Auditory cortex activity related to perceptual awareness versus masking of tone sequences

Sequences of repeating tones can be masked by other tones of different frequency. When these tone sequences are perceived, nevertheless, a prominent neural response in the auditory cortex is evoked by each tone of the sequence. When the targets are detected based on their isochrony, participants know that they are listening to the target once they detected it. To explore if the neural activity is more closely related to this detection task or to perceptual awareness, this magnetoencephalography (MEG) study used targets that could only be identified with cues provided after or before the masked target. In experiment 1, multiple mono-tone streams with jittered inter-stimulus interval were used, and the tone frequency of the target was indicated by a cue. Results showed no differential auditory cortex activity between hit and miss trials with post-stimulus cues. A late negative response for hit trials was only observed for pre-stimulus cues, suggesting a task-related component. Since experiment 1 provided no evidence for a link of a difference response with tone awareness, experiment 2 was planned to probe if detection of tone streams was linked to a difference response in auditory cortex. Random-tone sequences were presented in the presence of a multi-tone masker, and the sequence was repeated without masker thereafter. Results showed a prominent difference wave for hit compared to miss trials in experiment 2 evoked by targets in the presence of the masker. These results suggest that perceptual awareness of tone streams is linked to neural activity in auditory cortex.

[1]  R. Fay,et al.  Auditory perception of sound sources , 2007 .

[2]  Shihab A. Shamma,et al.  Hearing out repeating elements in randomly varying multitone sequences: a case of streaming?: From Sensory Processing to Perception , 2007 .

[3]  Alexander Gutschalk,et al.  A roadmap for the study of conscious audition and its neural basis , 2017, Philosophical Transactions of the Royal Society B: Biological Sciences.

[4]  Michael A. Pitts,et al.  Testing domain-general theories of perceptual awareness with auditory brain responses , 2015, Trends in Cognitive Sciences.

[5]  M. Posner,et al.  The attention system of the human brain: 20 years after. , 2012, Annual review of neuroscience.

[6]  S. Shamma,et al.  Interaction between Attention and Bottom-Up Saliency Mediates the Representation of Foreground and Background in an Auditory Scene , 2009, PLoS biology.

[7]  Bettina Sorger,et al.  Frequency-specific attentional modulation in human primary auditory cortex and midbrain , 2018, NeuroImage.

[8]  Alexander Gutschalk,et al.  Correlates of perceptual awareness in human primary auditory cortex revealed by an informational masking experiment , 2012, NeuroImage.

[9]  James A. O'Sullivan,et al.  Evidence for Neural Computations of Temporal Coherence in an Auditory Scene and Their Enhancement during Active Listening , 2015, The Journal of Neuroscience.

[10]  Sabine Heiland,et al.  Cortical networks for auditory detection with and without informational masking: Task effects and implications for conscious perception , 2018, NeuroImage.

[11]  L. V. Noorden Temporal coherence in the perception of tone sequences , 1975 .

[12]  F. Ohl,et al.  Representation of Auditory Task Components and of Their Relationships in Primate Auditory Cortex , 2020, Frontiers in Neuroscience.

[13]  S. Hillyard,et al.  Endogenous brain potentials associated with selective auditory attention. , 1980, Electroencephalography and clinical neurophysiology.

[14]  A. Oxenham,et al.  Neural Correlates of Auditory Perceptual Awareness under Informational Masking , 2008, PLoS biology.

[15]  M. Chait,et al.  Inattentional Deafness: Visual Load Leads to Time-Specific Suppression of Auditory Evoked Responses , 2015, The Journal of Neuroscience.

[16]  B. Shinn-Cunningham,et al.  Informational masking: counteracting the effects of stimulus uncertainty by decreasing target-masker similarity. , 2003, The Journal of the Acoustical Society of America.

[17]  Maria Chait,et al.  Auditory Figure-Ground Segregation Is Impaired by High Visual Load , 2017, The Journal of Neuroscience.

[18]  M. Chait,et al.  Brain Bases for Auditory Stimulus-Driven Figure–Ground Segregation , 2011, The Journal of Neuroscience.

[19]  P. H. Lindsay,et al.  Evoked Potential Correlates of Auditory Signal Detection , 1971, Science.

[20]  Uta Noppeney,et al.  Detecting tones in complex auditory scenes , 2015, NeuroImage.

[21]  R. Näätänen,et al.  Early selective-attention effect on evoked potential reinterpreted. , 1978, Acta psychologica.

[22]  D. Woods,et al.  Signal clustering modulates auditory cortical activity in humans , 1994, Perception & psychophysics.

[23]  M. Scherg,et al.  Neuromagnetic Correlates of Streaming in Human Auditory Cortex , 2005, The Journal of Neuroscience.

[24]  S. David,et al.  State-dependent encoding of sound and behavioral meaning in a tertiary region of the ferret auditory cortex , 2018, Nature Neuroscience.

[25]  D. Pressnitzer,et al.  Implicit versus explicit frequency comparisons: two mechanisms of auditory change detection. , 2011, Journal of experimental psychology. Human perception and performance.

[26]  D. M. Green,et al.  Masking produced by spectral uncertainty with multicomponent maskers , 1987, Perception & psychophysics.

[27]  John J. Foxe,et al.  At what time is the cocktail party? A late locus of selective attention to natural speech , 2012, The European journal of neuroscience.

[28]  J. Simon,et al.  Emergence of neural encoding of auditory objects while listening to competing speakers , 2012, Proceedings of the National Academy of Sciences.

[29]  R. Hari,et al.  Auditory attention affects two different areas in the human supratemporal cortex. , 1991, Electroencephalography and clinical neurophysiology.

[30]  Michael Brosch,et al.  Associations between sounds and actions in early auditory cortex of nonhuman primates , 2019, eLife.

[31]  Jonathan Z. Simon,et al.  Robust cortical entrainment to the speech envelope relies on the spectro-temporal fine structure , 2014, NeuroImage.

[32]  M. Posner Attention: the mechanisms of consciousness. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[33]  N A Macmillan,et al.  Detection theory analysis of group data: estimating sensitivity from average hit and false-alarm rates. , 1985, Psychological bulletin.

[34]  Andrew R. Dykstra,et al.  Does the mismatch negativity operate on a consciously accessible memory trace? , 2015, Science Advances.

[35]  Alexander Gutschalk,et al.  Functional lateralization in auditory cortex under informational masking and in silence , 2012, The European journal of neuroscience.

[36]  Andrew R. Dykstra,et al.  Neural Correlates of Auditory Perceptual Awareness and Release from Informational Masking Recorded Directly from Human Cortex: A Case Study , 2016, Front. Neurosci..

[37]  Lars Hausfeld,et al.  Effects of Cross-modal Asynchrony on Informational Masking in Human Cortex , 2017, Journal of Cognitive Neuroscience.

[38]  H S Colburn,et al.  Reducing informational masking by sound segregation. , 1994, The Journal of the Acoustical Society of America.

[39]  Patrick Berg,et al.  Artifact Correction of the Ongoing EEG Using Spatial Filters Based on Artifact and Brain Signal Topographies , 2002, Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society.

[40]  R. Desimone,et al.  Neural mechanisms of selective visual attention. , 1995, Annual review of neuroscience.