The c-fms proto-oncogene product is related to the receptor for the mononuclear phagocyte growth factor, CSF 1

The feline c-fms proto-oncogene product is a 170 kd glycoprotein with associated tyrosine kinase activity. This glycoprotein was expressed on mature cat macrophages from peritoneal inflammatory exudates and spleen. Similarly, the receptor for the murine colony-stimulating factor, CSF-1, is restricted to cells of the mononuclear phagocytic lineage and is a 165 kd glycoprotein with an associated tyrosine kinase. Rabbit antisera to a recombinant v-fms-coded polypeptide precipitated the feline c-fms product and specifically cross-reacted with a 165 kd glycoprotein from mouse macrophages. This putative product of the murine c-fms gene exhibited an associated tyrosine kinase activity in immune complexes, specifically bound murine CSF-1, and, in the presence of the growth factor, was phosphorylated on tyrosine in membrane preparations. The murine c-fms proto-oncogene product and the CSF-1 receptor are therefore related, and possibly identical, molecules.

[1]  P. Seeburg,et al.  Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells , 1984, Nature.

[2]  M. Gonda,et al.  Subcellular localization of glycoproteins encoded by the viral oncogene v-fms , 1984, Journal of virology.

[3]  E. Stanley,et al.  Factors regulating macrophage production and growth: identity of colony- stimulating factor and macrophage growth factor , 1976, The Journal of experimental medicine.

[4]  C. Stewart,et al.  Formation of Colonies by Mononuclear Phagocytes Outside the Bone Marrow , 1980 .

[5]  E. Stanley,et al.  Specific interaction of murine colony-stimulating factor with mononuclear phagocytic cells , 1980, Journal of Cell Biology.

[6]  E. Stanley,et al.  Methods for the purification, assay, characterization and target cell binding of a colony stimulating factor (CSF-1). , 1981, Journal of immunological methods.

[7]  C. Heldin,et al.  Stimulation of tyrosine-specific phosphorylation by platelet-derived growth factor , 1982, Nature.

[8]  J. H. Chen,et al.  The product of the c-fms proto-oncogene: a glycoprotein with associated tyrosine kinase activity. , 1985, Science.

[9]  D. Court,et al.  High-level expression in Escherichia coli of the carboxy-terminal sequences of the avian myelocytomatosis virus (MC29) v-myc protein. , 1983, Gene.

[10]  M. Barbacid,et al.  Gene products of McDonough feline sarcoma virus have an in vitro-associated protein kinase that phosphorylates tyrosine residues: lack of detection of this enzymatic activity in vivo , 1981, Journal of virology.

[11]  A. Burgess,et al.  Purification and properties of colony-stimulating factor from mouse lung-conditioned medium. , 1977, The Journal of biological chemistry.

[12]  Paul Stroobant,et al.  Platelet-derived growth factor is structurally related to the putative transforming protein p28sis of simian sarcoma virus , 1983, Nature.

[13]  E. Stanley,et al.  The regulation of mononuclear phagocyte entry into S phase by the colony stimulating factor CSF‐1 , 1985, Journal of cellular physiology.

[14]  E. Stanley,et al.  CSF‐1—A mononuclear phagocyte lineage‐specific hemopoietic growth factor , 1983, Journal of cellular biochemistry.

[15]  E. Stanley,et al.  The regulation of macrophage protein turnover by a colony stimulating factor (CSF‐1) , 1983, Journal of cellular physiology.

[16]  B. Roe,et al.  Human epidermal growth factor receptor cDNA is homologous to a variety of RNAs overproduced in A431 carcinoma cells , 1984, Nature.

[17]  B. Diamond,et al.  The generation of macrophage-like cell lines by transfection with SV40 origin defective DNA. , 1984, Journal of immunology.

[18]  I. Verma,et al.  Expression of cellular oncogenes in human malignancies. , 1984, Science.

[19]  I. Verma,et al.  Transcription of c-onc genes c-rasKi and c-fms during mouse development , 1983, Molecular and cellular biology.

[20]  S. Hakomori,et al.  Cell surface expression of the McDonough strain of feline sarcoma virus fms gene product (gp 140fms). , 1984, Cell.

[21]  J. Stephenson,et al.  Isolation of v-fms and its human cellular homolog. , 1983, Virology.

[22]  W. V. D. Van de Ven,et al.  Molecular cloning and characterization of feline cellular genetic sequences homologous to the oncogene of the McDonough strain of feline sarcoma virus. , 1985, Virology.

[23]  H. Lin,et al.  Clonal growth in vitro by mouse Kupffer cells. , 1979, Experimental Cell Research.

[24]  A. Hagemeijer,et al.  The 5q‐ chromosome abnormality in haematological disorders:|a collaborative study of 34 cases from the Netheralands , 1982 .

[25]  S. Das,et al.  Structure-function studies of a colony stimulating factor (CSF-1). , 1982, The Journal of biological chemistry.

[26]  A. Ullrich,et al.  Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences , 1984, Nature.

[27]  E. Stanley,et al.  Chemical crosslinking of the mononuclear phagocyte specific growth factor CSF-1 to its receptor at the cell surface. , 1984, Biochemical and biophysical research communications.

[28]  C. Sherr,et al.  Three independent isolates of feline sarcoma virus code for three distinct gag-x polyproteins , 1980, Journal of virology.

[29]  S. Anderson,et al.  Monoclonal antibodies to the transformation-specific glycoprotein encoded by the feline retroviral oncogene v-fms , 1982, Journal of virology.

