Decreased functional connectivity within a language subnetwork in benign epilepsy with centrotemporal spikes

Benign epilepsy with centrotemporal spikes (BECTS, also known as Rolandic epilepsy) is a common epilepsy syndrome that is associated with literacy and language impairments. The neural mechanisms of the syndrome are not known. The primary objective of this study was to test the hypothesis that functional connectivity within the language network is decreased in children with BECTS. We also tested the hypothesis that siblings of children with BECTS have similar abnormalities.

[1]  Martha Feucht,et al.  Combined electroencephalography and magnetoencephalography of interictal spikes in benign rolandic epilepsy of childhood , 2008, Clinical Neurophysiology.

[2]  N. Tzourio-Mazoyer,et al.  Automated Anatomical Labeling of Activations in SPM Using a Macroscopic Anatomical Parcellation of the MNI MRI Single-Subject Brain , 2002, NeuroImage.

[3]  E. Wirrell,et al.  A microRNA‐328 binding site in PAX6 is associated with centrotemporal spikes of rolandic epilepsy , 2016, Annals of clinical and translational neurology.

[4]  N. Turk-Browne,et al.  Optimizing real time fMRI neurofeedback for therapeutic discovery and development , 2014, NeuroImage: Clinical.

[5]  Walter H. Backes,et al.  Reduced funtional integration of the sensorimotor and language network in rolandic epilepsy , 2013 .

[6]  Ashwini Sharan,et al.  Resting‐state functional connectivity predicts the strength of hemispheric lateralization for language processing in temporal lobe epilepsy and normals , 2015, Human brain mapping.

[7]  S. Blom,et al.  Benign Epilepsy of Children with Centrotemporal EEG Foci. A Study of Incidence Rate in Outpatient Care , 1975, Epilepsia.

[8]  John O. Willis,et al.  Wechsler Abbreviated Scale of Intelligence , 2014 .

[9]  Anne de Saint Martin,et al.  GRIN2A mutations in acquired epileptic aphasia and related childhood focal epilepsies and encephalopathies with speech and language dysfunction , 2013, Nature Genetics.

[10]  N. Volkow,et al.  Resting Functional Connectivity of Language Networks: Characterization and Reproducibility , 2011, Molecular Psychiatry.

[11]  A. Cohen.  Review of SCAN-C test for auditory processing disorders in children: revised , 2005 .

[12]  Xiaoming Wang,et al.  Altered Structural and Functional Feature of Striato-Cortical Circuit in Benign Epilepsy with Centrotemporal Spikes , 2015, Int. J. Neural Syst..

[13]  E. Novotny,et al.  The Genetics of Reading Disability in an Often Excluded Sample: Novel Loci Suggested for Reading Disability in Rolandic Epilepsy , 2012, PloS one.

[14]  Wei Liao,et al.  Local Activity and Causal Connectivity in Children with Benign Epilepsy with Centrotemporal Spikes , 2015, PloS one.

[15]  Joseph T. Devlin,et al.  Early and Sustained Supramarginal Gyrus Contributions to Phonological Processing , 2012, Front. Psychology.

[16]  P. Lieberman,et al.  Pleiotropic effects of the 11p13 locus on developmental verbal dyspraxia and EEG centrotemporal sharp waves , 2010, Genes, brain, and behavior.

[17]  Tzipi Horowitz-Kraus,et al.  Increased resting-state functional connectivity of visual- and cognitive-control brain networks after training in children with reading difficulties , 2015, NeuroImage: Clinical.

[18]  Vivek Prabhakaran,et al.  Regional homogeneity (ReHo) changes in new onset versus chronic benign epilepsy of childhood with centrotemporal spikes (BECTS): A resting state fMRI study , 2015, Epilepsy Research.

[19]  J. Epstein,et al.  Conners Rating Scales-Revised. , 1999 .

[20]  Cheng Luo,et al.  Altered functional and effective connectivity in anticorrelated intrinsic networks in children with benign childhood epilepsy with centrotemporal spikes , 2016, Medicine.

[21]  Edward T. Bullmore,et al.  Network-based statistic: Identifying differences in brain networks , 2010, NeuroImage.

[22]  Y. Zang,et al.  Altered Regional Homogeneity in Rolandic Epilepsy: A Resting-State fMRI Study , 2014, BioMed research international.

[23]  Cathy J. Price,et al.  A review and synthesis of the first 20 years of PET and fMRI studies of heard speech, spoken language and reading , 2012, NeuroImage.

[24]  G. Tremont,et al.  A neurocognitive endophenotype associated with rolandic epilepsy , 2012, Epilepsia.

[25]  Dong Zhou,et al.  Functional brain connectome and sensorimotor networks in rolandic epilepsy , 2015, Epilepsy Research.

[26]  Olaf Sporns,et al.  Complex network measures of brain connectivity: Uses and interpretations , 2010, NeuroImage.

[27]  Yong He,et al.  BrainNet Viewer: A Network Visualization Tool for Human Brain Connectomics , 2013, PloS one.

[28]  Anna B. Smith,et al.  A meta‐analysis of literacy and language in children with rolandic epilepsy , 2015, Developmental medicine and child neurology.

[29]  Jerrold L. Boxerman,et al.  Is Rolandic epilepsy associated with abnormal findings on cranial MRI? , 2007, Epilepsy Research.

[30]  Xiaoqi Huang,et al.  Altered attention networks in benign childhood epilepsy with centrotemporal spikes (BECTS): A resting-state fMRI study , 2015, Epilepsy & Behavior.

[31]  John O. Willis,et al.  Test of Word Reading Efficiency , 2014 .

[32]  Leasha M. Lillywhite,et al.  Neuropsychological and functional MRI studies provide converging evidence of anterior language dysfunction in BECTS , 2009, Epilepsia.

[33]  Jacobus F. A. Jansen,et al.  Delayed convergence between brain network structure and function in rolandic epilepsy , 2014, Front. Hum. Neurosci..

[34]  Walter H. Backes,et al.  Aberrant functional connectivity between motor and language networks in rolandic epilepsy , 2013, Epilepsy Research.

[35]  D. Pal,et al.  Antiepileptic drug treatment of rolandic epilepsy and Panayiotopoulos syndrome: clinical practice survey and clinical trial feasibility , 2014, Archives of Disease in Childhood.

[36]  Zhen Jin,et al.  Interhemispheric Connectivity in Drug-Naive Benign Childhood Epilepsy With Centrotemporal Spikes , 2015, Medicine.

[37]  W. Liao,et al.  Decreased Network Efficiency in Benign Epilepsy with Centrotemporal Spikes. , 2017, Radiology.

[38]  D. Mandelbaum,et al.  Risk factors for reading disability in families with rolandic epilepsy , 2015, Epilepsy & Behavior.