2 Expression by Pro-Inflammatory Cytokines IL-1 and TNF-&agr; in Normal and Osteoarthritic Chondrocytes , 2003, The Journal of bone and joint surgery. American volume.

[28]  J. Clohisy,et al.  Tumor necrosis factor-α inhibits pre-osteoblast differentiation through its type-1 receptor , 2003 .

[29]  M. Caligiuri,et al.  Tumor Necrosis Factor-regulated Biphasic Activation of NF-κB Is Required for Cytokine-induced Loss of Skeletal Muscle Gene Products* , 2002, The Journal of Biological Chemistry.

[30]  H. Yoshikawa,et al.  Continuous Inhibition of MAPK Signaling Promotes the Early Osteoblastic Differentiation and Mineralization of the Extracellular Matrix , 2002, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[31]  E. Schwarz,et al.  Malignant reversion of a human osteosarcoma cell line, Saos-2, by inhibition of NFkappaB. , 2002, Biochemical and biophysical research communications.

[32]  G. Stein,et al.  Expression of the Osteoblast Differentiation Factor RUNX2 (Cbfa1/AML3/Pebp2αA) Is Inhibited by Tumor Necrosis Factor-α* , 2002, The Journal of Biological Chemistry.

[33]  T. Wirth,et al.  The IKK-2/Ikappa Balpha /NF-kappa B pathway plays a key role in the regulation of CCR3 and eotaxin-1 in fibroblasts. A critical link to dermatitis in Ikappa Balpha -deficient mice. , 2002, The Journal of biological chemistry.

[34]  J. Deng,et al.  The Novel Zinc Finger-Containing Transcription Factor Osterix Is Required for Osteoblast Differentiation and Bone Formation , 2002, Cell.

[35]  Jörg Fiedler,et al.  BMP‐2, BMP‐4, and PDGF‐bb stimulate chemotactic migration of primary human mesenchymal progenitor cells , 2002, Journal of cellular biochemistry.

[36]  G. Hotamisligil,et al.  Signaling pathways utilized by tumor necrosis factor receptor 1 in adipocytes to suppress differentiation , 2001, FEBS letters.

[37]  T. Wirth,et al.  Activation of NF-κB via the IκB Kinase Complex Is Both Essential and Sufficient for Proinflammatory Gene Expression in Primary Endothelial Cells* , 2001, The Journal of Biological Chemistry.

[38]  Yueqin Liu,et al.  The Role of Phosphatidylinositol 3-Kinase and the Mitogen-Activated Protein Kinases in Insulin-Like Growth Factor-I-Mediated Effects in Vascular Endothelial Cells. , 2001, Endocrinology.

[39]  E. Wouters,et al.  Inflammatory Cytokines Inhibit Myogenic Differentiation through Activation of Nuclear Factor-␬b , 2022 .

[40]  Xiaofei He,et al.  Inhibition of Osteoblast Differentiation by Tumor Necrosis Factor-α. , 2000, Endocrinology.

[41]  Yi-Ping Li,et al.  NF-κB mediates the protein loss induced by TNF-α in differentiated skeletal muscle myotubes , 2000 .

[42]  C. Y. Wang,et al.  NF-kappaB-induced loss of MyoD messenger RNA: possible role in muscle decay and cachexia. , 2000, Science.

[43]  R. Deans,et al.  Mesenchymal stem cells: biology and potential clinical uses. , 2000, Experimental hematology.

[44]  V. Lefebvre,et al.  Potent Inhibition of the Master Chondrogenic FactorSox9 Gene by Interleukin-1 and Tumor Necrosis Factor-α* , 2000, The Journal of Biological Chemistry.

[45]  F. Berberich-Siebelt,et al.  A1 expression is stimulated by CD40 in B cells and rescues WEHI 231 cells from anti‐IgM‐induced cell death , 1999, European journal of immunology.

[46]  A. Valentin‐Opran,et al.  Clinical evaluation of rhBMP-2/ACS in orthopedic trauma: a progress report. , 1999, Orthopedics.

