Peptides: A Package for Data Mining of Antimicrobial Peptides

Antimicrobial peptides (AMP) are a promising source of antibiotics with a broad spectrum activity against bacteria and low incidence of developing resistance. The mechanism by which an AMP executes its function depends on a set of computable physicochemical properties from the amino acid sequence. Peptides package was designed for allowing the quick and easy computation of ten structural characteristics own of the antimicrobial peptides, with the aim of generating data for increase the accuracy in classification and design of new amino acid sequences. Moreover, the options to read and plot XVG output files from GROMACS molecular dynamics package was included.

[1]  A Ikai,et al.  Thermostability and aliphatic index of globular proteins. , 1980, Journal of biochemistry.

[2]  David Eisenberg,et al.  The helical hydrophobic moment: a measure of the amphiphilicity of a helix , 1982, Nature.

[3]  R D Appel,et al.  Protein identification and analysis tools in the ExPASy server. , 1999, Methods in molecular biology.

[4]  Matthew R. Pocock,et al.  The Bioperl toolkit: Perl modules for the life sciences. , 2002, Genome research.

[5]  W. Nau,et al.  A conformational flexibility scale for amino acids in peptides. , 2003, Angewandte Chemie.

[6]  I. Longden,et al.  EMBOSS: the European Molecular Biology Open Software Suite. , 2000, Trends in genetics : TIG.

[7]  Shreyas Karnik,et al.  CAMP: a useful resource for research on antimicrobial peptides , 2009, Nucleic Acids Res..

[8]  Minoru Kanehisa,et al.  AAindex: amino acid index database, progress report 2008 , 2007, Nucleic Acids Res..

[9]  Lucie Bednárová,et al.  Lasiocepsin, a novel cyclic antimicrobial peptide from the venom of eusocial bee Lasioglossum laticeps (Hymenoptera: Halictidae) , 2011, Amino Acids.

[10]  S. Piotto,et al.  YADAMP: yet another database of antimicrobial peptides. , 2012, International journal of antimicrobial agents.

[11]  Michael R. Yeaman,et al.  Mechanisms of Antimicrobial Peptide Action and Resistance , 2003, Pharmacological Reviews.

[12]  H. G. Boman,et al.  Antibacterial peptides: basic facts and emerging concepts , 2003, Journal of internal medicine.

[13]  Xia Li,et al.  APD2: the updated antimicrobial peptide database and its application in peptide design , 2008, Nucleic Acids Res..

[14]  Martyn Plummer,et al.  The R Journal , 2012 .

[15]  R. Hancock,et al.  Cationic peptides: effectors in innate immunity and novel antimicrobials. , 2001, The Lancet. Infectious diseases.

[16]  D. Eisenberg Three-dimensional structure of membrane and surface proteins. , 1984, Annual review of biochemistry.

[17]  Ju Hyun Cho,et al.  De novo generation of short antimicrobial peptides with enhanced stability and cell specificity. , 2014, The Journal of antimicrobial chemotherapy.

[18]  G. Heijne,et al.  Molecular code for transmembrane-helix recognition by the Sec61 translocon , 2007, Nature.

[19]  M. W. Pandit,et al.  Correlation between stability of a protein and its dipeptide composition: a novel approach for predicting in vivo stability of a protein from its primary sequence. , 1990, Protein engineering.

[20]  Gianluca Pollastri,et al.  CPPpred: prediction of cell penetrating peptides , 2013, Bioinform..

[21]  Marc Torrent,et al.  Connecting Peptide Physicochemical and Antimicrobial Properties by a Rational Prediction Model , 2011, PloS one.

[22]  Katsumi Matsuzaki,et al.  Control of cell selectivity of antimicrobial peptides. , 2009, Biochimica et biophysica acta.

[23]  G J Williams,et al.  The Protein Data Bank: a computer-based archival file for macromolecular structures. , 1978, Archives of biochemistry and biophysics.

[24]  Patrick Gaillard,et al.  Molecular Lipophilicity Potential, a tool in 3D QSAR: Method and applications , 1994, J. Comput. Aided Mol. Des..

[25]  Dexter S. Moore,et al.  Amino acid and peptide net charges: A simple calculational procedure , 1985 .

[26]  G. Schneider,et al.  Designing antimicrobial peptides: form follows function , 2011, Nature Reviews Drug Discovery.