Tissue Engineering and Regenerative Medicine: Achievements, Future, and Sustainability in Asia

Exploring innovative solutions to improve the healthcare of the aging and diseased population continues to be a global challenge. Among a number of strategies toward this goal, tissue engineering and regenerative medicine (TERM) has gradually evolved into a promising approach to meet future needs of patients. TERM has recently received increasing attention in Asia, as evidenced by the markedly increased number of researchers, publications, clinical trials, and translational products. This review aims to give a brief overview of TERM development in Asia over the last decade by highlighting some of the important advances in this field and featuring major achievements of representative research groups. The development of novel biomaterials and enabling technologies, identification of new cell sources, and applications of TERM in various tissues are briefly introduced. Finally, the achievement of TERM in Asia, including important publications, representative discoveries, clinical trials, and examples of commercial products will be introduced. Discussion on current limitations and future directions in this hot topic will also be provided.

[1]  Juliana Botelho Moreira,et al.  Electrospun Nanofibers , 2020, Food Packaging.

[2]  K. Omori,et al.  Bone Marrow Stromal Cells Accelerate Hearing Recovery via Regeneration or Maintenance of Cochlear Fibrocytes in Mouse Spiral Ligaments , 2020, Anatomical record.

[3]  Torsten Möller,et al.  Origins , 2020, IEEE Computer Graphics and Applications.

[4]  Ishita Matai,et al.  Progress in 3D bioprinting technology for tissue/organ regenerative engineering. , 2020, Biomaterials.

[5]  Peng Liu,et al.  Remote eradication of biofilm on titanium implant via near-infrared light triggered photothermal/photodynamic therapy strategy. , 2019, Biomaterials.

[6]  K. Vijayalakshmi,et al.  Enhanced antibacterial and corrosion resistance properties of Ag substituted hydroxyapatite/functionalized multiwall carbon nanotube nanocomposite coating on 316L stainless steel for biomedical application. , 2019, Ultrasonics sonochemistry.

[7]  E. Choi,et al.  Effect of wet storage on the bioactivity of ultraviolet light- and non-thermal atmospheric pressure plasma-treated titanium and zirconia implant surfaces. , 2019, Materials science & engineering. C, Materials for biological applications.

[8]  R. Niranjan,et al.  PVA/alginate/hydroxyapatite films for controlled release of amoxicillin for the treatment of periodontal defects , 2019, Applied Surface Science.

[9]  H. Yatani,et al.  In vitro investigation of fracture load and aging resistance of high-speed sintered monolithic tooth-borne zirconia crowns. , 2019, Journal of prosthodontic research.

[10]  Du-Hyeong Lee,et al.  A New Antibacterial Agent-Releasing Polydimethylsiloxane Coating for Polymethyl Methacrylate Dental Restorations , 2019, Journal of clinical medicine.

[11]  P. Ji,et al.  Comparison of 3D-printed porous tantalum and titanium scaffolds on osteointegration and osteogenesis. , 2019, Materials science & engineering. C, Materials for biological applications.

[12]  Su-Min Lee,et al.  Initial Cytotoxicity of Mineral Trioxide Aggregate (MTA) during Setting on Human Mesenchymal Stem Cells , 2019, Advances in Materials Science and Engineering.

[13]  H. Kim,et al.  Evaluation of Strontium-Doped Nanobioactive Glass Cement for Dentin-Pulp Complex Regeneration Therapy. , 2019, ACS biomaterials science & engineering.

[14]  P. Giannoudis,et al.  Antibacterial properties and regenerative potential of Sr2+ and Ce3+ doped fluorapatites; a potential solution for peri-implantitis , 2019, Scientific Reports.

[15]  Yufeng Zheng,et al.  A functionalized TiO2/Mg2TiO4 nano-layer on biodegradable magnesium implant enables superior bone-implant integration and bacterial disinfection. , 2019, Biomaterials.

[16]  S. Heo,et al.  Human Stem Cell Responses and Surface Characteristics of 3D Printing Co-Cr Dental Material , 2019, Materials.

[17]  T. Diekwisch,et al.  Triple PLGA/PCL scaffold modification including silver-impregnation, collagen-coating, and electrospinning significantly improve biocompatibility, antimicrobial, and osteogenic properties for oro-facial tissue regeneration. , 2019, ACS applied materials & interfaces.

[18]  Yufeng Zheng,et al.  A Surface-engineered Multifunctional TiO2 Based Nano-layer Simultaneously Elevates the Corrosion Resistance, Osteoconductivity and Antimicrobial Property of Magnesium Alloy. , 2019, Acta biomaterialia.

[19]  Min-Ah Koo,et al.  Effective stacking and transplantation of stem cell sheets using exogenous ROS-producing film for accelerated wound healing. , 2019, Acta biomaterialia.

[20]  T. Hayakawa,et al.  Antimicrobial Activity of Protamine-Loaded Calcium Phosphates against Oral Bacteria , 2019, Materials.

[21]  A. Kishida,et al.  Re-epithelialization and remodeling of decellularized corneal matrix in a rabbit corneal epithelial wound model. , 2019, Materials science & engineering. C, Materials for biological applications.

[22]  Jing Ma,et al.  Applicability of adipose-derived mesenchymal stem cells in treatment of patients with type 2 diabetes , 2019, Stem Cell Research & Therapy.

[23]  Lixin Xie,et al.  Protectively Decellularized Porcine Cornea versus Human Donor Cornea for Lamellar Transplantation , 2019, Advanced Functional Materials.

[24]  Jin Han,et al.  Pre-Clinical Evaluation of CBD-NT3 Modified Collagen Scaffolds in Completely Spinal Cord Transected Non-Human Primates. , 2019, Journal of neurotrauma.

[25]  Jinmin Zhao,et al.  An injectable collagen-genipin-carbon dot hydrogel combined with photodynamic therapy to enhance chondrogenesis. , 2019, Biomaterials.

[26]  Xuesi Chen,et al.  Polymer Fiber Scaffolds for Bone and Cartilage Tissue Engineering , 2019, Advanced Functional Materials.

[27]  Lijie Sun,et al.  3D printing of biomimetic vasculature for tissue regeneration , 2019, Materials Horizons.

[28]  H. Meng,et al.  Novel 3-D helix-flexible nerve guide conduits repair nerve defects. , 2019, Biomaterials.

[29]  Huan Wang,et al.  Substrate stiffness- and topography-dependent differentiation of annulus fibrosus-derived stem cells is regulated by Yes-associated protein. , 2019, Acta biomaterialia.

[30]  Sie Chin Tjong,et al.  Electrospun Polyvinylidene Fluoride-Based Fibrous Scaffolds with Piezoelectric Characteristics for Bone and Neural Tissue Engineering , 2019, Nanomaterials.

[31]  Hyoun‐Ee Kim,et al.  Reduced fibrous capsule formation at nano-engineered silicone surfaces via tantalum ion implantation. , 2019, Biomaterials science.

[32]  Peng Liu,et al.  Biocompatible MoS2/PDA-RGD coating on titanium implant with antibacterial property via intrinsic ROS-independent oxidative stress and NIR irradiation. , 2019, Biomaterials.

[33]  Donghui Wang,et al.  Nanostructural Surfaces with Different Elastic Moduli Regulate the Immune Response by Stretching Macrophages. , 2019, Nano letters.

[34]  MaoQin,et al.  Gingiva-Derived Mesenchymal Stem Cell-Extracellular Vesicles Activate Schwann Cell Repair Phenotype and Promote Nerve Regeneration , 2019 .

[35]  K. Yeung,et al.  Minocycline hydrochloride loaded graphene oxide enables enhanced osteogenic activity in the presence of Gram-positive bacteria, Staphylococcus aureus , 2019, Journal of Materials Chemistry B.

[36]  Bai Yang,et al.  Skin‐Inspired Antibacterial Conductive Hydrogels for Epidermal Sensors and Diabetic Foot Wound Dressings , 2019, Advanced Functional Materials.

[37]  Bin Ding,et al.  3D Superelastic Scaffolds Constructed from Flexible Inorganic Nanofibers with Self‐Fitting Capability and Tailorable Gradient for Bone Regeneration , 2019, Advanced Functional Materials.

[38]  X. Bai,et al.  Layered nanofiber sponge with an improved capacity for promoting blood coagulation and wound healing. , 2019, Biomaterials.

[39]  Qiang Zhao,et al.  MSC-derived sEVs enhance patency and inhibit calcification of synthetic vascular grafts by immunomodulation in a rat model of hyperlipidemia. , 2019, Biomaterials.

[40]  Changsheng Liu,et al.  Robust hierarchical porous MBG scaffolds with promoted biomineralization ability. , 2019, Colloids and surfaces. B, Biointerfaces.

[41]  Yumin Yang,et al.  PAM/GO/gel/SA composite hydrogel conduit with bioactivity for repairing peripheral nerve injury. , 2019, Journal of biomedical materials research. Part A.

[42]  Wei Zhang,et al.  Aligned electrospun cellulose scaffolds coated with rhBMP-2 for both in vitro and in vivo bone tissue engineering. , 2019, Carbohydrate polymers.

[43]  Jianhua Zhou,et al.  Sustainable Dual Release of Antibiotic and Growth Factor from pH-Responsive Uniform Alginate Composite Microparticles to Enhance Wound Healing. , 2019, ACS applied materials & interfaces.

[44]  Y. S. Zhang,et al.  A Bioinspired Medical Adhesive Derived from Skin Secretion of Andrias davidianus for Wound Healing , 2019, Advanced Functional Materials.

[45]  Ji-Yeon Jung,et al.  Combination of mineral trioxide aggregate and propolis promotes odontoblastic differentiation of human dental pulp stem cells through ERK signaling pathway , 2019, Food Science and Biotechnology.

[46]  Haeshin Lee,et al.  Toxicity‐Attenuated Glycol Chitosan Adhesive Inspired by Mussel Adhesion Mechanisms , 2019, Advanced healthcare materials.

[47]  Xuesi Chen,et al.  Injectable Cholesterol‐Enhanced Stereocomplex Polylactide Thermogel Loading Chondrocytes for Optimized Cartilage Regeneration , 2019, Advanced healthcare materials.

[48]  M. Guo,et al.  Microfluidic Fabrication of Biomimetic Helical Hydrogel Microfibers for Blood‐Vessel‐on‐a‐Chip Applications , 2019, Advanced healthcare materials.

[49]  Y. Gan,et al.  Photosensitive Hydrogel Creates Favorable Biologic Niches to Promote Spinal Cord Injury Repair , 2019, Advanced healthcare materials.

[50]  T. Okano,et al.  Cell sheet tissue engineering: Cell sheet preparation, harvesting/manipulation, and transplantation. , 2019, Journal of biomedical materials research. Part A.

[51]  Sang-Hyug Park,et al.  Evaluation of mechanical strength and bone regeneration ability of 3D printed kagome-structure scaffold using rabbit calvarial defect model. , 2019, Materials science & engineering. C, Materials for biological applications.

[52]  Y. Tabata,et al.  Rapid treatment of full‐thickness skin loss using ovine tendon collagen type I scaffold with skin cells , 2019, Journal of tissue engineering and regenerative medicine.

[53]  Ludwig Cardon,et al.  Rapid 3D printing of functional nanoparticle-enhanced conduits for effective nerve repair. , 2019, Acta biomaterialia.

[54]  K. Matsumura,et al.  Effect of dual-drug-releasing micelle-hydrogel composite on wound healing in vivo in full-thickness excision wound rat model. , 2019, Journal of biomedical materials research. Part A.

[55]  Y. Chai,et al.  Progress in developing decellularized bioscaffolds for enhancing skin construction. , 2019, Journal of biomedical materials research. Part A.

[56]  Hiroki Nakamura,et al.  First-principles calculation of mechanical properties of simulated debris Zr x U1− x O2 , 2019, Journal of Nuclear Science and Technology.

[57]  F. Gao,et al.  Therapeutic role of miR-19a/19b in cardiac regeneration and protection from myocardial infarction , 2019, Nature Communications.

[58]  T. Zhu,et al.  Enhancement of Schwann Cells Function Using Graphene-Oxide-Modified Nanofiber Scaffolds for Peripheral Nerve Regeneration. , 2019, ACS biomaterials science & engineering.

