The Study of Sulfisoxazole Direct Photodegradation

In this paper, the photolytic behavior of the sulfonamide antibiotic sulfisoxazole in water was investigated in accordance with OECD Guideline 316 using a laboratory photoreactor approximating full-spectrum sunlight (SunTest CPS+). Direct photolysis of sulfisoxazole was relatively rapid, with a half-life of 3.1 h and 11.7 h, for the acid and neutral conditions, respectively. Direct photolysis rates was a pseudo-first order kinetics in neutral solution, but in acid solution after 2 h of photolysis the rate of SX rate increased. Identified photoproducts were sulfanilamide, and its OH addition products. The fragmentation of the isoxazole ring was also observed. These results suggest that photolytic processes could be a major removal mechanism of sulfisoxazole in aquatic systems.

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