Nanotech approaches to drug delivery and imaging.

Nanotechnology, a multidisciplinary scientific undertaking, involves creation and utilization of materials, devices or systems on the nanometer scale. The field of nanotechnology is currently undergoing explosive development on many fronts. The technology is expected to create innovations and play a critical role in various biomedical applications, not only in drug delivery, but also in molecular imaging, biomarkers and biosensors. Target-specific drug therapy and methods for early diagnosis of pathologies are the priority research areas where nanotechnology would play a vital role. This review considers different nanotechnology-based drug delivery and imaging approaches, and their economic impact on pharmaceutical and biomedical industries.

[1]  N. Shaik,et al.  Drug efflux transporters in the CNS. , 2003, Advanced drug delivery reviews.

[2]  S K Jain,et al.  Self-Assembled Carbohydrate-Stabilized Ceramic Nanoparticles for the Parenteral Delivery of Insulin , 2000, Drug development and industrial pharmacy.

[3]  Kerry K. Karukstis,et al.  Targeted Antiproliferative Drug Delivery to Vascular Smooth Muscle Cells With a Magnetic Resonance Imaging Nanoparticle Contrast Agent: Implications for Rational Therapy of Restenosis , 2002, Circulation.

[4]  V. Torchilin,et al.  Structure and design of polymeric surfactant-based drug delivery systems. , 2001, Journal of controlled release : official journal of the Controlled Release Society.

[5]  Lasic Dd,et al.  Sterically stabilized liposomes in cancer therapy and gene delivery. , 1999 .

[6]  T. Allen,et al.  Liposomes , 2012, Drugs.

[7]  Peter Mitchell,et al.  Turning the spotlight on cellular imaging , 2001, Nature Biotechnology.

[8]  F. Hirayama,et al.  Effects of structure of polyamidoamine dendrimer on gene transfer efficiency of the dendrimer conjugate with alpha-cyclodextrin. , 2002, Bioconjugate chemistry.

[9]  S. Jain,et al.  Dendrimer grafts for delivery of 5-fluorouracil. , 2002, Die Pharmazie.

[10]  S Blackwell,et al.  Novel effects with polyethylene glycol modified pharmaceuticals. , 2002, Cancer treatment reviews.

[11]  T. Okano,et al.  Selective delivery of adriamycin to a solid tumor using a polymeric micelle carrier system. , 1999, Journal of drug targeting.

[12]  P. Prasad,et al.  Silica nanobubbles containing an organic dye in a multilayered organic/inorganic heterostructure with enhanced luminescence , 2000 .

[13]  T. Okano,et al.  Reduction of the Side Effects of an Antitumor Agent, KRN5500, by Incorporation of the Drug into Polymeric Micelles , 1999, Japanese journal of cancer research : Gann.

[14]  S. Nie,et al.  Quantum-dot-tagged microbeads for multiplexed optical coding of biomolecules , 2001, Nature Biotechnology.

[15]  C. Passirani,et al.  Long-Circulating Nanopartides Bearing Heparin or Dextran Covalently Bound to Poly(Methyl Methacrylate) , 1998, Pharmaceutical Research.

[16]  Indrajit Roy,et al.  Calcium phosphate nanoparticles as novel non-viral vectors for targeted gene delivery. , 2003, International journal of pharmaceutics.

[17]  Sanyog Jain,et al.  RGD-anchored magnetic liposomes for monocytes/neutrophils-mediated brain targeting. , 2003, International journal of pharmaceutics.

[18]  P. Couvreur,et al.  Nanoparticles in cancer therapy and diagnosis. , 2002, Advanced drug delivery reviews.

[19]  Paul A Dayton,et al.  Targeted imaging using ultrasound , 2002, Journal of magnetic resonance imaging : JMRI.

[20]  J M Wilkinson,et al.  Nanotechnology applications in medicine. , 2003, Medical device technology.

[21]  Thomas Wisniewski,et al.  Detection of Alzheimer's amyloid in transgenic mice using magnetic resonance microimaging , 2003, Magnetic resonance in medicine.

[22]  S. Davis,et al.  Biomedical applications of nanotechnology--implications for drug targeting and gene therapy. , 1997, Trends in biotechnology.

[23]  Keiji Oi,et al.  Application of Nanoparticle Technology for the Prevention of Restenosis After Balloon Injury in Rats , 2003, Circulation research.

[24]  A. Bangham,et al.  Diffusion of univalent ions across the lamellae of swollen phospholipids. , 1965, Journal of molecular biology.

[25]  H. Maeda The enhanced permeability and retention (EPR) effect in tumor vasculature: the key role of tumor-selective macromolecular drug targeting. , 2001, Advances in enzyme regulation.

[26]  D. Crommelin,et al.  Superoxide dismutase entrapped in long-circulating liposomes: formulation design and therapeutic activity in rat adjuvant arthritis. , 2002, Biochimica et biophysica acta.

[27]  H. Klok,et al.  Advanced drug delivery devices via self-assembly of amphiphilic block copolymers. , 2001, Advanced drug delivery reviews.

