Short linear motifs: ubiquitous and functionally diverse protein interaction modules directing cell regulation.
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Aidan Budd | Norman E. Davey | Holger Dinkel | Robert J. Weatheritt | Bora Uyar | Markus Seiler | Kim Van Roey | Toby J Gibson | Robert J Weatheritt | Norman E Davey | T. Gibson | N. Davey | A. Budd | K. Van Roey | B. Uyar | Holger Dinkel | Markus Seiler
[1] Utz Fischer,et al. The HIV-1 Rev Activation Domain is a nuclear export signal that accesses an export pathway used by specific cellular RNAs , 1995, Cell.
[2] F. Melchior,et al. Concepts in sumoylation: a decade on , 2007, Nature Reviews Molecular Cell Biology.
[3] K. Nakayama,et al. Regulation of the cell cycle by SCF-type ubiquitin ligases. , 2005, Seminars in cell & developmental biology.
[4] Wesley I. Sundquist,et al. Structure of the Tsg101 UEV domain in complex with the PTAP motif of the HIV-1 p6 protein , 2002, Nature Structural Biology.
[5] C. Bokemeyer,et al. Cilengitide induces cellular detachment and apoptosis in endothelial and glioma cells mediated by inhibition of FAK/src/AKT pathway , 2008, Journal of experimental & clinical cancer research : CR.
[6] H. Nakagama,et al. Nuclear export signal in CDC25B. , 2004, Biochemical and biophysical research communications.
[7] S. Kawabata,et al. A new trisaccharide sugar chain linked to a serine residue in bovine blood coagulation factors VII and IX. , 1988, Journal of biochemistry.
[8] Y. Liou,et al. Prolyl isomerase Pin1 as a molecular switch to determine the fate of phosphoproteins. , 2011, Trends in biochemical sciences.
[9] D. Milewicz,et al. A mutation in FBN1 disrupts profibrillin processing and results in isolated skeletal features of the Marfan syndrome. , 1995, The Journal of clinical investigation.
[10] D. Baltimore,et al. The noncatalytic src homology region 2 segment of abl tyrosine kinase binds to tyrosine-phosphorylated cellular proteins with high affinity. , 1991, Proceedings of the National Academy of Sciences of the United States of America.
[11] A. Roverato,et al. Molecular analysis of the androgen receptor gene in testicular cancer. , 2005, Endocrine-related cancer.
[12] Jie-Oh Lee,et al. Structure of the retinoblastoma tumour-suppressor pocket domain bound to a peptide from HPV E7 , 1998, Nature.
[13] Andrzej Kudlicki,et al. High-resolution timing of cell cycle-regulated gene expression , 2007, Proceedings of the National Academy of Sciences.
[14] Pedro Beltrão,et al. Specificity and Evolvability in Eukaryotic Protein Interaction Networks , 2007, PLoS Comput. Biol..
[15] J. Hofsteenge,et al. Protein chemical and kinetic characterization of recombinant porcine ribonuclease inhibitor expressed in Saccharomyces cerevisiae. , 1990, Biochemistry.
[16] A. Green,et al. Novel exon 12 mutations in the HIF2A gene associated with erythrocytosis. , 2008, Blood.
[17] W. Rosenthal,et al. Mechanisms of protein kinase A anchoring. , 2010, International review of cell and molecular biology.
[18] L. Castagnoli,et al. Protein Interaction Networks by Proteome Peptide Scanning , 2004, PLoS biology.
[19] Radha Akella,et al. Substrate and docking interactions in serine/threonine protein kinases. , 2007, Chemical reviews.
[20] D. Barford,et al. Insights into Degron Recognition by APC/C Coactivators from the Structure of an Acm1-Cdh1 Complex , 2013, Molecular cell.
[21] J. Pines,et al. Ordered proteolysis in anaphase inactivates Plk1 to contribute to proper mitotic exit in human cells , 2004, The Journal of cell biology.
[22] Laurence H. Pearl,et al. Crystal Structure of Glycogen Synthase Kinase 3β Structural Basis for Phosphate-Primed Substrate Specificity and Autoinhibition , 2001, Cell.
[23] J. Clarke,et al. Remarkably Fast Coupled Folding and Binding of the Intrinsically Disordered Transactivation Domain of cMyb to CBP KIX , 2013, Journal of Physical Chemistry B.
[24] Enrico Ferraro,et al. False occurrences of functional motifs in protein sequences highlight evolutionary constraints , 2007, BMC Bioinformatics.
[25] V. Barr,et al. Dynamic molecular interactions linking the T cell antigen receptor to the actin cytoskeleton , 2005, Nature Immunology.
[26] Robert J. Weatheritt,et al. Linear motifs: lost in (pre)translation. , 2012, Trends in biochemical sciences.
[27] István Simon,et al. BIOINFORMATICS ORIGINAL PAPER doi:10.1093/bioinformatics/btm035 Structural bioinformatics Local structural disorder imparts plasticity on linear motifs , 2022 .
[28] P. Tompa. Intrinsically unstructured proteins. , 2002, Trends in biochemical sciences.
[29] Michal Sharon,et al. Mechanism of auxin perception by the TIR1 ubiquitin ligase , 2007, Nature.
[30] L. Schild,et al. A de novo missense mutation of the beta subunit of the epithelial sodium channel causes hypertension and Liddle syndrome, identifying a proline-rich segment critical for regulation of channel activity. , 1995, Proceedings of the National Academy of Sciences of the United States of America.
[31] K. Shimamoto,et al. Liddle’s Syndrome Caused by a Novel Mutation in the Proline-Rich PY Motif of the Epithelial Sodium Channel β-Subunit , 2005 .
[32] B. Kobe,et al. Role of flanking sequences and phosphorylation in the recognition of the simian-virus-40 large T-antigen nuclear localization sequences by importin-alpha. , 2003, The Biochemical journal.
[33] E. Glaser,et al. Processing peptidases in mitochondria and chloroplasts. , 2013, Biochimica et biophysica acta.
[34] T. Mak,et al. Structures of KIX domain of CBP in complex with two FOXO3a transactivation domains reveal promiscuity and plasticity in coactivator recruitment , 2012, Proceedings of the National Academy of Sciences.
[35] H. Dyson,et al. Mapping the interactions of the p53 transactivation domain with the KIX domain of CBP. , 2009, Biochemistry.
[36] John Kuriyan,et al. Structure of the C-Terminal Region of p21WAF1/CIP1 Complexed with Human PCNA , 1996, Cell.
[37] L. Hengst,et al. p27 binds cyclin–CDK complexes through a sequential mechanism involving binding-induced protein folding , 2004, Nature Structural &Molecular Biology.
[38] A. Forrest,et al. Regulation of CDC25B phosphatases subcellular localization , 2000, Oncogene.
[39] Zohar Itzhaki,et al. A Dynamic View of Domain-Motif Interactions , 2012, PLoS Comput. Biol..
[40] Norman E. Davey,et al. Linear motifs confer functional diversity onto splice variants , 2012, Nucleic acids research.
[41] M. Gelb,et al. Palmitoylation of Ha-Ras Facilitates Membrane Binding, Activation of Downstream Effectors, and Meiotic Maturation in Xenopus Oocytes (*) , 1996, The Journal of Biological Chemistry.
[42] B. Schraven,et al. A displaced PAG enhances proximal signaling and SDF‐1‐induced T cell migration , 2008, European journal of immunology.
[43] V. Uversky. Multitude of binding modes attainable by intrinsically disordered proteins: a portrait gallery of disorder-based complexes. , 2011, Chemical Society reviews.
[44] I. McEwan,et al. The Impact of Point Mutations in the Human Androgen Receptor: Classification of Mutations on the Basis of Transcriptional Activity , 2012, PloS one.
[45] M. Krstic-Demonacos,et al. PCAF is an HIF-1α cofactor that regulates p53 transcriptional activity in hypoxia , 2008, Oncogene.
[46] K. Taskén,et al. Specificity and spatial dynamics of protein kinase A signaling organized by A-kinase-anchoring proteins. , 2010, Journal of molecular endocrinology.
[47] Huan-Xiang Zhou,et al. Intrinsic disorder: signaling via highly specific but short-lived association. , 2012, Trends in biochemical sciences.
[48] M. Privalsky,et al. The role of corepressors in transcriptional regulation by nuclear hormone receptors. , 2004, Annual review of physiology.
[49] B. Chait,et al. Helicobacter pylori CagA Inhibits PAR1/MARK Family Kinases by Mimicking Host Substrates , 2009, Nature Structural &Molecular Biology.
[50] W. Annaert,et al. Inactivation of the proximal NPXY motif impairs early steps in LRP1 biosynthesis , 2009, Cellular and Molecular Life Sciences.
[51] J. Massagué,et al. Structural basis of Smad2 recognition by the Smad anchor for receptor activation. , 2000, Science.
[52] B. J. Mayer. Signal transduction: Clamping down on Src activity , 1997, Current Biology.
[53] S. Hebert,et al. Phosphorylation of the ATP-sensitive, Inwardly Rectifying K Channel, ROMK, by Cyclic AMP-dependent Protein Kinase (*) , 1996, The Journal of Biological Chemistry.
[54] Xiang-Jiao Yang,et al. A recurrent phospho-sumoyl switch in transcriptional repression and beyond. , 2006, Molecular cell.
[55] L. Molday,et al. Membrane Topology of the ATP Binding Cassette Transporter ABCR and Its Relationship to ABC1 and Related ABCA Transporters , 2001, The Journal of Biological Chemistry.
[56] S. Shenolikar,et al. From promiscuity to precision: protein phosphatases get a makeover. , 2009, Molecular cell.
[57] A. Bardwell,et al. Anthrax lethal factor-cleavage products of MAPK (mitogen-activated protein kinase) kinases exhibit reduced binding to their cognate MAPKs. , 2004, The Biochemical journal.
[58] J. Darnell,et al. Structure-function studies of FMRP RGG peptide recognition of an RNA duplex-quadruplex junction , 2011, Nature Structural &Molecular Biology.
