Correlation between Levels of Dehydroepiandrosterone-Sulphate and Prolactin in Human Breast Cyst Fluid

Concentration of dehydroepiandrosterone sulphate (DHAS), cortisol (F), aldosterone (A) and prolactin (PRL) were measured in 70 samples of breast cyst fluid (BCF) obtained by needle aspiration from patients having gross cystic disease of the breast. DHAS concentrations in our series of BCF were scattered over a broad range, up to values 200-fold higher than in plasma, with ample interindividual variability; Cortisol was present in BCF in very small amounts. Aldosterone and PRL values were in the same order of plasma levels; moreover, a significant correlation was found between DHAS and PRL concentrations in BCF.

[1]  E. Wynder,et al.  Breast secretion in finnish women: A metabolic epidemiologic study , 1981, Cancer.

[2]  M. Fleisher,et al.  Steroid hormone accumulation in human breast cyst fluid. , 1981, Cancer research.

[3]  J. Willems,et al.  Aspiration biopsy cytology of the pancreas. , 1980, Schweizerische medizinische Wochenschrift.

[4]  W. Miller,et al.  Dehydroepiandrosterone sulphate in breast secretions. , 1980, Journal of steroid biochemistry.

[5]  M. Fleisher,et al.  Accumulation of hormones in breast cyst fluid. , 1979, The Journal of clinical endocrinology and metabolism.

[6]  M. Metcalf,et al.  LACK OF EFFECT OF PROLACTIN SUPPRESSION ON PLASMA DEHYDROEPIANDROSTERONE SULPHATE , 1979, Clinical endocrinology.

[7]  H. Nagasawa.  Prolactin and human breast cancer: a review. , 1979, European journal of cancer.

[8]  L. Dogliotti,et al.  Treatment of benign breast disease with bromocriptine , 1979, Journal of endocrinological investigation.

[9]  C. Welsch.  Prolactin and the development and progression of early neoplastic mammary gland lesions. , 1978, Cancer research.

[10]  C. Clarke,et al.  Adrenal dehydroepiandrosterone and human mammary cancer. , 1978, Cancer research.

[11]  S. Andò,et al.  PROLACTIN AND ADRENAL ANDROGEN SECRETION , 1977, Clinical endocrinology.

[12]  A. Forrest,et al.  Oestrogen in breast fluid. (Letter) , 1977 .

[13]  A. Forrest,et al.  ŒSTROGEN IN BREAST FLUID , 1977, The Lancet.

[14]  A. Mcneilly,et al.  Adrenocortical function in hyperprolactinemic women. , 1977, The Journal of clinical endocrinology and metabolism.

[15]  E. Wynder,et al.  PROLACTIN, ŒSTROGEN, AND LIPIDS IN BREAST FLUID , 1977, The Lancet.

[16]  John B. Adams.  Steroid hormones and human breast cancer. An hypothesis , 1977, Cancer.

[17]  H. Nagasawa,et al.  Prolactin and murine mammary tumorigenesis: a review. , 1977, Cancer research.

[18]  C. Haagensen.  The relationship of gross cystic disease of the breast and carcinoma. , 1977, Annals of surgery.

[19]  M. Serio,et al.  PLASMA ANDROGENS IN WOMEN WITH HYPERPROLACTINAEMIC AMENORRHOES , 1977, Clinical endocrinology.

[20]  A. Forrest,et al.  Oestrogen in breast fluid. , 1977, Lancet.

[21]  J. Adams,et al.  Dehydroepiandrosterone sulfotransferase as a possible shunt for the control of steroid metabolism in human mammary carcinoma. , 1977, Cancer research.

[22]  S. Brooks.  The metabolism of steroid hormones in breast cancer: a reappraisal. , 1976, Current topics in molecular endocrinology.

[23]  Y. Abul-Hajj.  Metabolism of dehydroepiandrosterone by hormone dependent and hormone independent human breast carcinoma , 1975, Steroids.

[24]  A. Forrest,et al.  ŒSTRADIOL SYNTHESIS BY A HUMAN BREAST CARCINOMA , 1974 .

[25]  A. Forrest,et al.  Oestradiol synthesis by a human breast carcinoma. , 1974, Lancet.

[26]  B. Macmahon,et al.  Etiology of human breast cancer: a review. , 1973, Journal of the National Cancer Institute.

[27]  I. Falconer,et al.  The localization of prolactin labelled with radioactive iodine in rabbit mammary tissue. , 1972, The Journal of endocrinology.

[28]  K. Griffiths,et al.  Steroid metabolism by human breast tumours. , 1970, The Biochemical journal.

[29]  K. Griffiths,et al.  Short Communications. Steroid metabolism by human breast tumours , 1970 .

[30]  W. Teller.  Metabolism of adrenal cortical steroids during the newborn period. , 1969, Zeitschrift fur klinische Chemie und klinische Biochemie.