Comprehensive assessment of tumour budding by cytokeratin staining in colorectal cancer

Tumour budding in colorectal cancer (CRC) is a recognized prognostic parameter. The aim of this study was to address the use of cytokeratin immunostaining for the visualization and scoring of tumour buds.

[1]  Phil Quirke,et al.  Recommendations for reporting tumor budding in colorectal cancer based on the International Tumor Budding Consensus Conference (ITBCC) 2016 , 2017, Modern Pathology.

[2]  A. Rogers,et al.  Systematic review and meta-analysis of the impact of tumour budding in colorectal cancer , 2016, British Journal of Cancer.

[3]  Inti Zlobec,et al.  Tumor budding in colorectal cancer--ready for diagnostic practice? , 2016, Human pathology.

[4]  F. Offner,et al.  Tumor budding in colorectal cancer revisited: results of a multicenter interobserver study , 2015, Virchows Archiv.

[5]  M. Borner,et al.  Intratumoural budding (ITB) in preoperative biopsies predicts the presence of lymph node and distant metastases in colon and rectal cancer patients , 2013, British Journal of Cancer.

[6]  S. Gurzu,et al.  Possible neuroendocrine phenotype of poorly differentiated cell clusters in colorectal carcinoma, as a prognostic parameter. , 2014, The American journal of surgical pathology.

[7]  A. Rogers,et al.  Prognostic significance of tumor budding in rectal cancer biopsies before neoadjuvant therapy , 2014, Modern Pathology.

[8]  A. Radcliffe,et al.  Systematic review and meta‐analysis of histopathological factors influencing the risk of lymph node metastasis in early colorectal cancer , 2013, Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland.

[9]  N. Ordóñez Broad-spectrum immunohistochemical epithelial markers: a review. , 2013, Human pathology.

[10]  L. Terracciano,et al.  Tumor budding score based on 10 high-power fields is a promising basis for a standardized prognostic scoring system in stage II colorectal cancer. , 2013, Human pathology.

[11]  E. Patsouris,et al.  Proposal for a 10-high-power-fields scoring method for the assessment of tumor budding in colorectal cancer , 2013, Modern Pathology.

[12]  D. Kerr,et al.  Use of multivariate analysis to suggest a new molecular classification of colorectal cancer , 2013, The Journal of pathology.

[13]  G. Petris,et al.  Tumor Budding in Colorectal Carcinoma: Time to Take Notice , 2013 .

[14]  R. Riddell,et al.  Tumor budding in colorectal carcinoma: time to take notice , 2012, Modern Pathology.

[15]  K. Chayama,et al.  Management of T1 colorectal carcinoma with special reference to criteria for curative endoscopic resection , 2012, Journal of gastroenterology and hepatology.

[16]  S. Gurzu,et al.  Aberrant pattern of the cytokeratin 7/cytokeratin 20 immunophenotype in colorectal adenocarcinomas with BRAF mutations. , 2012, Pathology, research and practice.

[17]  J. O’Sullivan,et al.  Epithelial-Mesenchymal Transition (EMT) Protein Expression in a Cohort of Stage II Colorectal Cancer Patients With Characterized Tumor Budding and Mismatch Repair Protein Status , 2011, International Journal of Surgical Pathology.

[18]  Tadakazu Shimoda,et al.  Pathological prognostic factors predicting lymph node metastasis in submucosal invasive (T1) colorectal carcinoma , 2010, Modern Pathology.

[19]  L. Terracciano,et al.  CD8+ lymphocytes/ tumour-budding index: an independent prognostic factor representing a ‘pro-/anti-tumour’ approach to tumour host interaction in colorectal cancer , 2009, British Journal of Cancer.

[20]  Seung-Yong Jeong,et al.  Indications for Subsequent Surgery After Endoscopic Resection of Submucosally Invasive Colorectal Carcinomas: A Prospective Cohort Study , 2009, Diseases of the colon and rectum.

[21]  J. O’Sullivan,et al.  Tumor Budding is a Strong and Reproducible Prognostic Marker in T3N0 Colorectal Cancer , 2009, The American journal of surgical pathology.

[22]  H. Mitomi,et al.  Tumor Budding as an Index to Identify High-Risk Patients with Stage II Colon Cancer , 2008, Diseases of the colon and rectum.

[23]  F. Prall Tumour budding in colorectal carcinoma , 2007, Histopathology.

[24]  Hidetaka Mochizuki,et al.  Risk factors for an adverse outcome in early invasive colorectal carcinoma. , 2004, Gastroenterology.

[25]  H. Ueno,et al.  Tumour `budding' as an index to estimate the potential of aggressiveness in rectal cancer , 2002, Histopathology.

[26]  M. Morimatsu,et al.  An index for estimating the probability of lymph node metastasis in rectal cancers. Lymph node metastasis and the histopathology of actively invasive regions of cancer , 1989, Cancer.

[27]  L. Sobin,et al.  TNM Classification of Malignant Tumours , 1987, UICC International Union Against Cancer.