Prevalence of tremor in multiple sclerosis and associated disability in the Olmsted County population

We applied a clinical tremor rating scale and measures of disability to 200 of 201 multiple sclerosis patients from a prevalence cohort in Olmsted County, Minnesota. In a community‐based sample, tremor was found clinically in 51 (25%) patients, although only 6 (3%) patients had severe tremor. Within the population as a whole, tremor was strongly associated with impairment disability and handicap. © 2004 Movement Disorder Society

[1]  U. Shahani,et al.  Coherence between low-frequency activation of the motor cortex and tremor in patients with essential tremor , 2000, The Lancet.

[2]  F. J. Williams,et al.  Wilson's disease. An analysis of the cranial computerized tomographic appearances found in 60 patients and the changes in response to treatment with chelating agents. , 1981, Brain : a journal of neurology.

[3]  J. Timmer,et al.  Tremor-correlated cortical activity in essential tremor , 2001, The Lancet.

[4]  H. Imhof,et al.  Cranial MRI in Wilson's disease , 2004, Neuroradiology.

[5]  R. Kristeva-Feige,et al.  Tremor-correlated cortical activity detected by electroencephalography , 2000, Clinical Neurophysiology.

[6]  B. Day,et al.  Stimulation of the human motor cortex through the scalp , 1991, Experimental physiology.

[7]  A. Schnitzler,et al.  Synchronised oscillations of the human sensorimotor cortex. , 2000, Acta neurobiologiae experimentalis.

[8]  D. Silberberg,et al.  New diagnostic criteria for multiple sclerosis: Guidelines for research protocols , 1983, Annals of neurology.

[9]  L. Golbe,et al.  Parkinson's Disease and Movement Disorders: Diagnosis and Treatment Guidelines for the Practicing Physician , 2001 .

[10]  M. Komu,et al.  Magnetic resonance imaging and proton MR spectroscopy in Wilson's disease. , 1999, The British journal of radiology.

[11]  R. Slater.  Criteria and uses of the Minimal Record of Disability in multiple sclerosis , 1984, Acta neurologica Scandinavica. Supplementum.

[12]  A. Young,et al.  Wilson disease of the brain: MR imaging. , 1985, Radiology.

[13]  J. De Keyser,et al.  Tremor in multiple sclerosis , 2007, Journal of Neurology.

[14]  B. Conway,et al.  Synchronization between motor cortex and spinal motoneuronal pool during the performance of a maintained motor task in man. , 1995, The Journal of physiology.

[15]  R. Hari,et al.  Cortical control of human motoneuron firing during isometric contraction. , 1997, Journal of neurophysiology.

[16]  L. Friedman,et al.  Wilson's disease: current status. , 1992, The American journal of medicine.

[17]  A M Amjad,et al.  A framework for the analysis of mixed time series/point process data--theory and application to the study of physiological tremor, single motor unit discharges and electromyograms. , 1995, Progress in biophysics and molecular biology.

[18]  J. Baskerville,et al.  The natural history of multiple sclerosis: a geographically based study. 5. The clinical features and natural history of primary progressive multiple sclerosis. , 1999, Brain : a journal of neurology.

[19]  P. Bain,et al.  A study of tremor in multiple sclerosis. , 2001, Brain : a journal of neurology.

[20]  K. Kaufman,et al.  Surgical therapy for tremor in multiple sclerosis , 2001, Neurology.

[21]  J. Kurtzke.  Rating neurologic impairment in multiple sclerosis , 1983, Neurology.

[22]  I. Sternlieb,et al.  Neuropathological findings in penicillamine-treated patients with Wilson's disease. , 1988, Clinical neuropathology.

[23]  K. Kaufman,et al.  Surgical therapy for tremor in multiple sclerosis: An evaluation of outcome measures , 2001 .

[24]  B Bass,et al.  The natural history of multiple sclerosis: a geographically based study. I. Clinical course and disability. , 1989, Brain : a journal of neurology.

[25]  J. Dostrovsky,et al.  Neuronal activity in the globus pallidus of multiple system atrophy patients , 2004, Movement disorders : official journal of the Movement Disorder Society.

[26]  K. Davis,et al.  Computed tomography in wilson disease: Report of 2 cases , 1979, Annals of neurology.

[27]  A. Schnitzler,et al.  Cortical origin of mini-asterixis in hepatic encephalopathy , 2002, Neurology.

[28]  H. Freund,et al.  Cortico‐muscular synchronization during isometric muscle contraction in humans as revealed by magnetoencephalography , 2000, The Journal of physiology.

[29]  H. Freund,et al.  The cerebral oscillatory network of parkinsonian resting tremor. , 2003, Brain : a journal of neurology.

[30]  G. W. Ellison,et al.  A health-related quality of life measure for multiple sclerosis , 1995, Quality of Life Research.

[31]  S. Weigand,et al.  Quality of life is favorable for most patients with multiple sclerosis: a population-based cohort study. , 2004, Archives of neurology.