Is tissue-type plasminogen activator a neuromodulator?

[1]  C. Siao,et al.  Cell Type-Specific Roles for Tissue Plasminogen Activator Released by Neurons or Microglia after Excitotoxic Injury , 2003, The Journal of Neuroscience.

[2]  P. Carmeliet,et al.  Smad3-Dependent Induction of Plasminogen Activator Inhibitor-1 in Astrocytes Mediates Neuroprotective Activity of Transforming Growth Factor-β1 against NMDA-Induced Necrosis , 2002, Molecular and Cellular Neuroscience.

[3]  Alain Buisson,et al.  The proteolytic activity of tissue-plasminogen activator enhances NMDA receptor-mediated signaling , 2001, Nature Medicine.

[4]  G. Zhao,et al.  Microglial tissue plasminogen activator (tPA) triggers neuronal apoptosis in vitro , 2000, Glia.

[5]  D. Holtzman,et al.  Role of Tissue Plasminogen Activator Receptor LRP in Hippocampal Long-Term Potentiation , 2000, The Journal of Neuroscience.

[6]  Dominique Muller,et al.  Enhanced hippocampal long‐term potentiation and learning by increased neuronal expression of tissue‐type plasminogen activator in transgenic mice , 1999, The EMBO journal.

[7]  Mary Chen,et al.  Tissue Plasminogen Activator Contributes to the Late Phase of LTP and to Synaptic Growth in the Hippocampal Mossy Fiber Pathway , 1998, Neuron.

[8]  R. Morris,et al.  Serine Proteases in Rodent Hippocampus* , 1998, The Journal of Biological Chemistry.

[9]  S. Lipton,et al.  Tissue plasminogen activator (tPA) increase neuronal damage after focal cerebral ischemia in wild-type and tPA-deficient mice , 1998, Nature Medicine.

[10]  S. Tsirka,et al.  Neurotoxic responses by microglia elicited by excitotoxic injury in the mouse hippocampus , 1998, Current Biology.

[11]  J. Emeis,et al.  An Endothelial Storage Granule for Tissue-Type Plasminogen Activator , 1997, The Journal of cell biology.

[12]  S. Mahata,et al.  Tissue Plasminogen Activator (t-PA) Is Targeted to the Regulated Secretory Pathway , 1997, The Journal of Biological Chemistry.

[13]  E. Kandel,et al.  Mice lacking the gene encoding tissue-type plasminogen activator show a selective interference with late-phase long-term potentiation in both Schaffer collateral and mossy fiber pathways. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[14]  S. Strickland,et al.  Membrane depolarization induces calcium-dependent secretion of tissue plasminogen activator , 1996, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[15]  U. Frey,et al.  A different form of long-lasting potentiation revealed in tissue plasminogen activator mutant mice , 1996, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[16]  P. Carmeliet,et al.  Gene Manipulation and Transfer of the Plasminogen and Coagulation System in Mice , 1996, Seminars in thrombosis and hemostasis.

[17]  David R. Cox,et al.  A potassium channel mutation in weaver mice implicates membrane excitability in granule cell differentiation , 1995, Nature Genetics.

[18]  Sidney Strickland,et al.  Excitotoxin-induced neuronal degeneration and seizure are mediated by tissue plasminogen activator , 1995, Nature.

[19]  O. Saksela,et al.  Increased proteolytic activity of the granule neurons may contribute to neuronal death in the weaver mouse cerebellum. , 1995, Developmental biology.

[20]  W G Richards,et al.  The mouse tissue plasminogen activator gene 5' flanking region directs appropriate expression in development and a seizure-enhanced response in the CNS. , 1994, Development.

[21]  B. Hyman,et al.  Apolipoprotein E in sporadic Alzheimer's disease: Allelic variation and receptor interactions , 1993, Neuron.

[22]  D. Belin,et al.  Extracellular proteolysis in the adult murine brain. , 1993, The Journal of clinical investigation.

[23]  A. Schwartz,et al.  39-kD protein inhibits tissue-type plasminogen activator clearance in vivo. , 1993, The Journal of clinical investigation.

[24]  Eric R. Kandel,et al.  Tissue-plasminogen activator is induced as an immediate–early gene during seizure, kindling and long-term potentiation , 1993, Nature.

[25]  T. Bliss,et al.  A synaptic model of memory: long-term potentiation in the hippocampus , 1993, Nature.

[26]  G. Handelmann,et al.  Effects of apolipoprotein E, beta-very low density lipoproteins, and cholesterol on the extension of neurites by rabbit dorsal root ganglion neurons in vitro. , 1992, Journal of lipid research.

[27]  A. Schwartz,et al.  Low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor is an hepatic receptor for tissue-type plasminogen activator. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[28]  S. Vandenberg,et al.  Characterization and immunohistochemical localization of alpha 2-macroglobulin receptor (low-density lipoprotein receptor-related protein) in human brain. , 1992, The American journal of pathology.

[29]  M. Brown,et al.  39-kDa protein modulates binding of ligands to low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor. , 1991, The Journal of biological chemistry.

[30]  J. Schoonmaker,et al.  Cerebellar granule cell migration involves proteolysis. , 1990, Advances in experimental medicine and biology.

[31]  D. Monard.  Cell-derived proteases and protease inhibitors as regulators of neurite outgrowth , 1988, Trends in Neurosciences.

[32]  D. Choi.  Calcium-mediated neurotoxicity: relationship to specific channel types and role in ischemic damage , 1988, Trends in Neurosciences.

[33]  D. Choi,et al.  Glutamate neurotoxicity and diseases of the nervous system , 1988, Neuron.

[34]  N. Seeds,et al.  Peripheral neurons and Schwann cells secrete plasminogen activator , 1984, The Journal of cell biology.

[35]  R. H. Evans,et al.  Excitatory amino acid transmitters. , 1981, Annual review of pharmacology and toxicology.