Design Principles of Concentration-Dependent Transcriptome Deviations in Drug-Exposed Differentiating Stem Cells
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Raivo Kolde | Tanja Waldmann | Jan G. Hengstler | Marcel Leist | Jürgen Hescheler | Eugen Rempel | Jörg Rahnenführer | Agapios Sachinidis | R. Kolde | J. Rahnenführer | J. Hengstler | M. Leist | A. König | J. Hescheler | M. Henry | E. Rempel | A. Sachinidis | J. A. Gaspar | T. Waldmann | André König | Margit Henry | Nina V. Balmer | John Antonydas Gaspar
[1] R. Sharan,et al. Expander: from expression microarrays to networks and functions , 2010, Nature Protocols.
[2] David A. Orlando,et al. Selective Inhibition of Tumor Oncogenes by Disruption of Super-Enhancers , 2013, Cell.
[3] Philippe Grandjean,et al. Advancing the science of developmental neurotoxicity (DNT): testing for better safety evaluation. , 2012, ALTEX.
[4] L. Smirnova,et al. Metabolomics in toxicology and preclinical research. , 2013, ALTEX.
[5] H. Schlüter,et al. Identification of Thalidomide-Specific Transcriptomics and Proteomics Signatures during Differentiation of Human Embryonic Stem Cells , 2012, PloS one.
[6] Marcel Leist,et al. Food for thought ... considerations and guidelines for basic test method descriptions in toxicology. , 2010, ALTEX.
[7] Tanja Waldmann,et al. Extensive Transcriptional Regulation of Chromatin Modifiers during Human Neurodevelopment , 2012, PloS one.
[8] Christian Beste,et al. Translating neurobehavioural endpoints of developmental neurotoxicity tests into in vitro assays and readouts. , 2012, Neurotoxicology.
[9] Thomas Hartung,et al. The dawning of a new age of toxicology. , 2008, ALTEX.
[10] Marcel Leist,et al. Assessment of chemical-induced impairment of human neurite outgrowth by multiparametric live cell imaging in high-density cultures. , 2011, Toxicological sciences : an official journal of the Society of Toxicology.
[11] Marcel Leist,et al. Evaluation of Developmental Toxicants and Signaling Pathways in a Functional Test Based on the Migration of Human Neural Crest Cells , 2012, Environmental health perspectives.
[12] M. Tomishima,et al. Converting human pluripotent stem cells to neural tissue and neurons to model neurodegeneration. , 2011, Methods in molecular biology.
[13] Melvin E. Andersen,et al. New directions in toxicity testing. , 2011, Annual review of public health.
[14] Jeanette Wiltse,et al. Mode of Action: Inhibition of Histone Deacetylase, Altering WNT-Dependent Gene Expression, and Regulation of Beta-Catenin—Developmental Effects of Valproic Acid , 2005, Critical reviews in toxicology.
[15] M. Tomishima,et al. Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling , 2009, Nature Biotechnology.
[16] G. B. Gori,et al. Scientifically unfounded precaution drives European Commission's recommendations on EDC regulation, while defying common sense, well-established science and risk assessment principles. , 2013, Toxicology in vitro : an international journal published in association with BIBRA.
[17] Hedi Peterson,et al. Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach , 2012, Archives of Toxicology.
[18] Tanja Waldmann,et al. Markers of murine embryonic and neural stem cells, neurons and astrocytes: reference points for developmental neurotoxicity testing. , 2010, ALTEX.
[19] Jeroen L A Pennings,et al. Time-response evaluation by transcriptomics of methylmercury effects on neural differentiation of murine embryonic stem cells. , 2011, Toxicological sciences : an official journal of the Society of Toxicology.
[20] Gordon K. Smyth,et al. Use of within-array replicate spots for assessing differential expression in microarray experiments , 2005, Bioinform..
[21] Y. Benjamini,et al. THE CONTROL OF THE FALSE DISCOVERY RATE IN MULTIPLE TESTING UNDER DEPENDENCY , 2001 .
[22] Y. Benjamini,et al. Adaptive linear step-up procedures that control the false discovery rate , 2006 .
[23] M. Sztajnkrycer. Valproic Acid Toxicity: Overview and Management , 2002, Journal of toxicology. Clinical toxicology.