[59] Ian G. Mills,et al. Curvature of clathrin-coated pits driven by epsin , 2002, Nature.
[60] L. Chan,et al. Autoinhibition of X11/Mint scaffold proteins revealed by the closed conformation of the PDZ tandem , 2005, Nature Structural &Molecular Biology.
[61] H. Turner,et al. A Comparison of the Interaction of Shc and the Tyrosine Kinase ZAP-70 with the T Cell Antigen Receptor ζ Chain Tyrosine-based Activation Motif (*) , 1995, The Journal of Biological Chemistry.
[62] James E. Ferrell,et al. Mechanisms of specificity in protein phosphorylation , 2007, Nature Reviews Molecular Cell Biology.
[63] L. Parker,et al. Cdc14 Phosphatases Preferentially Dephosphorylate a Subset of Cyclin-dependent kinase (Cdk) Sites Containing Phosphoserine*♦ , 2011, The Journal of Biological Chemistry.
[64] S. Gallati,et al. Novel missense mutations in the TRPS1 transcription factor define the nuclear localization signal , 2004, European Journal of Human Genetics.
[65] R. Lifton,et al. Genetic heterogeneity of Barter's syndrome revealed by mutations in the K+ channel, ROMK , 1996, Nature Genetics.
[66] Y. Igarashi,et al. Identification of a nuclear localization signal in the retinitis pigmentosa-mutated RP26 protein, ceramide kinase-like protein. , 2006, Biochemical and biophysical research communications.
[67] S. Hsiao,et al. Tankyrase function at telomeres, spindle poles, and beyond. , 2008, Biochimie.
[68] M. A. Edeling,et al. Molecular switches involving the AP-2 beta2 appendage regulate endocytic cargo selection and clathrin coat assembly. , 2006, Developmental cell.
[69] F. Baas,et al. DYT6 dystonia: Mutation screening, phenotype, and response to deep brain stimulation , 2010, Movement disorders : official journal of the Movement Disorder Society.
[70] K. Sakaguchi,et al. Damage-mediated Phosphorylation of Human p53 Threonine 18 through a Cascade Mediated by a Casein 1-like Kinase , 2000, The Journal of Biological Chemistry.
[71] Iain D. Campbell,et al. Structural Analysis of the Interactions Between Paxillin LD Motifs and α-Parvin , 2008, Structure.
[72] D. Mann,et al. The Intricacies of p21 Phosphorylation: Protein/Protein Interactions, Subcellular Localization and Stability , 2006, Cell cycle.
[73] Diana M. Mitrea,et al. Cell cycle regulation by the intrinsically disordered proteins p21 and p27. , 2012, Biochemical Society transactions.
[74] Marc S. Cortese,et al. Structural Basis for Regulation of Protein Phosphatase 1 by Inhibitor-2* , 2007, Journal of Biological Chemistry.
[75] N. Gray,et al. Targeting cancer with small molecule kinase inhibitors , 2009, Nature Reviews Cancer.
[76] Ricardo M Biondi,et al. Signalling specificity of Ser/Thr protein kinases through docking-site-mediated interactions. , 2003, The Biochemical journal.
[77] Susan S. Taylor,et al. Structure of D-AKAP2:PKA RI complex: insights into AKAP specificity and selectivity. , 2010, Structure.
[78] W. Schulze,et al. The Journal of Clinical Endocrinology & Metabolism Printed in U.S.A. Copyright © 2000 by The Endocrine Society Significance of Mutations in the Androgen Receptor Gene in Males with Idiopathic Infertility* , 2022 .
[79] Gabriel Waksman,et al. Protein–protein interaction through β-strand addition , 2006 .
[80] Hao Wu,et al. Distinct molecular mechanism for initiating TRAF6 signalling , 2002, Nature.
[81] Etienne Gagnon,et al. Regulation of T Cell Receptor Activation by Dynamic Membrane Binding of the CD3ɛ Cytoplasmic Tyrosine-Based Motif , 2008, Cell.
[82] M. Estelle,et al. Auxin perception--structural insights. , 2010, Cold Spring Harbor perspectives in biology.
[83] Anindya Dutta,et al. CRL4Cdt2: master coordinator of cell cycle progression and genome stability. , 2011, Cell cycle.
[84] Renata Kaminska,et al. Kinetic basis for the competitive recruitment of TolB by the intrinsically disordered translocation domain of colicin E9. , 2012, Journal of molecular biology.
[85] Danijela Maric,et al. Molecular mechanisms of protein and lipid targeting to ciliary membranes , 2010, Journal of Cell Science.
[86] Ignacio E. Sánchez,et al. The eukaryotic linear motif resource ELM: 10 years and counting , 2013, Nucleic Acids Res..
[87] Juan I. Sbodio,et al. Identification of a Tankyrase-binding Motif Shared by IRAP, TAB182, and Human TRF1 but Not Mouse TRF1 , 2002, The Journal of Biological Chemistry.
[88] P. Lapunzina,et al. Novel (60%) and recurrent (40%) androgen receptor gene mutations in a series of 59 patients with a 46,XY disorder of sex development. , 2010, The Journal of clinical endocrinology and metabolism.
[89] D. Goldfarb,et al. Evolutionary specialization of the nuclear targeting apparatus. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[90] Kelley W. Moremen,et al. Vertebrate protein glycosylation: diversity, synthesis and function , 2012, Nature Reviews Molecular Cell Biology.
[91] S. Hell,et al. KDEL-cargo regulates interactions between proteins involved in COPI vesicle traffic: measurements in living cells using FRET. , 2001, Developmental cell.
[92] J. Calvete,et al. Evolution of snake venom disintegrins by positive Darwinian selection. , 2008, Molecular biology and evolution.
[93] Burkhard Rost,et al. NLSdb: database of nuclear localization signals , 2003, Nucleic Acids Res..
[94] Jürg Zimmermann,et al. Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr–Abl positive cells , 1996, Nature Medicine.
[95] I. Mills,et al. Role of the AP2 β-Appendage Hub in Recruiting Partners for Clathrin-Coated Vesicle Assembly , 2006, PLoS biology.
[96] Geng Wu,et al. Structure of a -TrCP1-Skp1--Catenin Complex , 2003 .
[97] M. Poupon,et al. Grb2‐SH3 ligand inhibits the growth of HER2+ cancer cells and has antitumor effects in human cancer xenografts alone and in combination with docetaxel , 2007, International journal of cancer.
[98] M. Pagano,et al. SCF ubiquitin ligases in the maintenance of genome stability. , 2012, Trends in biochemical sciences.
[99] R. Geahlen,et al. Synthesis of a phosphoserine mimetic prodrug with potent 14-3-3 protein inhibitory activity. , 2011, Chemistry & biology.
[100] T. Arakawa,et al. Dimerization of the extracellular domain of the erythropoietin (EPO) receptor by EPO: one high-affinity and one low-affinity interaction. , 1996, Biochemistry.
[101] Sreenath V. Sharma,et al. UCS15A, a novel small molecule, SH3 domain-mediated protein–protein interaction blocking drug , 2002, Oncogene.
[102] Michael J Ackerman,et al. Gain-of-function RAF1 mutations cause Noonan and LEOPARD syndromes with hypertrophic cardiomyopathy , 2007, Nature Genetics.
[103] G. Wahl,et al. A leucine‐rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking , 1999, The EMBO journal.
[104] Z. Weng,et al. A structure‐based benchmark for protein–protein binding affinity , 2011, Protein science : a publication of the Protein Society.
[105] A Keith Dunker,et al. Unfoldomics of human diseases: linking protein intrinsic disorder with diseases , 2009, BMC Genomics.
[106] M. Bollen,et al. Docking motif-guided mapping of the interactome of protein phosphatase-1. , 2009, Chemistry & biology.
[107] B. Valent,et al. Filamentous plant pathogen effectors in action , 2013, Nature Reviews Microbiology.
[108] François Stricher,et al. Analysis of disease-linked rhodopsin mutations based on structure, function, and protein stability calculations. , 2011, Journal of molecular biology.
[109] John D. Scott,et al. Anchoring Proteins as Regulators of Signaling Pathways , 2012, Circulation research.
[110] E. Friedman,et al. Mirk/Dyrk1B Mediates Survival during the Differentiation of C2C12 Myoblasts* , 2005, Journal of Biological Chemistry.
[111] M. Pagano,et al. Role of the SCFSkp2 Ubiquitin Ligase in the Degradation of p21Cip1 in S Phase* , 2003, Journal of Biological Chemistry.
[112] K. Helin,et al. Characterization of the retinoblastoma binding proteins RBP1 and RBP2. , 1993, Oncogene.
[113] David R McIlwain,et al. Caspase functions in cell death and disease. , 2013, Cold Spring Harbor perspectives in biology.
[114] Nels C. Elde,et al. The evolutionary conundrum of pathogen mimicry , 2009, Nature Reviews Microbiology.
[115] Caleb J Bashor,et al. The Ste5 Scaffold Allosterically Modulates Signaling Output of the Yeast Mating Pathway , 2006, Science.
[116] Marc S. Cortese,et al. Analysis of molecular recognition features (MoRFs). , 2006, Journal of molecular biology.
[117] C. Froment,et al. Study of the docking-dependent PLK1 phosphorylation of the CDC25B phosphatase. , 2011, Biochemical and biophysical research communications.
[118] M. A. Downs,et al. Epsin Binds to Clathrin by Associating Directly with the Clathrin-terminal Domain , 2000, The Journal of Biological Chemistry.
[119] Frederick A. Dick,et al. Molecular mechanisms underlying RB protein function , 2013, Nature Reviews Molecular Cell Biology.
[120] K D Paull,et al. Proteolytic inactivation of MAP-kinase-kinase by anthrax lethal factor. , 1998, Science.
[121] B. Zhao,et al. Loops Govern SH2 Domain Specificity by Controlling Access to Binding Pockets , 2010, Science Signaling.