[47]  K. Miyazono,et al.  Extracellular matrix-associated bone morphogenetic proteins are essential for differentiation of murine osteoblastic cells in vitro. , 1999, Endocrinology.

[48]  M. Pittenger,et al.  Multilineage potential of adult human mesenchymal stem cells. , 1999, Science.

[49]  R. Tuan,et al.  Mechanism of BMP‐2 stimulated adhesion of osteoblastic cells to titanium alloy , 1999, Biology of the cell.

[50]  S. Wilson,et al.  Bone morphogenic proteins 2 and 4 and their receptors in the adult human cornea. , 1998, Investigative ophthalmology & visual science.

[51]  M. Karin,et al.  The NF-kappa B activation pathway: its regulation and role in inflammation and cell survival. , 1998, The cancer journal from Scientific American.

[52]  J. Wozney The bone morphogenetic protein family: multifunctional cellular regulators in the embryo and adult. , 1998, European journal of oral sciences.

[53]  M J May,et al.  NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses. , 1998, Annual review of immunology.

[54]  V. Rosen,et al.  Bone morphogenetic protein and bone morphogenetic protein gene family in bone formation and repair. , 1998, Clinical orthopaedics and related research.

[55]  F. Lecanda,et al.  Regulation of bone matrix protein expression and induction of differentiation of human osteoblasts and human bone marrow stromal cells by bone morphogenetic protein‐2 , 1997, Journal of cellular biochemistry.

[56]  S. Gronthos,et al.  Integrin Expression and Function on Human Osteoblast‐like Cells , 1997, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[57]  S. Mundlos,et al.  Cbfa1, a Candidate Gene for Cleidocranial Dysplasia Syndrome, Is Essential for Osteoblast Differentiation and Bone Development , 1997, Cell.

[58]  Makoto Sato,et al.  Targeted Disruption of Cbfa1 Results in a Complete Lack of Bone Formation owing to Maturational Arrest of Osteoblasts , 1997, Cell.

[59]  G. Karsenty,et al.  Osf2/Cbfa1: A Transcriptional Activator of Osteoblast Differentiation , 1997, Cell.

[60]  David Baltimore,et al.  NF-κB: Ten Years After , 1996, Cell.

[61]  M. Schwartz,et al.  The regulation of growth and intracellular signaling by integrins. , 1996, Endocrine reviews.

[62]  V. Rosen,et al.  Bone morphogenetic protein-2 converts the differentiation pathway of C2C12 myoblasts into the osteoblast lineage [published erratum appears in J Cell Biol 1995 Feb;128(4):following 713] , 1994, The Journal of cell biology.

[63]  A I Caplan,et al.  The mesengenic process. , 1994, Clinics in plastic surgery.

[64]  W. Grzesik,et al.  Bone matrix RGD glycoproteins: Immunolocalization and interaction with human primary osteoblastic bone cells in vitro , 1994, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[65]  S. Dedhar,et al.  Integrin expression in human bone , 1993, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[66]  F M Watt,et al.  Regulation of development and differentiation by the extracellular matrix. , 1993, Development.

[67]  E. Wang,et al.  Bone morphogenetic protein-2 causes commitment and differentiation in C3H10T1/2 and 3T3 cells. , 1993, Growth factors.

[68]  R. Dodds,et al.  Integrin subunit expression by human osteoblasts and osteoclasts in situ and in culture. , 1992, Journal of cell science.

[69]  V. Rosen,et al.  The healing of segmental bone defects, induced by recombinant human bone morphogenetic protein (rhBMP-2). A radiographic, histological, and biomechanical study in rats. , 1992, The Journal of bone and joint surgery. American volume.

[70]  V. Rosen,et al.  Recombinant human bone morphogenetic protein-2 stimulates osteoblastic maturation and inhibits myogenic differentiation in vitro , 1991, The Journal of cell biology.

[71]  V. Rosen,et al.  The non-osteogenic mouse pluripotent cell line, C3H10T1/2, is induced to differentiate into osteoblastic cells by recombinant human bone morphogenetic protein-2. , 1990, Biochemical and biophysical research communications.

[72]  R. Roeder,et al.  Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. , 1983, Nucleic acids research.