[59]  Qing Wang,et al.  The Application of Microfluidic Techniques on Tissue Engineering in Orthopaedics. , 2019, Current pharmaceutical design.

[60]  Shi-Bin Wang,et al.  Microengineered Organ-on-a-chip Platforms towards Personalized Medicine. , 2019, Current pharmaceutical design.

[61]  A. Ahmadi,et al.  Microfluidic and cross-linking methods for encapsulation of living cells and bacteria - A review. , 2019, Analytica chimica acta.

[62]  Wei Chen,et al.  Bionic Poly(γ‐Glutamic Acid) Electrospun Fibrous Scaffolds for Preventing Hypertrophic Scars , 2019, Advanced healthcare materials.

[63]  B. Li,et al.  Engineering human ventricular heart tissue based on macroporous iron oxide scaffolds. , 2019, Acta biomaterialia.

[64]  Sahba Mobini,et al.  Advances in ex vivo models and lab-on-a-chip devices for neural tissue engineering. , 2019, Biomaterials.

[65]  Di Chen,et al.  Degenerative musculoskeletal diseases: Pathology and treatments , 2019, Journal of orthopaedic translation.

[66]  Luanluan Jia,et al.  Polydopamine-assisted surface modification for orthopaedic implants , 2019, Journal of orthopaedic translation.

[67]  Jiawei Shi,et al.  Modifying decellularized aortic valve scaffolds with stromal cell-derived factor-1α loaded proteolytically degradable hydrogel for recellularization and remodeling. , 2019, Acta biomaterialia.

[68]  Zhiyu He,et al.  Bone Marrow Mesenchymal Stem Cells and Endothelial Progenitor Cells Co-Culture Enhances Large Segment Bone Defect Repair. , 2019, Journal of biomedical nanotechnology.

[69]  Michael Pineda,et al.  Safe CRISPR: Challenges and Possible Solutions. , 2019, Trends in biotechnology.

[70]  X. Mo,et al.  Electrospun Nanofibers for Tissue Engineering with Drug Loading and Release , 2019, Pharmaceutics.

[71]  M. Cho,et al.  β-Glucan-Based Wet Dressing for Cutaneous Wound Healing. , 2019, Advances in wound care.

[72]  Her-Hsiung Huang,et al.  Multiform TiO2 nano-network enhances biological response to titanium surface for dental implant applications , 2019, Applied Surface Science.

[73]  Chengtie Wu,et al.  Grape Seed-Inspired Smart Hydrogel Scaffolds for Melanoma Therapy and Wound Healing. , 2019, ACS nano.

[74]  Jiang Chang,et al.  Multifunctional Zn doped hollow mesoporous silica/polycaprolactone electrospun membranes with enhanced hair follicle regeneration and antibacterial activity for wound healing. , 2019, Nanoscale.

[75]  Bong-Hyun Jun,et al.  Advances in dynamic microphysiological organ-on-a-chip: Design principle and its biomedical application , 2019, Journal of Industrial and Engineering Chemistry.

[76]  Xijiao Yu,et al.  Calcitonin gene related peptide gene-modified rat bone mesenchymal stem cells are effective seed cells in tissue engineering to repair skull defects. , 2019, Histology and histopathology.

[77]  F. Lin,et al.  Drug-loaded hyaluronic acid hydrogel as a sustained-release regimen with dual effects in early intervention of tendinopathy , 2019, Scientific Reports.

[78]  D. Hart,et al.  Intervertebral disc regeneration with an adipose mesenchymal stem cell-derived tissue-engineered construct in a rat nucleotomy model. , 2019, Acta biomaterialia.

[79]  Hao Zhang,et al.  The therapeutic effects of bone marrow-derived mesenchymal stromal cells in the acute lung injury induced by sulfur mustard , 2019, Stem Cell Research & Therapy.

[80]  Ruiyi Zhang,et al.  Bone Mesenchymal Stem Cell-Derived Extracellular Vesicles Promote Recovery Following Spinal Cord Injury via Improvement of the Integrity of the Blood-Spinal Cord Barrier , 2019, Front. Neurosci..

[81]  X. Niu,et al.  Exosomes secreted by urine-derived stem cells improve stress urinary incontinence by promoting repair of pubococcygeus muscle injury in rats , 2019, Stem cell research & therapy.

[82]  Tong Xu,et al.  Mussel-inspired dopamine oligomer intercalated tough and resilient gelatin methacryloyl (GelMA) hydrogels for cartilage regeneration. , 2019, Journal of materials chemistry. B.

[83]  H. Mao,et al.  Devising micro/nano-architectures in multi-channel nerve conduits towards a pro-regenerative matrix for the repair of spinal cord injury. , 2019, Acta biomaterialia.

[84]  Yo Tanaka,et al.  Recent advances in microfluidic cell sorting systems , 2019, Sensors and Actuators B: Chemical.

[85]  Guanwei Fan,et al.  A collagen hydrogel loaded with HDAC7-derived peptide promotes the regeneration of infarcted myocardium with functional improvement in a rodent model. , 2019, Acta biomaterialia.

[86]  C. Yao,et al.  Lithospermi radix extract-containing bilayer nanofiber scaffold for promoting wound healing in a rat model. , 2019, Materials science & engineering. C, Materials for biological applications.

[87]  Jiang Peng,et al.  Osteogenic magnesium incorporated into PLGA/TCP porous scaffold by 3D printing for repairing challenging bone defect. , 2019, Biomaterials.

[88]  B. Brown,et al.  Conduits harnessing spatially controlled cell-secreted neurotrophic factors improve peripheral nerve regeneration. , 2019, Biomaterials.

[89]  Shuhan Sun,et al.  PGS Scaffolds Promote the In Vivo Survival and Directional Differentiation of Bone Marrow Mesenchymal Stem Cells Restoring the Morphology and Function of Wounded Rat Uterus , 2019, Advanced healthcare materials.

[90]  Geunhyung Kim,et al.  The fabrication of uniaxially aligned micro-textured polycaprolactone struts and application for skeletal muscle tissue regeneration , 2019, Biofabrication.

[91]  Huilin Yang,et al.  In situ silk fibroin-mediated crystal formation of octacalcium phosphate and its application in bone repair. , 2019, Materials science & engineering. C, Materials for biological applications.

[92]  Shufang Zhang,et al.  Silicate-based bioceramic scaffolds for dual-lineage regeneration of osteochondral defect. , 2019, Biomaterials.

[93]  K. Tarte,et al.  Adipose mesenchymal stromal cells: Definition, immunomodulatory properties, mechanical isolation and interest for plastic surgery. , 2019, Annales de chirurgie plastique et esthetique.

[94]  Chengtie Wu,et al.  Lithium-containing biomaterials stimulate bone marrow stromal cell-derived exosomal miR-130a secretion to promote angiogenesis. , 2019, Biomaterials.

[95]  C. Colwell,et al.  Neuronal PAS domain 2 (Npas2) facilitated osseointegration of titanium implant with rough surface through a neuroskeletal mechanism. , 2019, Biomaterials.

[96]  K. Ou,et al.  The potential of the stem cells composite hydrogel wound dressings for promoting wound healing and skin regeneration: In vitro and in vivo evaluation. , 2019, Journal of biomedical materials research. Part B, Applied biomaterials.

[97]  Wei Xia,et al.  An injectable continuous stratified structurally and functionally biomimetic construct for enhancing osteochondral regeneration. , 2019, Biomaterials.

[98]  F. Jin,et al.  Bone marrow mesenchymal stem cells protect lungs from smoke inhalation injury by differentiating into alveolar epithelial cells via Notch signaling , 2019, Journal of Biosciences.

[99]  U. Bindal,et al.  Angiogenic effect of platelet-rich concentrates on dental pulp stem cells in inflamed microenvironment , 2019, Clinical Oral Investigations.

[100]  B. Li,et al.  Stiffness of Aligned Fibers Regulates the Phenotypic Expression of Vascular Smooth Muscle Cells. , 2019, ACS applied materials & interfaces.

[101]  Jin Fan,et al.  Exosomes Derived from Bone Mesenchymal Stem Cells Repair Traumatic Spinal Cord Injury by Suppressing the Activation of A1 Neurotoxic Reactive Astrocytes. , 2019, Journal of neurotrauma.

[102]  Boqing Zhang,et al.  Bionic cartilage acellular matrix microspheres as a scaffold for engineering cartilage. , 2019, Journal of materials chemistry. B.

[103]  J. Ge,et al.  5 Years of Serial Intravascular Imaging Outcomes of XINSORB Sirolimus-Eluting Bioresorbable Vascular Scaffold. , 2019, JACC. Cardiovascular interventions.

[104]  S. Kim,et al.  Comparison of Undifferentiated Versus Chondrogenic Predifferentiated Mesenchymal Stem Cells Derived From Human Umbilical Cord Blood for Cartilage Repair in a Rat Model , 2019, The American journal of sports medicine.

[105]  Ali Khademhosseini,et al.  Organ‐on‐a‐Chip for Cancer and Immune Organs Modeling , 2019, Advanced healthcare materials.

[106]  X. Mo,et al.  Three-dimensional electrospun nanofibrous scaffolds displaying bone morphogenetic protein-2-derived peptides for the promotion of osteogenic differentiation of stem cells and bone regeneration. , 2019, Journal of colloid and interface science.

[107]  Xiaoyan Yuan,et al.  Antibacterial PCL electrospun membranes containing synthetic polypeptides for biomedical purposes. , 2018, Colloids and surfaces. B, Biointerfaces.

[108]  Mengsu Yang,et al.  Recent advances in microfluidic technology for manipulation and analysis of biological cells (2007-2017). , 2018, Analytica chimica acta.

[109]  L. Deng,et al.  Enhanced Osteogenesis of Bone Marrow‐Derived Mesenchymal Stem Cells by a Functionalized Silk Fibroin Hydrogel for Bone Defect Repair , 2018, Advanced healthcare materials.

[110]  Shao-qiang Lin,et al.  Bone Marrow Mesenchymal Stem Cells (BMSCs) Restore Functional Endometrium in the Rat Model for Severe Asherman Syndrome , 2018, Reproductive Sciences.

[111]  S. Murakami,et al.  Transplantation of Olfactory Stem Cells with Biodegradable Hydrogel Accelerates Facial Nerve Regeneration After Crush Injury , 2018, Stem cells translational medicine.

[112]  H. Okano,et al.  Concise Review: Laying the Groundwork for a First‐In‐Human Study of an Induced Pluripotent Stem Cell‐Based Intervention for Spinal Cord Injury , 2018, Stem cells.

[113]  Peixi Liu,et al.  Rosuvastatin- and Heparin-Loaded Poly(l-lactide- co-caprolactone) Nanofiber Aneurysm Stent Promotes Endothelialization via Vascular Endothelial Growth Factor Type A Modulation. , 2018, ACS applied materials & interfaces.

[114]  Fan Liu,et al.  Natural Polymers for Organ 3D Bioprinting , 2018, Polymers.

[115]  L. Qin,et al.  A bone-targeting delivery system carrying osteogenic phytomolecule icaritin prevents osteoporosis in mice. , 2018, Biomaterials.

[116]  Yuanjin Zhao,et al.  Design of capillary microfluidics for spinning cell-laden microfibers , 2018, Nature Protocols.

[117]  Xiaoyan Yuan,et al.  Encapsulating Microorganisms inside Electrospun Microfibers as a Living Material Enables Room-Temperature Storage of Microorganisms. , 2018, ACS applied materials & interfaces.

[118]  Zong-ping Luo,et al.  Mechanical stretch induces antioxidant responses and osteogenic differentiation in human mesenchymal stem cells through activation of the AMPK‐SIRT1 signaling pathway , 2018, Free radical biology & medicine.

[119]  Youngmee Jung,et al.  Skin Regeneration with a Scaffold of Predefined Shape and Bioactive Peptide Hydrogels. , 2018, Tissue engineering. Part A.

[120]  Van Toi Vo,et al.  Optimization and characterization of electrospun polycaprolactone coated with gelatin-silver nanoparticles for wound healing application. , 2018, Materials science & engineering. C, Materials for biological applications.

[121]  Sung Hwan Choi,et al.  Effect of wet storage on the bioactivity of ultraviolet light- and non-thermal atmospheric pressure plasma-treated titanium and zirconia implant surfaces , 2018, Clinical Oral Implants Research.