[122] R. Mariuzza,et al. Structural basis for differential recognition of tyrosine‐phosphorylated sites in the linker for activation of T cells (LAT) by the adaptor Gads , 2004, The EMBO journal.
[123] Georges Bismuth,et al. SLP-76-ADAP adaptor module regulates LFA-1 mediated costimulation and T cell motility , 2009, Proceedings of the National Academy of Sciences.
[124] Jun Qin,et al. SCFbeta-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphatase. , 2003, Genes & development.
[125] James M. Roberts,et al. CDK Inhibitors : Cell Cycle Regulators and Beyond , 2008 .
[126] S. T. Kim,et al. Substrate Specificities and Identification of Putative Substrates of ATM Kinase Family Members* , 1999, The Journal of Biological Chemistry.
[127] Alex Bateman,et al. Tissue-Specific Splicing of Disordered Segments that Embed Binding Motifs Rewires Protein Interaction Networks , 2012, Molecular cell.
[128] Roberto Dominguez,et al. Structural basis of protein phosphatase 1 regulation , 2004, Nature.
[129] D. Labudde,et al. Cyclophilin A Binds to Linear Peptide Motifs Containing a Consensus That Is Present in Many Human Proteins* , 2005, Journal of Biological Chemistry.
[130] Michael Sattler,et al. U2AF-homology motif interactions are required for alternative splicing regulation by SPF45 , 2007, Nature Structural &Molecular Biology.
[131] Brendan D. Price,et al. Sequential Phosphorylation by Mitogen-activated Protein Kinase and Glycogen Synthase Kinase 3 Represses Transcriptional Activation by Heat Shock Factor-1* , 1996, The Journal of Biological Chemistry.
[132] Monilola A. Olayioye,et al. The ErbB signaling network: receptor heterodimerization in development and cancer , 2000, The EMBO journal.
[133] Anindya Dutta,et al. p21CIP1 and Cdc25A: competition between an inhibitor and an activator of cyclin-dependent kinases , 1997, Molecular and cellular biology.
[134] Stephen J. Elledge,et al. The SCFβ-TRCP–ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IκBα and β-catenin and stimulates IκBα ubiquitination in vitro , 1999 .
[135] Julien Michel,et al. Targeting the von Hippel–Lindau E3 Ubiquitin Ligase Using Small Molecules To Disrupt the VHL/HIF-1α Interaction , 2012, Journal of the American Chemical Society.
[136] V. Barr,et al. Persistence of Cooperatively Stabilized Signaling Clusters Drives T-Cell Activation , 2006, Molecular and Cellular Biology.
[137] M. Ohh,et al. The updated biology of hypoxia‐inducible factor , 2012, The EMBO journal.
[138] Wendell A. Lim,et al. Scaffold Proteins: Hubs for Controlling the Flow of Cellular Information , 2011, Science.
[139] R. D. Wade,et al. Amino acid sequence of human von Willebrand factor. , 1986, Biochemistry.
[140] S. Sahu,et al. Conserved themes in target recognition by the PAH1 and PAH2 domains of the Sin3 transcriptional corepressor. , 2008, Journal of molecular biology.
[141] Tom L Blundell,et al. On the Origins of Enzyme Inhibitor Selectivity and Promiscuity: A Case Study of Protein Kinase Binding to Staurosporine , 2009, Chemical biology & drug design.
[142] E. Petsalaki,et al. Interactions between the Fyn SH3‐domain and adaptor protein Cbp/PAG derived ligands, effects on kinase activity and affinity , 2008, The FEBS journal.
[143] E. Birney,et al. Pfam: the protein families database , 2013, Nucleic Acids Res..
[144] Z. Li,et al. Cloning of a novel T-cell protein FYB that binds FYN and SH2-domain-containing leukocyte protein 76 and modulates interleukin 2 production. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[145] A. J. Roman,et al. Autosomal dominant retinitis pigmentosa in a large family: a clinical and molecular genetic study. , 1994, Investigative ophthalmology & visual science.
[146] Tony Pawson,et al. A High-Affinity Arg-X-X-Lys SH3 Binding Motif Confers Specificity for the Interaction between Gads and SLP-76 in T Cell Signaling , 2002, Current Biology.
[147] S. Shoelson,et al. Crystal Structure of the Tyrosine Phosphatase SHP-2 , 1998, Cell.
[148] M. Mohamed,et al. A missense mutation in the nuclear localization signal sequence of CERKL (p.R106S) causes autosomal recessive retinal degeneration , 2008, Molecular vision.
[149] M. Inagaki,et al. 14‐3‐3γ mediates Cdc25A proteolysis to block premature mitotic entry after DNA damage , 2010, The EMBO journal.
[150] Takeshi Azuma,et al. Biological activity of the Helicobacter pylori virulence factor CagA is determined by variation in the tyrosine phosphorylation sites , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[151] R. Benarous,et al. NMR studies of the phosphorylation motif of the HIV-1 protein Vpu bound to the F-box protein beta-TrCP. , 2003, Biochemistry.
[152] Melissa J. Davis,et al. Rewiring the dynamic interactome. , 2012, Molecular bioSystems.
[153] E. Hartmann,et al. Nuclear translocation of hypoxia-inducible factors (HIFs): involvement of the classical importin alpha/beta pathway. , 2008, Biochimica et biophysica acta.
[154] B. Druker,et al. Lessons learned from the development of an abl tyrosine kinase inhibitor for chronic myelogenous leukemia. , 2000, The Journal of clinical investigation.
[155] Jae-Seong Yang,et al. Rewiring of PDZ Domain-Ligand Interaction Network Contributed to Eukaryotic Evolution , 2012, PLoS genetics.
[156] A. Musacchio,et al. Structural analysis reveals features of the spindle checkpoint kinase Bub1–kinetochore subunit Knl1 interaction , 2012, The Journal of cell biology.
[157] C. Marcinkiewicz,et al. Non-RGD-containing snake venom disintegrins, functional and structural relations. , 2011, Toxicon : official journal of the International Society on Toxinology.
[158] G Fischer,et al. Pin1-dependent prolyl isomerization regulates dephosphorylation of Cdc25C and tau proteins. , 2000, Molecular cell.
[159] Stefan Stamm,et al. Molecular basis of purine-rich RNA recognition by the human SR-like protein Tra2-β1 , 2011, Nature Structural &Molecular Biology.
[160] J. Pines,et al. Temporal and spatial control of cyclin B1 destruction in metaphase , 1999, Nature Cell Biology.
[161] D. H. Kim,et al. S165F mutation of junctophilin 2 affects Ca2+ signalling in skeletal muscle. , 2010, The Biochemical journal.
[162] A. Musacchio,et al. Panta rhei: The APC/C at steady state , 2013, The Journal of cell biology.
[163] R. Kingston,et al. Structural basis of histone H4 recognition by p55. , 2008, Genes & development.
[164] J. Kuriyan,et al. Structures of Src-family tyrosine kinases. , 1997, Current opinion in structural biology.
[165] Andrei L. Turinsky,et al. A Census of Human Soluble Protein Complexes , 2012, Cell.
[166] E. C. Dell'Angelica,et al. Clathrin-binding proteins: got a motif? Join the network! , 2001, Trends in cell biology.
[167] M. Malim,et al. Functional dissection of the HIV-1 Rev trans-activator—Derivation of a trans-dominant repressor of Rev function , 1989, Cell.
[168] Brett W. Engelmann,et al. SH2 Domains Recognize Contextual Peptide Sequence Information to Determine Selectivity* , 2010, Molecular & Cellular Proteomics.
[169] P. Evans,et al. Endocytosis and vesicle trafficking. , 2002, Current opinion in structural biology.
[170] T Pawson,et al. SH2 and SH3 domains , 1993, Current Biology.
[171] M. Steinmetz,et al. Structural insights into the EB1–APC interaction , 2005, The EMBO journal.
[172] Sharon E. Miller,et al. A structural explanation for the binding of endocytic dileucine motifs by the AP2 complex , 2008, Nature.
[173] P. Nash,et al. Evolution of SH2 domains and phosphotyrosine signalling networks , 2012, Philosophical Transactions of the Royal Society B: Biological Sciences.
[174] Stephen H. Bryant,et al. Domain size distributions can predict domain boundaries , 2000, Bioinform..
[175] T. Pawson,et al. Oncogenic re-wiring of cellular signaling pathways , 2007, Oncogene.
[176] Sanguthevar Rajasekaran,et al. Minimotif Miner 3.0: database expansion and significantly improved reduction of false-positive predictions from consensus sequences , 2011, Nucleic Acids Res..
[177] Shili Duan,et al. Molecular recognition of p53 and MDM2 by USP7/HAUSP , 2006, Nature Structural &Molecular Biology.
[178] S. Hanks,et al. Mechanisms of CAS Substrate Domain Tyrosine Phosphorylation by FAK and Src , 2001, Molecular and Cellular Biology.
[179] Toby J Gibson,et al. Cell regulation: determined to signal discrete cooperation. , 2009, Trends in biochemical sciences.
[180] J. Dixon,et al. Interactions of bacterial effector proteins with host proteins. , 2007, Current opinion in immunology.
[181] Wendell A. Lim,et al. Optimization of specificity in a cellular protein interaction network by negative selection , 2003, Nature.
[182] S. Yokoyama,et al. Characterization of the N-oligosaccharides attached to the atypical Asn-X-Cys sequence of recombinant human epidermal growth factor receptor. , 2000, Journal of biochemistry.
[183] David M. Heery,et al. A signature motif in transcriptional co-activators mediates binding to nuclear receptors , 1997, Nature.
[184] Julian Downward,et al. Association of Nck with tyrosine‐phosphorylated SLP‐76 in activated T lymphocytes , 1999, European journal of immunology.
[185] Diana M. Mitrea,et al. Disorder-function relationships for the cell cycle regulatory proteins p21 and p27 , 2012, Biological chemistry.
[186] C. Peng,et al. Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216. , 1997, Science.
