Crystallization and polymorphic transition behavior of chloramphenicol palmitate in 2-hydroxypropyl-β-cyclodextrin matrix

Chloramphenicol palmitate (CPP) was converted to an amorphous complex when spray-dried with 2-hydroxypropyl-β-cyclodextrin (HP-β-CyD), and no crystallization of CPP was observed for at least 2 months under the storage condition of 50°C and 50% relative humidity. The dissolution rate of CPP/HP-β-CyD complex in aqueous HCO-60 solution was much faster than CPP polymorphs (complex > metastable forms (B and subB) > stable form (A)), which was reflected in thein-vivo absorption behavior of CPP following oral administration in dogs.