Tricyclic 1,5-naphthyridinone oxabicyclooctane-linked novel bacterial topoisomerase inhibitors as broad-spectrum antibacterial agents-SAR of left-hand-side moiety (Part-2).

[1]  Sangita Patel,et al.  Oxabicyclooctane-linked novel bacterial topoisomerase inhibitors as broad spectrum antibacterial agents. , 2014, ACS medicinal chemistry letters.

[2]  C. Mayer,et al.  Non-quinolone inhibitors of bacterial type IIA topoisomerases: a feat of bioisosterism. , 2014, Chemical reviews.

[3]  James F Cuff,et al.  Systematic approach to conformational sampling for assigning absolute configuration using vibrational circular dichroism. , 2014, Journal of medicinal chemistry.

[4]  S. Dabbs,et al.  Novel hydroxyl tricyclics (e.g., GSK966587) as potent inhibitors of bacterial type IIA topoisomerases. , 2013, Bioorganic & medicinal chemistry letters.

[5]  M. Huband,et al.  Novel quinoline derivatives as inhibitors of bacterial DNA gyrase and topoisomerase IV. , 2013, Bioorganic & medicinal chemistry letters.

[6]  D. Ehmann,et al.  Novel N-linked aminopiperidine inhibitors of bacterial topoisomerase type II with reduced pK(a): antibacterial agents with an improved safety profile. , 2012, Journal of medicinal chemistry.

[7]  S. Dabbs,et al.  Novel cyclohexyl-amides as potent antibacterials targeting bacterial type IIA topoisomerases. , 2011, Bioorganic & medicinal chemistry letters.

[8]  S. Dabbs,et al.  Novel amino-piperidines as potent antibacterials targeting bacterial type IIA topoisomerases. , 2011, Bioorganic & medicinal chemistry letters.

[9]  C. Eyermann,et al.  Novel N-linked aminopiperidine inhibitors of bacterial topoisomerase type II: broad-spectrum antibacterial agents with reduced hERG activity. , 2011, Journal of medicinal chemistry.

[10]  Michael R. Mulvey,et al.  Prevalence of Antimicrobial-Resistant Pathogens in Canadian Hospitals: Results of the Canadian Ward Surveillance Study (CANWARD 2007) , 2009 .

[11]  Kristin K. Brown,et al.  Type IIA topoisomerase inhibition by a new class of antibacterial agents , 2010, Nature.

[12]  K. Coleman,et al.  New inhibitors of bacterial topoisomerase GyrA/ParC subunits. , 2009, Current opinion in investigational drugs.

[13]  J. Dumas,et al.  Chapter 19 Recent Advances in the Inhibition of Bacterial Type II Topoisomerases , 2009 .

[14]  D. Platel,et al.  Mechanism of Action of the Antibiotic NXL101, a Novel Nonfluoroquinolone Inhibitor of Bacterial Type II Topoisomerases , 2008, Antimicrobial Agents and Chemotherapy.

[15]  Roberta B Carey,et al.  Invasive methicillin-resistant Staphylococcus aureus infections in the United States. , 2007, JAMA.

[16]  John J. M. Wiener,et al.  Tetrahydroindazole inhibitors of bacterial type II topoisomerases. Part 2: SAR development and potency against multidrug-resistant strains. , 2007, Bioorganic & medicinal chemistry letters.

[17]  John J. M. Wiener,et al.  Novel pyrazole derivatives as potent inhibitors of type II topoisomerases. Part 1: synthesis and preliminary SAR analysis. , 2007, Bioorganic & medicinal chemistry letters.