[187] Alex Bateman,et al. Reuse of structural domain–domain interactions in protein networks , 2007, BMC Bioinformatics.
[188] S A Schneider,et al. THAP1 mutations (DYT6) are an additional cause of early-onset dystonia , 2010, Neurology.
[189] Poul Nissen,et al. Structural diversity of calmodulin binding to its target sites , 2013, The FEBS journal.
[190] Christopher J. Oldfield,et al. Functional anthology of intrinsic disorder. 1. Biological processes and functions of proteins with long disordered regions. , 2007, Journal of proteome research.
[191] L. Dimeglio,et al. Genotype-phenotype correlation in inherited severe insulin resistance. , 2002, Human molecular genetics.
[192] Tony Pawson,et al. Interaction Domains of Sos1/Grb2 Are Finely Tuned for Cooperative Control of Embryonic Stem Cell Fate , 2013, Cell.
[193] D. Livingston,et al. Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1α , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[194] K. Uematsu,et al. An antagonist of dishevelled protein-protein interaction suppresses beta-catenin-dependent tumor cell growth. , 2007, Cancer research.
[195] E. Brooks,et al. Missense mutation in exon 7 of the common gamma chain gene causes a moderate form of X-linked combined immunodeficiency. , 1995, The Journal of clinical investigation.
[196] C. Hoogenraad,et al. Microtubule plus-end-tracking proteins: mechanisms and functions. , 2005, Current opinion in cell biology.
[197] C. Bell,et al. Simultaneous binding of two peptidyl ligands by a SRC homology 2 domain. , 2011, Biochemistry.
[198] P. Graves,et al. Localization of human Cdc25C is regulated both by nuclear export and 14-3-3 protein binding , 2001, Oncogene.
[199] W. Richardson,et al. The nucleoplasmin nuclear location sequence is larger and more complex than that of SV-40 large T antigen , 1988, The Journal of cell biology.
[200] Xuedong Liu,et al. Ubiquitination of p21Cip1/WAF1 by SCFSkp2: substrate requirement and ubiquitination site selection. , 2005, Biochemistry.
[201] Hsuan-Cheng Huang,et al. ValidNESs: a database of validated leucine-rich nuclear export signals , 2012, Nucleic Acids Res..
[202] Norman E. Davey,et al. Attributes of short linear motifs. , 2012, Molecular bioSystems.
[203] Tony Pawson,et al. Structure of a regulatory complex involving the Abl SH3 domain, the Crk SH2 domain, and a Crk-derived phosphopeptide , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[204] H. Tabak,et al. Caenorhabditis elegans has a single pathway to target matrix proteins to peroxisomes , 2000, EMBO reports.
[205] S. Gygi,et al. Global Analysis of Cdk1 Substrate Phosphorylation Sites Provides Insights into Evolution , 2009, Science.
[206] F. van Roy,et al. Nuclear localization of the p120(ctn) Armadillo-like catenin is counteracted by a nuclear export signal and by E-cadherin expression. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[207] Anindya Dutta,et al. PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex. , 2008, Genes & development.
[208] W. Lim,et al. Systematic Functional Prioritization of Protein Posttranslational Modifications , 2012, Cell.
[209] Norman E. Davey,et al. The switches.ELM Resource: A Compendium of Conditional Regulatory Interaction Interfaces , 2013, Science Signaling.
[210] M. Habal,et al. Mutations in the gene encoding c-Abl-binding protein SH3BP2 cause cherubism , 2001, Nature Genetics.
[211] M. Bollen,et al. The PP1 binding code: a molecular‐lego strategy that governs specificity , 2013, The FEBS journal.
[212] D. Hammer,et al. The Adapter Protein SLP-76 Mediates “Outside-In” Integrin Signaling and Function in T Cells , 2009, Molecular and Cellular Biology.
[213] A. Iwamatsu,et al. Epsin binds to the EH domain of POB1 and regulates receptor-mediated endocytosis , 1999, Oncogene.
[214] Yumay Chen,et al. The Nuclear Localization Sequences of the BRCA1 Protein Interact with the Importin-α Subunit of the Nuclear Transport Signal Receptor* , 1996, The Journal of Biological Chemistry.
[215] C. Sawyers,et al. The phosphatidylinositol 3-Kinase–AKT pathway in human cancer , 2002, Nature Reviews Cancer.
[216] C. Shin,et al. Cell signalling and the control of pre-mRNA splicing , 2004, Nature Reviews Molecular Cell Biology.
[217] J. Walter,et al. Docking of a specialized PIP Box onto chromatin-bound PCNA creates a degron for the ubiquitin ligase CRL4Cdt2. , 2009, Molecular cell.
[218] A. Hodel,et al. Regulation of Nuclear Import by Phosphorylation Adjacent to Nuclear Localization Signals* , 2004, Journal of Biological Chemistry.
[219] M. Brandeis,et al. Securin degradation is mediated by fzy and fzr, and is required for complete chromatid separation but not for cytokinesis , 2001, The EMBO journal.
[220] H. Dyson,et al. Structural basis for recruitment of CBP/p300 coactivators by STAT1 and STAT2 transactivation domains , 2009, The EMBO journal.
[221] N. Seidah,et al. Evidence that furin is an authentic transforming growth factor-beta1-converting enzyme. , 2001, The American journal of pathology.
[222] J. Iñiguez-Lluhí,et al. The in Vivo Role of Androgen Receptor SUMOylation as Revealed by Androgen Insensitivity Syndrome and Prostate Cancer Mutations Targeting the Proline/Glycine Residues of Synergy Control Motifs* , 2012, The Journal of Biological Chemistry.
[223] R. Leduc,et al. Subtilase-like pro-protein convertases: from molecular specificity to therapeutic applications. , 2000, Journal of molecular endocrinology.
[224] Michael Way,et al. SLP-76 Coordinates Nck-Dependent Wiskott-Aldrich Syndrome Protein Recruitment with Vav-1/Cdc42-Dependent Wiskott-Aldrich Syndrome Protein Activation at the T Cell-APC Contact Site 1 , 2003, The Journal of Immunology.
[225] William D. Richardson,et al. A short amino acid sequence able to specify nuclear location , 1984, Cell.
[226] Jay Vyas,et al. Viral infection and human disease--insights from minimotifs. , 2008, Frontiers in bioscience : a journal and virtual library.
[227] Feiran Zhang,et al. Protein N-terminal processing: substrate specificity of Escherichia coli and human methionine aminopeptidases. , 2010, Biochemistry.
[228] M. Resh,et al. Dual Fatty Acylation of p59Fyn Is Required for Association with the T Cell Receptor ζ Chain through Phosphotyrosine–Src Homology Domain-2 Interactions , 1999, The Journal of cell biology.
[229] Ben Lehner,et al. Intrinsic Protein Disorder and Interaction Promiscuity Are Widely Associated with Dosage Sensitivity , 2009, Cell.
[230] A. Lindqvist,et al. Cdc25A localisation and shuttling: characterisation of sequences mediating nuclear export and import. , 2005, Experimental cell research.
[231] Jean-François Guichou,et al. Structural basis for the interaction between focal adhesion kinase and CD4. , 2008, Journal of molecular biology.
[232] Susan S. Taylor,et al. PDZK1: II. an anchoring site for the PKA-binding protein D-AKAP2 in renal proximal tubular cells. , 2003, Kidney international.
[233] V. Uversky,et al. Lipid-binding activity of intrinsically unstructured cytoplasmic domains of multichain immune recognition receptor signaling subunits. , 2006, Biochemistry.
[234] F. Fahrenholz,et al. Regulation of the α‐secretase ADAM10 by its prodomain and proprotein convertases , 2001 .
[235] J. Hurley,et al. Signaling and subcellular targeting by membrane-binding domains. , 2000, Annual review of biophysics and biomolecular structure.
[236] P. Jeffrey,et al. Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations. , 1994, Science.
[237] M. Eck,et al. The interplay of structural information and functional studies in kinase drug design: insights from BCR-Abl. , 2009, Current opinion in cell biology.
[238] Bridget S. Wilson,et al. High resolution mapping of mast cell membranes reveals primary and secondary domains of FcεRI and LAT , 2001, The Journal of cell biology.
[239] C. Ottmann,et al. Phosphorylation‐independent interaction between 14‐3‐3 and exoenzyme S: from structure to pathogenesis , 2007, The EMBO journal.
[240] E. Marcotte,et al. Disorder, Promiscuity, and Toxic Partnerships , 2009, Cell.
[241] A. Follis,et al. Intrinsic protein flexibility in regulation of cell proliferation: advantages for signaling and opportunities for novel therapeutics. , 2012, Advances in experimental medicine and biology.
[242] T. MacDonald,et al. Phase I clinical trial of cilengitide in children with refractory brain tumors: Pediatric Brain Tumor Consortium Study PBTC-012. , 2008, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[243] M. Blaser,et al. Helicobacter pylori CagA Phosphorylation Status Determines the gp130-activated SHP2/ERK and JAK/STAT Signal Transduction Pathways in Gastric Epithelial Cells* , 2010, The Journal of Biological Chemistry.
[244] R. Stupp,et al. Cilengitide: an RGD pentapeptide ανβ3 and ανβ5 integrin inhibitor in development for glioblastoma and other malignancies. , 2011, Future oncology.
[245] Jörg Gsponer,et al. Intrinsically disordered proteins: regulation and disease. , 2011, Current opinion in structural biology.
[246] C Terhorst,et al. Crystal structures of the XLP protein SAP reveal a class of SH2 domains with extended, phosphotyrosine-independent sequence recognition. , 1999, Molecular cell.
[247] Samir R Das,et al. Functional implications of the conformational switch in AICD peptide upon binding to Grb2-SH2 domain. , 2011, Journal of molecular biology.
[248] Norman E. Davey,et al. A Proteome-wide Screen for Mammalian SxIP Motif-Containing Microtubule Plus-End Tracking Proteins , 2012, Current Biology.
