The synthesis of [14C] labelled Eutypine

The synthesis of radiolabelled 4-hydroxy-3-(3-methyl-3-buten-1-ynyl) benzaldehyde (eutypine 1), a phytotoxic compound isolated from the culture media of the fungus Eutypa lata, responsible for vineyard die-back, is described. The radioisotope 14C was introduced via a Wittig reaction using [14C] methyl-iodide as precursor.