Isolation and partial characterization of a lentivirus from talapoin monkeys (Myopithecus talapoin).

We have identified a novel lentivirus prevalent in talapoin monkeys (Myopithecus talapoin), extending previous observations of human immunodeficiency virus-1 cross-reactive antibodies in the serum of these monkeys. We obtained a virus isolate from one of three seropositive monkeys initially available to us. The virus was tentatively named simian immunodeficiency virus from talapoin monkeys (SIVtal). Despite the difficulty of isolating this virus, it was readily passed between monkeys in captivity through unknown routes of transmission. The virus could be propagated for short terms in peripheral blood mononuclear cells of talapoin monkeys but not in human peripheral blood mononuclear cells or human T cell lines. The propagated virus was used to infect a naive talapoin monkey, four rhesus macaques (M. mulatta), and two cynomolgus macaques (M. fascicularis). All animals seroconverted and virus could be reisolated during a short period after experimental infection. A survey of SIVtal-infected captive talapoin monkeys revealed a relative decrease in CD4(+) cell numbers in chronically (>2 years) infected animals. No other signs of immunodeficiency were observed in any of the infected animals. PCR amplification followed by DNA sequencing of two fragments of the polymerase gene revealed that SIVtal is different from the presently known lentiviruses and perhaps most related to the SIV from Sykes monkeys.

[1]  M. Essex,et al.  The Origins of HIV‐1 and HTLV‐4/HIV‐2 , 1987, Annals of the New York Academy of Sciences.

[2]  J. Lewis,et al.  A Novel Simian Immunodeficiency Virus (SIVdrl)pol Sequence from the Drill Monkey, Mandrillus leucophaeus , 1998, Journal of Virology.

[3]  R. Desrosiers,et al.  Induction of AIDS-like disease in macaque monkeys with T-cell tropic retrovirus STLV-III. , 1985, Science.

[4]  S. Wain-Hobson,et al.  Functional classification of simian immunodeficiency virus isolated from a chimpanzee by transactivators. , 1992, Virology.

[5]  P. Fultz,et al.  Prevalence of natural infection with simian immunodeficiency virus and simian T-cell leukemia virus type I in a breeding colony of sooty mangabey monkeys. , 1990, AIDS.

[6]  P. Piot,et al.  Phylogenetic analysis of a new chimpanzee lentivirus SIVcpz-gab2 from a wild-captured chimpanzee from Gabon. , 1994, AIDS research and human retroviruses.

[7]  J. Alroy,et al.  Isolation of T-lymphotropic retrovirus related to HTLV-III/LAV from wild-caught African green monkeys. , 1985, Science.

[8]  Andreas Meyerhans,et al.  Genetic organization of a chimpanzee lentivirus related to HIV-1 , 1990, Nature.

[9]  D. Higgins,et al.  See Blockindiscussions, Blockinstats, Blockinand Blockinauthor Blockinprofiles Blockinfor Blockinthis Blockinpublication Clustal: Blockina Blockinpackage Blockinfor Blockinperforming Multiple Blockinsequence Blockinalignment Blockinon Blockina Minicomputer Article Blockin Blockinin Blockin , 2022 .

[10]  P. Johnson,et al.  Identification of a new subgroup of SIVagm in tantalus monkeys. , 1993, Virology.

[11]  P. Jahrling,et al.  Infection of rhesus and cynomolgus macaques with a rapidly fatal SIV (SIVSMM/PBj) isolate from sooty mangabeys. , 1992, AIDS research and human retroviruses.

[12]  P. Sharp,et al.  Sequence analysis of a highly divergent HIV-1-related lentivirus isolated from a wild captured chimpanzee. , 1996, Virology.

[13]  H. Tsujimoto,et al.  Isolation and characterization of simian immunodeficiency virus from mandrills in Africa and its relationship to other human and simian immunodeficiency viruses , 1988, Journal of virology.

[14]  R. B. Swenson,et al.  Isolation of a T-lymphotropic retrovirus from naturally infected sooty mangabey monkeys (Cercocebus atys). , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[15]  D. Ho,et al.  Natural Infection of a Homozygous Δ24 CCR5 Red-capped Mangabey with an R2b-Tropic Simian Immunodeficiency Virus , 1998, The Journal of experimental medicine.

[16]  N. Pedersen,et al.  Shared antigenic epitopes of the major core proteins of human and simian immunodeficiency virus isolates. , 1992, Journal of medical primatology.

