Molecular control of nitric oxide synthases in the cardiovascular system.

[1]  S. Mariotto,et al.  Rapid Inactivation of NOS-I by Lipopolysaccharide Plus Interferon-γ-induced Tyrosine Phosphorylation* , 1999, The Journal of Biological Chemistry.

[2]  W. Aird,et al.  A vascular bed–specific pathway regulates cardiac expression of endothelial nitric oxide synthase , 1999 .

[3]  P. Ortiz de Montellano,et al.  AMP‐activated protein kinase phosphorylation of endothelial NO synthase , 1999, FEBS letters.

[4]  B. Lévy,et al.  Neuronal nitric oxide synthase is expressed in rat vascular smooth muscle cells: activation by angiotensin II in hypertension. , 1998, Circulation research.

[5]  O. Carretero,et al.  Role of nNOS in blood pressure regulation in eNOS null mutant mice. , 1998, Hypertension.

[6]  M. Marrero,et al.  Inhibitory Interactions of the Bradykinin B2 Receptor with Endothelial Nitric-oxide Synthase* , 1998, The Journal of Biological Chemistry.

[7]  U. Laufs,et al.  Post-transcriptional Regulation of Endothelial Nitric Oxide Synthase mRNA Stability by Rho GTPase* , 1998, The Journal of Biological Chemistry.

[8]  M. Lisanti,et al.  Interaction between Caveolin-1 and the Reductase Domain of Endothelial Nitric-oxide Synthase , 1998, The Journal of Biological Chemistry.

[9]  D. Heistad,et al.  Vascular effects of LPS in mice deficient in expression of the gene for inducible nitric oxide synthase. , 1998, American journal of physiology. Heart and circulatory physiology.

[10]  M. Moskowitz,et al.  Stroke protection by 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors mediated by endothelial nitric oxide synthase. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[11]  U. Förstermann,et al.  Expressional control of the ‘constitutive’ isoforms of nitric oxide synthase (NOS I and NOS III) , 1998, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[12]  K. Wu,et al.  Transcriptional Regulation of Endothelial Nitric-oxide Synthase by Lysophosphatidylcholine* , 1998, The Journal of Biological Chemistry.

[13]  P. Huang,et al.  Sustained pulmonary hypertension and right ventricular hypertrophy after chronic hypoxia in mice with congenital deficiency of nitric oxide synthase 3. , 1998, The Journal of clinical investigation.

[14]  R. Busse,et al.  Ca2+-independent activation of the endothelial nitric oxide synthase in response to tyrosine phosphatase inhibitors and fluid shear stress. , 1998, Circulation research.

[15]  Roger Fan,et al.  Dynamic activation of endothelial nitric oxide synthase by Hsp90 , 1998, Nature.

[16]  U. Laufs,et al.  Upregulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitors. , 1998, Circulation.

[17]  R. Virmani,et al.  Interaction of genetic deficiency of endothelial nitric oxide, gender, and pregnancy in vascular response to injury in mice. , 1998, The Journal of clinical investigation.

[18]  P. Huang,et al.  Nitric oxide synthase modulates angiogenesis in response to tissue ischemia. , 1998, The Journal of clinical investigation.

[19]  R. D. Rudic,et al.  Direct evidence for the importance of endothelium-derived nitric oxide in vascular remodeling. , 1998, The Journal of clinical investigation.

[20]  H. Bidmon,et al.  Coronary hemodynamics in endothelial NO synthase knockout mice. , 1998, Circulation research.

[21]  U. Förstermann,et al.  Estrogens increase transcription of the human endothelial NO synthase gene: analysis of the transcription factors involved. , 1998, Hypertension.

[22]  L. McIntire,et al.  Nitric oxide production by cultured human aortic smooth muscle cells: stimulation by fluid flow. , 1998, American journal of physiology. Heart and circulatory physiology.

[23]  N. Maeda,et al.  Responses of carotid artery in mice deficient in expression of the gene for endothelial NO synthase. , 1998, American journal of physiology. Heart and circulatory physiology.

[24]  M. Moskowitz,et al.  Neuronal NOS-cGMP-dependent ACh-induced relaxation in pial arterioles of endothelial NOS knockout mice. , 1998, American journal of physiology. Heart and circulatory physiology.

[25]  S. Snyder,et al.  CAPON: A Protein Associated with Neuronal Nitric Oxide Synthase that Regulates Its Interactions with PSD95 , 1998, Neuron.