[122]  B. Yao,et al.  Beyond 2D: 3D bioprinting for skin regeneration , 2018, International wound journal.

[123]  Young-Sam Cho,et al.  Development and Evaluation of Hyaluronic Acid-Based Hybrid Bio-Ink for Tissue Regeneration , 2018, Tissue Engineering and Regenerative Medicine.

[124]  Lei Dong,et al.  Fungal Component Coating Enhances Titanium Implant‐Bone Integration , 2018, Advanced Functional Materials.

[125]  P. Supaphol,et al.  Cyclic tensile force stimulates BMP9 synthesis and in vitro mineralization by human periodontal ligament cells , 2018, Journal of cellular physiology.

[126]  Shujun Li,et al.  Bone cell responses to a low elastic modulus titanium alloy surface immobilized with the natural cross-linker genipin , 2018, Surface and Coatings Technology.

[127]  K. Mori,et al.  Application of three‐dimensional print in minor hepatectomy following liver partition between anterior and posterior sectors , 2018, ANZ journal of surgery.

[128]  Hyoun‐Ee Kim,et al.  Antibacterial and bioactive properties of stabilized silver on titanium with a nanostructured surface for dental applications , 2018, Applied Surface Science.

[129]  G. Nando,et al.  Hybrid electrospun fibers based on TPU-PDMS and spherical nanohydroxyapatite for bone tissue engineering , 2018, Materials Today Communications.

[130]  Weiming Chen,et al.  Lyophilized Scaffolds Fabricated from 3D-Printed Photocurable Natural Hydrogel for Cartilage Regeneration. , 2018, ACS applied materials & interfaces.

[131]  Heemin Kang,et al.  Remote Control of Intracellular Calcium Using Upconversion Nanotransducers Regulates Stem Cell Differentiation In Vivo , 2018, Advanced Functional Materials.

[132]  K. Park,et al.  In Situ Cross-Linkable Hydrogels as a Dynamic Matrix for Tissue Regenerative Medicine , 2018, Tissue Engineering and Regenerative Medicine.

[133]  Zhifeng Xiao,et al.  A collagen microchannel scaffold carrying paclitaxel-liposomes induces neuronal differentiation of neural stem cells through Wnt/β-catenin signaling for spinal cord injury repair. , 2018, Biomaterials.

[134]  K. Tsubota,et al.  Corneal Endothelial Regeneration Using Mesenchymal Stem Cells Derived from Human Umbilical Cord. , 2018, Stem cells and development.

[135]  Hyun Jong Lee,et al.  Bio‐Orthogonally Crosslinked, In Situ Forming Corneal Stromal Tissue Substitute , 2018, Advanced healthcare materials.

[136]  Qian Feng,et al.  Supramolecular hydrogels cross-linked by preassembled host–guest PEG cross-linkers resist excessive, ultrafast, and non-resting cyclic compression , 2018, NPG Asia Materials.

[137]  Huipin Yuan,et al.  Mussel-Inspired Tissue-Adhesive Hydrogel Based on the Polydopamine-Chondroitin Sulfate Complex for Growth-Factor-Free Cartilage Regeneration. , 2018, ACS applied materials & interfaces.

[138]  Kai Wang,et al.  Construction of a bilayered vascular graft with smooth internal surface for improved hemocompatibility and endothelial cell monolayer formation. , 2018, Biomaterials.

[139]  Changyou Gao,et al.  Mediating the invasion of smooth muscle cells into a cell-responsive hydrogel under the existence of immune cells. , 2018, Biomaterials.

[140]  Gwo‐Jaw Wang,et al.  Enhancement of chondrogenesis of adipose-derived stem cells in HA-PNIPAAm-CL hydrogel for cartilage regeneration in rabbits , 2018, Scientific Reports.

[141]  Huilin Yang,et al.  Strategies for Annulus Fibrosus Regeneration: From Biological Therapies to Tissue Engineering , 2018, Front. Bioeng. Biotechnol..

[142]  Mengyuan Xie,et al.  Cell-laden and orthogonal-multilayer tissue-engineered corneal stroma induced by a mechanical collagen microenvironment and transplantation in a rabbit model. , 2018, Acta biomaterialia.

[143]  Zhifeng Xiao,et al.  Functional Multichannel Poly(Propylene Fumarate)‐Collagen Scaffold with Collagen‐Binding Neurotrophic Factor 3 Promotes Neural Regeneration After Transected Spinal Cord Injury , 2018, Advanced healthcare materials.

[144]  Hongkai Wu,et al.  A Rapidly Self-Healing Host-Guest Supramolecular Hydrogel with High Mechanical Strength and Excellent Biocompatibility. , 2018, Angewandte Chemie.

[145]  Yang Zhang,et al.  Evaluation of an artificial vertebral body fabricated by a tantalum-coated porous titanium scaffold for lumbar vertebral defect repair in rabbits , 2018, Scientific Reports.

[146]  Xueling He,et al.  Cyclic biaxial tensile strain promotes bone marrow-derived mesenchymal stem cells to differentiate into cardiomyocyte-like cells by miRNA-27a. , 2018, The international journal of biochemistry & cell biology.

[147]  Dong-Woo Cho,et al.  3D cell printing of in vitro stabilized skin model and in vivo pre-vascularized skin patch using tissue-specific extracellular matrix bioink: A step towards advanced skin tissue engineering. , 2018, Biomaterials.

[148]  Chia-Che Ho,et al.  Mineral Trioxide Aggregate with Mussel‐inspired Surface Nanolayers for Stimulating Odontogenic Differentiation of Dental Pulp Cells , 2018, Journal of endodontics.

[149]  Zuxiang Liu,et al.  NT3-chitosan enables de novo regeneration and functional recovery in monkeys after spinal cord injury , 2018, Proceedings of the National Academy of Sciences.

[150]  Zhao Li,et al.  Tuning Alginate-Gelatin Bioink Properties by Varying Solvent and Their Impact on Stem Cell Behavior , 2018, Scientific Reports.

[151]  Jasamine Coles-Black,et al.  From ideas to long-term studies: 3D printing clinical trials review , 2018, International Journal of Computer Assisted Radiology and Surgery.

[152]  Laila Abelseth,et al.  3D Bioprinting Stem Cell Derived Tissues , 2018, Cellular and molecular bioengineering.

[153]  T. Nakagawa,et al.  A pilot study of transplantation of an autologous corneal epithelial cell sheet in a canine model of corneal injury , 2018 .

[154]  Guobin Wang,et al.  Photo-crosslinkable, injectable sericin hydrogel as 3D biomimetic extracellular matrix for minimally invasive repairing cartilage. , 2018, Biomaterials.

[155]  R. Reis,et al.  Biofunctionalized Lysophosphatidic Acid/Silk Fibroin Film for Cornea Endothelial Cell Regeneration , 2018, Nanomaterials.

[156]  I. M. Mohamed,et al.  A Multifunctional Zinc Oxide/Poly(Lactic Acid) Nanocomposite Layer Coated on Magnesium Alloys for Controlled Degradation and Antibacterial Function. , 2018, ACS biomaterials science & engineering.

[157]  C. Xiang,et al.  Transplantation of Human Menstrual Blood-Derived Mesenchymal Stem Cells Alleviates Alzheimer’s Disease-Like Pathology in APP/PS1 Transgenic Mice , 2018, Front. Mol. Neurosci..

[158]  Xin Xu,et al.  Nonviral gene editing via CRISPR/Cas9 delivery by membrane-disruptive and endosomolytic helical polypeptide , 2018, Proceedings of the National Academy of Sciences.

[159]  Kunyu Zhang,et al.  Near-infrared light-controlled regulation of intracellular calcium to modulate macrophage polarization. , 2018, Biomaterials.

[160]  Bing Chen,et al.  Controlled release of collagen-binding SDF-1α from the collagen scaffold promoted tendon regeneration in a rat Achilles tendon defect model. , 2018, Biomaterials.

[161]  S. Chun,et al.  Laminin and Platelet-Derived Growth Factor-BB Promote Neuronal Differentiation of Human Urine-Derived Stem Cells , 2018, Tissue Engineering and Regenerative Medicine.

[162]  Chunhui Yuan,et al.  Histone deacetylase inhibitor treated cell sheet from mouse tendon stem/progenitor cells promotes tendon repair. , 2018, Biomaterials.

[163]  A. Mikos,et al.  A neurotrophic peptide-functionalized self-assembling peptide nanofiber hydrogel enhances rat sciatic nerve regeneration , 2018, Nano Research.

[164]  E. Alarcon,et al.  Short peptide analogs as alternatives to collagen in pro-regenerative corneal implants , 2018, Acta biomaterialia.

[165]  E. Koonin,et al.  Anti-CRISPR proteins encoded by archaeal lytic viruses inhibit subtype I-D immunity , 2018, Nature Microbiology.

[166]  E. Ling,et al.  Peripheral Nerve‐Derived Matrix Hydrogel Promotes Remyelination and Inhibits Synapse Formation , 2018 .

[167]  Fei Gao,et al.  Direct 3D Printing of High Strength Biohybrid Gradient Hydrogel Scaffolds for Efficient Repair of Osteochondral Defect , 2018 .

[168]  H. Okano,et al.  iPSC-derived neural precursor cells: potential for cell transplantation therapy in spinal cord injury , 2018, Cellular and Molecular Life Sciences.

[169]  J. Ge,et al.  Healing score of the Xinsorb scaffold in the treatment of de novo lesions: 6-month imaging outcomes , 2018, The International Journal of Cardiovascular Imaging.

[170]  Chengtie Wu,et al.  Bioactive Scaffolds for Regeneration of Cartilage and Subchondral Bone Interface , 2018, Theranostics.

[171]  Hyun Ju Oh,et al.  Mechanically Reinforced Extracellular Matrix Scaffold for Application of Cartilage Tissue Engineering , 2018, Tissue Engineering and Regenerative Medicine.

[172]  M. Saidi,et al.  A microfabricated platform for the study of chondrogenesis under different compressive loads. , 2018, Journal of the mechanical behavior of biomedical materials.

[173]  Min-Ah Koo,et al.  Exogenous ROS-induced cell sheet transfer based on hematoporphyrin-polyketone film via a one-step process. , 2018, Biomaterials.

[174]  Yanzhong Zhang,et al.  An epigenetic bioactive composite scaffold with well-aligned nanofibers for functional tendon tissue engineering. , 2018, Acta biomaterialia.

[175]  Huatai Xu,et al.  In vivo simultaneous transcriptional activation of multiple genes in the brain using CRISPR–dCas9-activator transgenic mice , 2018, Nature Neuroscience.

[176]  Kim Vn RNA-targeting CRISPR comes of age , 2018 .

[177]  V. Kim RNA-targeting CRISPR comes of age , 2018, Nature Biotechnology.

[178]  Sung Eun Kim,et al.  Effects of Immobilizations of rhBMP-2 and/or rhPDGF-BB on Titanium Implant Surfaces on Osseointegration and Bone Regeneration , 2017 .

[179]  Naoki Kawazoe,et al.  Preparation of dexamethasone-loaded biphasic calcium phosphate nanoparticles/collagen porous composite scaffolds for bone tissue engineering. , 2017, Acta biomaterialia.

[180]  X. Xing,et al.  Antibacterial activity and osseointegration of silver-coated poly(ether ether ketone) prepared using the polydopamine-assisted deposition technique. , 2017, Journal of materials chemistry. B.

[181]  K. Park,et al.  Nitric oxide-releasing injectable hydrogels with high antibacterial activity through in situ formation of peroxynitrite. , 2017, Acta biomaterialia.

[182]  Su-Hwan Kim,et al.  Enzyme-mediated tissue adhesive hydrogels for meniscus repair. , 2017, International journal of biological macromolecules.

[183]  Chengtie Wu,et al.  Bioactive scaffolds with Li and Si ions-synergistic effects for osteochondral defects regeneration , 2017 .

[184]  B. J. Abdullah,et al.  Mesenchymal stem cell therapy for advanced liver cirrhosis: A case report , 2017, JGH open : an open access journal of gastroenterology and hepatology.

