Double-blind, placebo-controlled, dose-escalation study to evaluate the pharmacologic effect of CP-690,550 in patients with psoriasis.

[1]  M. Akiyama,et al.  Hair follicle stem cell-targeted gene transfer and reconstitution system , 2006, Gene Therapy.

[2]  A. Bowcock,et al.  Psoriasis pathophysiology: current concepts of pathogenesis , 2005, Annals of the rheumatic diseases.

[3]  L. Notarangelo,et al.  Jak3, severe combined immunodeficiency, and a new class of immunosuppressive drugs , 2005, Immunological reviews.

[4]  J. O’Shea,et al.  JAK3 inhibition, a viable new modality of immunosuppression for solid organ transplants. , 2004, Trends in molecular medicine.

[5]  J. Gudjonsson,et al.  Immunopathogenic mechanisms in psoriasis , 2004, Clinical and experimental immunology.

[6]  J. O’Shea,et al.  Prevention of Organ Allograft Rejection by a Specific Janus Kinase 3 Inhibitor , 2003, Science.

[7]  K. Asadullah,et al.  Inhibition of Keratinocyte Apoptosis by IL-15: A New Parameter in the Pathogenesis of Psoriasis?1 , 2000, The Journal of Immunology.

[8]  S. Cory,et al.  Efficient retroviral gene transfer to purified long-term repopulating hematopoietic stem cells. , 1994, Blood.

[9]  C. Eaves,et al.  Retrovirus-mediated gene transfer to purified hemopoietic stem cells with long-term lympho-myelopoietic repopulating ability. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[10]  N. Fusenig,et al.  Keratins of the human hair follicle: "hyperproliferative" keratins consistently expressed in outer root sheath cells in vivo and in vitro. , 1987, Differentiation; research in biological diversity.