CDK5 promotes apoptosis and attenuates chemoresistance in gastric cancer via E2F1 signaling

[1]  R. Yin,et al.  Higher Levels of Tumour-Infiltrating Lymphocytes (TILs) are Associated with a Better Prognosis, While CDK5 Plays a Different Role Between Nonmetastatic and Metastatic Colonic Carcinoma , 2023, Cancer control : journal of the Moffitt Cancer Center.

[2]  CME Exam 2: Helicobacter pylori–induced RASAL2 Through Activation of Nuclear Factor-κB Promotes Gastric Tumorigenesis via β-catenin Signaling Axis , 2022, Gastroenterology.

[3]  W. El-Rifai,et al.  Helicobacter pylori-induced RASAL2 through activation of NF-kB promotes gastric tumorigenesis via β-catenin signaling axis. , 2022, Gastroenterology.

[4]  Robert F. Gruener,et al.  oncoPredict: an R package for predicting in vivo or cancer patient drug response and biomarkers from cell line screening data , 2021, Briefings Bioinform..

[5]  Fenghua Wang,et al.  The Chinese Society of Clinical Oncology (CSCO): Clinical guidelines for the diagnosis and treatment of gastric cancer, 2021 , 2021, Cancer communications.

[6]  Xiaobing Jiang,et al.  CDK5 Knockdown inhibits proliferation and induces apoptosis and Cell Cycle Arrest in Human Glioblastoma , 2021, Journal of Cancer.

[7]  A. Jemal,et al.  Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries , 2021, CA: a cancer journal for clinicians.

[8]  Y. Lou,et al.  Fusobacterium nucleatum Promotes the Progression of Colorectal Cancer Through Cdk5-Activated Wnt/β-Catenin Signaling , 2021, Frontiers in Microbiology.

[9]  Chang-ming Huang,et al.  An immune checkpoint score system for prognostic evaluation and adjuvant chemotherapy selection in gastric cancer , 2020, Nature Communications.

[10]  Nanfei Yang,et al.  CDK5 Inhibition Abrogates TNBC Stem‐Cell Property and Enhances Anti‐PD‐1 Therapy , 2020, Advanced science.

[11]  Shuangbing Xu,et al.  CDK5 activates Hippo signaling to confer resistance to radiotherapy via upregulating TAZ in lung cancer. , 2020, International journal of radiation oncology, biology, physics.

[12]  W. El-Deiry,et al.  Targeting apoptosis in cancer therapy , 2020, Nature Reviews Clinical Oncology.

[13]  Japanese Gastric Cancer Association.  Japanese gastric cancer treatment guidelines 2018 (5th edition) , 2020, Gastric Cancer.

[14]  S. Singh,et al.  Cdk5: A main culprit in neurodegeneration , 2019, The International journal of neuroscience.

[15]  Tsung-Ying Yang,et al.  Future Aspects of CDK5 in Prostate Cancer: From Pathogenesis to Therapeutic Implications , 2019, International journal of molecular sciences.

[16]  Jianping Zhang,et al.  Cyclin-dependent kinase 5 acts as a promising biomarker in clear cell Renal Cell Carcinoma , 2019, BMC Cancer.

[17]  Yao Lin,et al.  CDK5 suppresses the metastasis of gastric cancer cells by interacting with and regulating PP2A , 2018, Oncology reports.

[18]  Chang-ming Huang,et al.  The prognostic value of Cyclin-Dependent Kinase 5 and Protein Phosphatase 2A in Gastric Cancer , 2018, Journal of Cancer.

[19]  P. Krammer,et al.  Tumor Immunology , 2018, Medical Immunology.

[20]  G. Mills,et al.  Clinical and genomic landscape of gastric cancer with a mesenchymal phenotype , 2018, Nature Communications.

[21]  Ita Novita Sari,et al.  Cancer Stem Cells (CSCs) in Drug Resistance and their Therapeutic Implications in Cancer Treatment , 2018, Stem cells international.

[22]  J. Rosales,et al.  Loss of Cdk5 in breast cancer cells promotes ROS-mediated cell death through dysregulation of the mitochondrial permeability transition pore , 2018, Oncogene.

[23]  Elizabeth J. Osterlund,et al.  BCL-2 family proteins: changing partners in the dance towards death , 2017, Cell Death and Differentiation.

[24]  Behzad Baradaran,et al.  The Different Mechanisms of Cancer Drug Resistance: A Brief Review , 2017, Advanced pharmaceutical bulletin.

[25]  S. Altekruse,et al.  Examining the gastric cancer survival gap between Asians and whites in the United States , 2017, Gastric Cancer.

[26]  Yao Lin,et al.  Expression of CRM1 and CDK5 shows high prognostic accuracy for gastric cancer , 2017, World journal of gastroenterology.

[27]  Haidong Zhao,et al.  Cdk5 links with DNA damage response and cancer , 2017, Molecular Cancer.

[28]  J. Bibb,et al.  The Emerging Role of Cdk5 in Cancer. , 2016, Trends in cancer.

[29]  Jin-bo Gao,et al.  Molecular mechanisms of chemoresistance in gastric cancer , 2016, World journal of gastrointestinal oncology.

