Dickkopf-1 and ROCK2 upregulation and associated protein aggregation in pseudoexfoliation syndrome and glaucoma.

[1]  Jeremy H. Herskowitz,et al.  Perspectives on ROCK2 as a Therapeutic Target for Alzheimer’s Disease , 2021, Frontiers in Cellular Neuroscience.

[2]  Hannah C. Webber,et al.  Full title: The canonical Wnt signaling pathway inhibits the glucocorticoid receptor signaling pathway in the trabecular meshwork. , 2021, The American journal of pathology.

[3]  F. Calon,et al.  Dickkopf-related protein-1 inhibition attenuates amyloid-beta pathology associated to Alzheimer's disease , 2020, Neurochemistry International.

[4]  M. Izdebska,et al.  Beta-Catenin in Pseudoexfoliation Syndrome , 2020, Applied Sciences.

[5]  Pranjya Paramita Mohanty,et al.  Epigenetic silencing of heat shock protein 70 through DNA hypermethylation in pseudoexfoliation syndrome and glaucoma , 2020, Journal of Human Genetics.

[6]  Birsen Can Demirdöğen,et al.  Evaluation of tear and aqueous humor level, and genetic variants of connective tissue growth factor as biomarkers for early detection of pseudoexfoliation syndrome/glaucoma. , 2019, Experimental eye research.

[7]  Birsen Can Demirdöğen,et al.  Evaluation of Tear Fluid and Aqueous Humor Concentration of Clusterin as Biomarkers for Early Diagnosis of Pseudoexfoliation Syndrome and Pseudoexfoliative Glaucoma , 2019, Current eye research.

[8]  G. Hilal,et al.  DKK1 promotes hepatocellular carcinoma inflammation, migration and invasion: Implication of TGF-β1 , 2019, PloS one.

[9]  Pranjya Paramita Mohanty,et al.  De novo variants in an extracellular matrix protein coding gene, fibulin-5 (FBLN5) are associated with pseudoexfoliation , 2019, European Journal of Human Genetics.

[10]  Melissa Key,et al.  The Effect of Molecular Weight on Passage of Proteins Through the Blood-Aqueous Barrier. , 2019, Investigative ophthalmology & visual science.

[11]  Pranjya Paramita Mohanty,et al.  Altered unfolded protein response and proteasome impairment in pseudoexfoliation pathogenesis , 2019, Experimental eye research.

[12]  S. Lovestone,et al.  Amyloid β synaptotoxicity is Wnt-PCP dependent and blocked by fasudil , 2018, Alzheimer's & Dementia.

[13]  K. Abu-Amero,et al.  Elevated levels of plasma tumor necrosis factor alpha in patients with pseudoexfoliation glaucoma , 2018, Clinical ophthalmology.

[14]  Biswajit Padhy,et al.  Pseudoexfoliation and Alzheimer’s associated CLU risk variant, rs2279590, lies within an enhancer element and regulates CLU, EPHX2 and PTK2B gene expression , 2017, Human molecular genetics.

[15]  M. Salathe,et al.  Modulation of Wnt signaling is essential for the differentiation of ciliated epithelial cells in human airways , 2017, FEBS letters.

[16]  Jian-xing Ma,et al.  Decreased Circulating Levels of Dickkopf-1 in Patients with Exudative Age-related Macular Degeneration , 2017, Scientific Reports.

[17]  Zhuo-wei Hu,et al.  The regulation of β-catenin activity and function in cancer: therapeutic opportunities , 2017, Oncotarget.

[18]  M. Fraga,et al.  Nuclear DICKKOPF-1 as a biomarker of chemoresistance and poor clinical outcome in colorectal cancer , 2015, Oncotarget.

[19]  Debananda Padhi,et al.  Role of an extracellular chaperone, Clusterin in the pathogenesis of Pseudoexfoliation Syndrome and Pseudoexfoliation Glaucoma. , 2014, Experimental eye research.

[20]  D. Alexopoulos,et al.  Pseudoexfoliation syndrome and cardiovascular diseases. , 2014, World journal of cardiology.

[21]  N. Anzai,et al.  The Rho-kinase inhibitor HA-1077 suppresses proliferation/migration and induces apoptosis of urothelial cancer cells , 2014, BMC Cancer.

[22]  C. Tournier.  The 2 Faces of JNK Signaling in Cancer. , 2013, Genes & cancer.

[23]  B. Cumurcu,et al.  Is There Any Relation Between Pseudoexfoliation Syndrome and Alzheimer’s Type Dementia? , 2013, Seminars in ophthalmology.

[24]  X. Bai,et al.  Plasma and vitreous fluid levels of Dickkopf-1 in patients with diabetic retinopathy , 2014, Eye.

[25]  Lumin Zhang,et al.  Dissecting the roles of ROCK isoforms in stress-induced cell detachment , 2013, Cell cycle.

[26]  M. Diamond,et al.  Cellular mechanisms of protein aggregate propagation. , 2012, Current opinion in neurology.

[27]  G. Breen,et al.  Clusterin regulates β-amyloid toxicity via Dickkopf-1-driven induction of the wnt–PCP–JNK pathway , 2012, Molecular Psychiatry.

[28]  Yuan Zhang,et al.  Inhibition of the canonical Wnt pathway by Dickkopf-1 contributes to the neurodegeneration in 6-OHDA-lesioned rats , 2012, Neuroscience Letters.

