Magnetic resonance imaging of the skin

A thorough examination of the skin is essential to screen various diseases accurately, evaluate the effectiveness of topically applied drugs and assess the results of dermatological surgeries such as skin grafts. The assessment of skin properties is also crucial in the cosmetics industry, where it is important to evaluate the effects skin care products have on these properties. The simplest and most widely used method of skin evaluation, the ‘naked eye’ assessment, enables researchers to assess only the skin surface and involves a large amount of inter‐observer variability. Thanks to a great progress that has been made in physics, electronics and computer engineering in recent years, sophisticated imaging methods are increasingly available in day‐to‐day studies. The aim of this review was to present one of these techniques, namely the magnetic resonance imaging (MRI), and to discuss its possible use in skin examination and analysis. We present basic principles of MRI, as well as several interesting applications in the field of dermatology, and discuss the advantages and limitations of this method.

[1]  P. Lauterbur,et al.  Image Formation by Induced Local Interactions: Examples Employing Nuclear Magnetic Resonance , 1973, Nature.

[2]  B. Querleux,et al.  Assessment of aging of the human skin by in vivo ultrasonic imaging. , 1989, The Journal of investigative dermatology.

[3]  I. Idy-Peretti,et al.  Magnetic resonance imaging: a new tool in the diagnosis of tumours of the nail apparatus , 1994, The British journal of dermatology.

[4]  R. Wickett,et al.  Structure and function of the epidermal barrier , 2006 .

[5]  S. Kinsey,et al.  Spatial resolution of transdermal water mobility using NMR microscopy. , 1997, Magnetic resonance imaging.

[6]  Fakhereh Mirrashed,et al.  In vivo quantitative analysis of the effect of hydration (immersion and Vaseline treatment) in skin layers using high‐resolution MRI and magnetisation transfer contrast * , 2004, Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging.

[7]  J. Hadgraft,et al.  GARField magnetic resonance profiling of the ingress of model skin-care product ingredients into human skin in vitro. , 2004, Journal of pharmaceutical sciences.

[8]  D. Zakowiecki,et al.  Advanced tools for in vivo skin analysis , 2010, International journal of dermatology.

[9]  P Crozat,et al.  High‐temperature superconducting surface coil for in vivo microimaging of the human skin , 2001, Magnetic resonance in medicine.

[10]  B. Querleux,et al.  Lymphedematous skin and subcutis: in vivo high resolution magnetic resonance imaging evaluation. , 1998, The Journal of investigative dermatology.

[11]  P. Glover,et al.  Stray field magnetic resonance imaging: a preliminary study of skin hydration , 2003 .

[12]  Surface coil for MR imaging of the skin , 1987, Magnetic resonance in medicine.

[13]  F. Wehrli,et al.  In vivo MR microscopy of the human skin , 1997, Magnetic resonance in medicine.

[14]  O Jolivet,et al.  In vivo proton relaxation times analysis of the skin layers by magnetic resonance imaging. , 1991, The Journal of investigative dermatology.

[15]  Rakesh Sharma,et al.  Microimaging of hairless rat skin by magnetic resonance at 900 MHz. , 2009, Magnetic resonance imaging.

[16]  O Jolivet,et al.  Characterization of the skin in vivo by high resolution magnetic resonance imaging: water behavior and age-related effects. , 1993, The Journal of investigative dermatology.

[17]  Bernard Querleux,et al.  Advances in MR imaging of the skin , 2006, NMR in biomedicine.

[18]  A Hemmingsson,et al.  High-resolution spectroscopic imaging of the human skin. , 2001, Magnetic resonance imaging.

[19]  L. Holmes,et al.  ENCYCLOPEDIA OF SPECTROSCOPY AND SPECTROMETRY , 2001 .

[20]  E. Sulyok,et al.  Physical water compartments: a revised concept of perinatal body water physiology. , 2006, Physiological research.

[21]  A. O. Rodríguez,et al.  Principles of magnetic resonance imaging , 2004 .

[22]  P. Robert,et al.  Contrast-enhanced dynamic MRI protocol with improved spatial and time resolution for in vivo microimaging of the mouse with a 1.5-T body scanner and a superconducting surface coil. , 2005, Magnetic resonance imaging.

[23]  Sébastien Aubry,et al.  Feasibility study of 3-T MR imaging of the skin , 2009, European Radiology.

[24]  B. Querleux,et al.  In vivo high-resolution MR imaging of the skin in a whole-body system at 1.5 T. , 1990, Radiology.

[25]  P. McDonald,et al.  Magnetic resonance profiling of human skin in vivo using GARField magnets. , 2005, Journal of pharmaceutical sciences.