Physical Activity/Exercise and Diabetes: A Position Statement of the American Diabetes Association

The adoption and maintenance of physical activity are critical foci for blood glucose management and overall health in individuals with diabetes and prediabetes. Recommendations and precautions vary depending on individual characteristics and health status. In this Position Statement, we provide a clinically oriented review and evidence-based recommendations regarding physical activity and exercise in people with type 1 diabetes, type 2 diabetes, gestational diabetes mellitus, and prediabetes. Physical activity includes all movement that increases energy use, whereas exercise is planned, structured physical activity. Exercise improves blood glucose control in type 2 diabetes, reduces cardiovascular risk factors, contributes to weight loss, and improves well-being (1,2). Regular exercise may prevent or delay type 2 diabetes development (3). Regular exercise also has considerable health benefits for people with type 1 diabetes (e.g., improved cardiovascular fitness, muscle strength, insulin sensitivity, etc.) (4). The challenges related to blood glucose management vary with diabetes type, activity type, and presence of diabetes-related complications (5,6). Physical activity and exercise recommendations, therefore, should be tailored to meet the specific needs of each individual. Physical activity recommendations and precautions may vary by diabetes type. The primary types of diabetes are type 1 and type 2. Type 1 diabetes (5%–10% of cases) results from cellular-mediated autoimmune destruction of the pancreatic β-cells, producing insulin deficiency (7). Although it can occur at any age, β-cell destruction rates vary, typically occurring more rapidly in youth than in adults. Type 2 diabetes (90%–95% of cases) results from a progressive loss of insulin secretion, usually also with insulin resistance. Gestational diabetes mellitus occurs during pregnancy, with screening typically occurring at 24–28 weeks of gestation in pregnant women not previously known to have diabetes. Prediabetes is diagnosed when blood glucose levels are above the normal range but not high enough to be classified as …

[1]  Physical Activity and Exercise During Pregnancy and the Postpartum Period: ACOG Committee Opinion, Number 804. , 2020, Obstetrics and gynecology.

[2]  R. MacIsaac,et al.  Does a single bout of resistance or aerobic exercise after insulin dose reduction modulate glycaemic control in type 2 diabetes? A randomised cross-over trial. , 2016, Journal of science and medicine in sport.

[3]  J. Kavookjian,et al.  Motivational interviewing and outcomes in adults with type 2 diabetes: A systematic review. , 2016, Patient education and counseling.

[4]  David W. Dunstan,et al.  Benefits for Type 2 Diabetes of Interrupting Prolonged Sitting With Brief Bouts of Light Walking or Simple Resistance Activities , 2016, Diabetes Care.

[5]  S. Bain,et al.  Algorithm that delivers an individualized rapid‐acting insulin dose after morning resistance exercise counters post‐exercise hyperglycaemia in people with Type 1 diabetes , 2016, Diabetic medicine : a journal of the British Diabetic Association.

[6]  R. Bracken,et al.  Similar magnitude of post‐exercise hyperglycemia despite manipulating resistance exercise intensity in type 1 diabetes individuals , 2016, Scandinavian journal of medicine & science in sports.

[7]  B. Sternfeld,et al.  Moderate and Vigorous Intensity Exercise During Pregnancy and Gestational Weight Gain in Women with Gestational Diabetes , 2016, Maternal and Child Health Journal.

[8]  R. Mermelstein,et al.  Association Between Daily Time Spent in Sedentary Behavior and Duration of Hyperglycemia in Type 2 Diabetes , 2016, Biological research for nursing.

[9]  C. Stettler,et al.  Accuracy of continuous glucose monitoring during differing exercise conditions. , 2016, Diabetes research and clinical practice.

[10]  T. Jones,et al.  Effect of Exercise Intensity on Glucose Requirements to Maintain Euglycemia During Exercise in Type 1 Diabetes. , 2016, The Journal of clinical endocrinology and metabolism.

[11]  K. Innes,et al.  Yoga for Adults with Type 2 Diabetes: A Systematic Review of Controlled Trials , 2015, Journal of diabetes research.

[12]  David G. Behm,et al.  Acute effects of muscle stretching on physical performance, range of motion, and injury incidence in healthy active individuals: a systematic review. , 2016, Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme.

[13]  J. Polańska,et al.  Reasons for the discontinuation of therapy of personal insulin pump in children with type 1 diabetes. , 2016, Pediatric endocrinology, diabetes, and metabolism.