[26]  G. Garcı́a-Cardeña,et al.  Nitric oxide production contributes to the angiogenic properties of vascular endothelial growth factor in human endothelial cells. , 1997, The Journal of clinical investigation.

[27]  H. Ju,et al.  Interaction of Neuronal Nitric-oxide Synthase with Caveolin-3 in Skeletal Muscle , 1997, The Journal of Biological Chemistry.

[28]  G. Garcı́a-Cardeña,et al.  17 beta-estradiol regulation of human endothelial cell basal nitric oxide release, independent of cytosolic Ca2+ mobilization. , 1997, Circulation research.

[29]  D. Harrison,et al.  Expression of multiple isoforms of nitric oxide synthase in normal and atherosclerotic vessels. , 1997, Arteriosclerosis, thrombosis, and vascular biology.

[30]  G. Garcı́a-Cardeña,et al.  Dissecting the Interaction between Nitric Oxide Synthase (NOS) and Caveolin , 1997, The Journal of Biological Chemistry.

[31]  A. López-Farré,et al.  Endothelial cytosolic proteins bind to the 3' untranslated region of endothelial nitric oxide synthase mRNA: regulation by tumor necrosis factor alpha , 1997, Molecular and cellular biology.

[32]  P. Kubes,et al.  Inducible nitric oxide synthase‐deficient mice have enhanced leukocyte–endothelium interactions in endotoxemia , 1997, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[33]  C. Estrada,et al.  Neuronal Nitric Oxide Synthase Activation by Vasoactive Intestinal Peptide in Bovine Cerebral Arteries , 1997, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[34]  H. Ju,et al.  Direct Interaction of Endothelial Nitric-oxide Synthase and Caveolin-1 Inhibits Synthase Activity* , 1997, The Journal of Biological Chemistry.

[35]  Douglas Hanahan,et al.  Signaling Vascular Morphogenesis and Maintenance , 1997, Science.

[36]  C. Rosenfeld,et al.  Estrogen acutely stimulates nitric oxide synthase activity in fetal pulmonary artery endothelium. , 1997, The American journal of physiology.

[37]  G. Garcı́a-Cardeña,et al.  Nitric oxide synthase inhibitors attenuate transforming-growth-factor-beta 1-stimulated capillary organization in vitro. , 1997, The American journal of pathology.

[38]  S. Snyder,et al.  Urinary bladder-urethral sphincter dysfunction in mice with targeted disruption of neuronal nitric oxide synthase models idiopathic voiding disorders in humans , 1997, Nature Medicine.

[39]  Yang Wang,et al.  A Novel, Testis-specific mRNA Transcript Encoding an NH2-terminal Truncated Nitric-oxide Synthase* , 1997, The Journal of Biological Chemistry.

[40]  晶夫 森,et al.  肺胞・気道障害と Gene transcription , 1997 .

[41]  Eric R Kandel,et al.  Long-Term Potentiation Is Reduced in Mice That Are Doubly Mutant in Endothelial and Neuronal Nitric Oxide Synthase , 1996, Cell.

[42]  H. S. Kim,et al.  Elevated blood pressures in mice lacking endothelial nitric oxide synthase. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[43]  R. Nerem,et al.  Phosphorylation of endothelial nitric oxide synthase in response to fluid shear stress. , 1996, Circulation research.

[44]  S. Snyder,et al.  PIN: An Associated Protein Inhibitor of Neuronal Nitric Oxide Synthase , 1996, Science.

[45]  G. Garcı́a-Cardeña,et al.  Endothelial Nitric Oxide Synthase Is Regulated by Tyrosine Phosphorylation and Interacts with Caveolin-1* , 1996, The Journal of Biological Chemistry.

[46]  G. Garcı́a-Cardeña,et al.  Palmitoylation of endothelial nitric oxide synthase is necessary for optimal stimulated release of nitric oxide: implications for caveolae localization. , 1996, Biochemistry.

[47]  S Glagov,et al.  Role of NO in flow-induced remodeling of the rabbit common carotid artery. , 1996, Arteriosclerosis, thrombosis, and vascular biology.

[48]  P. Huang,et al.  Neuronal constitutive nitric oxide synthase is involved in murine enteric inhibitory neurotransmission. , 1996, The Journal of clinical investigation.

[49]  J. Schulz,et al.  Striatal Malonate Lesions Are Attenuated in Neuronal Nitric Oxide Synthase Knockout Mice , 1996, Journal of neurochemistry.