[185]  Jae Seo Lee,et al.  Preparation of mechanically enhanced hydrogel scaffolds by incorporating interfacial polymer nanorods for nerve electrode application , 2017, Fibers and Polymers.

[186]  Young-Jin Kim,et al.  Bundle Gel Fibers with a Tunable Microenvironment for in Vitro Neuron Cell Guiding. , 2017, ACS applied materials & interfaces.

[187]  Changsheng Liu,et al.  Rapid initiation of guided bone regeneration driven by spatiotemporal delivery of IL-8 and BMP-2 from hierarchical MBG-based scaffold. , 2017, Biomaterials.

[188]  Ke Yang,et al.  Ion channel functional protein kinase TRPM7 regulates Mg ions to promote the osteoinduction of human osteoblast via PI3K pathway: In vitro simulation of the bone-repairing effect of Mg-based alloy implant. , 2017, Acta biomaterialia.

[189]  S. Ullah,et al.  Incorporation of zinc oxide nanoparticles into chitosan-collagen 3D porous scaffolds: Effect on morphology, mechanical properties and cytocompatibility of 3D porous scaffolds. , 2017, International journal of biological macromolecules.

[190]  S. Kwon,et al.  Potential of autologous adipose‐derived stem cells to regenerate atrophied muscle in a rat model , 2017, Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society.

[191]  S. Matsuda,et al.  Strontium and magnesium ions released from bioactive titanium metal promote early bone bonding in a rabbit implant model. , 2017, Acta biomaterialia.

[192]  Guanglong Li,et al.  3D Printing of Lotus Root‐Like Biomimetic Materials for Cell Delivery and Tissue Regeneration , 2017, Advanced science.

[193]  Chang Sup Kim,et al.  Diatom‐Inspired Silica Nanostructure Coatings with Controllable Microroughness Using an Engineered Mussel Protein Glue to Accelerate Bone Growth on Titanium‐Based Implants , 2017, Advanced materials.

[194]  Wenjie Zhang,et al.  Magnetically Controlled Growth‐Factor‐Immobilized Multilayer Cell Sheets for Complex Tissue Regeneration , 2017, Advanced materials.

[195]  M. Prabhakaran,et al.  Evaluation of electrospun biomimetic substrate surface-decorated with nanohydroxyapatite precipitation for osteoblasts behavior. , 2017, Materials science & engineering. C, Materials for biological applications.

[196]  Yanen Wang,et al.  Effect of composition and macropore percentage on mechanical and in vitro cell proliferation and differentiation properties of 3D printed HA/β-TCP scaffolds , 2017 .

[197]  Zhihua Wang,et al.  Electrospinning of Ag Nanowires/polyvinyl alcohol hybrid nanofibers for their antibacterial properties. , 2017, Materials science & engineering. C, Materials for biological applications.

[198]  Yuanjin Zhao,et al.  Microfluidic generation of Buddha beads-like microcarriers for cell culture , 2017, Science China Materials.

[199]  N. Jeon,et al.  A Low Permeability Microfluidic Blood-Brain Barrier Platform with Direct Contact between Perfusable Vascular Network and Astrocytes , 2017, Scientific Reports.

[200]  Y. Sasaki,et al.  Wound healing effect of bioactive ion released from Mg-smectite. , 2017, Materials science & engineering. C, Materials for biological applications.

[201]  Xiaoping Zhou,et al.  Analysis of human acellular nerve allograft reconstruction of 64 injured nerves in the hand and upper extremity: a 3 year follow‐up study , 2017, Journal of tissue engineering and regenerative medicine.

[202]  J. Law,et al.  Role of plasma-derived fibrin on keratinocyte and fibroblast wound healing , 2017, Cell and Tissue Banking.

[203]  Ji Hoon Park,et al.  BMP2-modified injectable hydrogel for osteogenic differentiation of human periodontal ligament stem cells , 2017, Scientific Reports.

[204]  Fei Yang,et al.  Fabrication of multi-stimuli responsive supramolecular hydrogels based on host–guest inclusion complexation of a tadpole-shaped cyclodextrin derivative with the azobenzene dimer , 2017 .

[205]  Yumin Yang,et al.  Chitosan degradation products facilitate peripheral nerve regeneration by improving macrophage-constructed microenvironments. , 2017, Biomaterials.

[206]  Shouan Zhu,et al.  Biomimetic tendon extracellular matrix composite gradient scaffold enhances ligament-to-bone junction reconstruction. , 2017, Acta biomaterialia.

[207]  Dan Lin,et al.  RhBMP-2 loaded MBG/PEGylated poly(glycerol sebacate) composite scaffolds for rapid bone regeneration. , 2017, Journal of materials chemistry. B.

[208]  J. Ge,et al.  A head to head comparison of XINSORB bioresorbable sirolimus-eluting scaffold versus metallic sirolimus-eluting stent: 180 days follow-up in a porcine model , 2017, The International Journal of Cardiovascular Imaging.

[209]  Boguang Yang,et al.  Injectable Fullerenol/Alginate Hydrogel for Suppression of Oxidative Stress Damage in Brown Adipose-Derived Stem Cells and Cardiac Repair. , 2017, ACS nano.

[210]  P. Ma,et al.  Interwoven Aligned Conductive Nanofiber Yarn/Hydrogel Composite Scaffolds for Engineered 3D Cardiac Anisotropy. , 2017, ACS nano.

[211]  D. Cho,et al.  Direct 3D cell-printing of human skin with functional transwell system , 2017, Biofabrication.

[212]  Qingbo Xu,et al.  Effect of Resveratrol on Modulation of Endothelial Cells and Macrophages for Rapid Vascular Regeneration from Electrospun Poly(ε-caprolactone) Scaffolds. , 2017, ACS applied materials & interfaces.

[213]  Yung-Cheng Chiu,et al.  The Characteristics of Mineral Trioxide Aggregate/Polycaprolactone 3‐dimensional Scaffold with Osteogenesis Properties for Tissue Regeneration , 2017, Journal of endodontics.

[214]  Xingyu Jiang,et al.  Pharmaceutical Intermediate-Modified Gold Nanoparticles: Against Multidrug-Resistant Bacteria and Wound-Healing Application via an Electrospun Scaffold. , 2017, ACS nano.

[215]  Wei Bai,et al.  Self‐Adjusting, Polymeric Multilayered Roll that can Keep the Shapes of the Blood Vessel Scaffolds during Biodegradation , 2017, Advanced materials.

[216]  Kyung Min Park,et al.  In Situ Forming and H2O2-Releasing Hydrogels for Treatment of Drug-Resistant Bacterial Infections. , 2017, ACS applied materials & interfaces.

[217]  N. Kawazoe,et al.  Biomimetic Assembly of Vascular Endothelial Cells and Muscle Cells in Microgrooved Collagen Porous Scaffolds. , 2017, Tissue engineering. Part C, Methods.

[218]  Ming-Gene Tu,et al.  Calcium Silicate/Chitosan-Coated Electrospun Poly (Lactic Acid) Fibers for Bone Tissue Engineering , 2017, Materials.

[219]  W. Liu,et al.  Stable subcutaneous cartilage regeneration of bone marrow stromal cells directed by chondrocyte sheet. , 2017, Acta biomaterialia.

[220]  Zhongze Gu,et al.  Bioinspired Helical Microfibers from Microfluidics , 2017, Advanced materials.

[221]  Deyuan Zhang,et al.  Long-term in vivo corrosion behavior, biocompatibility and bioresorption mechanism of a bioresorbable nitrided iron scaffold. , 2017, Acta biomaterialia.

[222]  Zhi Xiong,et al.  Structural basis of CRISPR–SpyCas9 inhibition by an anti-CRISPR protein , 2017, Nature.

[223]  Wei Zhang,et al.  Fabrication and characterization of electrospun cellulose/nano-hydroxyapatite nanofibers for bone tissue engineering. , 2017, International journal of biological macromolecules.

[224]  Xiaobing Fu,et al.  China's landscape in regenerative medicine. , 2017, Biomaterials.

[225]  I. Ana,et al.  Preparation of a calcium carbonate-based bone substitute with cinnamaldehyde crosslinking agent with potential anti-inflammatory properties. , 2017, Journal of biomedical materials research. Part A.

[226]  C. Xiang,et al.  Transplantation of Menstrual Blood-Derived Mesenchymal Stem Cells Promotes the Repair of LPS-Induced Acute Lung Injury , 2017, International journal of molecular sciences.

[227]  T. Okano,et al.  Middle ear mucosal regeneration by tissue-engineered cell sheet transplantation , 2017, npj Regenerative Medicine.

[228]  Sea-Fue Wang,et al.  Evaluation of Osseointegration in Titanium and Zirconia-Based Dental Implants with Surface Modification in a Miniature Pig Model , 2017 .

[229]  Shaoyang Ma,et al.  Functional Modification of Electrospun Poly(ε-caprolactone) Vascular Grafts with the Fusion Protein VEGF-HGFI Enhanced Vascular Regeneration. , 2017, ACS applied materials & interfaces.

[230]  S. Salehi,et al.  Poly (glycerol sebacate)-poly (ε-caprolactone) blend nanofibrous scaffold as intrinsic bio- and immunocompatible system for corneal repair. , 2017, Acta biomaterialia.

[231]  Guoxing Xu,et al.  Mechanical Loading Improves Tendon-Bone Healing in a Rabbit Anterior Cruciate Ligament Reconstruction Model by Promoting Proliferation and Matrix Formation of Mesenchymal Stem Cells and Tendon Cells , 2017, Cellular Physiology and Biochemistry.

[232]  Huabing Yin,et al.  Continuous Fabrication and Assembly of Spatial Cell-Laden Fibers for a Tissue-Like Construct via a Photolithographic-Based Microfluidic Chip. , 2017, ACS applied materials & interfaces.

[233]  Changyou Gao,et al.  A bioactive hyaluronic acid–based hydrogel cross-linked by Diels–Alder reaction for promoting neurite outgrowth of PC12 cells , 2017 .

[234]  B. Tavitian,et al.  ADSC-sheet Transplantation to Prevent Stricture after Extended Esophageal Endoscopic Submucosal Dissection. , 2017, Journal of visualized experiments : JoVE.

[235]  Jianzhong Fu,et al.  3D Bioprinting of Vessel-like Structures with Multilevel Fluidic Channels. , 2017, ACS biomaterials science & engineering.

[236]  Yumin Yang,et al.  Bone marrow mesenchymal stem cell-derived acellular matrix-coated chitosan/silk scaffolds for neural tissue regeneration. , 2017, Journal of materials chemistry. B.

[237]  Chen Yang,et al.  3D-Printed Bioactive Ca3SiO5 Bone Cement Scaffolds with Nano Surface Structure for Bone Regeneration. , 2017, ACS applied materials & interfaces.

[238]  Wutian Wu,et al.  Three-dimensional aligned nanofibers-hydrogel scaffold for controlled non-viral drug/gene delivery to direct axon regeneration in spinal cord injury treatment , 2017, Scientific Reports.

[239]  C. Kong,et al.  Maturation of human embryonic stem cell-derived cardiomyocytes (hESC-CMs) in 3D collagen matrix: Effects of niche cell supplementation and mechanical stimulation. , 2017, Acta biomaterialia.

[240]  K. Park,et al.  In situ forming gelatin hydrogels by dual-enzymatic cross-linking for enhanced tissue adhesiveness. , 2017, Journal of materials chemistry. B.

[241]  Tomohiko Yamazaki,et al.  Micromorphological effect of calcium phosphate coating on compatibility of magnesium alloy with osteoblast , 2017, Science and technology of advanced materials.

[242]  C. Xiang,et al.  Exosomes derived from human menstrual blood-derived stem cells alleviate fulminant hepatic failure , 2017, Stem Cell Research & Therapy.

[243]  Zhi Zhu,et al.  Hydrogel Droplet Microfluidics for High-Throughput Single Molecule/Cell Analysis. , 2017, Accounts of chemical research.

[244]  Yilin Cao,et al.  Repair of osteochondral defects with in vitro engineered cartilage based on autologous bone marrow stromal cells in a swine model , 2017, Scientific Reports.

[245]  Julian R. Jones,et al.  Strategies to direct vascularisation using mesoporous bioactive glass-based biomaterials for bone regeneration , 2017 .

