A study of fluid dynamics parameters for prediction of obstructive sleep apnea

Obstructive sleep apnea (OSA) is a syndrome characterized by the repetitive episodic collapse of the upper airway. The purpose of this study is to investigate the fluid dynamic parameters for the prediction of obstructive sleep apnea in the upper airway before and after setback surgery. Here, we analyzed the flow phenomena of inspiration and expiration in obstructive sleep apnea patients. The modeling of the upper airway was performed with facial 3 dimensional facial computed tomography images (3D facial CT). We used timedependent value for boundary conditions. The changes of pressure were studied with 3D facial CT taken both before and after the setback surgery. Further, it was found that the correlation between PSG data and non-dimensional pressure drop can be used to predict the severity of OSA. In all 6 patients except for patient 1, the average values of the non-dimensional pressure drops and PSG clinical data are inversely related. For each patient, the lower the pressure drop is, the higher the PSG values will be.

[1]  Bonnie K. Lind,et al.  Association of Sleep-Disordered Breathing, Sleep Apnea, and Hypertension in a Large Community-Based Study , 2000 .

[2]  G. Rettinger,et al.  Nasal mucosal temperature during respiration. , 2002, Clinical otolaryngology and allied sciences.

[3]  C. Shin,et al.  Prevalence of sleep-disordered breathing in middle-aged Korean men and women. , 2004, American journal of respiratory and critical care medicine.

[4]  C. Guilleminault,et al.  Efficacy of automated continuous positive airway pressure in children with sleep-related breathing disorders in an attended setting. , 2004, Pediatrics.

[5]  Guilherme J M Garcia,et al.  Atrophic rhinitis: a CFD study of air conditioning in the nasal cavity. , 2007, Journal of applied physiology.

[6]  C. Schulman,et al.  Prevalence of Sleep Apnea in Morbidly Obese Patients who Presented for Weight Loss Surgery Evaluation: More Evidence for Routine Screening for Obstructive Sleep Apnea before Weight Loss Surgery , 2008, The American surgeon.

[7]  D. Doorly,et al.  Inflow boundary profile prescription for numerical simulation of nasal airflow , 2010, Journal of The Royal Society Interface.

[8]  Parmjit Singh,et al.  The new AASM criteria for scoring hypopneas: impact on the apnea hypopnea index. , 2009, Sleep.

[9]  L. Kaban,et al.  Biomechanics of the upper airway: Changing concepts in the pathogenesis of obstructive sleep apnea. , 2010, International journal of oral and maxillofacial surgery.

[10]  Yang Na,et al.  Unsteady flow characteristics through a human nasal airway , 2010, Respiratory Physiology & Neurobiology.

[11]  F. Lobbezoo,et al.  Oral appliance therapy versus nasal continuous positive airway pressure in obstructive sleep apnea: a randomized, placebo-controlled trial on psychological distress , 2010, Clinical Oral Investigations.

[12]  C. Guilleminault,et al.  Maxillomandibular advancement for the treatment of obstructive sleep apnea: a systematic review and meta-analysis. , 2010, Sleep medicine reviews.

[13]  A. C. Santos,et al.  Volumetric analysis of the pharynx in patients with obstructive sleep apnea (OSA) treated with maxillomandibular advancement (MMA) , 2013, Sleep and Breathing.

[14]  C. Guilleminault,et al.  Maxillomandibular Expansion and Advancement for the Treatment of Sleep-Disordered Breathing in Children and Adults , 2012 .

[15]  S. Suh,et al.  Computational fluid dynamic modeling of femoral artery pseudoaneurysm , 2012 .

[16]  A. Pack,et al.  In-home, self-assembled sleep studies are useful in diagnosing sleep apnea in the elderly. , 2012, Sleep.

[17]  N. Bansback,et al.  Long-term effectiveness of oral appliance versus CPAP therapy and the emerging importance of understanding patient preferences. , 2013, Sleep.

[18]  N. Powell,et al.  Maxillomandibular Advancement and Tracheostomy for Morbidly Obese Obstructive Sleep Apnea , 2015, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

[19]  L. Sharples,et al.  Meta-analysis of randomised controlled trials of oral mandibular advancement devices and continuous positive airway pressure for obstructive sleep apnoea-hypopnoea , 2015, Sleep medicine reviews.

[20]  S. Tufik,et al.  Effectiveness of Maxillomandibular advancement (MMA) surgery in sleep apnea treatment: Case report , 2016, Sleep science.