Esophageal physiologic profiles within erosive esophagitis in China: Predominantly low‐grade esophagitis with low reflux burden

The Lyon Consensus defines LA grades C&D erosive esophagitis (EE) or acid exposure time (AET) >6% as the conclusive evidence for gastro‐esophageal reflux disease (GERD). However, most of EE is LA grade A&B and the rate of AET exceeding 6% is low in China. We aimed to evaluate patients with EE in the Chinese population based on the Lyon Criteria.

[1]  E. Savarino,et al.  Mean Nocturnal Baseline Impedance Correlates with Symptom Outcome When Acid Exposure Time is Inconclusive on Esophageal Reflux Monitoring. , 2020, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[2]  E. Savarino,et al.  Lack of improvement of impaired chemical clearance characterizes PPI‐refractory reflux‐related heartburn , 2018, The American Journal of Gastroenterology.

[3]  Minhu Chen,et al.  The Rome IV versus Rome III criteria for heartburn diagnosis: A comparative study , 2018, United European gastroenterology journal.

[4]  E. Savarino,et al.  Modern diagnosis of GERD: the Lyon Consensus , 2018, Gut.

[5]  M. Vaezi,et al.  Assessing Old and New Diagnostic Tests for Gastroesophageal Reflux Disease. , 2017, Gastroenterology.

[6]  E. Savarino,et al.  Postreflux swallow‐induced peristaltic wave index and nocturnal baseline impedance can link PPI‐responsive heartburn to reflux better than acid exposure time , 2017, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[7]  A. Farioli,et al.  Impairment of chemical clearance and mucosal integrity distinguishes hypersensitive esophagus from functional heartburn , 2017, Journal of Gastroenterology.

[8]  E. Savarino,et al.  The added diagnostic value of postreflux swallow‐induced peristaltic wave index and nocturnal baseline impedance in refractory reflux disease studied with on‐therapy impedance‐pH monitoring , 2017, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[9]  E. Savarino,et al.  The natural history of gastro-esophageal reflux disease: a comprehensive review. , 2016, Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus.

[10]  C. Gyawali,et al.  Distal mean nocturnal baseline impedance on pH‐impedance monitoring predicts reflux burden and symptomatic outcome in gastro‐oesophageal reflux disease , 2016, Alimentary pharmacology & therapeutics.

[11]  P J Kahrilas,et al.  The Chicago Classification of esophageal motility disorders, v3.0 , 2015, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[12]  N. Bouvy,et al.  The effect of endoscopic fundoplication and proton pump inhibitors on baseline impedance and heartburn severity in GERD patients , 2015, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[13]  W. D. de Jonge,et al.  Proton pump inhibitors partially restore mucosal integrity in patients with proton pump inhibitor-responsive esophageal eosinophilia but not eosinophilic esophagitis. , 2014, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[14]  E. Savarino,et al.  Esophageal baseline impedance levels in patients with pathophysiological characteristics of functional heartburn , 2014, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[15]  J. Pandolfino,et al.  Quantifying esophagogastric junction contractility with a novel HRM topographic metric, the EGJ‐Contractile Integral: normative values and preliminary evaluation in PPI non‐responders , 2014, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[16]  C. Gyawali,et al.  Multiple Rapid Swallow Responses During Esophageal High-Resolution Manometry Reflect Esophageal Body Peristaltic Reserve , 2013, The American Journal of Gastroenterology.

[17]  Christopher C Winchester,et al.  Update on the epidemiology of gastro-oesophageal reflux disease: a systematic review , 2013, Gut.

[18]  L. Frazzoni,et al.  Esophageal chemical clearance is impaired in gastro‐esophageal reflux disease – a 24‐h impedance‐pH monitoring assessment , 2013, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[19]  T. Hibi,et al.  Validation of the GerdQ questionnaire for the management of gastro-oesophageal reflux disease in Japan , 2013, United European gastroenterology journal.

[20]  Seth D. Crockett,et al.  Burden of gastrointestinal disease in the United States: 2012 update. , 2012, Gastroenterology.

[21]  F. Bazzoli,et al.  Systematic review: patterns of reflux-induced symptoms and esophageal endoscopic findings in large-scale surveys. , 2012, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[22]  Yuichiro Tanaka,et al.  Endoscopic Reflux Esophagitis and Helicobacter pylori Infection in Young Healthy Japanese Volunteers , 2012, Digestion.

[23]  S. Peng,et al.  Prevalence of erosive esophagitis and Barrett's esophagus in the adult Chinese population. , 2009, Endoscopy.

[24]  F. Bazzoli,et al.  Gastro-oesophageal reflux symptoms, oesophagitis and Barrett’s oesophagus in the general population: the Loiano–Monghidoro study , 2008, Gut.

[25]  P. Malfertheiner,et al.  Prospective Follow-Up Data from the ProGERD Study Suggest that GERD Is Not a Categorial Disease , 2006, The American Journal of Gastroenterology.

[26]  M. Vieth,et al.  High prevalence of gastroesophageal reflux symptoms and esophagitis with or without symptoms in the general adult Swedish population: A Kalixanda study report , 2005, Scandinavian journal of gastroenterology.

[27]  F. Mcmahon,et al.  Upper gastrointestinal endoscopy in normal asymptomatic volunteers. , 1986, Gastrointestinal endoscopy.

[28]  E. Savarino,et al.  Analyses of the Post-reflux Swallow-induced Peristaltic Wave Index and Nocturnal Baseline Impedance Parameters Increase the Diagnostic Yield of Impedance-pH Monitoring of Patients With Reflux Disease. , 2016, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[29]  R. Fass,et al.  Upper GI tract findings in patients with heartburn in whom proton pump inhibitor treatment failed versus those not receiving antireflux treatment. , 2010, Gastrointestinal endoscopy.