Strategies to identify ion channel modulators: current and novel approaches to target neuropathic pain.

[1]  W. Stühmer,et al.  Calcium channel characteristics conferred on the sodium channel by single mutations , 1992, Nature.

[2]  W. Catterall Structure and function of voltage-gated ion channels. , 1995, Annual review of biochemistry.

[3]  L. Sivilotti,et al.  A tetrodotoxin-resistant voltage-gated sodium channel expressed by sensory neurons , 1996, Nature.

[4]  P. Powers,et al.  Absence of the β subunit (cchb1) of the skeletal muscle dihydropyridine receptor alters expression of the α1 subunit and eliminates excitation-contraction coupling , 1996 .

[5]  K. Bley,et al.  Tetrodotoxin inhibits neuropathic ectopic activity in neuromas, dorsal root ganglia and dorsal horn neurons , 1997, PAIN.

[6]  R Y Tsien,et al.  Improved indicators of cell membrane potential that use fluorescence resonance energy transfer. , 1997, Chemistry & biology.

[7]  S. McMahon,et al.  Regulation of Expression of the Sensory Neuron-Specific Sodium Channel SNS in Inflammatory and Neuropathic Pain , 1997, Molecular and Cellular Neuroscience.

[8]  R. Eglen,et al.  Distribution of the Tetrodotoxin-Resistant Sodium Channel PN3 in Rat Sensory Neurons in Normal and Neuropathic Conditions , 1998, The Journal of Neuroscience.

[9]  B. Chait,et al.  The structure of the potassium channel: molecular basis of K+ conduction and selectivity. , 1998, Science.

[10]  Brian Cox,et al.  HTS approaches to voltage-gated ion channel drug discovery , 1998 .

[11]  R. LaMotte,et al.  Plasticity of sodium channel expression in DRG neurons in the chronic constriction injury model of neuropathic pain , 1999, PAIN®.

[12]  E. Mccleskey Calcium Channel Permeation: A Field in Flux , 1999, The Journal of general physiology.

[13]  J. Jen Calcium channelopathies in the central nervous system , 1999, Current Opinion in Neurobiology.

[14]  G. Terstappen,et al.  Functional analysis of native and recombinant ion channels using a high-capacity nonradioactive rubidium efflux assay. , 1999, Analytical biochemistry.

[15]  S. Boyce,et al.  The tetrodotoxin-resistant sodium channel SNS has a specialized function in pain pathways , 1999, Nature Neuroscience.

[16]  T. Carlstedt,et al.  Immunolocalization of SNS/PN3 and NaN/SNS2 sodium channels in human pain states , 2000, Pain.

[17]  W. Catterall Structure and regulation of voltage-gated Ca2+ channels. , 2000, Annual review of cell and developmental biology.

[18]  Gail Mandel,et al.  Nomenclature of Voltage-Gated Sodium Channels , 2000, Neuron.

[19]  K Mizuguchi,et al.  beta 3: an additional auxiliary subunit of the voltage-sensitive sodium channel that modulates channel gating with distinct kinetics. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[20]  S. Waxman,et al.  The neuron as a dynamic electrogenic machine: modulation of sodium-channel expression as a basis for functional plasticity in neurons. , 2000, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

[21]  S. McMahon,et al.  A role for the TTX-resistant sodium channel Nav 1.8 in NGF-induced hyperalgesia, but not neuropathic pain , 2001, Neuroreport.

[22]  B. Hille,et al.  Ionic channels of excitable membranes , 2001 .

[23]  Lei Wu,et al.  Ion-channel assay technologies: quo vadis? , 2001, Drug discovery today.

[24]  R. Greenberg,et al.  Phylogeny of ion channels: clues to structure and function. , 2001, Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology.

[25]  J. Chung,et al.  The changes in expression of three subtypes of TTX sensitive sodium channels in sensory neurons after spinal nerve ligation. , 2001, Brain research. Molecular brain research.

[26]  L. Isom Sodium Channel β Subunits: Anything but Auxiliary , 2001 .