[14]  Chris Boesch,et al.  Metabolic and hormonal response to intermittent high-intensity and continuous moderate intensity exercise in individuals with type 1 diabetes: a randomised crossover study , 2016, Diabetologia.

[15]  L. Spriet,et al.  CrossTalk opposing view: High intensity interval training does not have a role in risk reduction or treatment of disease , 2015, The Journal of physiology.

[16]  Kamlesh Khunti,et al.  Breaking Up Prolonged Sitting With Standing or Walking Attenuates the Postprandial Metabolic Response in Postmenopausal Women: A Randomized Acute Study , 2015, Diabetes Care.

[17]  Jill L Cook,et al.  Is there an association between tendinopathy and diabetes mellitus? A systematic review with meta-analysis , 2015, British Journal of Sports Medicine.

[18]  J. Cook,et al.  Does type 1 diabetes mellitus affect Achilles tendon response to a 10 km run? A case control study , 2015, BMC Musculoskeletal Disorders.

[19]  K Khunti,et al.  The effects of high‐intensity interval training on glucose regulation and insulin resistance: a meta‐analysis , 2015, Obesity reviews : an official journal of the International Association for the Study of Obesity.

[20]  B. Franklin,et al.  Updating ACSM's Recommendations for Exercise Preparticipation Health Screening. , 2015, Medicine and science in sports and exercise.

[21]  G. Charpentier,et al.  Insulin‐based strategies to prevent hypoglycaemia during and after exercise in adult patients with type 1 diabetes on pump therapy: the DIABRASPORT randomized study , 2015, Diabetes, obesity & metabolism.

[22]  P. Remington,et al.  Combined Diet and Physical Activity Promotion Programs to Prevent Type 2 Diabetes Among Persons at Increased Risk: A Systematic Review for the Community Preventive Services Task Force , 2015, Annals of Internal Medicine.

[23]  J. Jendle,et al.  Evaluation of glucose control when a new strategy of increased carbohydrate supply is implemented during prolonged physical exercise in type 1 diabetes , 2015, European Journal of Applied Physiology.

[24]  T. Pieber,et al.  Effects of High-Intensity Interval Exercise versus Moderate Continuous Exercise on Glucose Homeostasis and Hormone Response in Patients with Type 1 Diabetes Mellitus Using Novel Ultra-Long-Acting Insulin , 2015, PloS one.

[25]  A. García-Hermoso,et al.  Effectiveness of physical activity interventions on preventing gestational diabetes mellitus and excessive maternal weight gain: a meta‐analysis , 2015, BJOG : an international journal of obstetrics and gynaecology.

[26]  Alan M. Batterham,et al.  High-intensity interval exercise training for public health: a big HIT or shall we HIT it on the head? , 2015, International Journal of Behavioral Nutrition and Physical Activity.

[27]  J. Shaw,et al.  Breaking up of prolonged sitting over three days sustains, but does not enhance, lowering of postprandial plasma glucose and insulin in overweight and obese adults. , 2015, Clinical science.

[28]  Asker E. Jeukendrup,et al.  Acute Effects of Carbohydrate Supplementation on Intermittent Sports Performance , 2015, Nutrients.

[29]  Simin Liu,et al.  Effects of Exercise Training on Cardiorespiratory Fitness and Biomarkers of Cardiometabolic Health: A Systematic Review and Meta-Analysis of Randomized Controlled Trials , 2015, Journal of the American Heart Association.

[30]  C. Cobelli,et al.  Exercise effects on postprandial glucose metabolism in type 1 diabetes: a triple-tracer approach. , 2015, American journal of physiology. Endocrinology and metabolism.

[31]  M. Walker,et al.  Insulin therapy and dietary adjustments to normalize glycemia and prevent nocturnal hypoglycemia after evening exercise in type 1 diabetes: a randomized controlled trial , 2015, BMJ Open Diabetes Research and Care.

[32]  M. P. Francescato,et al.  Prolonged Exercise in Type 1 Diabetes: Performance of a Customizable Algorithm to Estimate the Carbohydrate Supplements to Minimize Glycemic Imbalances , 2015, PloS one.

[33]  P. Foley,et al.  Simulated games activity versus continuous running exercise: a novel comparison of the glycaemic and metabolic responses in T1DM patients , 2013 .

[34]  M. Riddell,et al.  The "ups" and "downs" of a bike race in people with type 1 diabetes: dramatic differences in strategies and blood glucose responses in the Paris-to-Ancaster Spring Classic. , 2015, Canadian journal of diabetes.

