Determinants of cell shape and orientation: A comparative Golgi analysis of cell‐axon interrelationships in the developing neocortex of normal and reeler mice

Patterns of dendritic development in the neocortex of normal and reeler E15‐17 mouse embryos are studied in Golgi impregnations. Interactions between dendrites and axon‐rich strata appear to be critical determinants of dendritic morphology in both genotypes. Firstly, axon‐dendrite proximity appears to stimulate dendritic sprouting, elongation and branching. Secondly, the position of the axon‐rich strata with respect to the differentiating cell appears to determine the direction of dendritic growth and thereby the ultimate configuration of the dendritic arbor. With regard to specific cell configuration, a multipolar form is generated when the cell is embedded in an axon‐rich zone. A monopolar or bipolar configuration is achieved when the cell lies in the axon‐poor cortical plate and addresses an axon‐rich stratum with one or both radially extended migratory processes. Such variations in the configuration of neurons with polar dendritic systems may be observed uniquely in the mutant cortex be cause axon‐rich zones are stratified anomalously at multiple levels in the cortical plate. As a consequence, polar dendritic systems develop from either the superior, the inferior or both somatic poles of postmigratory cells. Pyramidal cells may, therefore, develop a normal upright or an abnormal “upside‐down” disposition. Regardless of the orientation of the polar dendritic system, the axon emerges from the inferior aspect of the cell suggesting that there has been no rotation of the original migratory axis of the cell.

[1]  M. Berry,et al.  The Purkinje cell dendritic tree in mutant mouse cerebellum. A quantitative Golgi study of Weaver and Staggerer mice , 1978, Brain Research.

[2]  R. Sidman,et al.  Early cortical histogenesis in the primary olfactory cortex of the mouse , 1977, Brain Research.

[3]  M. Berry,et al.  Preferential orientation of stellate cell dendrites in the visual cortex of the dark-reared rat , 1976, Brain Research.

[4]  C. Sotelo,et al.  Development of Purkinje cells in absence of climbing fibers , 1976, Brain Research.

[5]  P. Bradley,et al.  The effects of reduced climbing and parallel fibre input on Purkinje cell dendritic growth , 1976, Brain Research.

[6]  A. Globus,et al.  The effect of continuous illumination on the development of cortical neurons in the rat: A Golgi study , 1976, Experimental Neurology.

[7]  A. Scheibel,et al.  Ontogenetic development of somatosensory thalamus I. Morphogenesis , 1976, Experimental Neurology.

[8]  C. Sotelo.  Anatomical, physiological and biochemical studies of the cerebellum from mutant mice. II. Morphological study of cerebellar cortical neurons and circuits in the weaver mouse , 1975, Brain Research.

[9]  P. Rakić,et al.  Role of cell interaction in development of dendritic patterns. , 1975, Advances in neurology.

[10]  C. Sotelo,et al.  Bergmann fibers and granular cell migration in the cerebellum of homozygous weaver mutant mouse. , 1974, Brain research.

[11]  L. T. Rutledge,et al.  Morphological changes in pyramidal cells of mammalian neocortex associated with increased use. , 1974, Experimental neurology.

[12]  Edward P. Sayre,et al.  Computer-aided three-dimensional reconstruction and quantitative analysis of cells from serial electron microscopic montages of foetal monkey brain , 1974, Nature.

[13]  P. Rakić,et al.  Neuronal migration, with special reference to developing human brain: a review. , 1973, Brain research.

[14]  R. Sidman,et al.  The hybrid reeler mouse. , 1972, The Journal of heredity.

[15]  F. Volkmar,et al.  Rearing Complexity Affects Branching of Dendrites in the Visual Cortex of the Rat , 1972, Science.

[16]  P. Rakić.  Guidance of neurons migrating to the fetal monkey neocortex. , 1971, Brain research.

[17]  A. Ruiz-Marcos,et al.  Dynamic architecture of the visual cortex. , 1970, Brain research.

[18]  K. Vukovich,et al.  Early Experience Effects upon Cortical Dendrites: A Proposed Model for Development , 1970, Science.

[19]  M. Colonnier.  The fine structural arrangement of the cortex. , 1967, Archives of neurology.

[20]  Aström Ke.  On the Early Development of the Isocortex in Fetal Sheep , 1967 .

[21]  R. Sidman,et al.  Autoradiographic Study of Cell Migration during Histogenesis of Cerebral Cortex in the Mouse , 1961, Nature.

[22]  W. His.  Die Entwickelung des menschlichen Gehirns : während der ersten Monate , 1904 .