Interleukin-17+CD8+ T Cells Are Enriched in the Joints of Patients With Psoriatic Arthritis and Correlate With Disease Activity and Joint Damage Progression

Psoriatic arthritis (PsA) is associated with HLA class I genes, in contrast to the association with HLA class II in rheumatoid arthritis (RA). Since IL‐17+ cells are considered important mediators of synovial inflammation, we sought to determine whether IL‐17–producing CD8+ T cells may be found in the joints of patients with PsA and whether these cells might contribute to the disease process.

[1]  I. González-Álvaro,et al.  Synovial cytokine expression in psoriatic arthritis and associations with lymphoid neogenesis and clinical features , 2012, Arthritis Research & Therapy.

[2]  P. Tak,et al.  Interleukin-17-positive mast cells contribute to synovial inflammation in spondylarthritis. , 2012, Arthritis and rheumatism.

[3]  J. R. Landis,et al.  The measurement of observer agreement for categorical data. , 1977, Biometrics.

[4]  C. Peterfy,et al.  Presence of significant synovitis in rheumatoid arthritis patients with disease-modifying antirheumatic drug-induced clinical remission: evidence from an imaging study may explain structural progression. , 2006, Arthritis and rheumatism.

[5]  O. Lantz,et al.  Human MAIT cells are xenobiotic-resistant, tissue-targeted, CD161hi IL-17-secreting T cells. , 2011, Blood.

[6]  A. Silman,et al.  UvA-DARE (Digital Academic Repository) 2010 Rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative Aletaha, , 2010 .

[7]  Ashley M. Miller,et al.  Mast cells express IL-17A in rheumatoid arthritis synovium. , 2010, Journal of immunology.

[8]  Olivier Meyer,et al.  Prognostic factors of 10-year radiographic outcome in early rheumatoid arthritis: a prospective study , 2008, Arthritis research & therapy.

[9]  J. Goodall,et al.  Frequency and phenotype of peripheral blood Th17 cells in ankylosing spondylitis and rheumatoid arthritis. , 2009, Arthritis and rheumatism.

[10]  M. Prevoo,et al.  Modified disease activity scores that include twenty-eight-joint counts. Development and validation in a prospective longitudinal study of patients with rheumatoid arthritis. , 1995, Arthritis and rheumatism.

[11]  V. Kuchroo,et al.  Interleukin-17 and type 17 helper T cells. , 2009, The New England journal of medicine.

[12]  Esperanza Naredo,et al.  Longitudinal power Doppler ultrasonographic assessment of joint inflammatory activity in early rheumatoid arthritis: predictive value in disease activity and radiologic progression. , 2007, Arthritis and rheumatism.

[13]  M. Genovese,et al.  IL-17 receptor and its functional significance in psoriatic arthritis , 2011, Molecular and Cellular Biochemistry.

[14]  R. Furie.  Effects of human immunodeficiency virus infection on the expression of rheumatic illness. , 1991, Rheumatic diseases clinics of North America.

[15]  Graham M Lord,et al.  In vivo activated monocytes from the site of inflammation in humans specifically promote Th17 responses , 2009, Proceedings of the National Academy of Sciences.

[16]  A. Silman,et al.  Investigating the role of the HLA-Cw*06 and HLA-DRB1 genes in susceptibility to psoriatic arthritis: comparison with psoriasis and undifferentiated inflammatory arthritis , 2007, Annals of the rheumatic diseases.

[17]  L Stafford,et al.  A prospective, clinical and radiological study of early psoriatic arthritis: an early synovitis clinic experience. , 2003, Rheumatology.

[18]  L. Maggi,et al.  Etanercept Downregulates the Th17 Pathway and Decreases the IL-17+/IL-10+ Cell Ratio in Patients with Psoriasis Vulgaris , 2012, Journal of Clinical Immunology.

[19]  Dafna Gladman,et al.  Classification criteria for psoriatic arthritis: development of new criteria from a large international study. , 2006, Arthritis and rheumatism.

[20]  Pilar Romero,et al.  IL‐17‐producing CD8+ T lymphocytes from psoriasis skin plaques are cytotoxic effector cells that secrete Th17‐related cytokines , 2009, Journal of leukocyte biology.

[21]  C. Tato,et al.  Innate IL-17-producing cells: the sentinels of the immune system , 2010, Nature Reviews Immunology.

[22]  S. Bull,et al.  Human leukocyte antigen alleles and susceptibility to psoriatic arthritis. , 2013, Human immunology.

[23]  Furie Ra.  Effects of human immunodeficiency virus infection on the expression of rheumatic illness. , 1991 .

[24]  S. Bull,et al.  Differential human leucocyte allele association between psoriasis and psoriatic arthritis: a family-based association study , 2012, Annals of the rheumatic diseases.

[25]  J. Goodall,et al.  Frequency and Phenotype of T Helper 17 Cells in Peripheral Blood and Synovial Fluid of Patients with Reactive Arthritis , 2010, The Journal of Rheumatology.

[26]  D. Veale,et al.  Immunopathology of psoriasis and psoriatic arthritis , 2005, Annals of the rheumatic diseases.

