An opinion paper on the maintenance of robustness: Towards a multimodal and intergenerational approach using digital twins

The increasing number of frail elderly people in our aging society is becoming problematic: about 11% of community‐dwelling older persons are frail and another 42% are pre‐frail. Consequently, a major challenge in the coming years will be to test people over the age of 60 years to detect pre‐frailty at the earliest stage and to return them to robustness using the targeted interventions that are becoming increasingly available. This challenge requires individual longitudinal monitoring (ILM) or follow‐up of community‐dwelling older persons using quantitative approaches. This paper briefly describes an effort to tackle this challenge. Extending the detection of the pre‐frail stages to other population groups is also suggested. Appropriate algorithms have been used to begin the tracing of faint physiological signals in order to detect transitions from robustness to pre‐frailty states and from pre‐frailty to frailty states. It is hoped that these studies will allow older adults to receive preventive treatment at the correct institutions and by the appropriate professionals as early as possible, which will prevent loss of autonomy. Altogether, ILM is conceived as an emerging property of databases (“digital twins”) and not the reverse. Furthermore, ILM should facilitate a coordinated set of actions by the caregivers, which is a complex challenge in itself. This approach should be gradually extended to all ages, because frailty has no age, as is testified by overwork, burnout, and post‐traumatic syndrome.

[1]  R. O’Caoimh,et al.  Defining frailty for healthcare practice and research: A qualitative systematic review with thematic analysis. , 2019, International journal of nursing studies.

[2]  S. Jazwinski,et al.  Examination of the Dimensions of Biological Age , 2019, Front. Genet..

[3]  Gustavo Duque,et al.  Current and emerging biomarkers of frailty in the elderly , 2019, Clinical interventions in aging.

[4]  Nicolas Vayatis,et al.  Balance Impairment in Radiation Induced Leukoencephalopathy Patients Is Coupled With Altered Visual Attention in Natural Tasks , 2019, Front. Neurol..

[5]  K. Walters,et al.  Transitions between frailty states among community-dwelling older people: A systematic review and meta-analysis , 2019, Ageing Research Reviews.

[6]  P. Vidal,et al.  Value of gait analysis for measuring disease severity using inertial sensors in patients with multiple sclerosis: protocol for a systematic review and meta-analysis , 2019, Systematic Reviews.

[7]  Susan J. Gordon,et al.  Feasibility of population screening tests to establish a healthy ageing trajectory , 2019, SAGE open medicine.

[8]  Nutritional interventions for the treatment of frailty in older adults: a systematic review protocol: Erratum , 2019, Medicine.

[9]  S. Bhasin,et al.  Impact of frailty on outcomes in surgical patients: A systematic review and meta-analysis. , 2019, American journal of surgery.

[10]  Pierre-Paul Vidal,et al.  Collaborative sensorimotor intelligence: the scrum as a model , 2018, BMJ Open Sport & Exercise Medicine.

[11]  G. Onder,et al.  Hypertension and frailty: a systematic review and meta-analysis , 2018, BMJ Open.

[12]  M. Illario,et al.  Frailty as the Future Core Business of Public Health: Report of the Activities of the A3 Action Group of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) , 2018, International journal of environmental research and public health.

[13]  Andrea Szwajcer,et al.  A systematic review of the association between sedentary behaviors with frailty , 2018, Experimental Gerontology.

[14]  J. Street,et al.  The impact of frailty and sarcopenia on postoperative outcomes in adult spine surgery. A systematic review of the literature. , 2018, The spine journal : official journal of the North American Spine Society.

[15]  Pierre-Paul Vidal,et al.  An Initial Passive Phase That Limits the Time to Recover and Emphasizes the Role of Proprioceptive Information , 2018, Front. Neurol..

[16]  Nicolas Vayatis,et al.  Template-Based Step Detection with Inertial Measurement Units , 2018, Sensors.

[17]  W. Lim,et al.  Frailty indexes in perioperative and critical care: A systematic review. , 2018, Archives of gerontology and geriatrics.

[18]  P. Peterson,et al.  Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases , 2018, Ageing Research Reviews.

[19]  B. Schoenmakers,et al.  Interventions for frail community-dwelling older adults have no significant effect on adverse outcomes: a systematic review and meta-analysis , 2018, BMC Geriatrics.

[20]  Hui-Shan Lin,et al.  Frailty and anesthesia – risks during and post-surgery , 2018, Local and regional anesthesia.

[21]  R. O’Caoimh,et al.  Population screening, monitoring and surveillance for frailty: three systematic reviews and a grey literature review. , 2018, Annali dell'Istituto superiore di sanita.

