A-scan ultrasonic system for real time automatic cataract detection

Cataract is an ocular condition associated to the loss of the normal crystalline lens transparency, and its progression can result in a total loss of vision. The gold standard diagnostic method consists on qualitative observation through a slit lamp. This method has two limitations: incipient cataract may not be detected and the cataract hardness is subjectively evaluated. It may delay the diagnosis, or result on phacoemulsification surgeries complications when cataract hardness is not correctly estimated. On this study we present a new prototype for objective cataract detection and characterization, based on ultrasounds. The Eye Scan Ultrasonic System (ESUS) acquires A-scan signals at a nominal frequency of 20 MHz. The lens interfaces can be automatically detected in real time, based on the analysis of signal energy levels. The detection and characterization of cataract type and severity is done by an automatic classification algorithm based on features extracted in time and frequency domain. The system performance has been tested on preclinical data, and the beginning of clinical studies is expected shortly.

[1]  Ronald H Silverman,et al.  Focused ultrasound in ophthalmology , 2016, Clinical ophthalmology.

[2]  Miguel Caixinha,et al.  New approach for objective cataract classification based on ultrasound techniques using multiclass SVM classifiers , 2014, 2014 IEEE International Ultrasonics Symposium.

[3]  Alvin F. Martin,et al.  The DET curve in assessment of detection task performance , 1997, EUROSPEECH.

[4]  Elena Velte,et al.  Automatic Cataract Classification based on Ultrasound Technique Using Machine Learning: A comparative Study , 2015 .

[5]  Elsie Chan,et al.  Complications of cataract surgery , 2010, Clinical & experimental optometry.

[6]  Ruben Abagyan,et al.  Lanosterol reverses protein aggregation in cataracts , 2015, Nature.

[7]  Miguel Caixinha,et al.  Using Ultrasound Backscattering Signals and Nakagami Statistical Distribution to Assess Regional Cataract Hardness , 2014, IEEE Transactions on Biomedical Engineering.

[8]  Mario J. Santos,et al.  Eye Scan Ultrasound System for Automatic Cataract Detection: From a Preclinical to a Clinical Prototype , 2019, IFMBE Proceedings.

[9]  Miguel Caixinha,et al.  In-Vivo Automatic Nuclear Cataract Detection and Classification in an Animal Model by Ultrasounds , 2016, IEEE Transactions on Biomedical Engineering.

[10]  Miguel Caixinha,et al.  Automatic Cataract Hardness Classification Ex Vivo by Ultrasound Techniques. , 2016, Ultrasound in medicine & biology.

[11]  Skaidra Kurapkiene,et al.  Ultrasound Quantitative Evaluation of Human Eye Cataract , 2007, Informatica.

[12]  M. C. Leske,et al.  The Lens Opacities Classification System III , 1993 .

[13]  J. Vinson Oxidative stress in cataracts. , 2006, Pathophysiology : the official journal of the International Society for Pathophysiology.

[14]  B. Pierscionek,et al.  Age‐related cataract and drug therapy: opportunities and challenges for topical antioxidant delivery to the lens , 2015, The Journal of pharmacy and pharmacology.

[15]  Mark S Humayun,et al.  Evaluation of lens hardness in cataract surgery using high-frequency ultrasonic parameters in vitro. , 2007, Ultrasound in medicine & biology.