[249] Martin Würtele,et al. Structural view of a fungal toxin acting on a 14‐3‐3 regulatory complex , 2003, The EMBO journal.
[250] H. Piwnica-Worms,et al. Chk1 Kinase Negatively Regulates Mitotic Function of Cdc25A Phosphatase through 14-3-3 Binding , 2003, Molecular and Cellular Biology.
[251] Eilon Sherman,et al. The LAT story: a tale of cooperativity, coordination, and choreography. , 2010, Cold Spring Harbor perspectives in biology.
[252] R. Kriwacki,et al. Regulation of cell division by intrinsically unstructured proteins: intrinsic flexibility, modularity, and signaling conduits. , 2008, Biochemistry.
[253] Min Goo Lee,et al. Dynamic Regulation of Cystic Fibrosis Transmembrane Conductance Regulator by Competitive Interactions of Molecular Adaptors* , 2007, Journal of Biological Chemistry.
[254] Alan Ashworth,et al. Structural basis for recruitment of BRCA2 by PALB2 , 2009, EMBO reports.
[255] Arnaud Céol,et al. 3did: identification and classification of domain-based interactions of known three-dimensional structure , 2010, Nucleic Acids Res..
[256] M. Selbach,et al. Global quantification of mammalian gene expression control , 2011, Nature.
[257] Thomas Szyperski,et al. A structure-based model of the c-Myc/Bin1 protein interaction shows alternative splicing of Bin1 and c-Myc phosphorylation are key binding determinants. , 2005, Journal of molecular biology.
[258] Allegra Via,et al. Phospho.ELM: a database of phosphorylation sites—update 2008 , 2007, Nucleic Acids Res..
[259] Ben Lehner,et al. Tissue specificity and the human protein interaction network , 2009, Molecular systems biology.
[260] P. Jemth,et al. The binding mechanisms of intrinsically disordered proteins. , 2014, Physical chemistry chemical physics : PCCP.
[261] P. Bork,et al. Towards a structural basis of human non-synonymous single nucleotide polymorphisms. , 2000, Trends in genetics : TIG.
[262] H. G. Brunner,et al. A novel D458V mutation in the SANS PDZ binding motif causes atypical Usher syndrome , 2005, Journal of Molecular Medicine.
[263] S. Harrison,et al. Crystal structures of c-Src reveal features of its autoinhibitory mechanism. , 1999, Molecular cell.
[264] Michele Pagano,et al. Mechanisms and function of substrate recruitment by F-box proteins , 2013, Nature Reviews Molecular Cell Biology.
[265] C. Prives,et al. Transcriptional regulation by p53. , 2010, Cold Spring Harbor perspectives in biology.
[266] L. Bardwell,et al. Mechanisms of MAPK signalling specificity. , 2006, Biochemical Society transactions.
[267] P. Puigserver,et al. O-GlcNAc Regulates FoxO Activation in Response to Glucose* , 2008, Journal of Biological Chemistry.
[268] Mark Yeager,et al. Disulfide bond stabilization of the hexameric capsomer of human immunodeficiency virus. , 2010, Journal of molecular biology.
[269] M. Bollen,et al. The extended PP1 toolkit: designed to create specificity. , 2010, Trends in biochemical sciences.
[270] Shengqing Gu,et al. Loss of Tankyrase-Mediated Destruction of 3BP2 Is the Underlying Pathogenic Mechanism of Cherubism , 2011, Cell.
[271] M. Scully,et al. Modulation of integrin-binding selectivity by mutation within the RGD-loop of snake venom proteins: a novel drug development approach. , 2003, Current Medicinal Chemistry - Cardiovascular & Hematological Agents.
[272] P. Permi,et al. SH3 domain ligand binding: What's the consensus and where's the specificity? , 2012, FEBS letters.
[273] Paramita Sarkar,et al. Structural basis for regulation of the Crk signaling protein by a proline switch , 2010, Nature chemical biology.
[274] M. Řezáčová,et al. Protein and its function based on a subcellular localization , 2011, Journal of cellular biochemistry.
[275] J. Murray,et al. A family of cyclin D homologs from plants differentially controlled by growth regulators and containing the conserved retinoblastoma protein interaction motif. , 1995, The Plant cell.
[276] V. Pospelov,et al. Cyclin-dependent kinase inhibitor p21Waf1: Contemporary view on its role in senescence and oncogenesis , 2012, Biochemistry (Moscow).
[277] Hao G. Nguyen,et al. Mechanism of Aurora-B Degradation and Its Dependency on Intact KEN and A-Boxes: Identification of an Aneuploidy-Promoting Property , 2005, Molecular and Cellular Biology.
[278] E. Kipreos,et al. Multiple degradation pathways regulate versatile CIP/KIP CDK inhibitors. , 2012, Trends in cell biology.
[279] S. Munro,et al. A C-terminal signal prevents secretion of luminal ER proteins , 1987, Cell.
[280] K. Madura. The Ubiquitin-Associated (UBA) Domain: On the Path from Prudence to Prurience , 2002, Cell cycle.
[281] H. Rahn,et al. Identification of the nuclear localization signal of p21cip1 and consequences of its mutation on cell proliferation , 2002, FEBS letters.
[282] Xiaodong Wang,et al. DFF, a Heterodimeric Protein That Functions Downstream of Caspase-3 to Trigger DNA Fragmentation during Apoptosis , 1997, Cell.
[283] Swapnika Ramu,et al. Anti-angiogenesis and RGD-containing snake venom disintegrins. , 2007, Current pharmaceutical design.
[284] F. Dick,et al. An Overlapping Kinase and Phosphatase Docking Site Regulates Activity of the Retinoblastoma Protein , 2010, Nature Structural &Molecular Biology.
[285] P. Tompa. Intrinsically disordered proteins: a 10-year recap. , 2012, Trends in biochemical sciences.
[286] Bernard Ducommun,et al. CDC25 phosphatases in cancer cells: key players? Good targets? , 2007, Nature Reviews Cancer.
[287] P. Howley,et al. Ubiquitination of p53 and p21 is differentially affected by ionizing and UV radiation , 1997, Molecular and cellular biology.
[288] Fangyi Zhu,et al. Targeting the p53 pathway in retinoblastoma with subconjunctival Nutlin-3a. , 2011, Cancer research.
[289] H. DeLuca,et al. Molecular structure of the rat vitamin D receptor ligand binding domain complexed with 2-carbon-substituted vitamin D3 hormone analogues and a LXXLL-containing coactivator peptide. , 2004, Biochemistry.
[290] N. L. La Thangue,et al. p300/CBP proteins: HATs for transcriptional bridges and scaffolds. , 2001, Journal of cell science.
[291] J. Pereira-Leal,et al. Evolution of intracellular compartmentalization. , 2013, The Biochemical journal.
[292] Yanping Zhang,et al. Nucleocytoplasmic Shuttling of p53 Is Essential for MDM2-Mediated Cytoplasmic Degradation but Not Ubiquitination , 2003, Molecular and Cellular Biology.
[293] Nir London,et al. The structural basis of peptide-protein binding strategies. , 2010, Structure.
[294] Christopher J. Oldfield,et al. Intrinsically disordered proteins in human diseases: introducing the D2 concept. , 2008, Annual review of biophysics.
[295] Bin Zhang,et al. PhosphoSitePlus: a comprehensive resource for investigating the structure and function of experimentally determined post-translational modifications in man and mouse , 2011, Nucleic Acids Res..
[296] M. Babu,et al. The rules of disorder or why disorder rules. , 2009, Progress in biophysics and molecular biology.
[297] S. Nelson,et al. Mutations in the PCNA-binding domain of CDKN1C cause IMAGE Syndrome , 2012, Nature Genetics.
[298] J. Nathans,et al. Rhodopsin mutation proline347-to-alanine in a family with autosomal dominant retinitis pigmentosa indicates an important role for proline at position 347. , 1995, Human molecular genetics.
[299] P. Evans,et al. A structural explanation for the recognition of tyrosine-based endocytotic signals. , 1998, Science.
[300] Michael B Yaffe,et al. Proteomic Screen Finds pSer/pThr-Binding Domain Localizing Plk1 to Mitotic Substrates , 2003, Science.
[301] Hao Wu,et al. Higher-Order Assemblies in a New Paradigm of Signal Transduction , 2013, Cell.
[302] Leann Tilley,et al. Malaria parasite proteins that remodel the host erythrocyte , 2009, Nature Reviews Microbiology.
[303] S. Enosawa,et al. Brap2 Functions as a Cytoplasmic Retention Protein for p21 during Monocyte Differentiation , 2004, Molecular and Cellular Biology.
[304] E. Lundberg,et al. Towards a knowledge-based Human Protein Atlas , 2010, Nature Biotechnology.
[305] R. Liddington. Structural basis of protein-protein interactions. , 2015, Methods in molecular biology.
[306] J. Walter,et al. Mechanism of CRL4(Cdt2), a PCNA-dependent E3 ubiquitin ligase. , 2011, Genes & development.
[307] H. Dyson,et al. Intrinsically unstructured proteins and their functions , 2005, Nature Reviews Molecular Cell Biology.
[308] Christopher J. Schofield,et al. Structural basis for the recognition of hydroxyproline in HIF-1α by pVHL , 2002, Nature.
[309] Sreenath S. Andrali,et al. Modulation of transcription factor function by O-GlcNAc modification. , 2010, Biochimica et biophysica acta.
[310] D. Wotton,et al. The Interaction of the Carboxyl Terminus-binding Protein with the Smad Corepressor TGIF Is Disrupted by a Holoprosencephaly Mutation in TGIF* , 2000, The Journal of Biological Chemistry.
[311] Ravi Iyengar,et al. Mutation in SHOC2 promotes aberrant protein N-myristoylation and underlies Noonan-like syndrome with loose anagen hair , 2009, Nature Genetics.
[312] D. E. Anderson,et al. Two 14-3-3 binding motifs are required for stable association of Forkhead transcription factor FOXO4 with 14-3-3 proteins and inhibition of DNA binding. , 2003, Biochemistry.
