Effect of Altered Arterial Carbon Dioxide Tensions on the Electroencephalogram During Hypothermia

The effect of strictly controlled changes in PaC02 on the electro‐encephalogram was observed in dogs under stable anaesthesia and moderate systemic hypothermia. Pulmonary ventilation and amounts of carbon dioxide given were regulated to produce: (1) relative hypocapnia, (2) a constant PaCO2, and (3) relative hypercapnia. Changes in PaCO2 did not significantly affect coldinduced depression of the electro‐encephalogram, thereby negating the prospect that the administration of carbon dioxide may prevent the depression of the electrical activity of the brain which accompanies hypothermia. Inertness of raised PaC02 on the electro‐encephalogram was demonstrated also in hypothermic patients.

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