The Effect of Treatment of Acute Lymphoblastic Leukemia on Dental Maturity in Children

Objective: The purpose of this study is to study the effect of Acute Lymphoblastic Leukemia (ALL) on dental age by comparing the same in healthy children. Methods: 47 ALL patients aged between 4-14 years and 47 healthy children of the same age and sex composed the study group. Dental age of the patients was determined by Demirjian method using panoramic radiographs taken for dental purposes. To minimize the error, each radiograph was evaluated by two dentists. To determine the difference between the groups independent T-test was done. Statistical significance level was chosen as p<0.05. Results: There was no statistically significant difference between genders in both groups in dental and chronological age, obtained from the panoramic radiographs using Demirjian method. Dental age of the children with ALL treatment was found to be statistically higher than that of the control group. For the group of patients who had both chemotherapy and radiotherapy, the dental age was observed to be higher when compared to the dental age of the group who had chemotherapy only, but the difference was found to be not statistically significant. Conclusion: It is found that chemotherapy and radiotherapy treatments affected the dental age of children who had ALL treatment.

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