[28]  M. Jones,et al.  Polymeric micelles - a new generation of colloidal drug carriers. , 1999, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[29]  S M Moghimi,et al.  Long-circulating and target-specific nanoparticles: theory to practice. , 2001, Pharmacological reviews.

[30]  Vladimir P. Torchilin,et al.  Immunomicelles: Targeted pharmaceutical carriers for poorly soluble drugs , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[31]  Francis C Szoka,et al.  Polyester dendritic systems for drug delivery applications: in vitro and in vivo evaluation. , 2002, Bioconjugate chemistry.

[32]  C. Cain,et al.  Comparison of methods for erythroblast selection: application to selecting fetal erythroblasts from maternal blood. , 2001, Cytometry.

[33]  Y. Sugiyama,et al.  Cisplatin-Loaded Polymer-Metal Complex Micelle with Time-Modulated Decaying Property as a Novel Drug Delivery System , 2001, Pharmaceutical Research.

[34]  V. Torchilin,et al.  Biodegradable long-circulating polymeric nanospheres. , 1994, Science.

[35]  G. Kwon,et al.  Block Copolymer Micelles for the Encapsulation and Delivery of Amphotericin B , 2002, Pharmaceutical Research.

[36]  Peter Babinec,et al.  High-Gradient Magnetic Capture of Ferrofluids: Implications for Drug Targeting and Tumor Embolization , 2001, Zeitschrift fur Naturforschung. C, Journal of biosciences.

[37]  H. Maeda,et al.  Pegylated zinc protoporphyrin: a water-soluble heme oxygenase inhibitor with tumor-targeting capacity. , 2002, Bioconjugate chemistry.

[38]  H E Junginger,et al.  In Vivo Uptake of Chitosan Microparticles by Murine Peyer's Patches: Visualization Studies using Confocal Laser Scanning Microscopy and Immunohistochemistry , 2001, Journal of drug targeting.

[39]  N Hussain,et al.  Recent advances in the understanding of uptake of microparticulates across the gastrointestinal lymphatics. , 2001, Advanced drug delivery reviews.

[40]  D D Allen,et al.  Nanoparticle Technology for Drug Delivery Across the Blood-Brain Barrier , 2002, Drug development and industrial pharmacy.

[41]  D. Begley,et al.  Direct Evidence That Polysorbate-80-Coated Poly(Butylcyanoacrylate) Nanoparticles Deliver Drugs to the CNS via Specific Mechanisms Requiring Prior Binding of Drug to the Nanoparticles , 2003, Pharmaceutical Research.

[42]  Raoul Kopelman,et al.  A fluorescent PEBBLE nanosensor for intracellular free zinc. , 2002, The Analyst.

[43]  Indrajit Roy,et al.  Ceramic-based nanoparticles entrapping water-insoluble photosensitizing anticancer drugs: a novel drug-carrier system for photodynamic therapy. , 2003, Journal of the American Chemical Society.

[44]  D. Maysinger,et al.  Micellar Nanocontainers Distribute to Defined Cytoplasmic Organelles , 2003, Science.

[45]  Gordon L. Amidon,et al.  The Mechanism of Uptake of Biodegradable Microparticles in Caco-2 Cells Is Size Dependent , 1997, Pharmaceutical Research.

[46]  D. Fischer,et al.  Surface-modified biodegradable albumin nano- and microspheres. II: effect of surface charges on in vitro phagocytosis and biodistribution in rats. , 1998, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[47]  Robert Langer,et al.  Moving smaller in drug discovery and delivery , 2002, Nature Reviews Drug Discovery.

[48]  E J Topol,et al.  Local intraluminal infusion of biodegradable polymeric nanoparticles. A novel approach for prolonged drug delivery after balloon angioplasty. , 1996, Circulation.

[49]  A. Maitra,et al.  Nanometer Silica Particles Encapsulating Active Compounds: A Novel Ceramic Drug Carrier , 1998 .

[50]  D. Huhn,et al.  Preclinical experiences with magnetic drug targeting: tolerance and efficacy. , 1996, Cancer research.

[51]  N. Nishiyama,et al.  Polymeric micelle drug carrier systems: PEG-PAsp(Dox) and second generation of micellar drugs. , 2003, Advances in experimental medicine and biology.

[52]  S. Nie,et al.  Luminescent quantum dots for multiplexed biological detection and imaging. , 2002, Current opinion in biotechnology.

[53]  V. Labhasetwar,et al.  Characterization of nanoparticle uptake by endothelial cells. , 2002, International journal of pharmaceutics.

[54]  R. Langer,et al.  Drug delivery and targeting. , 1998, Nature.

[55]  K. Kataoka,et al.  Block copolymer micelles for drug delivery: design, characterization and biological significance. , 2001, Advanced drug delivery reviews.

[56]  Alexander M. Klibanov,et al.  Conjugation to gold nanoparticles enhances polyethylenimine's transfer of plasmid DNA into mammalian cells , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[57]  R K Jain,et al.  Augmentation of transvascular transport of macromolecules and nanoparticles in tumors using vascular endothelial growth factor. , 1999, Cancer research.