[30]  Yao Lin,et al.  Low Expression of CDK5 and p27 Are Associated with Poor Prognosis in Patients with Gastric Cancer , 2016, Journal of Cancer.

[31]  R. Bourgon,et al.  Atezolizumab in patients with locally advanced and metastatic urothelial carcinoma who have progressed following treatment with platinum-based chemotherapy: a single-arm, multicentre, phase 2 trial , 2016, The Lancet.

[32]  J. Marin,et al.  Mechanisms of Resistance to Chemotherapy in Gastric Cancer. , 2016, Anti-cancer agents in medicinal chemistry.

[33]  M. Khaniani,et al.  Molecular mechanisms of apoptosis and roles in cancer development and treatment. , 2015, Asian Pacific journal of cancer prevention : APJCP.

[34]  Maohui Luo,et al.  Cyclin-Dependent Kinase 5 Decreases in Gastric Cancer and Its Nuclear Accumulation Suppresses Gastric Tumorigenesis , 2015, Clinical Cancer Research.

[35]  S. Carr,et al.  CDK5 is a major regulator of the tumor suppressor DLC1 , 2014, The Journal of cell biology.

[36]  T. Tan,et al.  Epithelial-mesenchymal transition spectrum quantification and its efficacy in deciphering survival and drug responses of cancer patients , 2014, EMBO molecular medicine.

[37]  S. Hsu,et al.  All-Trans Retinoic Acid Induces DU145 Cell Cycle Arrest through Cdk5 Activation , 2014, Cellular Physiology and Biochemistry.

[38]  Peter E. Czabotar,et al.  Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy , 2013, Nature Reviews Molecular Cell Biology.

[39]  S. Hsu,et al.  Retinoic Acid Induces Apoptosis of Prostate Cancer DU145 Cells through Cdk5 Overactivation , 2012, Evidence-based complementary and alternative medicine : eCAM.

[40]  Guangchuang Yu,et al.  clusterProfiler: an R package for comparing biological themes among gene clusters. , 2012, Omics : a journal of integrative biology.

[41]  H. Ryoo.  Pro-apoptotic signaling pathway by CDK5 and MEKK1 , 2012, Cell cycle.

[42]  H. Ryoo,et al.  Cdk5 and Mekk1 mediate a Pro-Apoptotic Signaling Response to Endoplasmic Reticulum Stress in a Drosophila Model of Autosomal Dominant Retinitis Pigmentosa , 2012, Nature Cell Biology.

[43]  Rebecca SY Wong,et al.  Apoptosis in cancer: from pathogenesis to treatment , 2011, Journal of experimental & clinical cancer research : CR.

[44]  P. Butler,et al.  Cyclin-Dependent Kinase 5 Promotes Pancreatic β-Cell Survival via Fak-Akt Signaling Pathways , 2011, Diabetes.

[45]  M. V. Vijayakumar,et al.  Cdk5 phosphorylates non-genotoxically overexpressed p53 following inhibition of PP2A to induce cell cycle arrest/apoptosis and inhibits tumor progression , 2010, Molecular Cancer.

[46]  Ben S. Wittner,et al.  Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1 , 2009, Nature.

[47]  M. Bhat,et al.  Cell cycle regulatory protein 5 (Cdk5) is a novel downstream target of ERK in carboplatin induced death of breast cancer cells. , 2008, Current cancer drug targets.

[48]  F. X. Pimentel-Muiños,et al.  A high-throughput screening for mammalian cell death effectors identifies the mitochondrial phosphate carrier as a regulator of cytochrome c release , 2008, Oncogene.

[49]  L. Buée,et al.  The complex p25/Cdk5 kinase in neurofibrillary degeneration and neuronal death: The missing link to cell cycle , 2007, Biotechnology journal.

[50]  Afshin Samali,et al.  Mediators of endoplasmic reticulum stress‐induced apoptosis , 2006, EMBO reports.

[51]  J. Juang,et al.  Involvement of Cdk5/p25 in Digoxin-triggered Prostate Cancer Cell Apoptosis* , 2004, Journal of Biological Chemistry.

[52]  Luquan Wang,et al.  Transcriptional Regulation during p21 WAF1/CIP1 -induced Apoptosis in Human Ovarian Cancer Cells* , 2002, The Journal of Biological Chemistry.

[53]  Li-Huei Tsai,et al.  A decade of CDK5 , 2001, Nature Reviews Molecular Cell Biology.

[54]  S. Urban,et al.  Expression and localization of cyclin-dependent kinase 5 in apoptotic human glioma cells. , 2001, Neuro-oncology.

[55]  S. Lowe,et al.  Apoptosis in cancer. , 2000, Carcinogenesis.

[56]  V. Garg,et al.  Intrinsic and extrinsic pathways of apoptosis: Role in cancer development and prognosis. , 2021, Advances in protein chemistry and structural biology.

[57]  M. Schwab,et al.  Role of ABC transporters in fluoropyrimidine-based chemotherapy response. , 2015, Advances in cancer research.

[58]  N. Babu,et al.  Apoptosis in cancer--an update. , 2012, Asian Pacific journal of cancer prevention : APJCP.