[35]  F. Sniehotta,et al.  Successful behavioural strategies to increase physical activity and improve glucose control in adults with Type 2 diabetes , 2015, Diabetic medicine : a journal of the British Diabetic Association.

[36]  E. Pimentel,et al.  Structural and biomechanical changes in the Achilles tendon after chronic treatment with statins. , 2015, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[37]  B. Whitcomb,et al.  Physical Activity Interventions in Pregnancy and Risk of Gestational Diabetes Mellitus: A Systematic Review and Meta-analysis , 2015, Obstetrics and gynecology.

[38]  S. Bus,et al.  Predictors of Barefoot Plantar Pressure during Walking in Patients with Diabetes, Peripheral Neuropathy and a History of Ulceration , 2015, PloS one.

[39]  M. Campbell,et al.  Impact of single and multiple sets of resistance exercise in type 1 diabetes , 2015, Scandinavian journal of medicine & science in sports.

[40]  J. Kuang,et al.  Effect of lifestyle intervention in patients with type 2 diabetes: a meta-analysis. , 2015, Metabolism: clinical and experimental.

[41]  D. Gordin,et al.  Leisure-time physical activity and development and progression of diabetic nephropathy in type 1 diabetes: the FinnDiane Study , 2015, Diabetologia.

[42]  R. Hovorka,et al.  Quantifying the Acute Changes in Glucose with Exercise in Type 1 Diabetes: A Systematic Review and Meta-Analysis , 2015, Sports Medicine.

[43]  D. Alter,et al.  Sedentary Time and Its Association With Risk for Disease Incidence, Mortality, and Hospitalization in Adults , 2015, Annals of Internal Medicine.

[44]  C. S. Shaw,et al.  What Doesn’t Kill You Makes You Fitter: A Systematic Review of High-Intensity Interval Exercise for Patients with Cardiovascular and Metabolic Diseases , 2015, Clinical Medicine Insights. Cardiology.

[45]  M. Riddell,et al.  Prevention of Exercise-Associated Dysglycemia: A Case Study–Based Approach , 2015, Diabetes Spectrum.

[46]  J K Mader,et al.  Accuracy of two continuous glucose monitoring systems: a head-to-head comparison under clinical research centre and daily life conditions , 2014, Diabetes, obesity & metabolism.

[47]  J. McGavock,et al.  A systematic review and meta-analysis of exercise interventions in adults with type 1 diabetes. , 2014, Diabetes research and clinical practice.

[48]  R. Sigal,et al.  Impairments in local heat loss in type 1 diabetes during exercise in the heat. , 2014, Medicine and science in sports and exercise.

[49]  B. Frier Hypoglycaemia in diabetes mellitus: epidemiology and clinical implications , 2014, Nature Reviews Endocrinology.

[50]  N. Owen,et al.  Alternating bouts of sitting and standing attenuate postprandial glucose responses. , 2014, Medicine and science in sports and exercise.

[51]  Sofia Dahlqvist,et al.  A clinical trial of the accuracy and treatment experience of the Dexcom G4 sensor (Dexcom G4 system) and Enlite sensor (guardian REAL-time system) tested simultaneously in ambulatory patients with type 1 diabetes. , 2014, Diabetes technology & therapeutics.

[52]  F. Greenway,et al.  Effect of a long-term behavioural weight loss intervention on nephropathy in overweight or obese adults with type 2 diabetes: a secondary analysis of the Look AHEAD randomised clinical trial. , 2014, The lancet. Diabetes & endocrinology.

[53]  X. Pi-Sunyer The Look AHEAD Trial: A Review and Discussion of Its Outcomes , 2014, Current Nutrition Reports.

[54]  Elizabeth J Lyons,et al.  Behavior Change Techniques Implemented in Electronic Lifestyle Activity Monitors: A Systematic Content Analysis , 2014, Journal of medical Internet research.

[55]  David W Dunstan,et al.  Managing Sedentary Behavior to Reduce the Risk of Diabetes and Cardiovascular Disease , 2014, Current Diabetes Reports.

[56]  M. Walker,et al.  Metabolic Implications when Employing Heavy Pre- and Post-Exercise Rapid-Acting Insulin Reductions to Prevent Hypoglycaemia in Type 1 Diabetes Patients: A Randomised Clinical Trial , 2014, PloS one.

[57]  N. Mutrie,et al.  A systematic review of physical activity and sedentary behavior intervention studies in youth with type 1 diabetes: study characteristics, intervention design, and efficacy , 2014, Pediatric diabetes.

