and Their Regulation by Nitric Oxide Biological Roles of Acid and Neutral Sphingomyelinases

[1]  E. Clementi,et al.  Acid sphingomyelinase activity triggers microparticle release from glial cells , 2009, The EMBO journal.

[2]  Jacopo Meldolesi,et al.  Shedding microvesicles: artefacts no more. , 2009, Trends in cell biology.

[3]  E. Clementi,et al.  Endothelial nitric oxide synthase overexpression by neuronal cells in neurodegeneration: a link between inflammation and neuroprotection , 2008, Journal of neurochemistry.

[4]  Petra Schwille,et al.  Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes , 2008, Science.

[5]  Yusuf A. Hannun,et al.  Principles of bioactive lipid signalling: lessons from sphingolipids , 2008, Nature Reviews Molecular Cell Biology.

[6]  Luigi Biancone,et al.  Endothelial progenitor cell derived microvesicles activate an angiogenic program in endothelial cells by a horizontal transfer of mRNA. , 2007, Blood.

[7]  E. Clementi,et al.  Nitric oxide boosts chemoimmunotherapy via inhibition of acid sphingomyelinase in a mouse model of melanoma. , 2007, Cancer research.

[8]  E. Gulbins,et al.  Biological aspects of ceramide-enriched membrane domains. , 2007, Progress in lipid research.

[9]  Chunbo Wang,et al.  Nitric oxide-enhanced caspase-3 and acidic sphingomyelinase interaction: a novel mechanism by which airway epithelial cells escape ceramide-induced apoptosis. , 2007, Experimental cell research.

[10]  A. Futerman.  Intracellular trafficking of sphingolipids: relationship to biosynthesis. , 2006, Biochimica et biophysica acta.

[11]  Shiyong Wu,et al.  Lipid Rafts Mediate Ultraviolet Light–induced Fas Aggregation in M624 Melanoma Cells , 2006, Photochemistry and photobiology.

[12]  F. Mollinedo,et al.  Fas/CD95 death receptor and lipid rafts: new targets for apoptosis-directed cancer therapy. , 2006, Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy.

[13]  E. Clementi,et al.  Endothelial Nitric Oxide Synthase Activation by Tumor Necrosis Factor α Through Neutral Sphingomyelinase 2, Sphingosine Kinase 1, and Sphingosine 1 Phosphate Receptors: A Novel Pathway Relevant to the Pathophysiology of Endothelium , 2006, Arteriosclerosis, thrombosis, and vascular biology.

[14]  E. Labelle,et al.  Nitric oxide stimulated vascular smooth muscle cells undergo apoptosis induced in part by arachidonic acid derived eicosanoids , 2005, Journal of cellular physiology.

[15]  S. Spiegel,et al.  Ceramide 1-Phosphate, a Mediator of Phagocytosis* , 2005, Journal of Biological Chemistry.

[16]  Z. Fuks,et al.  Caspase-dependent and -independent Activation of Acid Sphingomyelinase Signaling* , 2005, Journal of Biological Chemistry.

[17]  T. Möller,et al.  Astrocyte-Derived ATP Induces Vesicle Shedding and IL-1β Release from Microglia1 , 2005, The Journal of Immunology.

[18]  E. Clementi,et al.  Activation of Acid Sphingomyelinase and Its Inhibition by the Nitric Oxide/Cyclic Guanosine 3′,5′-Monophosphate Pathway: Key Events in Escherichia coli-Elicited Apoptosis of Dendritic Cells1 , 2004, The Journal of Immunology.

[19]  Jacek Bielawski,et al.  Role for Mammalian Neutral Sphingomyelinase 2 in Confluence-induced Growth Arrest of MCF7 Cells* , 2004, Journal of Biological Chemistry.

[20]  E. Labelle,et al.  NO induced apoptosis of vascular smooth muscle cells accompanied by ceramide increase , 2004, Journal of cellular physiology.

[21]  R. Kolesnick,et al.  Raft ceramide in molecular medicine , 2003, Oncogene.

[22]  Bernhard Brüne,et al.  Nitric oxide: NO apoptosis or turning it ON? , 2003, Cell Death and Differentiation.

[23]  Wenzheng Zhang,et al.  Protein interactions with nitric oxide synthases: controlling the right time, the right place, and the right amount of nitric oxide. , 2003, American journal of physiology. Renal physiology.