[17]  T. Masuda,et al.  Isolation of simian immunodeficiency virus from african green monkeys and seroepidemiologic survey of the virus in various non‐human primates , 1988, International journal of cancer.

[18]  Philip R. Johnson,et al.  Molecular Cloning of SIV From Sooty Mangabey Monkeys , 1989, Journal of medical primatology.

[19]  J. Thompson,et al.  CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. , 1994, Nucleic acids research.

[20]  Timothy M. Rose,et al.  Type C Retrovirus Released from Porcine Primary Peripheral Blood Mononuclear Cells Infects Human Cells , 1998, Journal of Virology.

[21]  P. Sharp,et al.  Mosaic genome structure of simian immunodeficiency virus from west African green monkeys. , 1994, The EMBO journal.

[22]  R. Kurth,et al.  Simian immunodeficiency virus from African green monkeys. , 1988 .

[23]  F. Gao,et al.  Origin of HIV-1 in the chimpanzee Pan troglodytes troglodytes , 1999, Nature.

[24]  J. R. Napier,et al.  The Natural History Of The Primates , 1985 .

[25]  A. Fomsgaard,et al.  Molecular characterization of simian lentiviruses from east African green monkeys. , 1990, Journal of medical primatology.

[26]  R. Lenroot,et al.  A distinct African lentivirus from Sykes' monkeys , 1993, Journal of virology.

[27]  F. Gao,et al.  Human infection by genetically diverse SIVSM-related HIV-2 in West Africa , 1992, Nature.

[28]  H. Tsujimoto,et al.  Sequence of simian immunodeficiency virus from African green monkey, a new member of the HIV/SIV group , 1988, Nature.

[29]  T. Miura,et al.  Survey of simian immunodeficiency virus among nonhuman primate populations. , 1994, Current topics in microbiology and immunology.

[30]  M. Robert-Guroff,et al.  Transformation of different phenotypic types of human bone marrow T‐lymphocytes by htlv‐1 , 1984, International journal of cancer.

[31]  P. Sharp,et al.  Characterization of a Novel Simian Immunodeficiency Virus (SIV) from L’Hoest Monkeys (Cercopithecus l’hoesti): Implications for the Origins of SIVmnd and Other Primate Lentiviruses , 1999, Journal of Virology.

[32]  M. Gardner.  SIV infected rhesus macaques: an AIDS model for immunoprevention and immunotherapy. , 1989, Advances in experimental medicine and biology.

[33]  K. Fransen,et al.  Isolation and characterization of a new chimpanzee lentivirus (simian immunodeficiency virus isolate cpz‐ant) from a wild‐captured chimpanzee , 1992, AIDS.

[34]  N. Pedersen,et al.  Seroepidemiologic survey of captive old‐world primates for antibodies to human and simian retroviruses, and isolation of a lentivirus from sooty mangabeys (Cercocebus atys) , 1986, International journal of cancer.

[35]  R. Kurth,et al.  Isolation of human immunodeficiency virus-related simian immunodeficiency viruses from African green monkeys. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[36]  W. Pichler,et al.  Comparison of the inhibitory activity of seven anti-T8 antibodies on specific cellular cytotoxicity. , 1984, Immunobiology.

[37]  Q. Sattentau,et al.  Structural analysis of the human immunodeficiency virus-binding domain of CD4. Epitope mapping with site-directed mutants and anti-idiotypes , 1989, The Journal of experimental medicine.

[38]  R. Gibbs,et al.  The use of primers from highly conserved pol regions to identify uncharacterized retroviruses by the polymerase chain reaction. , 1990, Journal of virological methods.

[39]  T. Gojobori,et al.  Sequence of a novel simian immunodeficiency virus from a wild-caught African mandrill , 1989, Nature.

[40]  R. Desrosiers,et al.  Lymphadenopathy in macaques experimentally infected with the simian immunodeficiency virus (SIV). , 1987, The American journal of pathology.

[41]  R. Kennedy,et al.  Isolation and characterization of simian immunodeficiency viruses from two subspecies of African green monkeys. , 1990, AIDS research and human retroviruses.

[42]  Zhiwei Chen,et al.  Natural Infection of a Household Pet Red-Capped Mangabey (Cercocebus torquatus torquatus) with a New Simian Immunodeficiency Virus , 1998, Journal of Virology.