[246]  David R. Liu,et al.  CRISPR-Based Technologies for the Manipulation of Eukaryotic Genomes , 2017, Cell.

[247]  Sheng Yan,et al.  Hybrid microfluidics combined with active and passive approaches for continuous cell separation , 2017, Electrophoresis.

[248]  Fuqiang Zhang,et al.  Caspase-8 and Caspase-9 Functioned Differently at Different Stages of the Cyclic Stretch-Induced Apoptosis in Human Periodontal Ligament Cells , 2016, PloS one.

[249]  A. Boccaccini,et al.  Effects of magnesium silicate on the mechanical properties, biocompatibility, bioactivity, degradability, and osteogenesis of poly(butylene succinate)-based composite scaffolds for bone repair. , 2016, Journal of materials chemistry. B.

[250]  Peng Wan,et al.  Biodegradable Mg-Cu alloy implants with antibacterial activity for the treatment of osteomyelitis: In vitro and in vivo evaluations. , 2016, Biomaterials.

[251]  Ali Khademhosseini,et al.  Direct 3D bioprinting of perfusable vascular constructs using a blend bioink. , 2016, Biomaterials.

[252]  Xiujun Zhang,et al.  A chemical-inducible CRISPR-Cas9 system for rapid control of genome editing. , 2016, Nature chemical biology.

[253]  Zihao Wang,et al.  PEGylated poly(glycerol sebacate)-modified calcium phosphate scaffolds with desirable mechanical behavior and enhanced osteogenic capacity. , 2016, Acta biomaterialia.

[254]  F. Wang,et al.  Nano-TiO2/collagen-chitosan porous scaffold for wound repairing. , 2016, International journal of biological macromolecules.

[255]  J. Xie,et al.  Highly aligned core-shell structured nanofibers for promoting phenotypic expression of vSMCs for vascular regeneration. , 2016, Nanoscale.

[256]  Y. Yoon,et al.  Cartilage Regeneration in Osteoarthritic Patients by a Composite of Allogeneic Umbilical Cord Blood‐Derived Mesenchymal Stem Cells and Hyaluronate Hydrogel: Results from a Clinical Trial for Safety and Proof‐of‐Concept with 7 Years of Extended Follow‐Up , 2016, Stem cells translational medicine.

[257]  S. Hoerstrup,et al.  Tissue Engineering and Regenerative Medicine - New Initiatives for Individual Treatment Offers , 2016, Transfusion Medicine and Hemotherapy.

[258]  Ying Yang,et al.  A comparative study of skin cell activities in collagen and fibrin constructs. , 2016, Medical engineering & physics.

[259]  H. Okano,et al.  Robust production of human neural cells by establishing neuroepithelial-like stem cells from peripheral blood mononuclear cell-derived feeder-free iPSCs under xeno-free conditions , 2016, Neuroscience Research.

[260]  Wei Liu,et al.  Directing the Differentiation of Parthenogenetic Stem Cells into Tenocytes for Tissue‐Engineered Tendon Regeneration , 2016, Stem cells translational medicine.

[261]  D. Patel,et al.  Type V CRISPR-Cas Cpf1 endonuclease employs a unique mechanism for crRNA-mediated target DNA recognition , 2016, Cell Research.

[262]  R. Mahla Stem Cells Applications in Regenerative Medicine and Disease Therapeutics , 2016, International journal of cell biology.

[263]  R. Schäfer,et al.  Mesenchymal Stem/Stromal Cells in Regenerative Medicine: Can Preconditioning Strategies Improve Therapeutic Efficacy , 2016, Transfusion Medicine and Hemotherapy.

[264]  F. Han,et al.  Preparation of collagen/hydroxyapatite/alendronate hybrid hydrogels as potential scaffolds for bone regeneration. , 2016, Colloids and surfaces. B, Biointerfaces.

[265]  M. Jeong,et al.  Fabrication and characteristics of dual functionalized vascular stent by spatio-temporal coating. , 2016, Acta biomaterialia.

[266]  Daixu Wei,et al.  A controlled double-duration inducible gene expression system for cartilage tissue engineering , 2016, Scientific Reports.

[267]  Yujiang Fan,et al.  Effects of Composition and Mechanical Property of Injectable Collagen I/II Composite Hydrogels on Chondrocyte Behaviors. , 2016, Tissue engineering. Part A.

[268]  X. Gu,et al.  Repair of Rat Sciatic Nerve Defects by Using Allogeneic Bone Marrow Mononuclear Cells Combined with Chitosan/Silk Fibroin Scaffold , 2016, Cell transplantation.

[269]  Wei Zhang,et al.  Human Cartilage-Derived Progenitor Cells From Committed Chondrocytes for Efficient Cartilage Repair and Regeneration , 2016, Stem cells translational medicine.

[270]  A. Atala,et al.  The hematopoietic system in the context of regenerative medicine. , 2016, Methods.

[271]  W. Liu,et al.  Aligned nanofibers direct human dermal fibroblasts to tenogenic phenotype in vitro and enhance tendon regeneration in vivo. , 2016, Nanomedicine.

[272]  Yong Fan,et al.  Introducing precise genetic modifications into human 3PN embryos by CRISPR/Cas-mediated genome editing , 2016, Journal of Assisted Reproduction and Genetics.

[273]  B. Min,et al.  Repair of partial thickness cartilage defects using cartilage extracellular matrix membrane-based chondrocyte delivery system in human Ex Vivo model , 2016, Tissue Engineering and Regenerative Medicine.

[274]  E. Ling,et al.  Autocrine fibronectin from differentiating mesenchymal stem cells induces the neurite elongation in vitro and promotes nerve fiber regeneration in transected spinal cord injury , 2016, Journal of biomedical materials research. Part A.

[275]  Yongting Wang,et al.  In vivo gene therapy potentials of CRISPR-Cas9 , 2016, Gene Therapy.

[276]  Pu Chen,et al.  Towards artificial tissue models: past, present, and future of 3D bioprinting , 2016, Biofabrication.

[277]  B. Yao,et al.  3D bioprinted extracellular matrix mimics facilitate directed differentiation of epithelial progenitors for sweat gland regeneration. , 2016, Acta biomaterialia.

[278]  Shu Liu,et al.  Graft of the NT-3 persistent delivery gelatin sponge scaffold promotes axon regeneration, attenuates inflammation, and induces cell migration in rat and canine with spinal cord injury. , 2016, Biomaterials.

[279]  Dong-Woo Cho,et al.  Computer-aided multiple-head 3D printing system for printing of heterogeneous organ/tissue constructs , 2016, Scientific Reports.

[280]  Zhanchun Li,et al.  Cyclic stretch enhances apoptosis in human lumbar ligamentum flavum cells via the induction of reactive oxygen species generation , 2016, The journal of spinal cord medicine.

[281]  Y. Bando,et al.  Boron nitride nanotube-enhanced osteogenic differentiation of mesenchymal stem cells. , 2016, Journal of biomedical materials research. Part B, Applied biomaterials.

[282]  Boguang Yang,et al.  Development of Electrically Conductive Double‐Network Hydrogels via One‐Step Facile Strategy for Cardiac Tissue Engineering , 2016, Advanced healthcare materials.

[283]  Yongfeng Zhou,et al.  An Injectable Enzymatically Crosslinked Carboxymethylated Pullulan/Chondroitin Sulfate Hydrogel for Cartilage Tissue Engineering , 2016, Scientific Reports.

[284]  Sundeep Mishra,et al.  Application of 3D printing in medicine , 2016, Indian heart journal.

[285]  N. Kawazoe,et al.  Gelatin Scaffolds with Controlled Pore Structure and Mechanical Property for Cartilage Tissue Engineering. , 2016, Tissue engineering. Part C, Methods.

[286]  Zhongze Gu,et al.  Controlled Fabrication of Bioactive Microfibers for Creating Tissue Constructs Using Microfluidic Techniques. , 2016, ACS applied materials & interfaces.

[287]  Shu-Hong Yu,et al.  Chitosan microspheres with an extracellular matrix-mimicking nanofibrous structure as cell-carrier building blocks for bottom-up cartilage tissue engineering. , 2016, Nanoscale.

[288]  Bing Chen,et al.  3D bioprinting of BMSC-laden methacrylamide gelatin scaffolds with CBD-BMP2-collagen microfibers , 2015, Biofabrication.

[289]  Xiaosong Gu,et al.  Progress and perspectives of neural tissue engineering , 2015, Frontiers of Medicine.

[290]  Yan Jin,et al.  Bone marrow mesenchymal stem cell aggregate: an optimal cell therapy for full-layer cutaneous wound vascularization and regeneration , 2015, Scientific Reports.

[291]  David J. Mooney,et al.  Regenerative medicine: Current therapies and future directions , 2015, Proceedings of the National Academy of Sciences.

[292]  S. Takeda,et al.  A novel closed cell culture device for fabrication of corneal epithelial cell sheets , 2015, Journal of tissue engineering and regenerative medicine.

[293]  Hai-Chao Han,et al.  SIRT1 and FOXO Mediate Contractile Differentiation of Vascular Smooth Muscle Cells under Cyclic Stretch , 2015, Cellular Physiology and Biochemistry.

[294]  Shiyu Li,et al.  Effects of Nanoscale Spatial Arrangement of Arginine-Glycine-Aspartate Peptides on Dedifferentiation of Chondrocytes. , 2015, Nano letters.

[295]  S. Horvath,et al.  Transcriptome analyses reveal molecular mechanisms underlying functional recovery after spinal cord injury , 2015, Proceedings of the National Academy of Sciences.

[296]  K. Ye,et al.  NT3-chitosan elicits robust endogenous neurogenesis to enable functional recovery after spinal cord injury , 2015, Proceedings of the National Academy of Sciences.

[297]  I. Ana,et al.  Behavior of POP-calcium carbonate hydrogel as bone substitute with controlled release capability: a study in rat. , 2015, Journal of biomedical materials research. Part A.

[298]  N. Sugimoto,et al.  The paracrine effect of adipose-derived stem cells inhibits osteoarthritis progression , 2015, BMC Musculoskeletal Disorders.

[299]  B. Peng,et al.  Autophagy in resin monomer-initiated toxicity of dental mesenchymal cells: a novel therapeutic target of N-acetyl cysteine. , 2015, Journal of materials chemistry. B.

[300]  Yujiang Cao,et al.  A poly(lactide-co-glycolide) film loaded with abundant bone morphogenetic protein-2: A substrate-promoting osteoblast attachment, proliferation, and differentiation in bone tissue engineering. , 2015, Journal of biomedical materials research. Part A.

[301]  Qingbo Xu,et al.  Enzyme-functionalized vascular grafts catalyze in-situ release of nitric oxide from exogenous NO prodrug. , 2015, Journal of controlled release : official journal of the Controlled Release Society.

[302]  Yilin Cao,et al.  Corneal Stroma Regeneration with Acellular Corneal Stroma Sheets and Keratocytes in a Rabbit Model , 2015, PloS one.

[303]  T. Sasho,et al.  Mechanical overloading causes mitochondrial superoxide and SOD2 imbalance in chondrocytes resulting in cartilage degeneration , 2015, Scientific Reports.

[304]  Jin Han,et al.  Functionalized Collagen Scaffold Neutralizing the Myelin-Inhibitory Molecules Promoted Neurites Outgrowth in Vitro and Facilitated Spinal Cord Regeneration in Vivo. , 2015, ACS applied materials & interfaces.

[305]  B. Li,et al.  The effect of the fibre orientation of electrospun scaffolds on the matrix production of rabbit annulus fibrosus-derived stem cells , 2015, Bone Research.

[306]  X. Weng,et al.  Influence of Nano-HA Coated Bone Collagen to Acrylic (Polymethylmethacrylate) Bone Cement on Mechanical Properties and Bioactivity , 2015, PloS one.

[307]  Yong Guo,et al.  Effect of the same mechanical loading on osteogenesis and osteoclastogenesis in vitro. , 2015, Chinese journal of traumatology = Zhonghua chuang shang za zhi.

[308]  Shichang Zhao,et al.  Three-dimensional zinc incorporated borosilicate bioactive glass scaffolds for rodent critical-sized calvarial defects repair and regeneration. , 2015, Colloids and surfaces. B, Biointerfaces.