[30]  E. Stanley,et al.  Lineage specific receptors used to identify a growth factor for developmentally early hemopoietic cells: Assay of hemopoietin‐2 , 1985, Journal of cellular physiology.

[31]  M. Barbacid,et al.  Biochemical and immunological characterization of polyproteins coded for by the McDonough, Gardner-Arnstein, and Snyder-Theilen strains of feline sarcoma virus , 1980, Journal of virology.

[32]  C. Heldin,et al.  Growth factors: Mechanism of action and relation to oncogenes , 1984, Cell.

[33]  A. Look,et al.  Cell surface expression of v-fms-coded glycoproteins is required for transformation , 1984, Molecular and cellular biology.

[34]  P. Cuatrecasas,et al.  Somatomedin-C stimulates the phosphorylation of the beta-subunit of its own receptor. , 1983, The Journal of biological chemistry.

[35]  E. Stanley,et al.  Synergism between hemopoietic growth factors (HGFs) detected by their effects on cells bearing receptors for a lineage specific HGF: Assay of hemopoietin‐1 , 1985, Journal of cellular physiology.

[36]  T. Hunter.  Cell-surface proteins: At last the insulin receptor , 1985, Nature.

[37]  S. Hakomori,et al.  Cell surface expression of the mcdonough strain of feline sarcoma virus fms gene product (gp140fms) , 1984, Cell.

[38]  P. Tynan,et al.  Survival of mononuclear phagocytes depends on a lineage-specific growth factor that the differentiated cells selectively destroy , 1982, Cell.

[39]  H. Berghe,et al.  A new hematologic syndrome with a distinct karyotype: the 5 q--chromosome. , 1975, Blood.

[40]  Tushinski Rj,et al.  The regulation of mononuclear phagocyte entry into S phase by the colony stimulating factor CSF-1. , 1985 .

[41]  J. Bishop.  Cellular oncogenes and retroviruses. , 1983, Annual review of biochemistry.

[42]  W. Hardy,et al.  A transmissible feline fibrosarcoma of viral origin. , 1971, Cancer research.

[43]  S. Cohen,et al.  Identification of phosphotyrosine as a product of epidermal growth factor-activated protein kinase in A-431 cell membranes. , 1980, The Journal of biological chemistry.

[44]  C. Kahn,et al.  Insulin stimulates tyrosine phosphorylation of the insulin receptor in a cell-free system , 1982, Nature.

[45]  E. Stanley,et al.  Regulation of Macrophage Production by a Colony-Stimulating Factor , 1980 .

[46]  F. Galibert,et al.  Nucleotide sequences of feline retroviral oncogenes (v-fes) provide evidence for a family of tyrosine-specific protein kinase genes , 1982, Cell.

[47]  R. Evans,et al.  Expression cloning of human EGF receptor complementary DNA: gene amplification and three related messenger RNA products in A431 cells. , 1984, Science.

[48]  E. Scolnick,et al.  Nature and distribution of feline sarcoma virus nucleotide sequences , 1979, Journal of virology.

[49]  F. Ruddle,et al.  Molecular cloning of the c-fms locus and its assignment to human chromosome 5 , 1983, Journal of virology.

[50]  C. Sherr,et al.  Transformation-defective mutants of feline sarcoma virus which express a product of the viral src gene , 1980, Journal of Virology.

[51]  I. Henderson,et al.  Mink cell line Mv 1 Lu (CCL 64). Focus formation and the generation of "nonproducer" transformed cell lines with murine and feline sarcoma viruses. , 1974, Virology.

[52]  I. Verma,et al.  Tissue and cell type-specific expression of two human c-onc genes , 1983, Nature.

[53]  K. Hirschhorn,et al.  Acquired partial deletions of the long arm of chromosome 5 in hematologic disorders , 1983, American journal of hematology.

[54]  J. Nishimura,et al.  Platelet-derived growth factor stimulates tyrosine-specific protein kinase activity in Swiss mouse 3T3 cell membranes. , 1982, Proceedings of the National Academy of Sciences of the United States of America.

[55]  E. Stanley.  Colony-stimulating factor (CSF) radioimmunoassay: detection of a CSF subclass stimulating macrophage production. , 1979, Proceedings of the National Academy of Sciences of the United States of America.

[56]  F. Galibert,et al.  Nucleotide sequence of the feline retroviral oncogene v-fms shows unexpected homology with oncogenes encoding tyrosine-specific protein kinases. , 1984, Proceedings of the National Academy of Sciences of the United States of America.

[57]  A. Look,et al.  Transmembrane orientation of glycoproteins encoded by the v-fms oncogene , 1985, Cell.

[58]  S. Anderson,et al.  McDonough feline sarcoma virus: characterization of the molecularly cloned provirus and its feline oncogene (v-fms) , 1982, Journal of virology.

[59]  J. Stephenson,et al.  Chromosomal localization of the human c-fms oncogene. , 1983, Nucleic acids research.

[60]  S. Adhya,et al.  Transcription antitermination by bacteriophage lambda N gene product. , 1980, Journal of molecular biology.

[61]  R F Doolittle,et al.  Simian sarcoma virus onc gene, v-sis, is derived from the gene (or genes) encoding a platelet-derived growth factor. , 1983, Science.

[62]  Stanley Er,et al.  Synergism between hemopoietic growth factors (HGFs) detected by their effects on cells bearing receptors for a lineage specific HGF: Assay of hemopoietin‐1 , 1985, Journal of cellular physiology.