[50]  G. Garcı́a-Cardeña,et al.  Targeting of nitric oxide synthase to endothelial cell caveolae via palmitoylation: implications for nitric oxide signaling. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[51]  C. Patterson,et al.  Suppression of Interleukin-1β-induced Nitric-oxide Synthase Promoter/Enhancer Activity by Transforming Growth Factor-β1 in Vascular Smooth Muscle Cells , 1996, The Journal of Biological Chemistry.

[52]  K. Hirata,et al.  Endothelial constitutive nitric oxide synthase protein and mRNA increased in rabbit atherosclerotic aorta despite impaired endothelium-dependent vascular relaxation. , 1996, The American journal of pathology.

[53]  D. Bredt,et al.  Neuronal Nitric-oxide Synthase-, an Alternatively Spliced Isoform Expressed in Differentiated Skeletal Muscle (*) , 1996, The Journal of Biological Chemistry.

[54]  S. Snyder,et al.  Review of Impotence Literature , 1996, International Journal of Impotence Research.

[55]  T. Dawson,et al.  Resistance to neurotoxicity in cortical cultures from neuronal nitric oxide synthase-deficient mice , 1996, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[56]  J. Pan,et al.  Tyrosine phosphorylation of inducible nitric oxide synthase: implications for potential post-translational regulation. , 1996, The Biochemical journal.

[57]  Richard G. W. Anderson,et al.  Acylation Targets Endothelial Nitric-oxide Synthase to Plasmalemmal Caveolae (*) , 1996, The Journal of Biological Chemistry.

[58]  D. Bredt,et al.  Interaction of Nitric Oxide Synthase with the Postsynaptic Density Protein PSD-95 and α1-Syntrophin Mediated by PDZ Domains , 1996, Cell.

[59]  Jonathan D. Cohen,et al.  The Cytokine Responsive Vascular Smooth Muscle Cell Enhancer of Inducible Nitric Oxide Synthase , 1995, The Journal of Biological Chemistry.

[60]  R M Nerem,et al.  Regulation of endothelial cell nitric oxide synthase mRNA expression by shear stress. , 1995, The American journal of physiology.

[61]  S. Snyder,et al.  Behavioural abnormalities in male mice lacking neuronal nitric oxide synthase , 1995, Nature.

[62]  O. Smithies,et al.  Mice lacking inducible nitric oxide synthase are not resistant to lipopolysaccharide-induced death. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[63]  T. Michel,et al.  Expression of constitutive endothelial nitric oxide synthase in human blood platelets. , 1995, Life sciences.

[64]  J. Liu,et al.  Biosynthesis and palmitoylation of endothelial nitric oxide synthase: mutagenesis of palmitoylation sites, cysteines-15 and/or -26, argues against depalmitoylation-induced translocation of the enzyme. , 1995, Biochemistry.

[65]  M. Moskowitz,et al.  Hypertension in mice lacking the gene for endothelial nitric oxide synthase , 1995, Nature.

[66]  K. Aldape,et al.  Nitric oxide synthase complexed with dystrophin and absent from skeletal muscle sarcolemma in Duchenne muscular dystrophy , 1995, Cell.

[67]  K. Wu,et al.  Role of Sp1 in transcriptional activation of human nitric oxide synthase type III gene. , 1995, Biochemical and biophysical research communications.

[68]  D. Harrison,et al.  Molecular regulation of the bovine endothelial cell nitric oxide synthase by transforming growth factor-beta 1. , 1995, Arteriosclerosis, thrombosis, and vascular biology.

[69]  J. Pollock,et al.  The Golgi Association of Endothelial Nitric Oxide Synthase Is Necessary for the Efficient Synthesis of Nitric Oxide(*) , 1995, The Journal of Biological Chemistry.

[70]  K. Wu,et al.  Transcriptional Induction of Endothelial Nitric Oxide Synthase Type III by Lysophosphatidylcholine (*) , 1995, The Journal of Biological Chemistry.

[71]  W. Min,et al.  Functional Analysis of the Human Endothelial Nitric Oxide Synthase Promoter , 1995, The Journal of Biological Chemistry.

[72]  I. Charles,et al.  Altered immune responses in mice lacking inducible nitric oxide synthase , 1995, Nature.

[73]  K. Hirata,et al.  Low concentration of oxidized low-density lipoprotein and lysophosphatidylcholine upregulate constitutive nitric oxide synthase mRNA expression in bovine aortic endothelial cells. , 1995, Circulation research.

