Integrative research outcomes of shrimp immunity , pathogenesis and microbiomics

Various diseases, currently threaten shrimp aquaculture, especially in developing countries of Asia. The WSD (white spot disease), caused by WSSV (white spot syndrome virus), and AHPND (acute hepatopancreatic necrosis disease), caused by a virulent strain of the Vibrio parahaemolyticus bacterium, are the two most harmful diseases prevalent in shrimp industry. These diseases have caused huge economic losses globally. Therefore, there is an urgent need to develop effective strategies to combat these diseases. A scientifically comprehensive (evidence-based research) approach is essential to determine ecofriendly and sustainable solutions. Our team uses a state-of-the-art integrated systems-biology approach to study complex biological phenomena, with a focus on translational research outcomes. In addition to basic science, we consistently seek practical ways to apply our research outcomes to reduce the impact of diseases in shrimp farming.

[1]  Deng-Chyang Wu,et al.  Consensus on the clinical management, screening‐to‐treat, and surveillance of Helicobacter pylori infection to improve gastric cancer control on a nationwide scale , 2017, Helicobacter.

[2]  Yi-Chun Yeh,et al.  H. pylori CagL-Y58/E59 Prime Higher Integrin α5β1 in Adverse pH Condition to Enhance Hypochlorhydria Vicious Cycle for Gastric Carcinogenesis , 2013, PloS one.

[3]  B. Sheu,et al.  The corpus‐predominant gastritis index may serve as an early marker of Helicobacter pylori‐infected patients at risk of gastric cancer , 2013, Alimentary pharmacology & therapeutics.

[4]  Hsiu‐Chi Cheng,et al.  Long‐term Celecoxib can Prevent the Progression of Persistent Gastric Intestinal Metaplasia After H. pylori Eradication , 2013, Helicobacter.

[5]  J. Wu,et al.  Helicobacter pylori colonization of the human gastric epithelium: A bug's first step is a novel target for us , 2010, Journal of gastroenterology and hepatology.

[6]  S. Chang,et al.  Enhanced Near-Field Imaging Contrasts of Silver Nanoparticles by Localized Surface Plasmon , 2008, IEEE Journal of Selected Topics in Quantum Electronics.

[7]  Hb Yang,et al.  Chronic celecoxib users more often show regression of gastric intestinal metaplasia after Helicobacter pylori eradication , 2006, Alimentary pharmacology & therapeutics.

[8]  J. Wu,et al.  Higher gastric cycloxygenase-2 expression and precancerous change in Helicobacter pylori-infected relatives of gastric cancer patients. , 2003, Clinical cancer research : an official journal of the American Association for Cancer Research.

[9]  F. Aussenegg,et al.  Enhanced substrate-induced coupling in two-dimensional gold nanoparticle arrays , 2002 .

[10]  S. Linden,et al.  Selective suppression of extinction within the plasmon resonance of gold nanoparticles , 2001 .