Benzo[a]pyrene phenols are more potent inducers of CYP1A1, CYP1B1 and COX-2 than benzo[a]pyrene glucuronides in cell lines derived from the human aerodigestive tract.

Taghreed Almahmeed, Jay O.Boyle, Erik G.Cohen, John F.Carew, Baoheng Du, Nasser K.Altorki, Levy Kopelovich, Jia-Long Fang, Philip Lazarus, Kotha Subbaramaiah and Andrew J.Dannenberg Memorial Sloan-Kettering Cancer Center, Head and Neck Service, Department of Surgery, New York, NY 10021, USA, Weill Medical College of Cornell University, Department of Medicine, New York, NY 10021, USA, Weill Medical College of Cornell University, Department of Otorhinolaryngology, New York, NY 10021, USA, Weill Medical College of Cornell University, Department of Cardiothoracic Surgery, New York, NY 10021, USA, CADRG, DCP, National Cancer Institute, Bethesda, Maryland, USA, H. Lee Moffitt Cancer Center and Research Institute, Divisions of Cancer Control and Molecular Oncology, Tampa, Florida, USA and Strang Cancer Prevention Center, New York, NY 10021, USA To whom correspondence should be addressed Email: ajdannen@med.cornell.edu