[58]  Hirofumi Tanaka,et al.  Continuous vs interval training on glycemic control and macro‐ and microvascular reactivity in type 2 diabetic patients , 2014, Scandinavian journal of medicine & science in sports.

[59]  K. Khunti,et al.  Diabetes Prevention in the Real World: Effectiveness of Pragmatic Lifestyle Interventions for the Prevention of Type 2 Diabetes and of the Impact of Adherence to Guideline Recommendations , 2014, Diabetes Care.

[60]  S. Qiu,et al.  Step counter use in type 2 diabetes: a meta-analysis of randomized controlled trials , 2014, BMC Medicine.

[61]  D. Klonoff,et al.  Hypoglycemia begets hypoglycemia: the order effect in the ASPIRE in-clinic study. , 2014, Diabetes technology & therapeutics.

[62]  Jennette P. Moreno,et al.  Cardiovascular Effects of Intensive Lifestyle Intervention in Type 2 Diabetes , 2014, Current Atherosclerosis Reports.

[63]  A. Vinik,et al.  Exercising With Peripheral or Autonomic Neuropathy: What Health Care Providers and Diabetic Patients Need to Know , 2014, The Physician and sportsmedicine.

[64]  B. Kestenbaum,et al.  Physical activity and change in estimated GFR among persons with CKD. , 2014, Journal of the American Society of Nephrology : JASN.

[65]  A. Farmer,et al.  Resistance Exercise Versus Aerobic Exercise for Type 2 Diabetes: A Systematic Review and Meta-Analysis , 2014, Sports Medicine.

[66]  L. Jovanovič,et al.  Prescribing physical activity to prevent and manage gestational diabetes. , 2013, World journal of diabetes.

[67]  J. Buckley,et al.  Standing-based office work shows encouraging signs of attenuating post-prandial glycaemic excursion , 2013, Occupational and Environmental Medicine.

[68]  S MacRury,et al.  The use of technology to promote physical activity in Type 2 diabetes management: a systematic review , 2013, Diabetic medicine : a journal of the British Diabetic Association.

[69]  Fernando Martín-Sánchez,et al.  Health outcomes and related effects of using social media in chronic disease management: A literature review and analysis of affordances , 2013, J. Biomed. Informatics.

[70]  H. P. van der Ploeg,et al.  Daily Sitting Time and All-Cause Mortality: A Meta-Analysis , 2013, PloS one.

[71]  B. Vandermeer,et al.  Lifestyle Interventions for Patients With and at Risk for Type 2 Diabetes , 2013, Annals of Internal Medicine.

[72]  Federico Schena,et al.  Both resistance training and aerobic training reduce hepatic fat content in type 2 diabetic subjects with nonalcoholic fatty liver disease (the RAED2 randomized trial) , 2013, Hepatology.

[73]  F. Hartgens,et al.  Effect of Moderate-Intensity Exercise Versus Activities of Daily Living on 24-Hour Blood Glucose Homeostasis in Male Patients With Type 2 Diabetes , 2013, Diabetes Care.

[74]  A. Gribok,et al.  Three 15-min Bouts of Moderate Postmeal Walking Significantly Improves 24-h Glycemic Control in Older People at Risk for Impaired Glucose Tolerance , 2013, Diabetes Care.

[75]  Kelly M. Naugle,et al.  Obesity and diabetes as accelerators of functional decline: Can lifestyle interventions maintain functional status in high risk older adults? , 2013, Experimental Gerontology.

[76]  R. Sigal,et al.  Whole-body heat loss during exercise in the heat is not impaired in type 1 diabetes. , 2013, Medicine and science in sports and exercise.

[77]  J. Horowitz,et al.  A Single Session of Low-Intensity Exercise Is Sufficient to Enhance Insulin Sensitivity Into the Next Day in Obese Adults , 2013, Diabetes Care.

[78]  R. Sigal,et al.  Do heat events pose a greater health risk for individuals with type 2 diabetes? , 2013, Diabetes technology & therapeutics.

[79]  D. Reeds,et al.  A ~60-min brisk walk increases insulin-stimulated glucose disposal but has no effect on hepatic and adipose tissue insulin sensitivity in older women. , 2013, Journal of applied physiology.

[80]  E. Renard,et al.  Accuracy assessment of online glucose monitoring by a subcutaneous enzymatic glucose sensor during exercise in patients with type 1 diabetes treated by continuous subcutaneous insulin infusion. , 2013, Diabetes & metabolism.

