Aerogenic Immunization of the Monkey and Guinea Pig with Live Tularemia Vaccine

Summary Studies were made on the clinical acceptability and immunogenicity of live tularemia vaccine administered to the monkey and guinea pig by the dermal or respiratory route. Aerogenic as well as dermal vaccination proved innocuous. Animals vaccinated aerogenically showed higher levels of antibody and comparable if not greater protection against challenge with a highly virulent strain of P. tularensis than animals vaccinated dermally.