[24]  Zvi Fuks,et al.  Tumor Response to Radiotherapy Regulated by Endothelial Cell Apoptosis , 2003, Science.

[25]  T. Hla.  Signaling and biological actions of sphingosine 1-phosphate. , 2003, Pharmacological research.

[26]  Y. Hannun,et al.  Biochemical Properties of Mammalian Neutral Sphingomyelinase2 and Its Role in Sphingolipid Metabolism* , 2003, The Journal of Biological Chemistry.

[27]  E. Clementi,et al.  Activation of endothelial nitric-oxide synthase by tumor necrosis factor-alpha: a novel pathway involving sequential activation of neutral sphingomyelinase, phosphatidylinositol-3' kinase, and Akt. , 2003, Molecular pharmacology.

[28]  K. Preissner,et al.  Intravascular tissue factor initiates coagulation via circulating microvesicles and platelets , 2003, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[29]  P. Oh,et al.  Transient Mechanoactivation of Neutral Sphingomyelinase in Caveolae to Generate Ceramide* , 2003, The Journal of Biological Chemistry.

[30]  Gianluca Damonte,et al.  Basic fibroblast growth factor activates endothelial nitric-oxide synthase in CHO-K1 cells via the activation of ceramide synthesis. , 2003, Molecular pharmacology.

[31]  C. Hetz,et al.  Caspase-dependent initiation of apoptosis and necrosis by the Fas receptor in lymphoid cells: onset of necrosis is associated with delayed ceramide increase , 2002, Journal of Cell Science.

[32]  A. de Thonel,et al.  Overexpression of Protein Kinase C (cid:1) Confers Protection Against Antileukemic Drugs by Inhibiting the Redox-Dependent Sphingomyelinase Activation , 2002 .

[33]  F. Goñi,et al.  Role of sphingomyelinase and ceramide in modulating rafts: do biophysical properties determine biologic outcome? , 2002, FEBS letters.

[34]  R. Borges,et al.  Pharmacological Regulation of the Late Steps of Exocytosis , 2002, Annals of the New York Academy of Sciences.

[35]  Alfred H. Merrill,et al.  De Novo Sphingolipid Biosynthesis: A Necessary, but Dangerous, Pathway* , 2002, The Journal of Biological Chemistry.

[36]  Yusuf A. Hannun,et al.  The Ceramide-centric Universe of Lipid-mediated Cell Regulation: Stress Encounters of the Lipid Kind* , 2002, The Journal of Biological Chemistry.

[37]  G. Salido,et al.  Effect of sodium nitroprusside and 8‐bromo cyclic GMP on nerve‐mediated and acetylcholine‐evoked secretory responses in the rat pancreas , 2002, British journal of pharmacology.

[38]  E. Giordano,et al.  Nitric oxide down-regulates brain-derived neurotrophic factor secretion in cultured hippocampal neurons , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[39]  B. Kemp,et al.  Localization of Endothelial Nitric-oxide Synthase Phosphorylated on Serine 1179 and Nitric Oxide in Golgi and Plasma Membrane Defines the Existence of Two Pools of Active Enzyme* , 2002, The Journal of Biological Chemistry.

[40]  K. Hirata,et al.  Involvement of Endothelial Nitric Oxide in Sphingosine-1-Phosphate–Induced Angiogenesis , 2001 .

[41]  W. Sessa,et al.  Post-translational control of endothelial nitric oxide synthase: why isn't calcium/calmodulin enough? , 2001, The Journal of pharmacology and experimental therapeutics.

[42]  C. Cooper,et al.  Nitric oxide synthases: structure, function and inhibition , 2001 .

[43]  O. Cuvillier,et al.  Involvement of FAN in TNF-induced apoptosis. , 2001, The Journal of clinical investigation.

[44]  I. Shiojima,et al.  Sphingosine 1-Phosphate Activates Akt, Nitric Oxide Production, and Chemotaxis through a GiProtein/Phosphoinositide 3-Kinase Pathway in Endothelial Cells* , 2001, The Journal of Biological Chemistry.