[309]  Wenhai Huang,et al.  Wound dressings composed of copper-doped borate bioactive glass microfibers stimulate angiogenesis and heal full-thickness skin defects in a rodent model. , 2015, Biomaterials.

[310]  Wei Wang,et al.  A Mechanically Strong, Highly Stable, Thermoplastic, and Self‐Healable Supramolecular Polymer Hydrogel , 2015, Advanced materials.

[311]  Xin Gao,et al.  Repair of urethral defects with polylactid acid fibrous membrane seeded with adipose-derived stem cells in a rabbit model , 2015, Connective tissue research.

[312]  Jie Du,et al.  Mechanical stretch‐induced endoplasmic reticulum stress, apoptosis and inflammation contribute to thoracic aortic aneurysm and dissection , 2015, The Journal of pathology.

[313]  Ying Sun,et al.  CRISPR/Cas9-mediated gene editing in human tripronuclear zygotes , 2015, Protein & Cell.

[314]  S. Yamanaka,et al.  Direct cardiac reprogramming: progress and challenges in basic biology and clinical applications. , 2015, Circulation research.

[315]  Bin Yu,et al.  Mechanical Strain Regulates Osteogenic and Adipogenic Differentiation of Bone Marrow Mesenchymal Stem Cells , 2015, BioMed research international.

[316]  Xiang-hang Luo,et al.  MicroRNA-188 regulates age-related switch between osteoblast and adipocyte differentiation. , 2015, The Journal of clinical investigation.

[317]  Masayuki Yamato,et al.  Cell sheet engineering and its application for periodontal regeneration , 2015, Journal of tissue engineering and regenerative medicine.

[318]  M. Prabhakaran,et al.  Protein adsorption on electrospun zinc doped hydroxyapatite containing nylon 6 membrane: kinetics and isotherm. , 2015, Journal of colloid and interface science.

[319]  G. Brüggemann,et al.  Effects of Cyclic Tensile Strain on Chondrocyte Metabolism: A Systematic Review , 2015, PloS one.

[320]  M. Guo,et al.  Non-covalent interaction cooperatively induced stretchy, tough and stimuli-responsive polyurethane-urea supramolecular (PUUS) hydrogels. , 2015, Journal of materials chemistry. B.

[321]  Qiujun Yu,et al.  Decreased osteogenesis of adult mesenchymal stem cells by reactive oxygen species under cyclic stretch: a possible mechanism of age related osteoporosis , 2015, Bone Research.

[322]  M. Kurosaka,et al.  Functional impact of integrin α5β1 on the homeostasis of intervertebral discs: a study of mechanotransduction pathways using a novel dynamic loading organ culture system. , 2015, The spine journal : official journal of the North American Spine Society.

[323]  Bo He,et al.  Safety and efficacy evaluation of a human acellular nerve graft as a digital nerve scaffold: a prospective, multicentre controlled clinical trial , 2015, Journal of tissue engineering and regenerative medicine.

[324]  C. Ai,et al.  Oxygen plasma immersion ion implantation treatment enhances the human bone marrow mesenchymal stem cells responses to titanium surface for dental implant application. , 2015, Clinical oral implants research.

[325]  Changqing Zhang,et al.  Three-dimensional printed strontium-containing mesoporous bioactive glass scaffolds for repairing rat critical-sized calvarial defects. , 2015, Acta biomaterialia.

[326]  W. Cui,et al.  Saccharides and temperature dual-responsive hydrogel layers for harvesting cell sheets. , 2015, Chemical communications.

[327]  Sei Kwang Hahn,et al.  In situ-forming injectable hydrogels for regenerative medicine , 2014 .

[328]  B. Peng,et al.  In vitro and in vivo evaluation of a nanoparticulate bioceramic paste for dental pulp repair. , 2014, Acta biomaterialia.

[329]  Yong He,et al.  Fabrication of low cost soft tissue prostheses with the desktop 3D printer , 2014, Scientific Reports.

[330]  Y. Liu,et al.  Reconstruction of Highly Proliferative Auto-Tissue-Engineered Lamellar Cornea Enhanced by Embryonic Stem Cell. , 2014, Tissue engineering. Part C, Methods.

[331]  Chengtie Wu,et al.  Advances in synthesis of calcium phosphate crystals with controlled size and shape. , 2014, Acta biomaterialia.

[332]  W. Liu,et al.  Repair of Achilles tendon defect with autologous ASCs engineered tendon in a rabbit model. , 2014, Biomaterials.

[333]  Yan Jin,et al.  Mesenchymal stem cells prevent hypertrophic scar formation via inflammatory regulation when undergoing apoptosis. , 2014, The Journal of investigative dermatology.

[334]  Daping Quan,et al.  Improved peripheral nerve regeneration using acellular nerve allografts loaded with platelet-rich plasma. , 2014, Tissue engineering. Part A.

[335]  F. Guillemot,et al.  Controlling laser-induced jet formation for bioprinting mesenchymal stem cells with high viability and high resolution , 2014, Biofabrication.

[336]  S. Yoo,et al.  Creating perfused functional vascular channels using 3D bio-printing technology. , 2014, Biomaterials.

[337]  N. Khandelwal,et al.  Efficacy and Safety of Autologous Bone Marrow-Derived Stem Cell Transplantation in Patients with Type 2 Diabetes Mellitus: A Randomized Placebo-Controlled Study , 2014, Cell transplantation.

[338]  Kensaku Mori,et al.  Application of a Three-dimensional Print of a Liver in Hepatectomy for Small Tumors Invisible by Intraoperative Ultrasonography: Preliminary Experience , 2014, World Journal of Surgery.

[339]  Sang-Mo Kwon,et al.  Injectable multifunctional microgel encapsulating outgrowth endothelial cells and growth factors for enhanced neovascularization. , 2014, Journal of controlled release : official journal of the Controlled Release Society.

[340]  N. Kawazoe,et al.  Highly active porous scaffolds of collagen and hyaluronic acid prepared by suppression of polyion complex formation. , 2014, Journal of materials chemistry. B.

[341]  Jian Xu,et al.  Etifoxine provides benefits in nerve repair with acellular nerve grafts , 2014, Muscle & nerve.

[342]  David F Williams,et al.  Neural tissue engineering options for peripheral nerve regeneration. , 2014, Biomaterials.

[343]  T. Notomi,et al.  Insulinogenic sucrose+amino acid mixture ingestion immediately after resistance exercise has an anabolic effect on bone compared with non-insulinogenic fructose+amino acid mixture in growing rats. , 2014, Bone.

[344]  M. Guo,et al.  Reactive macromolecular micelle crosslinked highly elastic hydrogel with water-triggered shape-memory behaviour , 2014 .

[345]  P. Li,et al.  Urine-derived stem cells: A novel and versatile progenitor source for cell-based therapy and regenerative medicine , 2014, Genes & diseases.

[346]  Bin Liu,et al.  Preparation of Three-Dimensional Vascularized MSC Cell Sheet Constructs for Tissue Regeneration , 2014, BioMed research international.

[347]  Jia Luo,et al.  Genome-wide identification of CRISPR/Cas9 off-targets in human genome , 2014, Cell Research.

[348]  Guifang Gao,et al.  Human cartilage tissue fabrication using three-dimensional inkjet printing technology. , 2014, Journal of visualized experiments : JoVE.

[349]  Deok‐Ho Kim,et al.  Printing three-dimensional tissue analogues with decellularized extracellular matrix bioink , 2014, Nature Communications.

[350]  Jianwu Dai,et al.  Transplantation of bone marrow mesenchymal stem cells on collagen scaffolds for the functional regeneration of injured rat uterus. , 2014, Biomaterials.

[351]  Arun R. Shrivats,et al.  Bone tissue engineering: state of the union. , 2014, Drug discovery today.

[352]  W. Liu,et al.  Regeneration of human-ear-shaped cartilage by co-culturing human microtia chondrocytes with BMSCs. , 2014, Biomaterials.

[353]  F. Figueroa,et al.  The Promising Potential of Menstrual Stem Cells for Antenatal Diagnosis and Cell Therapy , 2014, Front. Immunol..

[354]  E. W. Meijer,et al.  Tough stimuli-responsive supramolecular hydrogels with hydrogen-bonding network junctions. , 2014, Journal of the American Chemical Society.

[355]  N. Kawazoe,et al.  Pore size effect of collagen scaffolds on cartilage regeneration. , 2014, Acta biomaterialia.

[356]  Xiaosong Gu,et al.  Neurotrophic and neuroprotective actions of Achyranthes bidentata polypeptides on cultured dorsal root ganglia of rats and on crushed common peroneal nerve of rabbits , 2014, Neuroscience Letters.

[357]  Xiumei Mo,et al.  The effect of mechanical stimulation on the maturation of TDSCs-poly(L-lactide-co-e-caprolactone)/collagen scaffold constructs for tendon tissue engineering. , 2014, Biomaterials.

[358]  Seon Yeong Jeong,et al.  Auricular Reconstruction Using Tissue-Engineered Alloplastic Implants for Improved Clinical Outcomes , 2014, Plastic and reconstructive surgery.

[359]  Jui-Sheng Sun,et al.  Mechanical stress-induced apoptosis of nucleus pulposus cells: an in vitro and in vivo rat model , 2014, Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association.

[360]  Yumin Yang,et al.  Chitosan/silk fibroin-based, Schwann cell-derived extracellular matrix-modified scaffolds for bridging rat sciatic nerve gaps. , 2014, Biomaterials.

[361]  Q. Guo,et al.  Improvement in Nerve Regeneration through a Decellularized Nerve Graft by Supplementation with Bone Marrow Stromal Cells in Fibrin , 2014, Cell transplantation.

[362]  D. Cho,et al.  3D printing of composite tissue with complex shape applied to ear regeneration , 2014, Biofabrication.

[363]  V. Tabar,et al.  Pluripotent stem cells in regenerative medicine: challenges and recent progress , 2014, Nature Reviews Genetics.

[364]  D. Baker,et al.  Forced Protein Unfolding Leads to Highly Elastic and Tough Protein Hydrogels , 2013, Nature Communications.

[365]  Yanjie Bai,et al.  A scalable synthesis of non-agglomerated and low-aspect ratio hydroxyapatite nanocrystals using gelatinized starch matrix , 2013 .

[366]  Masayuki Yamato,et al.  Corneal regeneration by transplantation of corneal epithelial cell sheets fabricated with automated cell culture system in rabbit model. , 2013, Biomaterials.

[367]  Yubo Fan,et al.  Performance of a multilayered small-diameter vascular scaffold dual-loaded with VEGF and PDGF. , 2013, Biomaterials.

[368]  Taira Kobayashi,et al.  Current status of zirconia restoration. , 2013, Journal of prosthodontic research.

[369]  A. Atala,et al.  Multipotential differentiation of human urine‐derived stem cells: Potential for therapeutic applications in urology , 2013, Stem cells.

[370]  Yan Jin,et al.  Construction of tissue-engineered cornea composed of amniotic epithelial cells and acellular porcine cornea for treating corneal alkali burn. , 2013, Biomaterials.

[371]  Li Qian,et al.  Direct Reprogramming of Human Fibroblasts toward a Cardiomyocyte-like State , 2013, Stem cell reports.

[372]  S. Toh,et al.  Variation of the effect of calcium phosphate enhancement of implanted silk fibroin ligament bone integration. , 2013, Biomaterials.

[373]  Shinsuke Yuasa,et al.  Induction of human cardiomyocyte-like cells from fibroblasts by defined factors , 2013, Proceedings of the National Academy of Sciences.

[374]  G. Pan,et al.  Thermo-responsive hydrogel layers imprinted with RGDS peptide: a system for harvesting cell sheets. , 2013, Angewandte Chemie.

[375]  Richard T. Lee,et al.  Cardiac stem cell therapy and the promise of heart regeneration. , 2013, Cell stem cell.

[376]  Shoji Takeuchi,et al.  Metre-long cell-laden microfibres exhibit tissue morphologies and functions. , 2013, Nature materials.

[377]  A. Mikos,et al.  Repair of osteochondral defects with rehydrated freeze-dried oligo[poly(ethylene glycol) fumarate] hydrogels seeded with bone marrow mesenchymal stem cells in a porcine model. , 2013, Tissue engineering. Part A.