[313] I. Reischl,et al. Dual Role of SLP-76 in Mediating T Cell Receptor-induced Activation of Phospholipase C-γ1* , 2007, Journal of Biological Chemistry.
[314] P. Gleeson,et al. New insights into membrane trafficking and protein sorting. , 2007, International review of cytology.
[315] E. Nishida,et al. A conserved docking motif in MAP kinases common to substrates, activators and regulators , 2000, Nature Cell Biology.
[316] Ying Qi,et al. Phosphorylation by Glycogen Synthase Kinase-3 Controls c-Myc Proteolysis and Subnuclear Localization* , 2003, Journal of Biological Chemistry.
[317] Niall J. Haslam,et al. Understanding eukaryotic linear motifs and their role in cell signaling and regulation. , 2008, Frontiers in bioscience : a journal and virtual library.
[318] A. Wentzel,et al. Inhibition of platelet aggregation by grafting RGD and KGD sequences on the structural scaffold of small disulfide-rich proteins , 2006, Platelets.
[319] Richard W. Kriwacki,et al. Cdk-Inhibitory Activity and Stability of p27 Kip1 Are Directly Regulated by Oncogenic Tyrosine Kinases , 2007, Cell.
[320] J. Pines,et al. Cyclin a Is Destroyed in Prometaphase and Can Delay Chromosome Alignment and Anaphase , 2001, The Journal of cell biology.
[321] Yigong Shi,et al. Structural Basis of Competitive Recognition of p53 and MDM2 by HAUSP/USP7: Implications for the Regulation of the p53–MDM2 Pathway , 2006, PLoS biology.
[322] Ivo Tews,et al. Specificity determinants of recruitment peptides bound to phospho-CDK2/cyclin A. , 2002, Biochemistry.
[323] C. Maki,et al. Cdk2-dependent Inhibition of p21 Stability via a C-terminal Cyclin-binding Motif* , 2005, Journal of Biological Chemistry.
[324] C. Arrowsmith,et al. Further insight into substrate recognition by USP7: structural and biochemical analysis of the HdmX and Hdm2 interactions with USP7. , 2010, Journal of molecular biology.
[325] N. Sagata,et al. Beta-TrCP recognizes a previously undescribed nonphosphorylated destruction motif in Cdc25A and Cdc25B phosphatases. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[326] Tony Hunter,et al. Why nature chose phosphate to modify proteins , 2012, Philosophical Transactions of the Royal Society B: Biological Sciences.
[327] A. Sorokin,et al. Nucleocytoplasmic transport of proteins , 2007, Biochemistry (Moscow).
[328] Peter E. Wright,et al. Graded enhancement of p53 binding to CREB-binding protein (CBP) by multisite phosphorylation , 2010, Proceedings of the National Academy of Sciences.
[329] H Jane Dyson,et al. Expanding the proteome: disordered and alternatively folded proteins , 2011, Quarterly Reviews of Biophysics.
[330] E. Decroly,et al. Maturation of HIV envelope glycoprotein precursors by cellular endoproteases. , 2000, Biochimica et biophysica acta.
[331] T. Fojo,et al. p53 Inhibits Hypoxia-inducible Factor-stimulated Transcription* , 1998, The Journal of Biological Chemistry.
[332] P. Simpson,et al. Crystallographic Analysis of Polypyrimidine Tract-Binding Protein-Raver1 Interactions Involved in Regulation of Alternative Splicing , 2011, Structure.
[333] C. Foresta,et al. Male infertility and androgen receptor gene mutations: clinical features and identification of seven novel mutations , 2006, Clinical endocrinology.
[334] Horst Kessler,et al. Cilengitide: The First Anti-Angiogenic Small Molecule Drug Candidate. Design, Synthesis and Clinical Evaluation , 2010, Anti-cancer agents in medicinal chemistry.
[335] Fergal P. Casey,et al. Approved Drug Mimics of Short Peptide Ligands from Protein Interaction Motifs , 2008, J. Chem. Inf. Model..
[336] Fabrizio Manetti,et al. Identification of the first non-peptidic small molecule inhibitor of the c-Abl/14-3-3 protein-protein interactions able to drive sensitive and Imatinib-resistant leukemia cells to apoptosis. , 2010, Bioorganic & medicinal chemistry letters.
[337] Sreenath V. Sharma,et al. Synthetic inhibitors of proline-rich ligand-mediated protein-protein interaction: potent analogs of UCS15A. , 2003, Chemistry & biology.
[338] Y Taya,et al. Activation of the ATM kinase by ionizing radiation and phosphorylation of p53. , 1998, Science.
[339] C. Maki,et al. The MDM2 RING-finger domain is required to promote p53 nuclear export , 2000, Nature Cell Biology.
[340] J Wade Harper,et al. Structure of a Fbw7-Skp1-cyclin E complex: multisite-phosphorylated substrate recognition by SCF ubiquitin ligases. , 2007, Molecular cell.
[341] D. Deretic,et al. Ciliary targeting motif VxPx directs assembly of a trafficking module through Arf4 , 2009, The EMBO journal.
[342] P. Pandolfi,et al. Role of SUMO-1-modified PML in nuclear body formation. , 2000, Blood.
[343] L. Hengst,et al. p27 Phosphorylation by Src Regulates Inhibition of Cyclin E-Cdk2 , 2007, Cell.
[344] Xianglin Shi,et al. Arsenite-induced Cdc25C degradation is through the KEN-box and ubiquitin–proteasome pathway , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[345] N. Pavletich,et al. Crystal structure of the tetramerization domain of the p53 tumor suppressor at 1.7 angstroms , 1995, Science.
[346] Yong Tae Kwon,et al. The N-end rule pathway. , 2012, Annual review of biochemistry.
[347] M Marsh,et al. The Simian Immunodeficiency Virus Envelope Glycoprotein Contains Multiple Signals that Regulate its Cell Surface Expression and Endocytosis , 2000, Traffic.
[348] A. Fischer,et al. A hypermorphic IκBα mutation is associated with autosomal dominant anhidrotic ectodermal dysplasia and T cell immunodeficiency , 2003 .
[349] G. Guy,et al. Structural basis for a novel intrapeptidyl H‐bond and reverse binding of c‐Cbl‐TKB domain substrates , 2008, The EMBO journal.
[350] A. Sali,et al. Structural basis for the specific interaction of lysine-containing proline-rich peptides with the N-terminal SH3 domain of c-Crk. , 1995, Structure.
[351] T. Pawson,et al. Reading protein modifications with interaction domains , 2006, Nature Reviews Molecular Cell Biology.
[352] R. Russell,et al. WD40 proteins propel cellular networks. , 2010, Trends in biochemical sciences.
[353] S. Carroll,et al. Evolution of an insect‐specific GROUCHO‐interaction motif in the ENGRAILED selector protein , 2008, Evolution & development.
[354] Cyrus Chothia,et al. Protein Family Expansions and Biological Complexity , 2006, PLoS Comput. Biol..
[355] Olivier Michielin,et al. Sequence Determinants of a Microtubule Tip Localization Signal (MtLS)* , 2012, The Journal of Biological Chemistry.
[356] N. Seidah,et al. The Multifaceted Proprotein Convertases: Their Unique, Redundant, Complementary, and Opposite Functions* , 2013, The Journal of Biological Chemistry.
[357] Joonhee Kim,et al. Structural basis for the recognition of N-end rule substrates by the UBR box of ubiquitin ligases , 2010, Nature Structural &Molecular Biology.
[358] R. Kingston,et al. WDR5 Interacts with Mixed Lineage Leukemia (MLL) Protein via the Histone H3-binding Pocket* , 2008, Journal of Biological Chemistry.
[359] E. Eisenmesser,et al. Structural and Biochemical Characterization of the Human Cyclophilin Family of Peptidyl-Prolyl Isomerases , 2010, PLoS biology.
[360] Jean-Yves Blay,et al. Effect of the MDM2 antagonist RG7112 on the P53 pathway in patients with MDM2-amplified, well-differentiated or dedifferentiated liposarcoma: an exploratory proof-of-mechanism study. , 2012, The Lancet. Oncology.
[361] Richard G. W. Anderson,et al. The J. D. mutation in familial hypercholesterolemia: Amino acid substitution in cytoplasmic domain impedes internalization of LDL receptors , 1986, Cell.
[362] R Kiplin Guy,et al. Novel selective inhibitors of the interaction of individual nuclear hormone receptors with a mutually shared steroid receptor coactivator 2. , 2003, Journal of the American Chemical Society.
[363] W. Gu,et al. p53 regulation by ubiquitin , 2011, FEBS letters.
[364] O. Bachs,et al. Binding of Calmodulin to the Carboxy-Terminal Region of p21 Induces Nuclear Accumulation via Inhibition of Protein Kinase C-Mediated Phosphorylation of Ser153 , 2005, Molecular and Cellular Biology.
[365] Norman E. Davey,et al. How viruses hijack cell regulation. , 2011, Trends in biochemical sciences.
[366] D. Bashford,et al. Incomplete Folding upon Binding Mediates Cdk4/Cyclin D Complex Activation by Tyrosine Phosphorylation of Inhibitor p27 Protein* , 2011, The Journal of Biological Chemistry.
[367] K. Han,et al. Post-translational chemical modification(s) of proteins. , 1992, The International journal of biochemistry.
[368] S. Teichmann,et al. Tight Regulation of Unstructured Proteins: From Transcript Synthesis to Protein Degradation , 2008, Science.
[369] H. Lane,et al. ERBB receptors and cancer: the complexity of targeted inhibitors , 2005, Nature Reviews Cancer.
[370] H. Dyson,et al. Intrinsically unstructured proteins: re-assessing the protein structure-function paradigm. , 1999, Journal of molecular biology.
[371] C. Marshall,et al. All ras proteins are polyisoprenylated but only some are palmitoylated , 1989, Cell.
