Canine oral papillomatosis. I. Virus assay and observations on the various stages of the experimental infection.

T h e infect ious na tu r e of c an ine oral papil loma tos i s was descr ibed by P e n b e r t h y (5) and by M ' F a d y e a n a n d H o b d a y (4) in 1898. A virus was s h o w n to be the causa t ive a g e n t of the disease by :Findlay (~) in 1980. Later , D e M o n b r e u n and G o o d p a s t u r e (1) a n d G o o d l o w (8) i nocu l a t ed y o u n g dogs wi th t u m o r ex t rac t s and f i l t rates and s t ud i ed t he progress ion and t he regress ion of t he pap i l lomas . T h e p re sen t s t u d y was u n d e r t a k e n to ga in m o r e c o m p r e h e n s i v e i n f o r m a t i o n a b o u t the v i rus a n d the in fec t ion i t causes and to inves t iga t e new technics t h a t m i g h t fac i l i ta te f u r t he r work wi th th is virus.