[24] G. B. Gori,et al. Scientifically unfounded precaution drives European Commission's recommendations on EDC regulation, while defying common sense, well-established science and risk assessment principles. , 2013, Toxicon : official journal of the International Society on Toxinology.
[25] K. Meganathan,et al. Current status of human pluripotent stem cell based in vitro toxicity tests. , 2013, Frontiers in bioscience.
[26] Peter Rodgers,et al. Constructing Area-Proportional Venn and Euler Diagrams with Three Circles , 2005 .
[27] H M Bolt,et al. Challenging dogma: thresholds for genotoxic carcinogens? The case of vinyl acetate. , 2003, Annual review of pharmacology and toxicology.
[28] Harvey J Clewell,et al. Can case study approaches speed implementation of the NRC report: "toxicity testing in the 21st century: a vision and a strategy?". , 2011, ALTEX.
[29] R. Sharan,et al. Genome-wide in silico identification of transcriptional regulators controlling the cell cycle in human cells. , 2003, Genome research.
[30] W. Koh,et al. Coordinated waves of gene expression during neuronal differentiation of embryonic stem cells as basis for novel approaches to developmental neurotoxicity testing , 2011, Cell Death and Differentiation.
[31] Marcel Leist,et al. GFAP‐independent inflammatory competence and trophic functions of astrocytes generated from murine embryonic stem cells , 2012, Glia.
[32] Giorgia Pallocca,et al. miRNA expression profiling in a human stem cell-based model as a tool for developmental neurotoxicity testing , 2013, Cell Biology and Toxicology.
[33] J. Dopazo,et al. A function-centric approach to the biological interpretation of microarray time-series. , 2006, Genome informatics. International Conference on Genome Informatics.
[34] Kim Kultima,et al. Valproic acid-induced deregulation in vitro of genes associated in vivo with neural tube defects. , 2009, Toxicological sciences : an official journal of the Society of Toxicology.
[35] R Core Team,et al. R: A language and environment for statistical computing. , 2014 .
[36] T. Knudsen,et al. A roadmap for the development of alternative (non-animal) methods for systemic toxicity testing. , 2012, ALTEX.
[37] Flora M. Haaijer-Ruskamp,et al. Post-Approval Safety Issues with Innovative Drugs: A European Cohort Study , 2013, Drug Safety.
[38] Melvin E. Andersen,et al. Temporal concordance between apical and transcriptional points of departure for chemical risk assessment. , 2013, Toxicological sciences : an official journal of the Society of Toxicology.
[39] Valérie Zuang,et al. Alternative (non-animal) methods for cosmetics testing: current status and future prospects—2010 , 2011, Archives of Toxicology.
[40] Dorit Merhof,et al. Evaluation of a human neurite growth assay as specific screen for developmental neurotoxicants , 2013, Archives of Toxicology.
[41] Jeroen L A Pennings,et al. Transcriptomic concentration-response evaluation of valproic acid, cyproconazole, and hexaconazole in the neural embryonic stem cell test (ESTn). , 2012, Toxicological sciences : an official journal of the Society of Toxicology.
[42] David A. Orlando,et al. Master Transcription Factors and Mediator Establish Super-Enhancers at Key Cell Identity Genes , 2013, Cell.
[43] Karl-Heinz Krause,et al. The biological and ethical basis of the use of human embryonic stem cells for in vitro test systems or cell therapy. , 2008, ALTEX.
[44] Tanja Waldmann,et al. Epigenetic changes and disturbed neural development in a human embryonic stem cell-based model relating to the fetal valproate syndrome. , 2012, Human molecular genetics.
[45] R. Young,et al. Super-Enhancers in the Control of Cell Identity and Disease , 2013, Cell.
[46] K. Meganathan,et al. A tanscriptomics study to elucidate the toxicological mechanism of methylmercury chloride in a human stem cell based in vitro test. , 2012, Current medicinal chemistry.
[47] Russell S. Thomas,et al. Application of transcriptional benchmark dose values in quantitative cancer and noncancer risk assessment. , 2011, Toxicological sciences : an official journal of the Society of Toxicology.
[48] Marcel Leist,et al. Sensitivity of dopaminergic neuron differentiation from stem cells to chronic low-dose methylmercury exposure. , 2011, Toxicological sciences : an official journal of the Society of Toxicology.