论文信息 - Depth-resolved monitoring of glucose diffusion in tissues by using optical coherence tomography.

Depth-resolved monitoring of glucose diffusion in tissues by using optical coherence tomography.

We demonstrate the capability of the optical coherence tomography (OCT) technique for depth-resolved monitoring and quantifying of glucose diffusion in fibrous tissues (sclera). The depth-resolved and average permeability coefficients of glucose were calculated. We found that the glucose diffusion rate is not uniform throughout the tissue and is increased from approximately 2.39+/-0.73 x 10(-6) cm/s at the epithelial side to 8.63+/-0.27 x 10(-6) cm/s close to the endothelial side of the sclera. Results demonstrated that the OCT technique is capable of depth-resolved monitoring and quantification of glucose diffusion in sclera with a resolution of approximately 40 mum.

[1] M. Prausnitz,et al. Fiber matrix model of sclera and corneal stroma for drug delivery to the eye , 1998 .

[2] Valery V. Tuchin,et al. Optical clearing of tissues and blood using the immersion method , 2005 .

[3] T. Ushiki,et al. The three-dimensional organization of collagen fibrils in the human cornea and sclera. , 1991, Investigative ophthalmology & visual science.

[4] Valery V. Tuchin,et al. Optical Clearing of Tissues and Blood , 2005 .

[5] J. Fujimoto,et al. Optical Coherence Tomography , 1991 .

[6] M. Prausnitz,et al. Permeability of cornea, sclera, and conjunctiva: a literature analysis for drug delivery to the eye. , 1998, Journal of pharmaceutical sciences.

[7] R. Esenaliev,et al. Noninvasive monitoring of glucose concentration with optical coherence tomography , 2001 .

[8] J. Stuart Nelson,et al. Measuring the effects of topically applied skin optical clearing agents and modeling the effects and consequences for laser therapies , 2005, SPIE BiOS.