[372] L. Schild,et al. Liddle disease caused by a missense mutation of beta subunit of the epithelial sodium channel gene. , 1996, The Journal of clinical investigation.
[373] K. Gustafson,et al. Erioflorin Stabilizes the Tumor Suppressor Pdcd4 by Inhibiting Its Interaction with the E3-ligase β-TrCP1 , 2012, PloS one.
[374] S. Arold,et al. Alternative Splicing Modulates Autoinhibition and SH3 Accessibility in the Src Kinase Fyn , 2009, Molecular and Cellular Biology.
[375] Wolfgang Link,et al. Protein localization in disease and therapy , 2011, Journal of Cell Science.
[376] Lawrence E. Samelson,et al. Early Phosphorylation Kinetics of Proteins Involved in Proximal TCR-Mediated Signaling Pathways , 2005, The Journal of Immunology.
[377] Tony Pawson,et al. Positive Selection of Tyrosine Loss in Metazoan Evolution , 2009, Science.
[378] Y. Shamoo,et al. Structural and thermodynamic analysis of human PCNA with peptides derived from DNA polymerase-delta p66 subunit and flap endonuclease-1. , 2004, Structure.
[379] Tony Pawson,et al. Modular evolution of phosphorylation-based signalling systems , 2012, Philosophical Transactions of the Royal Society B: Biological Sciences.
[380] G. Powis,et al. HIF-1 regulation: not so easy come, easy go. , 2008, Trends in biochemical sciences.
[381] A. Bauer,et al. RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling , 2011, Nature Cell Biology.
[382] Linda Smith,et al. Role of LXCXE motif-dependent interactions in the activity of the retinoblastoma protein , 2001, Oncogene.
[383] J Kuriyan,et al. Crystallographic analysis of the specific yet versatile recognition of distinct nuclear localization signals by karyopherin alpha. , 2000, Structure.
[384] V. Barr,et al. c-Cbl-Mediated Regulation of LAT-Nucleated Signaling Complexes , 2007, Molecular and Cellular Biology.
[385] L. Schild,et al. Defective regulation of the epithelial Na+ channel by Nedd4 in Liddle's syndrome. , 1999, The Journal of clinical investigation.
[386] Norman E. Davey,et al. Motif switches: decision-making in cell regulation. , 2012, Current opinion in structural biology.
[387] P. Snyder,et al. Nedd4-2 Catalyzes Ubiquitination and Degradation of Cell Surface ENaC* , 2007, Journal of Biological Chemistry.
[388] Philip D. Jeffrey,et al. Crystal structure of the p27Kip1 cyclin-dependent-kinase inibitor bound to the cyclin A–Cdk2 complex , 1996, Nature.
[389] T. Pawson,et al. Cell Signaling in Space and Time: Where Proteins Come Together and When They’re Apart , 2009, Science.
[390] M. McMullin,et al. Two new mutations in the HIF2A gene associated with erythrocytosis , 2012, American journal of hematology.
[391] Xinchen Wang,et al. Tissue-specific alternative splicing remodels protein-protein interaction networks. , 2012, Molecular cell.
[392] Toby J. Gibson,et al. Evidence for the Concerted Evolution between Short Linear Protein Motifs and Their Flanking Regions , 2009, PloS one.
[393] J. Pouwels,et al. Integrin inactivators: balancing cellular functions in vitro and in vivo , 2013, Nature Reviews Molecular Cell Biology.
[394] K. Praveen,et al. Nuclear bodies: random aggregates of sticky proteins or crucibles of macromolecular assembly? , 2009, Developmental cell.
[395] Joachim Nickel,et al. Dynamic Changes in C-Raf Phosphorylation and 14-3-3 Protein Binding in Response to Growth Factor Stimulation , 2004, Journal of Biological Chemistry.
[396] V. Uversky,et al. Why are “natively unfolded” proteins unstructured under physiologic conditions? , 2000, Proteins.
[397] M. Myers,et al. Phosphorylation-regulated Cleavage of the Tumor Suppressor PTEN by Caspase-3 , 2003, Journal of Biological Chemistry.
[398] Rakesh Joshi,et al. Phosphotyrosine recognition domains: the typical, the atypical and the versatile , 2012, Cell Communication and Signaling.
[399] A. Levine,et al. Structure of the MDM2 Oncoprotein Bound to the p53 Tumor Suppressor Transactivation Domain , 1996, Science.
[400] R. Zamoyska,et al. T cell receptor signalling networks: branched, diversified and bounded , 2013, Nature Reviews Immunology.
[401] B. Brüne,et al. p300 relieves p53-evoked transcriptional repression of hypoxia-inducible factor-1 (HIF-1). , 2004, The Biochemical journal.
[402] M. Tatham,et al. RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation , 2008, Nature Cell Biology.
[403] Vladimir Vacic,et al. Disease-Associated Mutations Disrupt Functionally Important Regions of Intrinsic Protein Disorder , 2012, PLoS Comput. Biol..
[404] B. Price,et al. Glycogen synthase kinase3 beta phosphorylates serine 33 of p53 and activates p53's transcriptional activity , 2001, BMC Cell Biology.
[405] A. Ramos,et al. Molecular basis of FIR-mediated c-myc transcriptional control , 2010, Nature Structural &Molecular Biology.
[406] Monika Fuxreiter,et al. Close encounters of the third kind: disordered domains and the interactions of proteins , 2009, BioEssays : news and reviews in molecular, cellular and developmental biology.
[407] Y. Nishimura,et al. The neural repressor NRSF/REST binds the PAH1 domain of the Sin3 corepressor by using its distinct short hydrophobic helix. , 2005, Journal of molecular biology.
[408] José D Faraldo-Gómez,et al. Molecular Mechanism of Selective Recruitment of Syk Kinases by the Membrane Antigen-Receptor Complex* , 2011, The Journal of Biological Chemistry.
[409] B. Gabrielli,et al. Mitotic Phosphorylation of Cdc25B Ser321 Disrupts 14-3-3 Binding to the High Affinity Ser323 Site* , 2010, The Journal of Biological Chemistry.
[410] P. Gilson,et al. Recent insights into the export of PEXEL/HTS-motif containing proteins in Plasmodium parasites. , 2012, Current opinion in microbiology.
[411] G. Feldmann,et al. Elucidation of a Universal Size-Control Mechanism in Drosophila and Mammals , 2007, Cell.
[412] J. H. Clements,et al. Protein-ligand interactions: thermodynamic effects associated with increasing nonpolar surface area. , 2011, Journal of the American Chemical Society.
[413] P. Hogan,et al. Balanced interactions of calcineurin with AKAP79 regulate Ca2+–calcineurin–NFAT signaling , 2012, Nature Structural &Molecular Biology.
[414] P Cicchetti,et al. Identification of a ten-amino acid proline-rich SH3 binding site. , 1993, Science.
[415] L. Vassilev,et al. In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2 , 2004, Science.
[416] A Keith Dunker,et al. Protein disorder in the human diseasome: unfoldomics of human genetic diseases , 2009, BMC Genomics.
[417] J. Greaves,et al. Jcb: Mini-review Introduction , 2022 .
[418] L. Samelson,et al. LAT: a T lymphocyte adapter protein that couples the antigen receptor to downstream signaling pathways. , 2004, BioEssays : news and reviews in molecular, cellular and developmental biology.
[419] M. Clarke,et al. A Bipartite Nuclear Localization Signal Is Required for p53 Nuclear Import Regulated by a Carboxyl-terminal Domain* , 1999, The Journal of Biological Chemistry.
[420] J. Kissil,et al. Identification and characterization of small molecule antagonists of pRb inactivation by viral oncoproteins. , 2012, Chemistry & biology.
[421] Vishva M. Dixit,et al. Ubiquitylation in apoptosis: a post-translational modification at the edge of life and death , 2011, Nature Reviews Molecular Cell Biology.
[422] O. Jensen. Modification-specific proteomics: characterization of post-translational modifications by mass spectrometry. , 2004, Current opinion in chemical biology.
[423] B. Clurman,et al. The SV40 Large T Antigen Contains a Decoy Phosphodegron That Mediates Its Interactions with Fbw7/hCdc4*♦ , 2005, Journal of Biological Chemistry.
[424] Kurt Wüthrich,et al. An EB1-Binding Motif Acts as a Microtubule Tip Localization Signal , 2009, Cell.
[425] Patrick Aloy,et al. Contextual Specificity in Peptide-Mediated Protein Interactions , 2008, PloS one.
[426] L. Nicholson,et al. Prolyl cis-trans isomerization as a molecular timer. , 2007, Nature chemical biology.
[427] J. Donaldson,et al. Localization and function of Arf family GTPases. , 2005, Biochemical Society transactions.
[428] B. Ducommun,et al. Differential mitotic degradation of the CDC25B phosphatase variants , 2007, Oncogene.
[429] J. Schwabe,et al. Mechanism of the nuclear receptor molecular switch. , 2004, Trends in biochemical sciences.
[430] C. Prives,et al. Cyclin A-CDK Phosphorylation Regulates MDM2 Protein Interactions* , 2001, The Journal of Biological Chemistry.
[431] R. Russell,et al. Linear motifs: Evolutionary interaction switches , 2005, FEBS letters.
[432] L. Zou,et al. Direct Role for Proliferating Cell Nuclear Antigen in Substrate Recognition by the E3 Ubiquitin Ligase CRL4Cdt2* , 2012, The Journal of Biological Chemistry.
[433] R. Heilker,et al. Recognition of sorting signals by clathrin adaptors , 1999, BioEssays : news and reviews in molecular, cellular and developmental biology.
[434] Joshua D. Schnell,et al. Epsins and Vps27p/Hrs contain ubiquitin-binding domains that function in receptor endocytosis , 2002, Nature Cell Biology.
[435] C. Pickart,et al. Ubiquitin: structures, functions, mechanisms. , 2004, Biochimica et biophysica acta.
[436] K. Takamune,et al. A family with Liddle's syndrome caused by a new missense mutation in the beta subunit of the epithelial sodium channel. , 1998, The Journal of clinical endocrinology and metabolism.