[45]  T. Billiar,et al.  Sphingosine 1-Phosphate Protects Human Umbilical Vein Endothelial Cells from Serum-deprived Apoptosis by Nitric Oxide Production* , 2001, The Journal of Biological Chemistry.

[46]  E. Clementi,et al.  Activation of the Endothelial Nitric-oxide Synthase by Tumor Necrosis Factor-α , 2001, The Journal of Biological Chemistry.

[47]  S. Menéndez,et al.  Cell Autonomous Apoptosis Defects in Acid Sphingomyelinase Knockout Fibroblasts* , 2001, The Journal of Biological Chemistry.

[48]  A. Quest,et al.  Caveolin-1 down-regulates inducible nitric oxide synthase via the proteasome pathway in human colon carcinoma cells. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[49]  T. Michel,et al.  Agonist-modulated Targeting of the EDG-1 Receptor to Plasmalemmal Caveolae , 2000, The Journal of Biological Chemistry.

[50]  S. Jung,et al.  Identification of Multiple Forms of Membrane‐Associated Neutral Sphingomyelinase in Bovine Brain , 2000, Journal of neurochemistry.

[51]  Deborah A. Brown,et al.  Structure and Function of Sphingolipid- and Cholesterol-rich Membrane Rafts* , 2000, The Journal of Biological Chemistry.

[52]  W. Stoffel,et al.  Cloning and characterization of the mammalian brain-specific, Mg2+-dependent neutral sphingomyelinase. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[53]  E. Clementi,et al.  Nitric oxide inhibits tumor necrosis factor-alpha-induced apoptosis by reducing the generation of ceramide. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[54]  K. Sandhoff,et al.  Purification and Characterization of a Magnesium-dependent Neutral Sphingomyelinase from Bovine Brain* , 2000, The Journal of Biological Chemistry.

[55]  Y. Hannun,et al.  Function of the Cloned Putative Neutral Sphingomyelinase as Lyso-platelet Activating Factor-Phospholipase C* , 1999, The Journal of Biological Chemistry.

[56]  J. Stamler,et al.  NO: an inhibitor of cell death , 1999, Cell Death and Differentiation.

[57]  E. Clementi,et al.  Generation of Nitric Oxide by the Inducible Nitric Oxide Synthase Protects γδ T Cells from Mycobacterium tuberculosis-Induced Apoptosis , 1999, The Journal of Immunology.

[58]  J. Ahn,et al.  TNF-alpha-mediated apoptosis is initiated in caveolae-like domains. , 1999, Journal of immunology.

[59]  V. Briner,et al.  Nitric oxide stimulates chronic ceramide formation in glomerular endothelial cells. , 1999, Biochemical and biophysical research communications.

[60]  T. Uchiyama,et al.  Ceramide Generation in Nitric Oxide-induced Apoptosis , 1999, The Journal of Biological Chemistry.

[61]  J. Jaffrezou,et al.  Signalling sphingomyelinases: which, where, how and why? , 1999, Biochimica et biophysica acta.

[62]  B. Liu,et al.  Purification and Characterization of a Membrane Bound Neutral pH Optimum Magnesium-dependent and Phosphatidylserine-stimulated Sphingomyelinase from Rat Brain* , 1998, The Journal of Biological Chemistry.

[63]  Y. Hannun,et al.  The role of ceramide in cell signaling. , 1998, Biochimica et biophysica acta.

[64]  W. Stoffel,et al.  Concordance of gene genealogies reveals reproductive isolation in the pathogenic fungus Coccidioides immitis , 1998 .

[65]  M. Krönke,et al.  TNF Receptor Death Domain-associated Proteins TRADD and FADD Signal Activation of Acid Sphingomyelinase* , 1998, The Journal of Biological Chemistry.

[66]  T. Meyer,et al.  Acidic Sphingomyelinase Mediates Entry of N. gonorrhoeae into Nonphagocytic Cells , 1997, Cell.

[67]  E. Clementi,et al.  Autocrine Nitric Oxide Modulates CD95-induced Apoptosis in γδ T Lymphocytes* , 1997, The Journal of Biological Chemistry.

[68]  Y. Hannun,et al.  Phospholipase A2 Is Necessary for Tumor Necrosis Factor α-induced Ceramide Generation in L929 Cells* , 1997, The Journal of Biological Chemistry.