[27]  Roderick MacKinnon,et al.  Energetic optimization of ion conduction rate by the K+ selectivity filter , 2001, Nature.

[28]  G. Tomaselli,et al.  Molecular Architecture of the Voltage-Dependent Na Channel , 2001, The Journal of general physiology.

[29]  M. Gold,et al.  Inhibition of neuropathic pain by decreased expression of the tetrodotoxin-resistant sodium channel, NaV1.8 , 2002, Pain.

[30]  E. Stefani,et al.  Aging, ion channel expression, and vascular function. , 2002, Vascular pharmacology.

[31]  M. Chao,et al.  Annexin II light chain regulates sensory neuron-specific sodium channel expression , 2002, Nature.

[32]  Andreas Sewing,et al.  High-Throughput Screening for Ion Channel Modulators , 2002, Journal of biomolecular screening.

[33]  C. Woolf,et al.  Progressive tactile hypersensitivity after a peripheral nerve crush: non-noxious mechanical stimulus-induced neuropathic pain , 2002, Pain.

[34]  Youxing Jiang,et al.  The open pore conformation of potassium channels , 2002, Nature.

[35]  S. Dib-Hajj,et al.  Diverse functions and dynamic expression of neuronal sodium channels. , 2002, Novartis Foundation symposium.

[36]  Youxing Jiang,et al.  Crystal structure and mechanism of a calcium-gated potassium channel , 2002, Nature.

[37]  William A Catterall,et al.  Reduced sodium channel density, altered voltage dependence of inactivation, and increased susceptibility to seizures in mice lacking sodium channel β2-subunits , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[38]  C. Peers Hypoxic regulation of ion channel function and expression , 2002, Experimental physiology.

[39]  Samuel F. Berkovic,et al.  Channelopathies as a genetic cause of epilepsy. , 2003 .

[40]  Youxing Jiang,et al.  The principle of gating charge movement in a voltage-dependent K+ channel , 2003, Nature.

[41]  S. Waxman,et al.  Upregulation of Sodium Channel Nav1.3 and Functional Involvement in Neuronal Hyperexcitability Associated with Central Neuropathic Pain after Spinal Cord Injury , 2003, The Journal of Neuroscience.

[42]  P. Christophersen,et al.  High throughput electrophysiology: new perspectives for ion channel drug discovery. , 2003, Receptors & channels.

[43]  Derek J Trezise,et al.  IonWorks™ HT: A New High-Throughput Electrophysiology Measurement Platform , 2003, Journal of biomolecular screening.

[44]  Rafael J. Taboryski,et al.  Upscaling and Automation of Electrophysiology: Toward High Throughput Screening in Ion Channel Drug Discovery , 2003 .

[45]  U. Warrior,et al.  Functional analysis of large conductance Ca2(+)-activated K(+) channels: ion flux studies by atomic absorption spectrometry. , 2003, Assay and drug development technologies.

[46]  P. Chatelain,et al.  Comparative Study of Membrane Potential-Sensitive Fluorescent Probes and their Use in Ion Channel Screening Assays , 2003, Journal of biomolecular screening.

[47]  P. Distefano,et al.  Sodium Channel β4, a New Disulfide-Linked Auxiliary Subunit with Similarity to β2 , 2003, The Journal of Neuroscience.

[48]  D. Weinreich,et al.  Redistribution of NaV1.8 in Uninjured Axons Enables Neuropathic Pain , 2003, The Journal of Neuroscience.

[49]  M. Cadene,et al.  X-ray structure of a voltage-dependent K+ channel , 2003, Nature.

[50]  K. Campbell,et al.  Auxiliary subunits: essential components of the voltage-gated calcium channel complex , 2003, Current Opinion in Neurobiology.

[51]  Clay W Scott,et al.  A medium-throughput functional assay of KCNQ2 potassium channels using rubidium efflux and atomic absorption spectrometry. , 2003, Analytical biochemistry.

[52]  B. Zhorov,et al.  Potassium, sodium, calcium and glutamate‐gated channels: pore architecture and ligand action , 2004, Journal of neurochemistry.