Genetic, DNA methylation, and immune profile discrepancies between early-stage single primary lung cancer and synchronous multiple primary lung cancer

[1]  A. Moore,et al.  DNA methylation signatures reveal that distinct combinations of transcription factors specify human immune cell epigenetic identity. , 2021, Immunity.

[2]  Jie He,et al.  Presentation of EGFR mutations in 162 family probands with multiple primary lung cancer , 2021, Translational lung cancer research.

[3]  W. Liang,et al.  The impact of postoperative EGFR-TKIs treatment on residual GGO lesions after resection for lung cancer , 2021, Signal Transduction and Targeted Therapy.

[4]  W. Liang,et al.  Management for Residual Ground-Glass Opacity Lesions After Resection of Main Tumor in Multifocal Lung Cancer: A Case Report and Literature Review , 2021, Cancer management and research.

[5]  F. Bai,et al.  Decoding the multicellular ecosystem of lung adenocarcinoma manifested as pulmonary subsolid nodules by single-cell RNA sequencing , 2021, Science Advances.

[6]  É. Vivier,et al.  Tumor-Infiltrating Natural Killer Cells. , 2020, Cancer discovery.

[7]  Hongbing Shen,et al.  Tumor evolutionary trajectories during the acquisition of invasiveness in early stage lung adenocarcinoma , 2020, Nature Communications.

[8]  M. Tsuboi,et al.  Osimertinib in Resected EGFR-Mutated Non-Small-Cell Lung Cancer. , 2020, The New England journal of medicine.

[9]  Xiaoyuan Chen,et al.  Engineering Macrophages for Cancer Immunotherapy and Drug Delivery , 2020, Advanced materials.

[10]  X. Yi,et al.  CCND1 Amplification Contributes to Immunosuppression and Is Associated With a Poor Prognosis to Immune Checkpoint Inhibitors in Solid Tumors , 2020, Frontiers in Immunology.

[11]  C. Zahnow,et al.  Epigenetic therapy inhibits metastases by disrupting premetastatic niches , 2020, Nature.

[12]  T. Ohira,et al.  Profiles of lung adenocarcinoma with multiple ground glass opacities and the fate of residual lesion. , 2020, The Annals of thoracic surgery.

[13]  T. Schumacher,et al.  CD8+ T cell states in human cancer: insights from single-cell analysis , 2020, Nature Reviews Cancer.

[14]  Hyungjin Kim,et al.  A novel algorithm to differentiate between multiple primary lung cancers and intrapulmonary metastasis in multiple lung cancers with multiple pulmonary sites of involvement. , 2020, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.

[15]  Yirun Li,et al.  Promoter aberrant methylation status of ADRA1A is associated with hepatocellular carcinoma , 2020, Epigenetics.

[16]  Zi-Xuan Wang,et al.  Molecular profiling of key driver genes improves staging accuracy in multifocal non-small cell lung cancer. , 2019, The Journal of thoracic and cardiovascular surgery.

[17]  Joshua D. Campbell,et al.  Genomic and immune profiling of pre-invasive lung adenocarcinoma , 2019, Nature Communications.

[18]  Yi-long Wu,et al.  Genomic Landscape and Immune Microenvironment Features of Preinvasive and Early-Invasive Lung Adenocarcinoma. , 2019, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.

[19]  Roger R. Wang,et al.  Connecting blood and intratumoral Treg cell activity in predicting future relapse in breast cancer , 2019, Nature Immunology.

[20]  Y. Jiang,et al.  Safety, efficacy and tumor mutational burden as a biomarker of overall survival benefit in chemo-refractory gastric cancer treated with toripalimab, a PD-1 antibody in phase Ib/II clinical trial NCT02915432 , 2019, Annals of oncology : official journal of the European Society for Medical Oncology.

[21]  Xiang Wang,et al.  Multiple primary lung cancer: a rising challenge. , 2019, Journal of thoracic disease.

[22]  N. Altorki,et al.  The lung microenvironment: an important regulator of tumour growth and metastasis , 2018, Nature Reviews Cancer.

[23]  T A Chan,et al.  Development of tumor mutation burden as an immunotherapy biomarker: utility for the oncology clinic , 2018, Annals of oncology : official journal of the European Society for Medical Oncology.

[24]  P. Carmeliet,et al.  Phenotype molding of stromal cells in the lung tumor microenvironment , 2018, Nature Medicine.