[81]  R. Sigal,et al.  Is whole-body thermoregulatory function impaired in type 1 diabetes mellitus? , 2013, Current diabetes reviews.

[82]  Catrine Tudor-Locke,et al.  A step-defined sedentary lifestyle index: <5000 steps/day. , 2013, Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme.

[83]  Ahmad Haidar,et al.  Evaluating the accuracy and large inaccuracy of two continuous glucose monitoring systems. , 2013, Diabetes technology & therapeutics.

[84]  Ronald J Sigal,et al.  Insulin pump therapy is associated with less post-exercise hyperglycemia than multiple daily injections: an observational study of physically active type 1 diabetes patients. , 2013, Diabetes technology & therapeutics.

[85]  Ronald J Sigal,et al.  Point accuracy of interstitial continuous glucose monitoring during exercise in type 1 diabetes. , 2013, Diabetes technology & therapeutics.

[86]  S. Weisnagel,et al.  Glucose or intermittent high-intensity exercise in glargine/glulisine users with T1DM. , 2013, Medicine and science in sports and exercise.

[87]  A. Hevener,et al.  Metabolic syndrome and insulin resistance: underlying causes and modification by exercise training. , 2013, Comprehensive Physiology.

[88]  S. Berthoin,et al.  Effects of Different Types of Acute and Chronic (Training) Exercise on Glycaemic Control in Type 1 Diabetes Mellitus , 2012, Sports Medicine.

[89]  R. Song,et al.  Effects of Tai Chi Exercise on glucose control, neuropathy scores, balance, and quality of life in patients with type 2 diabetes and neuropathy. , 2012, Journal of alternative and complementary medicine.

[90]  Darren Flynn,et al.  Changing Physical Activity Behavior in Type 2 Diabetes , 2012, Diabetes Care.

[91]  Claudio Cobelli,et al.  The Effect of Walking on Postprandial Glycemic Excursion in Patients With Type 1 Diabetes and Healthy People , 2012, Diabetes Care.

[92]  U. Nöthlings,et al.  Physical Activity and Mortality in Individuals With Diabetes Mellitus: A Prospective Study and Meta-analysis. , 2012, Archives of internal medicine.

[93]  T. Jones,et al.  The effect of a short sprint on postexercise whole-body glucose production and utilization rates in individuals with type 1 diabetes mellitus. , 2012, The Journal of clinical endocrinology and metabolism.

[94]  Comparison of Glucose Monitoring Methods during Steady-State Exercise in Women , 2012, Nutrients.

[95]  K. Khunti,et al.  Sedentary time in adults and the association with diabetes, cardiovascular disease and death: systematic review and meta-analysis , 2012, Diabetologia.

[96]  D. Nathan,et al.  A clinical trial to maintain glycemic control in youth with type 2 diabetes. , 2012, The New England journal of medicine.

[97]  M. Tarnopolsky,et al.  Acute high‐intensity interval exercise reduces the postprandial glucose response and prevalence of hyperglycaemia in patients with type 2 diabetes , 2012, Diabetes, obesity & metabolism.

[98]  V. Rousson,et al.  Exercise dose and insulin sensitivity: relevance for diabetes prevention. , 2012, Medicine and science in sports and exercise.

[99]  J. Shaw,et al.  Breaking Up Prolonged Sitting Reduces Postprandial Glucose and Insulin Responses , 2012, Diabetes Care.

[100]  M. Ristow,et al.  Improvement of HbA1c and stable weight loss 2 years after an outpatient treatment and teaching program for patients with type 2 diabetes without insulin therapy based on urine glucose self-monitoring , 2012, International journal of general medicine.

[101]  R. Sigal,et al.  Effects of Performing Resistance Exercise Before Versus After Aerobic Exercise on Glycemia in Type 1 Diabetes , 2012, Diabetes Care.

[102]  P. Fournier,et al.  Is the response of continuous glucose monitors to physiological changes in blood glucose levels affected by sensor life? , 2012, Diabetes technology & therapeutics.

[103]  E. Barrett-Connor,et al.  Resistance Versus Aerobic Exercise Acute effects on glycemia in type 1 diabetes , 2012 .

[104]  T. Pang,et al.  What are the health benefits of physical activity in type 1 diabetes mellitus? A literature review , 2012, Diabetologia.

[105]  M. Tarnopolsky,et al.  Low-volume high-intensity interval training reduces hyperglycemia and increases muscle mitochondrial capacity in patients with type 2 diabetes. , 2011, Journal of applied physiology.