[22]  R. O’Caoimh,et al.  Transitions and trajectories in frailty states over time: a systematic review of the European Joint Action ADVANTAGE. , 2018, Annali dell'Istituto superiore di sanita.

[23]  R. O’Caoimh,et al.  Incidence of frailty: a systematic review of scientific literature from a public health perspective. , 2018, Annali dell'Istituto superiore di sanita.

[24]  G. Onder,et al.  The essence of frailty: A systematic review and qualitative synthesis on frailty concepts and definitions. , 2018, European journal of internal medicine.

[25]  F. Matthews,et al.  Frailty trajectories to identify end of life: a longitudinal population-based study , 2018, BMC Medicine.

[26]  G. Kempen,et al.  The impact of multidimensional frailty on dependency in activities of daily living and the moderating effects of protective factors. , 2018, Archives of gerontology and geriatrics.

[27]  A. Clegg,et al.  Frailty and the endocrine system. , 2018, The lancet. Diabetes & endocrinology.

[28]  Ó. Ribeiro,et al.  Assessing the social dimension of frailty in old age: A systematic review. , 2018, Archives of gerontology and geriatrics.

[29]  M. Nalls,et al.  Shared biological pathways for frailty and cognitive impairment: A systematic review , 2018, Ageing Research Reviews.

[30]  B. Kostov,et al.  Pre Frail 80: Multifactorial Intervention to Prevent Progression of Pre-Frailty to Frailty in the Elderly , 2018, The journal of nutrition, health & aging.

[31]  Abdulmotaleb El Saddik,et al.  Digital Twins: The Convergence of Multimedia Technologies , 2018 .

[32]  A. Nouvenne,et al.  Gut microbiota, cognitive frailty and dementia in older individuals: a systematic review , 2018, Clinical interventions in aging.

[33]  M. Izquierdo,et al.  Physical strategies to prevent disuse-induced functional decline in the elderly , 2018, Ageing Research Reviews.

[34]  P. Schuetz,et al.  Refeeding syndrome in the frail elderly population: prevention, diagnosis and management , 2018, Clinical and experimental gastroenterology.

[35]  H. Gwyther,et al.  A realist review to understand the efficacy and outcomes of interventions designed to minimise, reverse or prevent the progression of frailty , 2018, Health psychology review.

[36]  P. Vidal,et al.  Inconsistent anticipatory postural adjustments (APAs) in rugby players: a source of injuries? , 2018, BMJ Open Sport & Exercise Medicine.

[37]  G. Corazza,et al.  Frailty and the gut. , 2018, Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver.

[38]  K. Rockwood,et al.  Relationship between frailty and Alzheimer's disease biomarkers: A scoping review , 2018, Alzheimer's & dementia.

[39]  S. Jang,et al.  Mapping the knowledge structure of frailty in journal articles by text network analysis , 2018, PloS one.

[40]  K. Walters,et al.  Prevalence of frailty and prefrailty among community-dwelling older adults in low-income and middle-income countries: a systematic review and meta-analysis , 2018, BMJ Open.

[41]  Julien Audiffren,et al.  On the importance of local dynamics in statokinesigram: A multivariate approach for postural control evaluation in elderly , 2018, PloS one.

[42]  L. Gianotti,et al.  Systematic review and meta‐analysis of frailty as a predictor of morbidity and mortality after major abdominal surgery , 2017, BJS open.

[43]  M. Cesari,et al.  Feasibility, acceptability and diagnostic test accuracy of frailty screening instruments in community-dwelling older people within the Australian general practice setting: a study protocol for a cross-sectional study , 2017, BMJ Open.

[44]  J. Millán-Calenti,et al.  Nutritional determinants of frailty in older adults: A systematic review , 2017, BMC Geriatrics.

[45]  N. Steverink,et al.  Social frailty in older adults: a scoping review , 2017, European journal of ageing.

[46]  H. Boter,et al.  Prevalence of Frailty in Community‐Dwelling Older Persons: A Systematic Review , 2012, Journal of the American Geriatrics Society.

[47]  D. Stephens,et al.  Acceptability, benefit and costs of early screening for hearing disability: a study of potential screening tests and models. , 2007, Health technology assessment.

[48]  L. Ferrucci,et al.  Untangling the concepts of disability, frailty, and comorbidity: implications for improved targeting and care. , 2004, The journals of gerontology. Series A, Biological sciences and medical sciences.

[49]  L. Fried,et al.  Frailty and the older man. , 1999, The Medical clinics of North America.