[25]  S. Christensen.  Recent advances in field cancerization and management of multiple cutaneous squamous cell carcinomas , 2018, F1000Research.

[26]  Stephen Broderick,et al.  Neoadjuvant PD‐1 Blockade in Resectable Lung Cancer , 2018, The New England journal of medicine.

[27]  B. Dai,et al.  Identification and Validation of Stromal Immunotype Predict Survival and Benefit from Adjuvant Chemotherapy in Patients with Muscle-Invasive Bladder Cancer , 2018, Clinical Cancer Research.

[28]  T. Graham,et al.  An evolutionary perspective on field cancerization , 2017, Nature Reviews Cancer.

[29]  D. Shen,et al.  Early metastasis detected in patients with multifocal pulmonary ground-glass opacities (GGOs) , 2017, Thorax.

[30]  A. Borczuk,et al.  Use of Oncogenic Driver Mutations in Staging of Multiple Primary Lung Carcinomas: A Single‐Center Experience , 2017, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.

[31]  Peng Zhang,et al.  Discrepancy of epidermal growth factor receptor mutation in lung adenocarcinoma presenting as multiple ground-glass opacities. , 2016, European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery.

[32]  Dongmei Lin,et al.  Genomic heterogeneity of multiple synchronous lung cancer , 2016, Nature Communications.

[33]  Y. Shentu,et al.  Pembrolizumab versus Chemotherapy for PD-L1-Positive Non-Small-Cell Lung Cancer. , 2016, The New England journal of medicine.

[34]  Charles H. Yoon,et al.  Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq , 2016, Science.

[35]  Ji Wang,et al.  Novel Strategy for Synchronous Multiple Primary Lung Cancer Displaying Unique Molecular Profiles. , 2016, The Annals of thoracic surgery.

[36]  J. Crowley,et al.  The IASLC Lung Cancer Staging Project: Proposals for Revision of the TNM Stage Groupings in the Forthcoming (Eighth) Edition of the TNM Classification for Lung Cancer , 2016, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.

[37]  Stephan Beck,et al.  Probe Lasso: A novel method to rope in differentially methylated regions with 450K DNA methylation data , 2015, Methods.

[38]  Yang Zhang,et al.  The prognostic and predictive value of solid subtype in invasive lung adenocarcinoma , 2014, Scientific Reports.

[39]  Masahiko Kusumoto,et al.  Radiographically determined noninvasive adenocarcinoma of the lung: survival outcomes of Japan Clinical Oncology Group 0201. , 2013, The Journal of thoracic and cardiovascular surgery.

[40]  John V Heymach,et al.  CXCR2 expression in tumor cells is a poor prognostic factor and promotes invasion and metastasis in lung adenocarcinoma. , 2013, Cancer research.

[41]  Kenji Suzuki,et al.  A Prospective Radiological Study of Thin-Section Computed Tomography to Predict Pathological Noninvasiveness in Peripheral Clinical IA Lung Cancer (Japan Clinical Oncology Group 0201) , 2011, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.

[42]  H. Asamura.  Multiple primary cancers or multiple metastases, that is the question. , 2010, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.

[43]  B. Meyers,et al.  Special treatment issues in lung cancer: ACCP evidence-based clinical practice guidelines (2nd edition). , 2007, Chest.

[44]  P. Shannon,et al.  Cytoscape: A Software Environment for Integrated Models of Biomolecular Interaction Networks , 2003 .

[45]  M. Melamed,et al.  Multiple primary lung cancers. , 1975, The Journal of thoracic and cardiovascular surgery.

[46]  Ash A. Alizadeh,et al.  SUPPLEMENTARY NOTE , 1879, Botanical Gazette.

[47]  Wei Chen,et al.  Favorable prognosis and high discrepancy of genetic features in surgical patients with multiple primary lung cancers , 2018, The Journal of thoracic and cardiovascular surgery.

[48]  Yi-long Wu,et al.  Genetic and Immune Profiles of Solid Predominant Lung Adenocarcinoma Reveal Potential Immunotherapeutic Strategies , 2018, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.

[49]  Frank C. Detterbeck,et al.  The Eighth Edition Lung Cancer Stage Classification , 2017, Chest.

[50]  Cheng Li,et al.  Adjusting batch effects in microarray expression data using empirical Bayes methods. , 2007, Biostatistics.

[51]  Hilde van der Togt,et al.  Publisher's Note , 2003, J. Netw. Comput. Appl..