[437] G. Wahl,et al. The p53 orchestra: Mdm2 and Mdmx set the tone. , 2010, Trends in cell biology.
[438] Yasunori Kanaho,et al. Regulation of Bin1 SH3 domain binding by phosphoinositides , 2004, The EMBO journal.
[439] J. Chai,et al. Structural basis of EZH2 recognition by EED. , 2007, Structure.
[440] L. Langeberg,et al. Coordination of Three Signaling Enzymes by AKAP79, a Mammalian Scaffold Protein , 1996, Science.
[441] Martin E M Noble,et al. The Role of the Phospho-CDK2/Cyclin A Recruitment Site in Substrate Recognition* , 2006, Journal of Biological Chemistry.
[442] Irwin D Kuntz,et al. A selective irreversible inhibitor targeting a PDZ protein interaction domain. , 2003, Journal of the American Chemical Society.
[443] E. Appella,et al. Binding specificity of multiprotein signaling complexes is determined by both cooperative interactions and affinity preferences. , 2004, Biochemistry.
[444] Florian Gnad,et al. Mapping N-glycosylation sites across seven evolutionarily distant species reveals a divergent substrate proteome despite a common core machinery. , 2012, Molecular cell.
[445] Wendell A. Lim,et al. The pathogen protein EspFU hijacks actin polymerization using mimicry and multivalency , 2008, Nature.
[446] Alex Braiman,et al. Oligomerization of signaling complexes by the multipoint binding of GRB2 to both LAT and SOS1 , 2006, Nature Structural &Molecular Biology.
[447] Jimin Pei,et al. Cell-free Formation of RNA Granules: Low Complexity Sequence Domains Form Dynamic Fibers within Hydrogels , 2012, Cell.
[448] N. Reich,et al. Tracking STAT nuclear traffic , 2006, Nature Reviews Immunology.
[449] S. Teichmann,et al. The folding and evolution of multidomain proteins , 2007, Nature Reviews Molecular Cell Biology.
[450] Peter Tompa,et al. Unstructural biology coming of age. , 2011, Current opinion in structural biology.
[451] T. Strom,et al. Polypeptide GalNAc-transferase T3 and Familial Tumoral Calcinosis , 2006, Journal of Biological Chemistry.
[452] Jan Bayer,et al. Beta-catenin mutations in hepatocellular carcinoma correlate with a low rate of loss of heterozygosity , 1999, Oncogene.
[453] C. Fisher,et al. Antisense phosphorothioate oligonucleotides specifically down‐regulate cdc25B causing S‐phase delay and persistent antiproliferative effects , 1998, International journal of cancer.
[454] Stefanie Dimmeler,et al. Akt-Dependent Phosphorylation of p21Cip1 Regulates PCNA Binding and Proliferation of Endothelial Cells , 2001, Molecular and Cellular Biology.
[455] Yong Tae Kwon,et al. The N-end rule pathway: emerging functions and molecular principles of substrate recognition , 2011, Nature Reviews Molecular Cell Biology.
[456] L. Johnson,et al. Protein Kinase Inhibitors: Insights into Drug Design from Structure , 2004, Science.
[457] S. Master,et al. Erythrocytosis-associated HIF-2α Mutations Demonstrate a Critical Role for Residues C-terminal to the Hydroxylacceptor Proline* , 2009, Journal of Biological Chemistry.
[458] C. Dean,et al. Environmental-Dependent Acceleration of a Developmental Switch: The Floral Transition , 2000, Science's STKE.
[459] T. Pawson,et al. Post-translational modifications in signal integration , 2010, Nature Structural &Molecular Biology.
[460] H. Jane Dyson,et al. Cooperative regulation of p53 by modulation of ternary complex formation with CBP/p300 and HDM2 , 2009, Proceedings of the National Academy of Sciences.
[461] K. Pandey. Small peptide recognition sequence for intracellular sorting. , 2010, Current opinion in biotechnology.
[462] P. Philibert,et al. Isolated micropenis reveals partial androgen insensitivity syndrome confirmed by molecular analysis. , 2010, Asian journal of andrology.
[463] R. Roskoski. ERK1/2 MAP kinases: structure, function, and regulation. , 2012, Pharmacological research.
[464] Jean Chmielewski,et al. Inhibiting protein-protein interactions using designed molecules. , 2005, Current opinion in structural biology.
[465] Elaine Fuchs,et al. A common human skin tumour is caused by activating mutations in β-catenin , 1999, Nature Genetics.
[466] W. Lim,et al. Docking interactions in protein kinase and phosphatase networks. , 2006, Current opinion in structural biology.
[467] Andrea Carter. Integrins as target: first phase III trial launches, but questions remain. , 2010, Journal of the National Cancer Institute.
[468] G. Deuschl,et al. Prevalence of THAP1 sequence variants in German patients with primary dystonia , 2010, Movement disorders : official journal of the Movement Disorder Society.
[469] T. Pawson,et al. Enteropathogenic E. coli Tir binds Nck to initiate actin pedestal formation in host cells , 2001, Nature Cell Biology.
[470] R. Hay,et al. SUMO‐1 modification activates the transcriptional response of p53 , 1999, The EMBO journal.
[471] K. Schulze-Osthoff,et al. Many cuts to ruin: a comprehensive update of caspase substrates , 2003, Cell Death and Differentiation.
[472] L. Samelson,et al. Mutation of the phospholipase C-γ1–binding site of LAT affects both positive and negative thymocyte selection , 2005, The Journal of experimental medicine.
[473] J. Schlessinger,et al. Solution structure of the SH2 domain of Grb2 complexed with the Shc-derived phosphotyrosine-containing peptide. , 1999, Journal of molecular biology.
[474] R. D. Fisher,et al. Structure and Ubiquitin Binding of the Ubiquitin-interacting Motif* , 2003, Journal of Biological Chemistry.
[475] D. Hildebrand,et al. Protein Kinase C Delta (PKCδ) Affects Proliferation of Insulin-Secreting Cells by Promoting Nuclear Extrusion of the Cell Cycle Inhibitor p21Cip1/WAF1 , 2011, PloS one.
[476] L. Pearl,et al. Molecular recognition of transcriptional repressor motifs by the WD domain of the Groucho/TLE corepressor. , 2006, Molecular cell.
[477] Yingming Zhao,et al. Modification‐specific proteomics: Strategies for characterization of post‐translational modifications using enrichment techniques , 2009, Proteomics.
[478] B. Wendland. Epsins: adaptors in endocytosis? , 2002, Nature Reviews Molecular Cell Biology.
[479] Chiou-Hong Lin,et al. Structural and functional roles of Daxx SIM phosphorylation in SUMO paralog-selective binding and apoptosis modulation. , 2011, Molecular cell.
[480] G. Guy,et al. Additional Serine/Threonine Phosphorylation Reduces Binding Affinity but Preserves Interface Topography of Substrate Proteins to the c-Cbl TKB Domain , 2010, PloS one.
[481] J. Schwabe,et al. Nuclear hormone receptor co-repressors: Structure and function , 2012, Molecular and Cellular Endocrinology.
[482] T. Pawson,et al. Structural Basis and Sequence Rules for Substrate Recognition by Tankyrase Explain the Basis for Cherubism Disease , 2011, Cell.
[483] Ki Duk Park,et al. Identification of a lacosamide binding protein using an affinity bait and chemical reporter strategy: 14-3-3 ζ. , 2011, Journal of the American Chemical Society.
[484] K. Lumb,et al. Structurally distinct modes of recognition of the KIX domain of CBP by Jun and CREB. , 2002, Biochemistry.
[485] A. Kosaki,et al. Insulin-resistant diabetes due to a point mutation that prevents insulin proreceptor processing. , 1988, Science.
[486] G. Kozlov,et al. Structural basis of substrate recognition and specificity in the N-end rule pathway , 2010, Nature Structural &Molecular Biology.
[487] Gavin MacBeath,et al. A quantitative protein interaction network for the ErbB receptors using protein microarrays , 2006, Nature.
[488] M. Pagano,et al. Dual mode of degradation of Cdc25 A phosphatase , 2002, The EMBO journal.
[489] K. Kersse,et al. The death-fold superfamily of homotypic interaction motifs. , 2011, Trends in biochemical sciences.
[490] A. Giordano,et al. RB and cell cycle progression , 2006, Oncogene.
[491] R. Duden,et al. The α- and β′-COP WD40 Domains Mediate Cargo-selective Interactions with Distinct Di-lysine Motifs , 2003 .
[492] M. Pagano,et al. Structural basis of the Cks1-dependent recognition of p27(Kip1) by the SCF(Skp2) ubiquitin ligase. , 2005, Molecular cell.
[493] Christopher R. Jones,et al. An hPer2 Phosphorylation Site Mutation in Familial Advanced Sleep Phase Syndrome , 2001, Science.
[494] S. Puig,et al. A SUMOylation-defective MITF germline mutation predisposes to melanoma and renal carcinoma , 2011, Nature.
[495] A. Bougdour,et al. A Toxoplasma dense granule protein, GRA24, modulates the early immune response to infection by promoting a direct and sustained host p38 MAPK activation , 2013, The Journal of experimental medicine.
[496] Gerhard Wagner,et al. Structural basis for negative regulation of hypoxia-inducible factor-1α by CITED2 , 2003, Nature Structural Biology.
[497] E. Nishida,et al. Plk1 promotes nuclear translocation of human Cdc25C during prophase , 2002, EMBO reports.
[498] M. Sutcliffe,et al. Three-dimensional structure of the RGD-containing neurotoxin homologue dendroaspin , 1994, Nature Structural Biology.
[499] P. Hargrave,et al. Regulation of sorting and post-Golgi trafficking of rhodopsin by its C-terminal sequence QVS(A)PA. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[500] A. Forrest,et al. 14-3-3 Acts as an Intramolecular Bridge to Regulate cdc25B Localization and Activity* , 2003, Journal of Biological Chemistry.