Quantifying the origins of population variability in cardiac electrical activity through sensitivity analysis of the electrocardiogram

•  We used a novel high performance computing approach to conduct a sensitivity analysis of emergent properties of simulated ECGs from a transmural cable of cells. •  The rapid delayed rectifier and inward rectifying potassium currents are the primary determinants of the height of the T wave in this system. •  Theight is correlated with the temporal dispersion of repolarisation in the transmural cable while Tpeak– Tend is correlated with the interval from the time of maximum total rate of repolarisation to the end of repolarisation in the cable of cells. •  This study advances our understanding of the molecular basis of T wave morphology and the role of epistatis in the modification of cardiac electrical phenotypes.

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