[74]  C. Nathan,et al.  Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase , 1995, Cell.

[75]  Y. Vodovotz,et al.  Vesicle membrane association of nitric oxide synthase in primary mouse macrophages. , 1995, Journal of immunology.

[76]  F. Murad,et al.  Two closely linked but separable promoters for human neuronal nitric oxide synthase gene transcription. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[77]  K. Hirata,et al.  Inhibition of endothelial nitric oxide synthase activity by protein kinase C. , 1995, Hypertension.

[78]  J. Liao,et al.  Oxidized Low-density Lipoprotein Decreases the Expression of Endothelial Nitric Oxide Synthase (*) , 1995, The Journal of Biological Chemistry.

[79]  Yang Wang,et al.  Structural organization of the human neuronal nitric oxide synthase gene (NOS1). , 1994, The Journal of biological chemistry.

[80]  S Amerini,et al.  Nitric oxide mediates angiogenesis in vivo and endothelial cell growth and migration in vitro promoted by substance P. , 1994, The Journal of clinical investigation.

[81]  E. Garvey,et al.  Potent and selective inhibition of human nitric oxide synthases. Inhibition by non-amino acid isothioureas. , 1994, The Journal of biological chemistry.

[82]  M. Moskowitz,et al.  Effects of cerebral ischemia in mice deficient in neuronal nitric oxide synthase. , 1994, Science.

[83]  C. Nathan,et al.  Role of interferon regulatory factor 1 in induction of nitric oxide synthase , 1994, The Journal of experimental medicine.

[84]  E R Kandel,et al.  Endothelial NOS and the blockade of LTP by NOS inhibitors in mice lacking neuronal NOS. , 1994, Science.

[85]  T. Billiar,et al.  New insights into the regulation of inducible nitric oxide synthesis. , 1994, The American journal of physiology.

[86]  I. Charles,et al.  Induction of calcium-dependent nitric oxide synthases by sex hormones. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[87]  C. Nathan,et al.  Regulation of biosynthesis of nitric oxide. , 1994, The Journal of biological chemistry.

[88]  N. Ishida,et al.  Promoter analysis of human inducible nitric oxide synthase gene associated with cardiovascular homeostasis. , 1994, Biochemical and biophysical research communications.

[89]  W. Sessa,et al.  Identification of covalently bound amino-terminal myristic acid in endothelial nitric oxide synthase. , 1994, The Journal of biological chemistry.

[90]  T. Taniguchi,et al.  Requirement for transcription factor IRF-1 in NO synthase induction in macrophages. , 1994, Science.

[91]  C. Nathan,et al.  Role of transcription factor NF-kappa B/Rel in induction of nitric oxide synthase. , 1994, The Journal of biological chemistry.

[92]  F. Marumo,et al.  Induction of nitric oxide synthase by cyclic AMP in rat vascular smooth muscle cells. , 1994, The Journal of clinical investigation.

[93]  K. Pritchard,et al.  Chronic exercise in dogs increases coronary vascular nitric oxide production and endothelial cell nitric oxide synthase gene expression. , 1994, Circulation research.

[94]  P. Söderkvist,et al.  Different induction mechanisms of mRNA for inducible nitric oxide synthase in rat smooth muscle cells in culture and in aortic strips , 1994, FEBS letters.

[95]  S. Snyder,et al.  Targeted disruption of the neuronal nitric oxide synthase gene , 1993, Cell.

[96]  S. Snyder,et al.  Macrophage nitric oxide synthase gene: two upstream regions mediate induction by interferon gamma and lipopolysaccharide. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[97]  S. Scherer,et al.  Structure and chromosomal localization of the human constitutive endothelial nitric oxide synthase gene. , 1993, The Journal of biological chemistry.

[98]  Y. Vodovotz,et al.  Mechanisms of suppression of macrophage nitric oxide release by transforming growth factor beta , 1993, The Journal of experimental medicine.

[99]  T. Michel,et al.  Phosphorylation and subcellular translocation of endothelial nitric oxide synthase. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[100]  M. Yoshizumi,et al.  Tumor necrosis factor downregulates an endothelial nitric oxide synthase mRNA by shortening its half-life. , 1993, Circulation research.

[101]  C. Nathan,et al.  Promoter of the mouse gene encoding calcium-independent nitric oxide synthase confers inducibility by interferon gamma and bacterial lipopolysaccharide , 1993, The Journal of experimental medicine.

