论文信息 - Biallelic expression of nanog protein in mouse embryonic stem cells.

Biallelic expression of nanog protein in mouse embryonic stem cells.

Transcription factors (TFs) and their networks are central effectors controlling pluripotency (Young, 2011). Numerous involved TFs have been identified, but a subset of core pluripotency TFs regulates the majority of others. One such factor, Nanog, is expressed in pluripotent cells, is required for self-renewal of mouse embryonic stem cells (ESCs) in vitro, is able to force ESC self-renewal upon overexpression in the absence of LIF, and is necessary for the normal development of early mouse embryos (reviewed in Young, 2011).

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