Melanoma. Associated antigens in benign melanocytic disorders.

Three instances of depigmentation occurring in children with congenital large nevocytic nevi are reported. Serologic studies for tumour-associated antigens to melanoma were performed by indirect immunofluorescence and complement fixation on these patients and others with benign melanocytic disorders. Positive reactivity in several children was observed. The small numbers studied and lack of uniformity of other testing methods leave open the question of relevance of such reactivity to malignant conversion or protection in congenital nevi.

[1]  A. Peserico,et al.  Autoantibodies in vitiligo. , 1976, Archives of dermatology.

[2]  N. Georgiade,et al.  CONGENITAL GIANT NEVI: CLINICAL AND PATHOLOGICAL CONSIDERATIONS , 1976, Plastic and reconstructive surgery.

[3]  W. E. Smith,et al.  Multiple halo neurofibromas. , 1976, Archives of dermatology.

[4]  J. Bystryn,et al.  Epidermal cytoplasmic antibodies: incidence and type in normal persons and patients with melanoma. , 1976, The Journal of investigative dermatology.

[5]  R. Gupta,et al.  Suggestive evidence for in vivo binding of specific antitumor antibodies of human melanomas. , 1975, Cancer research.

[6]  R. N. Macsween,et al.  Serum anti‐tumour antibodies and auto‐antibodies in vitiligo , 1975, The British journal of dermatology.

[7]  W. D. Rowland,et al.  Metastatic malignant melanoma in prepubertal children. , 1975, Pediatrics.

[8]  R. Marks,et al.  An explanation for the ‘placebo’ effect of bland ointment bases * , 1975, The British journal of dermatology.

[9]  F. Trezzi,et al.  The biogenesis of mitochondria in Neurospora crassa: ultrastructural changes induced by nutrients. , 1974, Cell differentiation.

[10]  M. S. Blois,et al.  Halo nevi and melanoma. , 1973, JAMA.

[11]  T. Phillips,et al.  Immunological associations of the halo naevus with cutaneous malignant melanoma * , 1973, The British journal of dermatology.

[12]  G. Milton,et al.  Malignant Melanoma and Vitiligo , 1971, The Australasian journal of dermatology.

[13]  J. Voorhees,et al.  Multiple congenital giant nevocellular nevi with halos. A clinical and electron microscopic study. , 1971, Archives of dermatology.

[14]  D. Morton,et al.  Sarcoma-specific antigens: detection by complement fixation with serum from sarcoma patients. , 1970, Journal of the National Cancer Institute.

[15]  T. Phillips,et al.  Tumour-specific Antibodies in Human Malignant Melanoma and their Relationship to the Extent of the Disease , 1969, British medical journal.

[16]  M. Medenica,et al.  Multiple halo nevi. Histopathological findings in a 14-year-old boy. , 1969, Archives of dermatology.

[17]  D. Morton,et al.  Demonstration of antibodies against human malignant melanoma by immunofluorescence. , 1968, Surgery.

[18]  A. Kopf,et al.  Broad spectrum of leukoderma acquisitum centrifugum. , 1965, Archives of dermatology.

[19]  W. Reed,et al.  CONGENITAL LIPODYSTROPHIC DIABETES WITH ACANTHOSIS NIGRICANS: THE SEIP-LAWRENCE SYNDROME. , 1965, Archives of dermatology.

[20]  S. B. Frank,et al.  THE HALO NEVUS. , 1964, Archives of dermatology.

[21]  G. Pack,et al.  Nevus giganticus pigmentosus with malignant transformation. , 1961, Surgery.

[22]  O. H. Lowry,et al.  Protein measurement with the Folin phenol reagent. , 1951, The Journal of biological chemistry.