Blocking the MyD88-dependent pathway protects the myocardium from ischemia/reperfusion injury in rat hearts.

[1]  David L. Williams,et al.  NF-κB activation is required for the development of cardiac hypertrophy in vivo , 2004 .

[2]  E. Verrier,et al.  Toll-like receptor 4 mediates ischemia/reperfusion injury of the heart. , 2004, The Journal of thoracic and cardiovascular surgery.

[3]  David L. Williams,et al.  Modulating Toll-like receptor mediated signaling by (1-->3)-beta-D-glucan rapidly induces cardioprotection. , 2004, Cardiovascular research.

[4]  J. Kalbfleisch,et al.  Modulation of the Phosphoinositide 3-Kinase Pathway Alters Innate Resistance to Polymicrobial Sepsis 1 , 2004, The Journal of Immunology.

[5]  J. Tschopp,et al.  MyD88S, a splice variant of MyD88, differentially modulates NF‐κB‐ and AP‐1‐dependent gene expression , 2003, FEBS letters.

[6]  J. Oyama,et al.  Reduced Myocardial Ischemia-Reperfusion Injury in Toll-Like Receptor 4-Deficient Mice , 2003, Circulation.

[7]  K. Vuori,et al.  Phosphatidylinositol 3‐kinase is involved in Toll‐like receptor 4‐mediated cytokine expression in mouse macrophages , 2003, European journal of immunology.

[8]  J. Harlan,et al.  The Fas-associated death domain protein suppresses activation of NF-κB by LPS and IL-1β , 2002 .

[9]  Dirk E. Smith,et al.  Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction , 2001, Nature.

[10]  David L. Williams,et al.  Early activation of IKKβ during in vivo myocardial ischemia , 2001 .

[11]  P. Godowski,et al.  Toll-like receptor 2–mediated NF-κB activation requires a Rac1-dependent pathway , 2000, Nature Immunology.

[12]  B. Thorens,et al.  Dominant Negative MyD88 Proteins Inhibit Interleukin-1β/Interferon-γ-mediated Induction of Nuclear Factor κB-dependent Nitrite Production and Apoptosis in β Cells* , 2000, The Journal of Biological Chemistry.

[13]  A. Aderem,et al.  Toll-like receptors in the induction of the innate immune response , 2000, Nature.

[14]  P. Godowski,et al.  The apoptotic signaling pathway activated by Toll‐like receptor‐2 , 2000, The EMBO journal.

[15]  R. Kitsis,et al.  Akt promotes survival of cardiomyocytes in vitro and protects against ischemia-reperfusion injury in mouse heart. , 2000, Circulation.

[16]  R. Kao,et al.  Adenosine prevents activation of transcription factor NF-kappa B and enhances activator protein-1 binding activity in ischemic rat heart. , 2000, Surgery.

[17]  R. Kao,et al.  Early activation of transcription factor NF-κB during ischemia in perfused rat heart. , 1999, American journal of physiology. Heart and circulatory physiology.

[18]  A. Toker,et al.  Phosphatidylinositol 3‐kinase is recruited to a specific site in the activated IL‐1 receptor I , 1998, FEBS letters.

[19]  C. Janeway,et al.  MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways. , 1998, Molecular cell.

[20]  F. Martinon,et al.  MyD88, an Adapter Protein Involved in Interleukin-1 Signaling* , 1998, The Journal of Biological Chemistry.

[21]  Z. Cao,et al.  MyD88: an adapter that recruits IRAK to the IL-1 receptor complex. , 1997, Immunity.

[22]  Y. Kaneda,et al.  A novel strategy for myocardial protection using in vivo transfection of cis element 'decoy' against NFkappaB binding site: evidence for a role of NFkappaB in ischemia-reperfusion injury. , 1997, Circulation.

[23]  T. Ogihara,et al.  In vivo transfection of cis element “decoy” against nuclear factor- κB binding site prevents myocardial infarction , 1997, Nature Medicine.

[24]  C. Janeway,et al.  A human homologue of the Drosophila Toll protein signals activation of adaptive immunity , 1997, Nature.

[25]  David Baltimore,et al.  NF-κB: Ten Years After , 1996, Cell.

[26]  M. McGuinness,et al.  NF-κB as an integrator of diverse signaling pathways , 2007, Cardiovascular Toxicology.

[27]  S. Ghosh,et al.  Toll-like receptor-mediated NF-kappaB activation: a phylogenetically conserved paradigm in innate immunity. , 2001, The Journal of clinical investigation.