[106]  K. Fukao,et al.  Impact of diabetes on muscle mass, muscle strength, and exercise tolerance in patients after coronary artery bypass grafting. , 2011, Journal of cardiology.

[107]  Takemi Sugiyama,et al.  Adults' sedentary behavior determinants and interventions. , 2011, American journal of preventive medicine.

[108]  J. Spence,et al.  How many steps/day are enough? for adults , 2011, The international journal of behavioral nutrition and physical activity.

[109]  Ilse de Bourdeaudhuij,et al.  How many steps/day are enough? For older adults and special populations , 2011, The international journal of behavioral nutrition and physical activity.

[110]  M. Riddell,et al.  Preventing exercise-induced hypoglycemia in type 1 diabetes using real-time continuous glucose monitoring and a new carbohydrate intake algorithm: an observational field study. , 2011, Diabetes technology & therapeutics.

[111]  C. Tudor-Locke,et al.  Accelerometer steps/day translation of moderate-to-vigorous activity. , 2011, Preventive medicine.

[112]  M. Riddell,et al.  Continuous moderate‐intensity exercise with or without intermittent high‐intensity work: effects on acute and late glycaemia in athletes with Type 1 diabetes mellitus , 2011, Diabetic medicine : a journal of the British Diabetic Association.

[113]  B. Franklin,et al.  American College of Sports Medicine position stand. Quantity and quality of exercise for developing and maintaining cardiorespiratory, musculoskeletal, and neuromotor fitness in apparently healthy adults: guidance for prescribing exercise. , 2011, Medicine and science in sports and exercise.

[114]  Sarah A. Moore,et al.  Resistance exercise reduces liver fat and its mediators in non-alcoholic fatty liver disease independent of weight loss , 2011, Gut.

[115]  Daniel Umpierre,et al.  Physical activity advice only or structured exercise training and association with HbA1c levels in type 2 diabetes: a systematic review and meta-analysis. , 2011, JAMA.

[116]  C. Abraham,et al.  Systematic review of reviews of intervention components associated with increased effectiveness in dietary and physical activity interventions , 2011, BMC public health.

[117]  F. Toledo,et al.  Effects of weight loss and exercise on insulin resistance, and intramyocellular triacylglycerol, diacylglycerol and ceramide , 2011, Diabetologia.

[118]  V. Rigalleau,et al.  Detection of silent myocardial ischemia in asymptomatic patients with diabetes: results of a randomized trial and meta-analysis assessing the effectiveness of systematic screening , 2011, Trials.

[119]  B. Fernhall,et al.  Exercise and Type 2 Diabetes , 2010, Diabetes Care.

[120]  Neil M. Johannsen,et al.  Effects of aerobic and resistance training on hemoglobin A1c levels in patients with type 2 diabetes: a randomized controlled trial. , 2010, JAMA.

[121]  A. Nicolucci,et al.  Effect of an intensive exercise intervention strategy on modifiable cardiovascular risk factors in subjects with type 2 diabetes mellitus: a randomized controlled trial: the Italian Diabetes and Exercise Study (IDES). , 2010, Archives of internal medicine.

[122]  H. Chase,et al.  Preventing post-exercise nocturnal hypoglycemia in children with type 1 diabetes. , 2010, The Journal of pediatrics.

[123]  Alberto Maran,et al.  Continuous glucose monitoring reveals delayed nocturnal hypoglycemia after intermittent high-intensity exercise in nontrained patients with type 1 diabetes. , 2010, Diabetes technology & therapeutics.

[124]  C. Schiavone,et al.  Limited Joint Mobility in Diabetes and Ageing: Recent Advances in Pathogenesis and Therapy , 2010, International journal of immunopathology and pharmacology.

[125]  R. Tanenberg,et al.  Confirmation of hypoglycemia in the "dead-in-bed" syndrome, as captured by a retrospective continuous glucose monitoring system. , 2010, Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists.

[126]  Sheri R. Colberg,et al.  Balance Training Reduces Falls Risk in Older Individuals With Type 2 Diabetes , 2010, Diabetes Care.

[127]  Andrew D. Williams,et al.  Effect of intradialytic versus home-based aerobic exercise training on physical function and vascular parameters in hemodialysis patients: a randomized pilot study. , 2010, American journal of kidney diseases : the official journal of the National Kidney Foundation.

[128]  R. Manders,et al.  Low-intensity exercise reduces the prevalence of hyperglycemia in type 2 diabetes. , 2010, Medicine and science in sports and exercise.

