Racemic and chiral sulfoxides as potential prodrugs of 4-pyrone COX-2 inhibitors.

[1]  F. Caturla,et al.  Synthesis and biological evaluation of 2-phenylpyran-4-ones: a new class of orally active cyclooxygenase-2 inhibitors. , 2004, Journal of medicinal chemistry.

[2]  S. Shin,et al.  A prodrug approach to COX-2 inhibitors with methylsulfone. , 2004, Bioorganic & medicinal chemistry letters.

[3]  Garret A. FitzGerald,et al.  COX-2 and beyond: approaches to prostaglandin inhibition in human disease , 2003, Nature Reviews Drug Discovery.

[4]  N. Godessart,et al.  Naphthalene derivatives: A new series of selective cyclooxygenase-2 inhibitors. , 2001, Bioorganic & medicinal chemistry letters.

[5]  V. Segarra,et al.  Synthesis and biological evaluation of 3,4-diaryloxazolones: A new class of orally active cyclooxygenase-2 inhibitors. , 2000, Journal of medicinal chemistry.

[6]  M. Maccoss,et al.  Pyrroles and other heterocycles as inhibitors of p38 kinase. , 1998, Bioorganic & medicinal chemistry letters.

[7]  C. Bolm,et al.  Asymmetric Sulfide Oxidation with Vanadium Catalysts and H2O2 , 1996 .

[8]  J. Brunel,et al.  Highly Enantioselective Oxidation of Sulfides Mediated by a Chiral Titanium Complex , 1995 .

[9]  S. Iacobelli,et al.  Biochemical and pharmacological characterization of the cyclooxygenase activity of human blood prostaglandin endoperoxide synthases. , 1994, The Journal of pharmacology and experimental therapeutics.

[10]  I. Ojima,et al.  Catalytic Asymmetric Synthesis , 1993 .

[11]  F. Furia,et al.  Synthesis of Chiral Sulfoxides by Metal-Catalyzed Oxidation with t-Butyl Hydroperoxide , 1984 .