[29]  G. Terstappen,et al.  Increased Dickkopf‐1 expression in transgenic mouse models of neurodegenerative disease , 2010, Journal of neurochemistry.

[30]  U. Schlötzer-Schrehardt,et al.  Exploring functional candidate genes for genetic association in german patients with pseudoexfoliation syndrome and pseudoexfoliation glaucoma. , 2009, Investigative ophthalmology & visual science.

[31]  N. Nukina,et al.  Inhibition of Rho Kinases Enhances the Degradation of Mutant Huntingtin* , 2009, Journal of Biological Chemistry.

[32]  F. Bosman,et al.  Altered expression of CD44 and DKK1 in the progression of Barrett’s esophagus to esophageal adenocarcinoma , 2009, Virchows Archiv.

[33]  F. Journé,et al.  Assessment of Circulating Dickkopf-1 with a New Two-Site Immunoassay in Healthy Subjects and Women with Breast Cancer and Bone Metastases , 2009, Calcified Tissue International.

[34]  J. Shaughnessy,et al.  The role of Dickkopf-1 in bone development, homeostasis, and disease. , 2009, Blood.

[35]  P. Mitchell,et al.  Genetic analysis of the clusterin gene in pseudoexfoliation syndrome , 2008, Molecular vision.

[36]  M. Peters,et al.  Serum concentrations of DKK‐1 correlate with the extent of bone disease in patients with multiple myeloma , 2008, European journal of haematology.

[37]  W. Birchmeier,et al.  Wnt signalling and its impact on development and cancer , 2008, Nature Reviews Cancer.

[38]  E. Vilain,et al.  Wnt4 inhibits β‐catenin/TCF signalling by redirecting β‐catenin to the cell membrane , 2008 .

[39]  G. Naumann,et al.  Impaired cytoprotective mechanisms in eyes with pseudoexfoliation syndrome/glaucoma. , 2007, Investigative ophthalmology & visual science.

[40]  M. Nevitt,et al.  Wnt signaling antagonists are potential prognostic biomarkers for the progression of radiographic hip osteoarthritis in elderly Caucasian women. , 2007, Arthritis and rheumatism.

[41]  F. Journé,et al.  Increased Dickkopf-1 expression in breast cancer bone metastases , 2007, British Journal of Cancer.

[42]  Y. Miyagi,et al.  Dikkopf-1 as a novel serologic and prognostic biomarker for lung and esophageal carcinomas. , 2007, Cancer research.

[43]  M. Montcouquiol,et al.  Noncanonical Wnt signaling and neural polarity. , 2006, Annual review of neuroscience.

[44]  G. Naumann,et al.  Clusterin deficiency in eyes with pseudoexfoliation syndrome may be implicated in the aggregation and deposition of pseudoexfoliative material. , 2006, Investigative ophthalmology & visual science.

[45]  C Zimmer,et al.  Glioma assessment using quantitative blood volume maps generated by T1-weighted dynamic contrast-enhanced magnetic resonance imaging: a receiver operating characteristic study , 2006, Acta radiologica.

[46]  G. Naumann,et al.  Differential gene expression in pseudoexfoliation syndrome. , 2005, Investigative ophthalmology & visual science.

[47]  A. Muñoz,et al.  The Wnt antagonist DICKKOPF-1 gene is a downstream target of β-catenin/TCF and is downregulated in human colon cancer , 2005, Oncogene.

[48]  Choun-Ki Joo,et al.  Wnt/β-Catenin/Tcf Signaling Induces the Transcription of Axin2, a Negative Regulator of the Signaling Pathway , 2002, Molecular and Cellular Biology.

[49]  T. Oka,et al.  Reduction of intraocular pressure by topical administration of an inhibitor of the Rho-associated protein kinase , 2001, Current eye research.

[50]  K. Robison,et al.  Functional and structural diversity of the human Dickkopf gene family. , 1999, Gene.

[51]  M. Kraus,et al.  Isolation and Biochemical Characterization of the Human Dkk-1 Homologue, a Novel Inhibitor of Mammalian Wnt Signaling* , 1999, The Journal of Biological Chemistry.

[52]  G. Naumann,et al.  Pseudoexfoliation syndrome for the comprehensive ophthalmologist. Intraocular and systemic manifestations. , 1998, Ophthalmology.

[53]  W. Birchmeier,et al.  Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta. , 1998, Science.

[54]  P. Martus,et al.  Correlation of pseudoexfoliative material and optic nerve damage in pseudoexfoliation syndrome. , 1997, Investigative ophthalmology & visual science.

[55]  L. Chylack,et al.  Propagation and immortalization of human lens epithelial cells in culture. , 1994, Investigative ophthalmology & visual science.

[56]  C. Metz.  Basic principles of ROC analysis. , 1978, Seminars in nuclear medicine.

[57]  A. Hatzopoulos,et al.  Continuous antagonism by Dkk1 counter activates canonical Wnt signaling and promotes cardiomyocyte differentiation of embryonic stem cells. , 2012, Stem cells and development.

[58]  R. Ritch,et al.  Exfoliation syndrome. , 2001, Survey of ophthalmology.

[59]  N. Nguyen,et al.  The blood-aqueous barrier in eyes with pseudoexfoliation syndrome. , 1995, Ophthalmic research.

[60]  R. Ritch.  Exfoliation syndrome and occludable angles. , 1994, Transactions of the American Ophthalmological Society.