Comparative QSAR studies on PAMPA/modified PAMPA for high throughput profiling of drug absorption potential with respect to Caco-2 cells and human intestinal absorption
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[1] S. Ekins,et al. Progress in predicting human ADME parameters in silico. , 2000, Journal of pharmacological and toxicological methods.
[2] Kiyohiko Sugano,et al. Prediction of human intestinal permeability using artificial membrane permeability. , 2003, International journal of pharmaceutics.
[3] I. Hidalgo,et al. Assessing the absorption of new pharmaceuticals. , 2001, Current topics in medicinal chemistry.
[4] E. Kerns,et al. High throughput physicochemical profiling for drug discovery. , 2001, Journal of pharmaceutical sciences.
[5] R. M. Muir,et al. Correlation of Biological Activity of Phenoxyacetic Acids with Hammett Substituent Constants and Partition Coefficients , 1962, Nature.
[6] Kazuya Nakao,et al. Relationships between structure and high-throughput screening permeability of diverse drugs with artificial membranes: application to prediction of Caco-2 cell permeability. , 2005, Bioorganic & medicinal chemistry.
[7] M. Machida,et al. High Throughput Prediction of Oral Absorption: Improvement of the Composition of the Lipid Solution Used in Parallel Artificial Membrane Permeation Assay , 2001, Journal of biomolecular screening.
[8] Kin-Kai Hwang,et al. A comparative study of artificial membrane permeability assay for high throughput profiling of drug absorption potential. , 2002, European journal of medicinal chemistry.
[9] Kiyohiko Sugano,et al. Prediction of passive intestinal absorption using bio-mimetic artificial membrane permeation assay and the paracellular pathway model. , 2002, International journal of pharmaceutics.
[10] K Gubernator,et al. Physicochemical high throughput screening: parallel artificial membrane permeation assay in the description of passive absorption processes. , 1998, Journal of medicinal chemistry.
[11] Stephen R. Johnson,et al. Molecular properties that influence the oral bioavailability of drug candidates. , 2002, Journal of medicinal chemistry.
[12] E. Lien,et al. QSAR analysis of membrane permeability to organic compounds. , 1996, Journal of drug targeting.
[13] Li Di,et al. Combined application of parallel artificial membrane permeability assay and Caco-2 permeability assays in drug discovery. , 2004, Journal of pharmaceutical sciences.
[14] Tudor I. Oprea,et al. Property distribution of drug-related chemical databases* , 2000, J. Comput. Aided Mol. Des..
[15] K. Luthman,et al. Correlation of drug absorption with molecular surface properties. , 1996, Journal of pharmaceutical sciences.
[16] C. Selassie,et al. QSAR: then and now. , 2002, Current topics in medicinal chemistry.
[17] D. E. Clark,et al. Rapid calculation of polar molecular surface area and its application to the prediction of transport phenomena. 2. Prediction of blood-brain barrier penetration. , 1999, Journal of pharmaceutical sciences.
[18] Ulrich J. Krull,et al. The structure and electrochemical properties of a polymer-supported lipid biosensor , 1980 .
[19] D. E. Patterson,et al. Crossvalidation, Bootstrapping, and Partial Least Squares Compared with Multiple Regression in Conventional QSAR Studies , 1988 .
[20] U Norinder,et al. Theoretical calculation and prediction of drug transport processes using simple parameters and partial least squares projections to latent structures (PLS) statistics. The use of electrotopological state indices. , 2001, Journal of pharmaceutical sciences.
[21] J. Goodwin,et al. Physicochemical determinants of passive membrane permeability: role of solute hydrogen-bonding potential and volume. , 2001, Journal of medicinal chemistry.
[22] D. E. Clark,et al. Prediction of intestinal absorption and blood-brain barrier penetration by computational methods. , 2001, Combinatorial chemistry & high throughput screening.
[23] P J Sinko,et al. Development of predictive pharmacokinetic simulation models for drug discovery. , 2000, Journal of controlled release : official journal of the Controlled Release Society.
[24] A. Leo,et al. Chem-bioinformatics: comparative QSAR at the interface between chemistry and biology. , 2002, Chemical reviews.
[25] P. Proulx. Structure-function relationships in intestinal brush border membranes. , 1991, Biochimica et biophysica acta.
[26] C. Hansch,et al. Comparative QSAR and the radical toxicity of various functional groups. , 2002, Chemical reviews.
[27] Thomas J. Vidmar,et al. A non-aqueous partitioning system for predicting the oral absorption potential of peptides , 1994 .
[28] T I Oprea,et al. Toward minimalistic modeling of oral drug absorption. , 1999, Journal of molecular graphics & modelling.
[29] P. Mura,et al. Development and evaluation of an in vitro method for prediction of human drug absorption II. Demonstration of the method suitability. , 2006, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
[30] B. Testa,et al. Physicochemical profiling in drug research: a brief survey of the state-of-the-art of experimental techniques , 2002, Cellular and Molecular Life Sciences CMLS.
[31] Li Di,et al. High throughput artificial membrane permeability assay for blood-brain barrier. , 2003, European journal of medicinal chemistry.
[32] K. Terada,et al. Optimized conditions of bio-mimetic artificial membrane permeation assay. , 2001, International journal of pharmaceutics.
[33] B. Faller,et al. High-throughput permeability pH profile and high-throughput alkane/water log P with artificial membranes. , 2001, Journal of medicinal chemistry.