[58]  W. Pan,et al.  Interleukin-10 as a CNS therapeutic: the obstacle of the blood-brain/blood-spinal cord barrier. , 2003, Brain research. Molecular brain research.

[59]  W. Ford,et al.  Surface modification of colloidal silica , 1990 .

[60]  Jayanth Panyam,et al.  Rapid endo‐lysosomal escape of poly(DL‐lactide‐coglycolide) nanoparticles: implications for drug and gene delivery , 2002, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[61]  T. Okano,et al.  Development of the polymer micelle carrier system for doxorubicin. , 2001, Journal of controlled release : official journal of the Controlled Release Society.

[62]  Jayanth Panyam,et al.  Fluorescence and electron microscopy probes for cellular and tissue uptake of poly(D,L-lactide-co-glycolide) nanoparticles. , 2003, International journal of pharmaceutics.

[63]  Robert S Fisher,et al.  Potential New Methods for Antiepileptic Drug Delivery , 2002, CNS drugs.

[64]  H. Clark,et al.  Optical nanosensors for chemical analysis inside single living cells. 2. Sensors for pH and calcium and the intracellular application of PEBBLE sensors. , 1999, Analytical chemistry.

[65]  R. McDermott,et al.  Ultrasensitive magnetic biosensor for homogeneous immunoassay. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[66]  J Henke,et al.  Magnetofection: enhancing and targeting gene delivery by magnetic force in vitro and in vivo , 2002, Gene Therapy.

[67]  A. Sbarbati,et al.  In Vitro and In Vivo Study of Solid Lipid Nanoparticles Loaded with Superparamagnetic Iron Oxide , 2003, Journal of drug targeting.

[68]  Jayanth Panyam,et al.  Biodegradable nanoparticles for drug and gene delivery to cells and tissue. , 2003, Advanced drug delivery reviews.

[69]  Thommey P. Thomas,et al.  Design and Function of a Dendrimer-Based Therapeutic Nanodevice Targeted to Tumor Cells Through the Folate Receptor , 2002, Pharmaceutical Research.

[70]  M. Roco Nanotechnology: convergence with modern biology and medicine. , 2003, Current opinion in biotechnology.

[71]  Christopher G Thanos,et al.  Nanotechnology and medicine , 2003, Expert opinion on biological therapy.

[72]  James R. Dewald,et al.  A New Class of Polymers: Starburst-Dendritic Macromolecules , 1985 .

[73]  G. Tsavellas,et al.  Flow cytometry correlates with RT-PCR for detection of spiked but not circulating colorectal cancer cells , 2004, Clinical & Experimental Metastasis.

[74]  N. Nishiyama,et al.  Cisplatin‐incorporated Polymeric Micelles Eliminate Nephrotoxicity, While Maintaining Antitumor Activity , 2001, Japanese journal of cancer research : Gann.

[75]  G. Kwon,et al.  Amphotericin B encapsulated in micelles based on poly(ethylene oxide)-block-poly(L-amino acid) derivatives exerts reduced in vitro hemolysis but maintains potent in vivo antifungal activity. , 2003, Biomacromolecules.

[76]  Hiroyuki Honda,et al.  Tumor regression by combined immunotherapy and hyperthermia using magnetic nanoparticles in an experimental subcutaneous murine melanoma , 2003, Cancer science.

[77]  Mihail C. Roco,et al.  Converging Technologies for Improving Human Performance , 2003 .

[78]  Y. Barenholz,et al.  Development of liposomal anthracyclines: from basics to clinical applications. , 1998, Journal of controlled release : official journal of the Controlled Release Society.

[79]  V. Labhasetwar,et al.  Efficiency of Dispatch ® and Infiltrator ® Cardiac Infusion Catheters in Arterial Localization of Nanoparticles in a Porcine Coronary Model of Restenosis , 2002, Journal of drug targeting.

[80]  V. Labhasetwar,et al.  Sustained cytoplasmic delivery of drugs with intracellular receptors using biodegradable nanoparticles. , 2004, Molecular pharmaceutics.

[81]  John Samuel,et al.  Analysis of Poly(D,L-Lactic-Co-Glycolic Acid) Nanosphere Uptake by Human Dendritic Cells and Macrophages In Vitro , 2002, Pharmaceutical Research.

[82]  Y. Kawashima,et al.  Biodegradable nanoparticles for targeted drug delivery in treatment of inflammatory bowel disease. , 2001, The Journal of pharmacology and experimental therapeutics.

[83]  Gordon L. Amidon,et al.  Gastrointestinal Uptake of Biodegradable Microparticles: Effect of Particle Size , 1996, Pharmaceutical Research.

[84]  T. Okano,et al.  Doxorubicin-loaded poly(ethylene glycol)-poly(beta-benzyl-L-aspartate) copolymer micelles: their pharmaceutical characteristics and biological significance. , 2000, Journal of controlled release : official journal of the Controlled Release Society.

[85]  J. M. Harris,et al.  Effect of pegylation on pharmaceuticals , 2003, Nature Reviews Drug Discovery.

[86]  Erkki Ruoslahti,et al.  Nanocrystal targeting in vivo , 2002, Proceedings of the National Academy of Sciences of the United States of America.