Bayesian optimum designs for discriminating between models with any distribution

The Bayesian KL-optimality criterion is useful for discriminating between any two statistical models in the presence of prior information. If the rival models are not nested then, depending on which model is true, two different Kullback-Leibler distances may be defined. The Bayesian KL-optimality criterion is a convex combination of the expected values of these two possible Kullback-Leibler distances between the competing models. These expectations are taken over the prior distributions of the parameters and the weights of the convex combination are given by the prior probabilities of the models. Concavity of the Bayesian KL-optimality criterion is proved, thus classical results of Optimal Design Theory can be applied. A standardized version of the proposed criterion is also given in order to take into account possible different magnitudes of the two Kullback-Leibler distances. Some illustrative examples are provided.

[1]  Anthony C. Atkinson,et al.  The Design of Experiments to Discriminate Between Two Rival Generalized Linear Models , 1992 .

[2]  Chiara Tommasi,et al.  Optimal Designs for Discriminating among Several Non-Normal Models , 2007 .

[3]  A. Atkinson,et al.  The design of experiments for discriminating between two rival models , 1975 .

[4]  Holger Dette,et al.  On the number of support points of maximin and Bayesian optimal designs , 2007, 0708.1901.

[5]  Jesús López Fidalgo,et al.  Moda 8 - Advances in Model-Oriented Design and Analysis , 2007 .

[6]  Paula Camelia Trandafir,et al.  Optimal designs for discriminating between some extensions of the Michaelis–Menten model , 2005 .

[7]  J. López-Fidalgo,et al.  Construction of marginally and conditionally restricted designs using multiplicative algorithms , 2007, Comput. Stat. Data Anal..

[8]  A. Atkinson,et al.  Optimum experimental design for discriminating between two rival models in the presence of prior information , 1991 .

[9]  K. Chaloner,et al.  Optimal Bayesian design applied to logistic regression experiments , 1989 .

[10]  Henry P. Wynn,et al.  MODA 7 - advances in model-oriented design and analysis : proceedings of the 7th international workshop on Model-oriented design and analysis, held in Heeze, The Netherlands, June 14-18, 2004 , 2004 .

[11]  A. Atkinson,et al.  Optimal design : Experiments for discriminating between several models , 1975 .

[12]  Kathryn Chaloner,et al.  A note on optimal Bayesian design for nonlinear problems , 1993 .

[13]  J. López–Fidalgo,et al.  An optimal experimental design criterion for discriminating between non‐normal models , 2007 .

[14]  D. Wiens Robust discrimination designs , 2009 .

[15]  Debasis Kundu,et al.  Discriminating between the Weibull and log‐normal distributions , 2004 .

[16]  Holger Dette,et al.  Designing Experiments with Respect to ‘Standardized’ Optimality Criteria , 1997 .

[17]  Andrej Pázman,et al.  Applications of necessary and sufficient conditions for maximin efficient designs , 1998 .

[18]  Holger Dette,et al.  Improving updating rules in multiplicative algorithms for computing D-optimal designs , 2008, Comput. Stat. Data Anal..

[19]  Holger Dette,et al.  Optimal discrimination designs , 2009, 0908.1912.

[20]  J. Kiefer,et al.  The Equivalence of Two Extremum Problems , 1960, Canadian Journal of Mathematics.

[21]  Susan M. Lewis,et al.  Design selection criteria for discrimination/estimation for nested models and a binomial response , 2008 .