Angiotensin converting enzyme I/D polymorphism and sarcoidosis risk.

BACKGROUND This meta-analysis investigates the associations of angiotensin-converting enzyme (ACE) polymorphism and risk of sarcoidosis. MATERIAL AND METHOD Two reviewers independently searched three databases including PubMed, EMBASE, and Cochrane database to identify published studies. Full texts of the selected studies were accessed and related data was extracted using a standardized data extraction form. RESULTS A total of 18 studies contained a total of 1626 patients with sarcoidosis in case group and 2465 healthy controls in control group. Results of the current meta-analysis revealed that ACE DD genotype was associated with a significantly increased risk of sarcoidosis (OR=1.21; 95% CI, 1.06-1.38; I2=48%). In the race subgroup analysis, Asians with ACE DD genotype showed no significant increased risk of sarcoidosis (OR=1.37; 95% CI, 0.94-1.99; I2=78%). Caucasians with ACE DD genotype had an increased sarcoidosis risk (OR=1.16; 95% CI, 1.01-1.36; I2=24%). CONCLUSIONS Our meta-analysis indicated that the ACE DD genotype correlated with an increased risk of sarcoidosis.

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