[102]  R M Nerem,et al.  Molecular cloning and characterization of the constitutive bovine aortic endothelial cell nitric oxide synthase. , 1992, The Journal of clinical investigation.

[103]  M J Peach,et al.  Molecular cloning and expression of a cDNA encoding endothelial cell nitric oxide synthase. , 1992, The Journal of biological chemistry.

[104]  C. Nathan,et al.  Calmodulin is a subunit of nitric oxide synthase from macrophages , 1992, The Journal of experimental medicine.

[105]  P. Tempst,et al.  Endothelial nitric oxide synthase: molecular cloning and characterization of a distinct constitutive enzyme isoform. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[106]  S. Snyder,et al.  Nitric oxide synthase regulatory sites. Phosphorylation by cyclic AMP-dependent protein kinase, protein kinase C, and calcium/calmodulin protein kinase; identification of flavin and calmodulin binding sites. , 1992, The Journal of biological chemistry.

[107]  F. Murad,et al.  Purification and characterization of particulate endothelium-derived relaxing factor synthase from cultured and native bovine aortic endothelial cells. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[108]  F. Murad,et al.  Phosphorylation by calcium calmodulin-dependent protein kinase II and protein kinase C modulates the activity of nitric oxide synthase. , 1991, Biochemical and biophysical research communications.

[109]  S. Snyder,et al.  Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase , 1991, Nature.

[110]  J. Vane,et al.  Involvement of nitric oxide in the reflex relaxation of the stomach to accommodate food or fluid , 1991, Nature.

[111]  S. Moncada,et al.  Nitric oxide: physiology, pathophysiology, and pharmacology. , 1991, Pharmacological reviews.

[112]  F. Murad,et al.  Calmodulin-dependent endothelium-derived relaxing factor/nitric oxide synthase activity is present in the particulate and cytosolic fractions of bovine aortic endothelial cells. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[113]  C. Nathan,et al.  Nitric oxide. A macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells , 1989, The Journal of experimental medicine.

[114]  S Moncada,et al.  Role of endothelium-derived nitric oxide in the regulation of blood pressure. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[115]  O. Griffith,et al.  NG-methylarginine, an inhibitor of endothelium-derived nitric oxide synthesis, is a potent pressor agent in the guinea pig: does nitric oxide regulate blood pressure in vivo? , 1989, Biochemical and biophysical research communications.

[116]  J. Hibbs,et al.  Nitric oxide: a cytotoxic activated macrophage effector molecule. , 1988, Biochemical and biophysical research communications.

[117]  L. Ignarro,et al.  Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[118]  S. Moncada,et al.  Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor , 1987, Nature.

[119]  J. Hibbs,et al.  Macrophage cytotoxicity: role for L-arginine deiminase and imino nitrogen oxidation to nitrite. , 1987, Science.

[120]  B L Langille,et al.  Reductions in arterial diameter produced by chronic decreases in blood flow are endothelium-dependent. , 1986, Science.

[121]  M. Marletta,et al.  Mammalian nitrate biosynthesis: mouse macrophages produce nitrite and nitrate in response to Escherichia coli lipopolysaccharide. , 1985, Proceedings of the National Academy of Sciences of the United States of America.

[122]  R. Furchgott,et al.  The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine , 1980, Nature.

[123]  Vlad I. Morariu,et al.  Expression , 2015, Principles of Molecular Virology.

[124]  D. Garcia-Dorado,et al.  Cardiovascular Research , 1966 .

[125]  N. Clark,et al.  Direct Evidence , 1934 .

[126]  A. Aljada,et al.  Nitric oxide synthase. , 1998, Methods in molecular biology.

[127]  G. Garcı́a-Cardeña,et al.  Bacterial infection induces nitric oxide synthase in human neutrophils. , 1997, The Journal of clinical investigation.

[128]  U. Förstermann,et al.  Expression and expressional control of nitric oxide synthases in various cell types. , 1995, Advances in pharmacology.

[129]  F. Murad,et al.  Transcription of the human neuronal nitric oxide synthase gene in the central nervous system is mediated by multiple promoters. , 1995, Advances in pharmacology.

[130]  Yang Wang,et al.  Nitric oxide synthases: gene structure and regulation. , 1995, Advances in pharmacology.

[131]  E. Garvey,et al.  Potent and Selective Inhibition of Human Nitric Oxide Synthases , 1994 .

[132]  J. Balligand,et al.  Control of cardiac muscle cell function by an endogenous nitric oxide signaling system. , 1993, Proceedings of the National Academy of Sciences of the United States of America.