Polyethylenimine-coated magnetic nanoparticles with improved biocompatibility for hyperthermia

Biocomfortable polyethylenimine (PEI) coated Fe<sub>3</sub>O<sub>4</sub> nanoparticles (NPs) have been successfully fabricated for their magnetic hyperthermia performance. After coating with PEI, the sample reveals a tiptop performance of magnetic property and an enhanced biocompatibility. Compared with Fe<sub>3</sub>O<sub>4</sub> NPs, PEI-coated Fe<sub>3</sub>O<sub>4</sub> NPs do not induce notable cell cytotoxic effect at their higher concentration, which indicates that PEI-coated Fe<sub>3</sub>O<sub>4</sub> NPs has improved biocompatibility. The results show that PEI-coated Fe<sub>3</sub>O<sub>4</sub> NPs not only possess effective magnetic property for cancer hyperthermia treatment or gene delivery, but also demonstrates an improved biocompatibility for various biomedical applications.

[1]  J. Cheon,et al.  Iron Oxide Based Nanoparticles for Multimodal Imaging and Magnetoresponsive Therapy. , 2015, Chemical reviews.

[2]  Bobbi K Lewis,et al.  A model of lysosomal metabolism of dextran coated superparamagnetic iron oxide (SPIO) nanoparticles: implications for cellular magnetic resonance imaging , 2005, NMR in biomedicine.

[3]  Kailash C Gupta,et al.  Novel polyethylenimine-derived nanoparticles for in vivo gene delivery , 2013, Expert opinion on drug delivery.

[4]  Sung-Wook Choi,et al.  Multifunctional magnetic nanoparticles modified with polyethylenimine and folic acid for biomedical theranostics. , 2013, Langmuir : the ACS journal of surfaces and colloids.

[5]  R. Weissleder,et al.  Cellular Uptake and Trafficking of a Prototypical Magnetic Iron Oxide Label In Vitro , 1995, Investigative radiology.

[6]  V. Mody,et al.  Magnetic nanoparticle drug delivery systems for targeting tumor , 2014, Applied Nanoscience.

[7]  Lei Zhang,et al.  Assembly of polyethylenimine-functionalized iron oxide nanoparticles as agents for DNA transfection with magnetofection technique. , 2014, Journal of materials chemistry. B.

[8]  Jun Ding,et al.  Magnetic nanoparticle-loaded polymer nanospheres as magnetic hyperthermia agents. , 2014, Journal of materials chemistry. B.

[9]  Morteza Mahmoudi,et al.  A new approach for the in vitro identification of the cytotoxicity of superparamagnetic iron oxide nanoparticles. , 2010, Colloids and surfaces. B, Biointerfaces.

[10]  Morteza Milani,et al.  Magnetic nanoparticles: Applications in gene delivery and gene therapy , 2015, Artificial cells, nanomedicine, and biotechnology.

[11]  A. Curtis,et al.  Dextran and albumin derivatised iron oxide nanoparticles: influence on fibroblasts in vitro. , 2003, Biomaterials.

[12]  Taeghwan Hyeon,et al.  Chemical synthesis and assembly of uniformly sized iron oxide nanoparticles for medical applications. , 2015, Accounts of chemical research.

[13]  G. G. Stokes.  "J." , 1890, The New Yale Book of Quotations.

[14]  Tsutomu Yamada,et al.  Transfection efficiency influenced by aggregation of DNA/polyethylenimine max/magnetic nanoparticle complexes , 2013, Journal of Nanoparticle Research.

[15]  Daidi Fan,et al.  Human-like collagen protein-coated magnetic nanoparticles with high magnetic hyperthermia performance and improved biocompatibility , 2015, Nanoscale Research Letters.