[69]  Y. Hannun,et al.  Cytokine Response Modifier A (CrmA) Inhibits Ceramide Formation in Response to Tumor Necrosis Factor (TNF)-α: CrmA and Bcl-2 Target Distinct Components in the Apoptotic Pathway , 1997, The Journal of experimental medicine.

[70]  Seamus J. Martin,et al.  Acid Sphingomyelinase–Deficient Human Lymphoblasts and Mice Are Defective in Radiation-Induced Apoptosis , 1996, Cell.

[71]  G. Garcı́a-Cardeña,et al.  Targeting of nitric oxide synthase to endothelial cell caveolae via palmitoylation: implications for nitric oxide signaling. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[72]  D. Bredt,et al.  Interaction of Nitric Oxide Synthase with the Postsynaptic Density Protein PSD-95 and α1-Syntrophin Mediated by PDZ Domains , 1996, Cell.

[73]  A. Bielawska,et al.  Role of Ceramide in Cellular Senescence (*) , 1995, The Journal of Biological Chemistry.

[74]  D. Perl,et al.  Acid sphingomyelinase deficient mice: a model of types A and B Niemann–Pick disease , 1995, Nature Genetics.

[75]  W. Stoffel,et al.  Acid sphingomyelinase-deficient mice mimic the neurovisceral form of human lysosomal storage disease (Niemann-Pick disease) , 1995, Cell.

[76]  K. Sandhoff,et al.  Occurrence of two molecular forms of human acid sphingomyelinase. , 1994, The Biochemical journal.

[77]  K. Sandhoff,et al.  The tricyclic antidepressant desipramine causes proteolytic degradation of lysosomal sphingomyelinase in human fibroblasts. , 1994, Biological chemistry Hoppe-Seyler.

[78]  K. Sandhoff,et al.  Processing of human acid sphingomyelinase in normal and I-cell fibroblasts. , 1994, The Journal of biological chemistry.

[79]  Y. Hannun,et al.  Programmed cell death induced by ceramide. , 1993, Science.

[80]  R. Desnick,et al.  Structural organization and complete nucleotide sequence of the gene encoding human acid sphingomyelinase (SMPD1). , 1992, Genomics.

[81]  R. Salvayre,et al.  Different pathways of uptake and degradation of sphingomyelin by lymphoblastoid cells and the potential participation of the neutral sphingomyelinase. , 1991, The Journal of biological chemistry.

[82]  S. Moncada,et al.  Nitric oxide: physiology, pathophysiology, and pharmacology. , 1991, Pharmacological reviews.

[83]  A. Bielawska,et al.  Role of ceramide as a lipid mediator of 1 alpha,25-dihydroxyvitamin D3-induced HL-60 cell differentiation. , 1990, The Journal of biological chemistry.

[84]  Y. Hannun,et al.  Sphingomyelin turnover induced by vitamin D3 in HL-60 cells. Role in cell differentiation. , 1989, The Journal of biological chemistry.

[85]  R. Kolesnick.  Sphingomyelinase action inhibits phorbol ester-induced differentiation of human promyelocytic leukemic (HL-60) cells. , 1989, The Journal of biological chemistry.

[86]  R. Kolesnick.  1,2-Diacylglycerols but not phorbol esters stimulate sphingomyelin hydrolysis in GH3 pituitary cells. , 1987, The Journal of biological chemistry.

[87]  M. Berridge.  Inositol trisphosphate and diacylglycerol as second messengers. , 1984, The Biochemical journal.

[88]  E. P. Kennedy,et al.  Sphingomyelinase in normal human spleens and in spleens from subjects with Niemann-Pick disease. , 1967, Journal of lipid research.

[89]  R. Kolesnick,et al.  Acid sphingomyelinase-derived ceramide signaling in apoptosis. , 2002, Sub-cellular biochemistry.

[90]  D. Kabelitz,et al.  Ceramide: does it matter for T cells? , 2002, Trends in immunology.

[91]  J. Dichgans,et al.  Fas/CD95/Apo-I activates the acidic sphingomyelinase via Caspases , 1998, Cell Death and Differentiation.

[92]  E. Schuchman,et al.  Functional characterization of the N-glycosylation sites of human acid sphingomyelinase by site-directed mutagenesis. , 1997, European journal of biochemistry.