[378]  H. Kuo,et al.  Shear stress modulates macrophage-induced urokinase plasminogen activator expression in human chondrocytes , 2013, Arthritis Research & Therapy.

[379]  J. Goh,et al.  Aligned fibrous scaffolds for enhanced mechanoresponse and tenogenesis of mesenchymal stem cells. , 2013, Tissue engineering. Part A.

[380]  Hyunjae Lee,et al.  Engineering of functional, perfusable 3D microvascular networks on a chip. , 2013, Lab on a chip.

[381]  Yubo Fan,et al.  Dual-delivery of VEGF and PDGF by double-layered electrospun membranes for blood vessel regeneration. , 2013, Biomaterials.

[382]  Mitsuo Umezu,et al.  In vitro fabrication of functional three-dimensional tissues with perfusable blood vessels , 2013, Nature Communications.

[383]  Robert L Mauck,et al.  Tissue engineering and regenerative medicine: recent innovations and the transition to translation. , 2013, Tissue engineering. Part B, Reviews.

[384]  Zhengguo Wang,et al.  Allogeneic Adipose-Derived Stem Cells with Low Immunogenicity Constructing Tissue-Engineered Bone for Repairing Bone Defects in Pigs , 2012, Cell transplantation.

[385]  Mara Hvistendahl,et al.  China's push in tissue engineering. , 2012, Science.

[386]  A. Jackson,et al.  Cell viability in intervertebral disc under various nutritional and dynamic loading conditions: 3d finite element analysis. , 2012, Journal of biomechanics.

[387]  D. Long,et al.  The influence of delayed compressive stress on TGF-β1-induced chondrogenic differentiation of rat BMSCs through Smad-dependent and Smad-independent pathways. , 2012, Biomaterials.

[388]  Richard T. Lee,et al.  Mammalian Heart Renewal by Preexisting Cardiomyocytes , 2012, Nature.

[389]  Yan Jin,et al.  Construction of bilayered tissue-engineered skin with human amniotic mesenchymal cells and human amniotic epithelial cells. , 2012, Artificial organs.

[390]  M. Hertz The Registry of the International Society for Heart and Lung Transplantation--Introduction to the 2012 annual reports: new leadership, same vision. , 2012, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

[391]  B. Zhang,et al.  Adipose-derived stem cells induced dendritic cells undergo tolerance and inhibit Th1 polarization. , 2012, Cellular immunology.

[392]  Atsushi Izawa,et al.  hESC-Derived Cardiomyocytes Electrically Couple and Suppress Arrhythmias in Injured Hearts , 2012, Nature.

[393]  C. Robles-Medranda,et al.  Endoscopic submucosal dissection , 2012 .

[394]  A. Mikos,et al.  Injectable biodegradable hydrogels for embryonic stem cell transplantation: improved cardiac remodelling and function of myocardial infarction , 2012, Journal of cellular and molecular medicine.

[395]  Shantikumar V. Nair,et al.  Flexible and microporous chitosan hydrogel/nano ZnO composite bandages for wound dressing: in vitro and in vivo evaluation. , 2012, ACS applied materials & interfaces.

[396]  Jiang Peng,et al.  Recellularized nerve allografts with differentiated mesenchymal stem cells promote peripheral nerve regeneration , 2012, Neuroscience Letters.

[397]  Mitsuo Umezu,et al.  Fabrication of functional three-dimensional tissues by stacking cell sheets in vitro , 2012, Nature Protocols.

[398]  S. Niinimäki The relationship between musculoskeletal stress markers and biomechanical properties of the humeral diaphysis. , 2012, American journal of physical anthropology.

[399]  Shibi Lu,et al.  Surgical repair of a 30 mm long human median nerve defect in the distal forearm by implantation of a chitosan–PGA nerve guidance conduit , 2012, Journal of tissue engineering and regenerative medicine.

[400]  Tai-Horng Young,et al.  Control of cell attachment on pH-responsive chitosan surface by precise adjustment of medium pH. , 2012, Biomaterials.

[401]  A. Khademhosseini,et al.  Carbon nanotube reinforced hybrid microgels as scaffold materials for cell encapsulation. , 2012, ACS nano.

[402]  Shouhui Wang,et al.  Treadmill training regulates β-catenin signaling through phosphorylation of GSK-3β in lumbar vertebrae of ovariectomized rats , 2012, European Journal of Applied Physiology.

[403]  Yan Liu,et al.  Joint Use of a Chitosan/PLGA Scaffold and MSCs to Bridge an Extra Large Gap in Dog Sciatic Nerve , 2012, Neurorehabilitation and neural repair.

[404]  W. Chan,et al.  Bone Marrow Mesenchymal Stem Cells in a Three-Dimensional Gelatin Sponge Scaffold Attenuate Inflammation, Promote Angiogenesis, and Reduce Cavity Formation in Experimental Spinal Cord Injury , 2011, Cell transplantation.

[405]  Li Wang,et al.  Autologous bone marrow stem cell transplantation for the treatment of type 2 diabetes mellitus. , 2011, Chinese medical journal.

[406]  Akira Harada,et al.  Redox-responsive self-healing materials formed from host–guest polymers , 2011, Nature communications.

[407]  Josef Stehlik,et al.  The Registry of the International Society for Heart and Lung Transplantation: Twenty-eighth Adult Heart Transplant Report--2011. , 2011, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

[408]  Y. Huang,et al.  Continuous cyclic mechanical tension inhibited Runx2 expression in mesenchymal stem cells through RhoA‐ERK1/2 pathway , 2011, Journal of cellular physiology.

[409]  H. Nakauchi,et al.  Generation of Germline-Competent Rat Induced Pluripotent Stem Cells , 2011, PloS one.

[410]  Xiaosong Gu,et al.  Repair of rat sciatic nerve gap by a silk fibroin-based scaffold added with bone marrow mesenchymal stem cells. , 2011, Tissue engineering. Part A.

[411]  R. Suuronen,et al.  The Potential of Adipose Stem Cells in Regenerative Medicine , 2011, Stem Cell Reviews and Reports.

[412]  Hsueh-Chuan Hsu,et al.  Preparation and characterization of four different compositions of calcium phosphate scaffolds for bone tissue engineering , 2011 .

[413]  Yan Liu,et al.  Repair of nerve defect with acellular nerve graft supplemented by bone marrow stromal cells in mice , 2011, Microsurgery.

[414]  W. Lu,et al.  Mixture of Fibroblasts and Adipose Tissue-Derived Stem Cells Can Improve Epidermal Morphogenesis of Tissue-Engineered Skin , 2011, Cells Tissues Organs.

[415]  O. Yamamoto,et al.  Significant effect of a carbon layer coating on interfacial bond strength between bone and Ti implant , 2011 .

[416]  O. Yamamoto,et al.  Surface characterization and biological response of carbon-coated oxygen-diffused titanium having different topographical surfaces , 2011, Journal of materials science. Materials in medicine.

[417]  Xiaosong Gu,et al.  Construction of tissue engineered nerve grafts and their application in peripheral nerve regeneration , 2011, Progress in Neurobiology.

[418]  Boon Chin Heng,et al.  Efficacy of hESC-MSCs in knitted silk-collagen scaffold for tendon tissue engineering and their roles. , 2010, Biomaterials.

[419]  Wei Sun,et al.  Biofabrication of a three-dimensional liver micro-organ as an in vitro drug metabolism model , 2010, Biofabrication.

[420]  Chang-Soo Lee,et al.  Synthesis and utilization of E. coli-encapsulated PEG-based microdroplet using a microfluidic chip for biological application. , 2010, Biotechnology and bioengineering.

[421]  Yan Huang,et al.  Effect of fluid shear stress on cardiomyogenic differentiation of rat bone marrow mesenchymal stem cells. , 2010, Archives of medical research.

[422]  F. Cui,et al.  Hyaluronic acid hydrogel modified with nogo-66 receptor antibody and poly-L-lysine to promote axon regrowth after spinal cord injury. , 2010, Journal of biomedical materials research. Part B, Applied biomaterials.

[423]  Hong Huang,et al.  Adipose-derived stem cells modified genetically in vivo promote reconstruction of bone defects. , 2010, Cytotherapy.

[424]  L. C. Li,et al.  Strontium borate glass: potential biomaterial for bone regeneration , 2010, Journal of The Royal Society Interface.

[425]  Xiaobing Fu,et al.  In vitro constitution and in vivo implantation of engineered skin constructs with sweat glands. , 2010, Biomaterials.

[426]  K. Oh,et al.  Secondary revisions due to unfavourable results after microtia reconstruction. , 2010, Journal of plastic, reconstructive & aesthetic surgery : JPRAS.

[427]  Chee Kai Chua,et al.  Porous polycaprolactone scaffold for cardiac tissue engineering fabricated by selective laser sintering. , 2010, Acta biomaterialia.

[428]  Wei Lu,et al.  Cross-linked collagen-chondroitin sulfate-hyaluronic acid imitating extracellular matrix as scaffold for dermal tissue engineering. , 2010, Tissue engineering. Part C, Methods.

[429]  K. Morishima,et al.  Bio rapid prototyping by extruding/aspirating/refilling thermoreversible hydrogel , 2010, Biofabrication.

[430]  Zhaoyang Yang,et al.  The repair of the injured adult rat hippocampus with NT-3-chitosan carriers. , 2010, Biomaterials.

[431]  Jackie Y Ying,et al.  Hydrodynamic spinning of hydrogel fibers. , 2010, Biomaterials.

[432]  Hai-bin Wang,et al.  Both the transplantation of somatic cell nuclear transfer- and fertilization-derived mouse embryonic stem cells with temperature-responsive chitosan hydrogel improve myocardial performance in infarcted rat hearts. , 2010, Tissue engineering. Part A.

[433]  Xiaoling Zhang,et al.  In vitro and in vivo evaluation of akermanite bioceramics for bone regeneration. , 2009, Biomaterials.

[434]  Ke Yang,et al.  In vivo evaluation of biodegradable magnesium alloy bone implant in the first 6 months implantation. , 2009, Journal of biomedical materials research. Part A.

[435]  Takashi Nakamura,et al.  Fully functional bioengineered tooth replacement as an organ replacement therapy , 2009, Proceedings of the National Academy of Sciences.

[436]  Shaorong Gao,et al.  Cell Stem Cell Brief Report Ips Cells Can Support Full-term Development of Tetraploid Blastocyst-complemented Embryos Cell Stem Cell Brief Report , 2022 .

[437]  Qi Zhou,et al.  iPS cells produce viable mice through tetraploid complementation , 2009, Nature.

[438]  Hideo Nakajima,et al.  Metallic Scaffolds for Bone Regeneration , 2009, Materials.

[439]  A. Khademhosseini,et al.  Electrochemical desorption of self-assembled monolayers for engineering cellular tissues. , 2009, Biomaterials.

[440]  B. Bauer Reconstruction of Microtia , 2009, Plastic and reconstructive surgery.

[441]  M. Hsu,et al.  Nano/submicron-scale TiO2 network on titanium surface for dental implant application , 2009 .

[442]  Masayuki Yamato,et al.  Cell sheet technology and cell patterning for biofabrication , 2009, Biofabrication.

[443]  Zi Yin,et al.  Stepwise Differentiation of Human Embryonic Stem Cells Promotes Tendon Regeneration by Secreting Fetal Tendon Matrix and Differentiation Factors , 2009, Stem cells.

[444]  Yuncang Li,et al.  Ti6Ta4Sn alloy and subsequent scaffolding for bone tissue engineering. , 2009, Tissue engineering. Part A.

[445]  L. Tang,et al.  Functional bilayered skin substitute constructed by tissue-engineered extracellular matrix and microsphere-incorporated gelatin hydrogel for wound repair. , 2009, Tissue engineering. Part A.

[446]  Gang Zhou,et al.  Antigen expression of human eccrine sweat glands , 2009, Journal of cutaneous pathology.

[447]  D. Watson Tissue engineering for rhinoplasty. , 2009, Facial plastic surgery clinics of North America.

[448]  Zhaoyang Yang,et al.  Repair of thoracic spinal cord injury by chitosan tube implantation in adult rats. , 2009, Biomaterials.

[449]  Sheng Ding,et al.  Generation of rat and human induced pluripotent stem cells by combining genetic reprogramming and chemical inhibitors. , 2009, Cell stem cell.

