Metabolic support of tumor-infiltrating regulatory T cells by lactic acid

[1]  Linda V. Sinclair,et al.  Single Cell Glucose Uptake Assays: A Cautionary Tale , 2020, Immunometabolism.

[2]  J. Rothstein,et al.  Monocarboxylate transporter 1 in Schwann cells contributes to maintenance of sensory nerve myelination during aging , 2020, Glia.

[3]  J. Rothstein,et al.  Monocarboxylate transporter 1 in Schwann cells is critical for maintenance of sensory nerve myelination during aging , 2019, bioRxiv.

[4]  Y. Najjar,et al.  Tumor cell oxidative metabolism as a barrier to PD-1 blockade immunotherapy in melanoma. , 2019, JCI insight.

[5]  D. Ford,et al.  TLR8-Mediated Metabolic Control of Human Treg Function: A Mechanistic Target for Cancer Immunotherapy. , 2019, Cell metabolism.

[6]  M. Mehta,et al.  Mitochondrial complex III is essential for suppressive function of regulatory T cells , 2019, Nature.

[7]  Kelsey K. Finn,et al.  Cutting Edge: TGF-β and Phosphatidylinositol 3-Kinase Signals Modulate Distinct Metabolism of Regulatory T Cell Subsets , 2018, The Journal of Immunology.

[8]  J. Bluestone,et al.  Targeting EZH2 Reprograms Intratumoral Regulatory T Cells to Enhance Cancer Immunity , 2018, Cell reports.

[9]  H. Young,et al.  Early TCR Signaling Induces Rapid Aerobic Glycolysis Enabling Distinct Acute T Cell Effector Functions , 2018, Cell reports.

[10]  Joshua D. Rabinowitz,et al.  Glucose feeds the TCA cycle via circulating lactate , 2017, Nature.

[11]  Ping-Chih Ho,et al.  Metabolic Regulation of Tregs in Cancer: Opportunities for Immunotherapy. , 2017, Trends in cancer.

[12]  D. Wallace,et al.  Foxp3 Reprograms T Cell Metabolism to Function in Low-Glucose, High-Lactate Environments. , 2017, Cell metabolism.

[13]  J. Kirkwood,et al.  Interferon-γ Drives Treg Fragility to Promote Anti-tumor Immunity , 2017, Cell.

[14]  F. Issa.  Foxp3 and Toll-Like Receptor Signaling Balance Treg Cell Anabolic Metabolism for Suppression , 2017 .

[15]  M. Warmoes,et al.  Foxp3 and Toll-like receptor signaling balance Treg cell anabolic metabolism for suppression , 2016, Nature Immunology.

[16]  G. Schiera,et al.  Lactate as a Metabolite and a Regulator in the Central Nervous System , 2016, International journal of molecular sciences.

[17]  Simon C Watkins,et al.  The Tumor Microenvironment Represses T Cell Mitochondrial Biogenesis to Drive Intratumoral T Cell Metabolic Insufficiency and Dysfunction. , 2016, Immunity.

[18]  Xinyu Liu,et al.  Cyanine-based 1-amino-1-deoxyglucose as fluorescent probes for glucose transporter mediated bioimaging. , 2016, Biochemical and biophysical research communications.

[19]  J. C. Love,et al.  PD-1 marks dysfunctional regulatory T cells in malignant gliomas. , 2016, JCI insight.

[20]  F. Carbone,et al.  The Proteomic Landscape of Human Ex Vivo Regulatory and Conventional T Cells Reveals Specific Metabolic Requirements , 2016, Immunity.

[21]  F. Sanchez-Garcia,et al.  Lactate Contribution to the Tumor Microenvironment: Mechanisms, Effects on Immune Cells and Therapeutic Relevance , 2016, Front. Immunol..

[22]  J. Locasale,et al.  Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses , 2015, Cell.

[23]  Yuh-Seog Jung,et al.  CD200: Association with cancer stem cell features and response to chemoradiation in head and neck squamous cell carcinoma , 2015, Head & neck.