[129]  H. Nygaard,et al.  Slow postmeal walking reduces postprandial glycemia in middle-aged women. , 2009, Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme.

[130]  D. Swain,et al.  Postprandial walking is better for lowering the glycemic effect of dinner than pre-dinner exercise in type 2 diabetic individuals. , 2009, Journal of the American Medical Directors Association.

[131]  M. Staten,et al.  Effects of 7 days of exercise training on insulin sensitivity and responsiveness in type 2 diabetes mellitus. , 2009, American journal of physiology. Endocrinology and metabolism.

[132]  L. Heinemann,et al.  Changes in Basal Insulin Infusion Rates With Subcutaneous Insulin Infusion , 2009, Diabetes Care.

[133]  E. Barrett,et al.  Cardiac outcomes after screening for asymptomatic coronary artery disease in patients with type 2 diabetes: the DIAD study: a randomized controlled trial. , 2009, JAMA.

[134]  E. Carmeli,et al.  Effects of Low-Intensity Exercise on Patients with Peripheral Artery Disease , 2009, The Physician and sportsmedicine.

[135]  S. Fraser,et al.  Resistance training improves metabolic health in type 2 diabetes: a systematic review. , 2009, Diabetes research and clinical practice.

[136]  Luigi Ferrucci,et al.  Treadmill exercise and resistance training in patients with peripheral arterial disease with and without intermittent claudication: a randomized controlled trial. , 2009, JAMA.

[137]  Sarah E Lamb,et al.  Interventions for preventing falls in older people living in the community. , 2009, The Cochrane database of systematic reviews.

[138]  Michael J. Mueller,et al.  Effect of Weight-Bearing Activity on Foot Ulcer Incidence in People With Diabetic Peripheral Neuropathy: Feet First Randomized Controlled Trial , 2008, Physical Therapy.

[139]  Darrell M. Wilson,et al.  Low‐fat vs. high‐fat bedtime snacks in children and adolescents with type 1 diabetes , 2008, Pediatric diabetes.

[140]  S. Kalra,et al.  METABOLIC RESPONSES TO REDUCED DAILY STEPS IN HEALTHY NONEXERCISING MEN , 2008 .

[141]  J. Shaw,et al.  Breaks in Sedentary Time , 2008, Diabetes Care.

[142]  M. Gail,et al.  Cardiovascular Risk Factors, Mortality, and Overweight—Reply , 2008 .

[143]  J. Levine,et al.  The Role of Free-Living Daily Walking in Human Weight Gain and Obesity , 2008, Diabetes.

[144]  Sanjay Kalra,et al.  OBJECTIVELY MEASURED LIGHT‐INTENSITY PHYSICAL ACTIVITY IS INDEPENDENTLY ASSOCIATED WITH 2‐H PLASMA GLUCOSE , 2008 .

[145]  J. Hawley,et al.  Exercise training‐induced improvements in insulin action , 2007, Acta physiologica.

[146]  L. Sidossis,et al.  Improved insulin sensitivity after a single bout of exercise is curvilinearly related to exercise energy expenditure. , 2008, Clinical science.

[147]  M. McDonnell Combination Therapy With New Targets in Type 2 Diabetes: A REVIEW OF AVAILABLE AGENTS WITH A FOCUS ON PRE-EXERCISE ADJUSTMENT , 2007, Journal of cardiopulmonary rehabilitation and prevention.

[148]  T. Jones,et al.  A 10-s sprint performed prior to moderate-intensity exercise prevents early post-exercise fall in glycaemia in individuals with type 1 diabetes , 2007, Diabetologia.

[149]  Will G. Hopkins,et al.  Effects of Different Modes of Exercise Training on Glucose Control and Risk Factors for Complications in Type 2 Diabetic Patients: a Meta-Analysis , 2007, Diabetes Care.

[150]  J. Shaw,et al.  Association of television viewing with fasting and 2-h postchallenge plasma glucose levels in adults without diagnosed diabetes. , 2007, Diabetes care.

[151]  T. Jones,et al.  Effect of intermittent high-intensity compared with continuous moderate exercise on glucose production and utilization in individuals with type 1 diabetes. , 2007, American journal of physiology. Endocrinology and metabolism.

[152]  E. Renard,et al.  Accuracy of continuous subcutaneous glucose monitoring with the GlucoDay in type 1 diabetic patients treated by subcutaneous insulin infusion during exercise of low versus high intensity. , 2006, Diabetes & metabolism.