[27]  R. de Waal Malefyt,et al.  Interleukin-17 and interferon-gamma synergize in the enhancement of proinflammatory cytokine production by human keratinocytes. , 1998, The Journal of investigative dermatology.

[28]  R. Du,et al.  Pleural Mesothelial Cells Promote Expansion of IL-17–Producing CD8+ T Cells in Tuberculous Pleural Effusion , 2013, Journal of Clinical Immunology.

[29]  Leonie S. Taams,et al.  Linking Power Doppler Ultrasound to the Presence of Th17 Cells in the Rheumatoid Arthritis Joint , 2010, PloS one.

[30]  James T. Elder,et al.  Induction of IL-17+ T Cell Trafficking and Development by IFN-γ: Mechanism and Pathological Relevance in Psoriasis1 , 2008, The Journal of Immunology.

[31]  P. Teeling,et al.  Overrepresentation of IL-17A and IL-22 Producing CD8 T Cells in Lesional Skin Suggests Their Involvement in the Pathogenesis of Psoriasis , 2010, PloS one.

[32]  Christian Gieger,et al.  Common variants at TRAF3IP2 are associated with susceptibility to psoriatic arthritis and psoriasis , 2010, Nature Genetics.

[33]  L. Cosmi,et al.  Distinctive features of classic and nonclassic (Th17 derived) human Th1 cells , 2012, European journal of immunology.

[34]  D. M. van der Heijde,et al.  Efficacy and safety of secukinumab, a fully human anti-interleukin-17A monoclonal antibody, in patients with moderate-to-severe psoriatic arthritis: a 24-week, randomised, double-blind, placebo-controlled, phase II proof-of-concept trial , 2013, Annals of the rheumatic diseases.

[35]  J. Edmonds,et al.  Synovial membrane cytokine expression is predictive of joint damage progression in rheumatoid arthritis: a two-year prospective study (the DAMAGE study cohort). , 2006, Arthritis and rheumatism.

[36]  A. Silman,et al.  Rheumatoid arthritis classifi cation criteria : an American College of Rheumatology / European League Against Rheumatism collaborative initiative , 2010 .

[37]  A. Skapenko,et al.  Role of Th17 cells in human autoimmune arthritis. , 2010, Arthritis and rheumatism.

[38]  J. Andersson,et al.  Impaired Expression of Perforin and Granulysin in CD8+ T Cells at the Site of Infection in Human Chronic Pulmonary Tuberculosis , 2007, Infection and Immunity.

[39]  D. Speiser,et al.  Increased numbers of circulating polyfunctional Th17 memory cells in patients with seronegative spondylarthritides. , 2008, Arthritis and rheumatism.

[40]  E. Christophers.  Psoriasis − epidemiology and clinical spectrum , 2001, Clinical and experimental dermatology.

[41]  Y. Hayami,et al.  The Th17/IL-23 Axis and Natural Immunity in Psoriatic Arthritis , 2012, International journal of rheumatology.

[42]  B. Bresnihan,et al.  Predominance of CD8+ T lymphocytes in psoriatic arthritis. , 1999, The Journal of rheumatology.

[43]  F. Morel,et al.  A role for T cell‐derived interleukin 22 in psoriatic skin inflammation , 2007, Clinical and experimental immunology.

[44]  R. Clark,et al.  CD8(+) T cells in the lesional skin of atopic dermatitis and psoriasis patients are an important source of IFN-γ, IL-13, IL-17, and IL-22. , 2013, The Journal of investigative dermatology.

[45]  C. Gieger,et al.  Variants in RUNX3 contribute to susceptibility to psoriatic arthritis, exhibiting further common ground with ankylosing spondylitis. , 2013, Arthritis and rheumatism.

[46]  Jeung-Hoon Lee,et al.  T‐helper 17 cells: The driving force of psoriasis and psoriatic arthritis , 2012, International journal of rheumatic diseases.

[47]  Lisa C. Zaba,et al.  Th17 cytokines interleukin (IL)‐17 and IL‐22 modulate distinct inflammatory and keratinocyte‐response pathways , 2008, The British journal of dermatology.

[48]  L. Bradbury,et al.  Enrichment of circulating interleukin-17-secreting interleukin-23 receptor-positive γ/δ T cells in patients with active ankylosing spondylitis. , 2012, Arthritis and rheumatism.

[49]  C. Bunker,et al.  HIV-associated psoriasis: pathogenesis, clinical features, and management. , 2010, The Lancet. Infectious diseases.

[50]  O. Meyer,et al.  Psoriatic arthritis in Sub-Saharan Africa. , 2012, Joint, bone, spine : revue du rhumatisme.

[51]  O. Corneth,et al.  IL-17/Th17 mediated synovial inflammation is IL-22 independent , 2013, Annals of the rheumatic diseases.

[52]  G. Kingsley,et al.  Joint damage and disability in rheumatoid arthritis: an updated systematic review. , 2003, Clinical and experimental rheumatology.

[53]  R. Winchester,et al.  Nucleotide Sequencing of Psoriatic Arthritis Tissue before and during Methotrexate Administration Reveals a Complex Inflammatory T Cell Infiltrate with Very Few Clones Exhibiting Features That Suggest They Drive the Inflammatory Process by Recognizing Autoantigens1 , 2004, The Journal of Immunology.