[24]  G. Cline,et al.  Functional polarization of tumour-associated macrophages by tumour-derived lactic acid , 2014, Nature.

[25]  J. Rathmell,et al.  The glucose transporter Glut1 is selectively essential for CD4 T cell activation and effector function. , 2014, Cell metabolism.

[26]  A. Rudensky,et al.  Metabolites produced by commensal bacteria promote peripheral regulatory T cell generation , 2013, Nature.

[27]  D. Finkelstein,et al.  Stability and function of regulatory T cells is maintained by a neuropilin-1–semaphorin-4a axis , 2013, Nature.

[28]  W. Garrett,et al.  The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic Treg Cell Homeostasis , 2013, Science.

[29]  B. Faubert,et al.  Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis , 2013, Cell.

[30]  A. Halestrap,et al.  The monocarboxylate transporter family—Role and regulation , 2012, IUBMB life.

[31]  M. V. Vander Heiden,et al.  Aerobic glycolysis: meeting the metabolic requirements of cell proliferation. , 2011, Annual review of cell and developmental biology.

[32]  C. Benoist,et al.  A cluster of coregulated genes determines TGF-β–induced regulatory T-cell (Treg) dysfunction in NOD mice , 2011, Proceedings of the National Academy of Sciences.

[33]  Marcel Martin.  Cutadapt removes adapter sequences from high-throughput sequencing reads , 2011 .

[34]  J. Rathmell,et al.  Cutting Edge: Distinct Glycolytic and Lipid Oxidative Metabolic Programs Are Essential for Effector and Regulatory CD4+ T Cell Subsets , 2011, The Journal of Immunology.

[35]  D. Hanahan,et al.  Hallmarks of Cancer: The Next Generation , 2011, Cell.

[36]  Christophe Benoist,et al.  Stability of the Regulatory T Cell Lineage in Vivo , 2010, Science.

[37]  D. Vignali,et al.  T cell islet accumulation in type 1 diabetes is a tightly regulated, cell-autonomous event. , 2009, Immunity.

[38]  D. Ostanin,et al.  T cell transfer model of chronic colitis: concepts, considerations, and tricks of the trade. , 2009, American journal of physiology. Gastrointestinal and liver physiology.

[39]  F. Kamme,et al.  Lactate Inhibits Lipolysis in Fat Cells through Activation of an Orphan G-protein-coupled Receptor, GPR81* , 2009, Journal of Biological Chemistry.

[40]  T. Nomura,et al.  Regulatory T Cells and Immune Tolerance , 2008, Cell.

[41]  E. Chi,et al.  Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces. , 2008, Immunity.

[42]  Gregor Rothe,et al.  Inhibitory effect of tumor cell-derived lactic acid on human T cells. , 2007, Blood.

[43]  A. Halestrap,et al.  The Kinetics, Substrate, and Inhibitor Specificity of the Monocarboxylate (Lactate) Transporter of Rat Liver Cells Determined Using the Fluorescent Intracellular pH Indicator, 2′,7′-Bis(carboxyethyl)-5(6)-carboxyfluorescein (*) , 1996, The Journal of Biological Chemistry.

[44]  A. Consoli,et al.  Contribution of liver and skeletal muscle to alanine and lactate metabolism in humans. , 1990, The American journal of physiology.

[45]  B. Robinson,et al.  3‐Mercaptopicolinic acid, a preferential inhibitor of the cytosolic phosphoenolpyruvate carboxykinase , 1975, FEBS letters.

[46]  Simon C Watkins,et al.  The Tumor Microenvironment Represses T Cell Mitochondrial Biogenesis to Drive Intratumoral T Cell Metabolic Insufficiency and Dysfunction. , 2016, Immunity.

[47]  G. Collins.  The next generation. , 2006, Scientific American.

[48]  R. Oswald.  A cautionary tale. , 1994, Accident and emergency nursing.