[153]  S. Weisnagel,et al.  Is early and late post-meal exercise so different in type 1 diabetic lispro users? , 2006, Diabetes research and clinical practice.

[154]  J. Manson,et al.  A prospective study of pregravid physical activity and sedentary behaviors in relation to the risk for gestational diabetes mellitus. , 2006, Archives of internal medicine.

[155]  T. Jones,et al.  The 10-s maximal sprint: a novel approach to counter an exercise-mediated fall in glycemia in individuals with type 1 diabetes. , 2006, Diabetes care.

[156]  Bruce A Buckingham,et al.  The effects of aerobic exercise on glucose and counterregulatory hormone concentrations in children with type 1 diabetes. , 2006, Diabetes care.

[157]  Bruce A Buckingham,et al.  Impact of exercise on overnight glycemic control in children with type 1 diabetes mellitus. , 2005, The Journal of pediatrics.

[158]  M. Phillip,et al.  Exercise With and Without an Insulin Pump Among Children and Adolescents With Type 1 Diabetes Mellitus , 2005, Pediatrics.

[159]  T. Jones,et al.  The decline in blood glucose levels is less with intermittent high-intensity compared with moderate exercise in individuals with type 1 diabetes. , 2005, Diabetes care.

[160]  Frida Leonetti,et al.  Exercise training can modify the natural history of diabetic peripheral neuropathy. , 2005, Journal of diabetes and its complications.

[161]  D. Owens,et al.  Effects of exercise on the absorption of insulin glargine in patients with type 1 diabetes. , 2005, Diabetes care.

[162]  M. Clark,et al.  Interindividual Variation in Posture Allocation: Possible Role in Human Obesity , 2005, Science.

[163]  E. Cauza,et al.  Continuous Glucose Monitoring in Diabetic Long Distance Runners , 2005, International journal of sports medicine.

[164]  A. Vinik,et al.  Effects of 8 weeks of flexibility and resistance training in older adults with type 2 diabetes. , 2004, Diabetes care.

[165]  Robert M. Anderson,et al.  5. Prevention or Delay of Type 2 Diabetes , 2016, Diabetes Care.

[166]  J. Berryman,et al.  The American college of sports medicine , 2004 .

[167]  Maria A. Fiatarone Singh,et al.  Battling insulin resistance in elderly obese people with type 2 diabetes: bring on the heavy weights. , 2003, Diabetes care.

[168]  Walter C Willett,et al.  Television watching and other sedentary behaviors in relation to risk of obesity and type 2 diabetes mellitus in women. , 2003, JAMA.

[169]  D. Swain,et al.  Use of heart rate reserve and rating of perceived exertion to prescribe exercise intensity in diabetic autonomic neuropathy. , 2003, Diabetes care.

[170]  D. Chisholm,et al.  Target-seeking behavior of plasma glucose with exercise in type 1 diabetes. , 2003, Diabetes care.

[171]  J. Wojtaszewski,et al.  Invited review: effect of acute exercise on insulin signaling and action in humans. , 2002, Journal of applied physiology.

[172]  M. Vranic,et al.  Intense exercise has unique effects on both insulin release and its roles in glucoregulation: implications for diabetes. , 2002, Diabetes.

[173]  G A Colditz,et al.  Physical activity and television watching in relation to risk for type 2 diabetes mellitus in men. , 2001, Archives of internal medicine.

[174]  R. Rabasa-Lhoret,et al.  Guidelines for premeal insulin dose reduction for postprandial exercise of different intensities and durations in type 1 diabetic subjects treated intensively with a basal-bolus insulin regimen (ultralente-lispro). , 2001, Diabetes care.

[175]  F. Dela,et al.  Interaction of sulfonylureas and exercise on glucose homeostasis in type 2 diabetic patients. , 1999, Diabetes care.

[176]  J. Levine,et al.  Role of nonexercise activity thermogenesis in resistance to fat gain in humans. , 1999, Science.

[177]  A. Kriska,et al.  Insulin-dependent diabetes mellitus, physical activity, and death. , 1993, American journal of epidemiology.

[178]  Lawrence A Leiter,et al.  Hyperglycemia After Intense Exercise in IDDM Subjects During Continuous Subcutaneous Insulin Infusion , 1988, Diabetes Care.

[179]  Michael J MacDonald,et al.  Postexercise Late-Onset Hypoglycemia in Insulin-Dependent Diabetic Patients , 1987, Diabetes Care.

[180]  BOULIN,et al.  [Classification and diagnosis of diabetes]. , 1953, Concours medical.