[450]  Meng Liu,et al.  Generation of induced pluripotent stem cells from adult rhesus monkey fibroblasts. , 2008, Cell stem cell.

[451]  Q. Guo,et al.  Effects of local release of hepatocyte growth factor on peripheral nerve regeneration in acellular nerve grafts , 2008, Experimental Neurology.

[452]  Zi Yin,et al.  Ligament regeneration using a knitted silk scaffold combined with collagen matrix. , 2008, Biomaterials.

[453]  Xiaohong Li,et al.  Electrospun fibrous mats with high porosity as potential scaffolds for skin tissue engineering. , 2008, Biomacromolecules.

[454]  Gang Zhou,et al.  Comparison of proliferating cells between human adult and fetal eccrine sweat glands , 2008, Archives of Dermatological Research.

[455]  Wei Liu,et al.  Development and evaluation of silk fibroin-based nerve grafts used for peripheral nerve regeneration. , 2007, Biomaterials.

[456]  Joseph P Vacanti,et al.  Tissue engineering and regenerative medicine. , 2007, Proceedings of the American Philosophical Society.

[457]  Masayuki Yamato,et al.  Reconstruction of functional tissues with cell sheet engineering. , 2007, Biomaterials.

[458]  Hao Wang,et al.  Endometrial regenerative cells: A novel stem cell population , 2007, Journal of Translational Medicine.

[459]  R. Tang,et al.  Role of hydroxyapatite nanoparticle size in bone cell proliferation , 2007 .

[460]  Yan Jin,et al.  Reconstruction of a tissue‐engineered skin containing melanocytes , 2007, Cell biology international.

[461]  X. Yu,et al.  Hyaluronic acid hydrogels with IKVAV peptides for tissue repair and axonal regeneration in an injured rat brain , 2007, Biomedical materials.

[462]  T. Ichisaka,et al.  Generation of germline-competent induced pluripotent stem cells , 2007, Nature.

[463]  R. Yang,et al.  Ductile titanium alloy with low Poisson's ratio. , 2007, Physical review letters.

[464]  S. Kyo,et al.  Menstrual blood-derived cells confer human dystrophin expression in the murine model of Duchenne muscular dystrophy via cell fusion and myogenic transdifferentiation. , 2007, Molecular biology of the cell.

[465]  Yan Jin,et al.  Survival and integration of tissue-engineered corneal stroma in a model of corneal ulcer , 2007, Cell and Tissue Research.

[466]  R. Yang,et al.  Elastic deformation behaviour of Ti-24Nb-4Zr-7.9Sn for biomedical applications. , 2007, Acta biomaterialia.

[467]  Larry L. Hench,et al.  The story of Bioglass® , 2006, Journal of materials science. Materials in medicine.

[468]  S. Yamanaka,et al.  Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors , 2006, Cell.

[469]  Hong Jiang,et al.  Creation of Engineered Cardiac Tissue In Vitro From Mouse Embryonic Stem Cells , 2006, Circulation.

[470]  K. Yanaga,et al.  Clinical Application of Cultured Autologous Human Auricular Chondrocytes with Autologous Serum for Craniofacial or Nasal Augmentation and Repair , 2006, Plastic and reconstructive surgery.

[471]  Wei Dong,et al.  Collagen-based implants reinforced by chitin fibres in a goat shank bone defect model. , 2006, Biomaterials.

[472]  Wei Lui,et al.  Tissue engineering of nearly transparent corneal stroma. , 2005, Tissue engineering.

[473]  Jian Qin,et al.  Adhesion strength of human tenocytes to extracellular matrix component-modified poly(DL-lactide-co-glycolide) substrates. , 2005, Biomaterials.

[474]  Jiang Chang,et al.  The self-setting properties and in vitro bioactivity of tricalcium silicate. , 2005, Biomaterials.

[475]  Siew Lok Toh,et al.  Assembly of bone marrow stromal cell sheets with knitted poly (L-lactide) scaffold for engineering ligament analogs. , 2005, Journal of biomedical materials research. Part B, Applied biomaterials.

[476]  F. Cui,et al.  The repair of brain lesion by implantation of hyaluronic acid hydrogels modified with laminin , 2005, Journal of Neuroscience Methods.

[477]  Junzo Tanaka,et al.  The effect of calcium ion concentration on osteoblast viability, proliferation and differentiation in monolayer and 3D culture. , 2005, Biomaterials.

[478]  Xiaosong Gu,et al.  Dog sciatic nerve regeneration across a 30-mm defect bridged by a chitosan/PGA artificial nerve graft. , 2005, Brain : a journal of neurology.

[479]  C K Chua,et al.  Development of tissue scaffolds using selective laser sintering of polyvinyl alcohol/hydroxyapatite biocomposite for craniofacial and joint defects , 2004, Journal of materials science. Materials in medicine.

[480]  F. Cui,et al.  Hierarchically biomimetic bone scaffold materials: nano-HA/collagen/PLA composite. , 2004, Journal of biomedical materials research. Part B, Applied biomaterials.

[481]  Masayuki Yamato,et al.  Functional bioengineered corneal epithelial sheet grafts from corneal stem cells expanded ex vivo on a temperature-responsive cell culture surface , 2004, Transplantation.

[482]  S. Teoh,et al.  Knitted poly-lactide-co-glycolide scaffold loaded with bone marrow stromal cells in repair and regeneration of rabbit Achilles tendon. , 2003, Tissue engineering.

[483]  Frederick J Schoen,et al.  Cardiovascular tissue engineering. , 2002, Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology.

[484]  Z Yang,et al.  Tissue engineering of the musculo-skeletal system--basic research and clinical applications. , 2000, Hand surgery : an international journal devoted to hand and upper limb surgery and related research : journal of the Asia-Pacific Federation of Societies for Surgery of the Hand.

[485]  Salim Yusuf,et al.  Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure. , 1991, The New England journal of medicine.

[486]  Yuichi Mori,et al.  Cell Culture on a Thermo-Responsive Polymer Surface , 1990, Bio/Technology.

[487]  L A PEER,et al.  EXTENDED USE OF DICED CARTILAGE GRAFTS , 1954, Plastic and reconstructive surgery.

[488]  Lei Yang,et al.  Cell sheet technology: a promising strategy in regenerative medicine. , 2019, Cytotherapy.

[489]  R. Shanti,et al.  Gingiva-Derived Mesenchymal Stem Cell-Extracellular Vesicles Activate Schwann Cell Repair Phenotype and Promote Nerve Regeneration. , 2019, Tissue engineering. Part A.

[490]  T. Okano,et al.  Thermally‐triggered fabrication of cell sheets for tissue engineering and regenerative medicine , 2019, Advanced drug delivery reviews.

[491]  Ali Khademhosseini,et al.  Organ-on-a-Chip for Cancer and Immune Organs Modeling. , 2019, Advanced healthcare materials.

[492]  Han-Sung Jung,et al.  Craniofacial Bone Regeneration using iPS Cell-Derived Neural Crest Like Cells , 2018 .

[493]  L. Ren,et al.  Collagen-based materials combined with microRNA for repairing cornea wounds and inhibiting scar formation. , 2018, Biomaterials science.

[494]  Xueqin Zhang,et al.  Preparation of polymer/calcium phosphate porous composite as bone tissue scaffolds. , 2017, Materials science & engineering. C, Materials for biological applications.

[495]  C. Kao,et al.  Mesoporous Calcium Silicate Nanoparticles with Drug Delivery and Odontogenesis Properties , 2017, Journal of endodontics.

[496]  Fuqiang Zhang,et al.  Cyclic-stretch induces apoptosis in human periodontal ligament cells by activation of caspase-5. , 2017, Archives of oral biology.

[497]  Xiaofeng Cui,et al.  Bioprinting Cartilage Tissue from Mesenchymal Stem Cells and PEG Hydrogel. , 2017, Methods in molecular biology.

[498]  H. Santos,et al.  Electrospun Photocrosslinkable Hydrogel Fibrous Scaffolds for Rapid In Vivo Vascularized Skin Flap Regeneration , 2017 .

[499]  Dong-Woo Cho,et al.  3D printed complex tissue construct using stem cell-laden decellularized extracellular matrix bioinks for cardiac repair. , 2017, Biomaterials.

[500]  Fei Gao,et al.  A Mineralized High Strength and Tough Hydrogel for Skull Bone Regeneration , 2017 .

[501]  J. Weng,et al.  Hybrid use of combined and sequential delivery of growth factors and ultrasound stimulation in porous multilayer composite scaffolds to promote both vascularization and bone formation in bone tissue engineering. , 2016, Journal of biomedical materials research. Part A.

[502]  Huilin Yang,et al.  Modulation of the gene expression of annulus fibrosus-derived stem cells using poly(ether carbonate urethane)urea scaffolds of tunable elasticity. , 2016, Acta biomaterialia.

[503]  Huifang Zhou,et al.  The role of miR-135-modified adipose-derived mesenchymal stem cells in bone regeneration. , 2016, Biomaterials.

[504]  M. Pittenger,et al.  Unraveling the Mesenchymal Stromal Cells' Paracrine Immunomodulatory Effects. , 2016, Transfusion medicine reviews.

[505]  Zhengwei You,et al.  Hybrid small-diameter vascular grafts: Anti-expansion effect of electrospun poly ε-caprolactone on heparin-coated decellularized matrices. , 2016, Biomaterials.

[506]  Feng-Huei Lin,et al.  Hydroxyapatite-calcium sulfate-hyaluronic acid composite encapsulated with collagenase as bone substitute for alveolar bone regeneration. , 2016, Biomaterials.

[507]  P. Chu,et al.  Controlled chondrogenesis from adipose-derived stem cells by recombinant transforming growth factor-β3 fusion protein in peptide scaffolds. , 2015, Acta biomaterialia.

[508]  Yujiang Fan,et al.  Enhanced effect of β-tricalcium phosphate phase on neovascularization of porous calcium phosphate ceramics: in vitro and in vivo evidence. , 2015, Acta biomaterialia.

[509]  Chunhua Lu,et al.  In vivo investigation of biological responses to tricalcium silicate pastes in muscle tissue , 2014 .

[510]  Yilin Cao,et al.  The influence of Gelatin/PCL ratio and 3-D construct shape of electrospun membranes on cartilage regeneration. , 2014, Biomaterials.

[511]  E. Tanaka,et al.  Fabrications of zinc-releasing biocement combining zinc calcium phosphate to calcium phosphate cement. , 2014, Journal of the mechanical behavior of biomedical materials.

[512]  Masayuki Yamato,et al.  Latest status of the clinical and industrial applications of cell sheet engineering and regenerative medicine , 2013, Archives of pharmacal research.

[513]  Hong Wu,et al.  Long-term outcome of the repair of 50 mm long median nerve defects in rhesus monkeys with marrow mesenchymal stem cells-containing, chitosan-based tissue engineered nerve grafts. , 2013, Biomaterials.

[514]  P. Esteso Direct cardiac reprogramming , 2013 .

[515]  Wenjian Weng,et al.  Light-induced cell detachment for cell sheet technology. , 2013, Biomaterials.

[516]  Nuno Sousa,et al.  Tissue engineering and regenerative medicine: past, present, and future. , 2013, International review of neurobiology.

[517]  Guoping Chen,et al.  Silicate bioceramics induce angiogenesis during bone regeneration. , 2012, Acta biomaterialia.

[518]  S. Eustace,et al.  Bone Marrow , 2009 .

[519]  Masaki Ieda,et al.  Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors. , 2010, Cell.

[520]  Takashi Aoi,et al.  Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts , 2008, Nature Biotechnology.

[521]  Xiaosong Gu,et al.  Repairing a 35‐mm‐long median nerve defect with a chitosan/PGA artificial nerve graft in the human: A case study , 2008, Microsurgery.

[522]  T. Ichisaka,et al.  GENERATION OF GERMLINECOMPETENT INDUCED PLURIPOTENT STEM CELLS , 2007 .

[523]  N. Henderson OF BONE. , 2005 .

[524]  G. Flageul,et al.  [Injectable collagen]. , 2004, Annales de chirurgie plastique et esthetique.

[525]  P. Franzone,et al.  An in vivo evaluation , 1989 .